Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 341

Gene

ZNF341

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 76C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri322 – 344C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 497C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri503 – 525C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 564C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri566 – 588C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 677C2H2-type 11PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri683 – 705C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 341
Gene namesi
Name:ZNF341
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15992. ZNF341.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131061.
PharmGKBiPA38076.

Polymorphism and mutation databases

BioMutaiZNF341.
DMDMi76803837.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475411 – 854Zinc finger protein 341Add BLAST854

Proteomic databases

MaxQBiQ9BYN7.
PaxDbiQ9BYN7.
PeptideAtlasiQ9BYN7.
PRIDEiQ9BYN7.

PTM databases

iPTMnetiQ9BYN7.
PhosphoSitePlusiQ9BYN7.

Expressioni

Gene expression databases

BgeeiENSG00000131061.
CleanExiHS_ZNF341.
ExpressionAtlasiQ9BYN7. baseline and differential.
GenevisibleiQ9BYN7. HS.

Organism-specific databases

HPAiHPA023240.
HPA024607.
HPA067108.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CENPPQ6IPU03EBI-9089622,EBI-10250303
CSTF2P332403EBI-9089622,EBI-711360
KLHL38Q2WGJ63EBI-9089622,EBI-6426443
MAGEB4O154813EBI-9089622,EBI-751857
WDYHV1Q96HA83EBI-9089622,EBI-741158

Protein-protein interaction databases

BioGridi124344. 7 interactors.
IntActiQ9BYN7. 11 interactors.
STRINGi9606.ENSP00000344308.

Structurei

3D structure databases

ProteinModelPortaliQ9BYN7.
SMRiQ9BYN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi143 – 186Pro-richAdd BLAST44

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 76C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri322 – 344C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 497C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri503 – 525C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 564C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri566 – 588C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 677C2H2-type 11PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri683 – 705C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00390000000546.
HOGENOMiHOG000232006.
HOVERGENiHBG056415.
InParanoidiQ9BYN7.
OMAiHTGCSKE.
OrthoDBiEOG091G01QZ.
PhylomeDBiQ9BYN7.
TreeFamiTF333164.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
3.30.40.10. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQAIFEALE GMDNQTVLAV QSLLDGQGAV PDPTGQSVNA PPAIQPLDDE
60 70 80 90 100
DVFLCGKCKK QFNSLPAFMT HKREQCQGNA PALATVSLAT NSIYPPSAAP
110 120 130 140 150
TAVQQAPTPA NRQISTYITV PPSPLIQTLV QGNILVSDDV LMSAMSAFTS
160 170 180 190 200
LDQPMPQGPP PVQSSLNMHS VPSYLTQPPP PPPPPPPLPP PPPPQPPPPP
210 220 230 240 250
PQSLGPPGRP NPGGNGVVEV YSAAAPLAGS GTVEIQALGM QPYPPLEVPN
260 270 280 290 300
QCVEPPVYPT PTVYSPGKQG FKPKGPNPAA PMTSATGGTV ATFDSPATLK
310 320 330 340 350
TRRAKGARGL PEAAGKPKAQ KLKCSYCDKS FTKNFDLQQH IRSHTGEKPF
360 370 380 390 400
QCIACGRAFA QKSNVKKHMQ THKVWPPGHS GGTVSRNSVT VQVMALNPSR
410 420 430 440 450
QEDEESTGLG QPLPGAPQPQ ALSTAGEEEG DKPESKQVVL IDSSYLCQFC
460 470 480 490 500
PSKFSTYFQL KSHMTQHKNE QVYKCVVKSC AQTFPKLDTF LEHIKSHQEE
510 520 530 540 550
LSYRCHLCGK DFPSLYDLGV HQYSHSLLPQ HSPKKDNAVY KCVKCVNKYS
560 570 580 590 600
TPEALEHHLQ TATHNFPCPH CQKVFPCERY LRRHLPTHGS GGRFKCQVCK
610 620 630 640 650
KFFRREHYLK LHAHIHSGEK PYKCSVCESA FNRKDKLKRH MLIHEPFKKY
660 670 680 690 700
KCPFSTHTGC SKEFNRPDKL KAHILSHSGM KLHKCALCSK SFSRRAHLAE
710 720 730 740 750
HQRAHTGNYK FRCAGCAKGF SRHKYLKDHR CRLGPQKDKD LQTRRPPQRR
760 770 780 790 800
AAPRSCGSGG RKVLTPLPDP LGLEELKDTG AGLVPEAVPG KPPFAEPDAV
810 820 830 840 850
LSIVVGGAVG AETELVVPGH AEGLGSNLAL AELQAGAEGP CAMLAVPVYI

QASE
Note: No experimental confirmation available.
Length:854
Mass (Da):92,728
Last modified:September 27, 2005 - v2
Checksum:i1198203F2C7ECF07
GO
Isoform 2 (identifier: Q9BYN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     306-312: Missing.

Note: Gene prediction based on EST data.
Show »
Length:847
Mass (Da):92,047
Checksum:iF386C0D71EDB6936
GO

Sequence cautioni

The sequence BAB55193 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti659G → D in BAB55193 (PubMed:14702039).Curated1
Sequence conflicti706T → M in BAB55193 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027218306 – 312Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050349 Genomic DNA. Translation: CAI21796.2.
CH471077 Genomic DNA. Translation: EAW76295.1.
BC132873 mRNA. Translation: AAI32874.1.
BC144188 mRNA. Translation: AAI44189.1.
BC146811 mRNA. Translation: AAI46812.1.
BC157823 mRNA. Translation: AAI57824.1.
AK027550 mRNA. Translation: BAB55193.1. Different initiation.
CCDSiCCDS13227.1. [Q9BYN7-2]
CCDS74719.1. [Q9BYN7-1]
RefSeqiNP_001269862.1. NM_001282933.1. [Q9BYN7-1]
NP_001269864.1. NM_001282935.1.
NP_116208.3. NM_032819.4. [Q9BYN7-2]
UniGeneiHs.516989.

Genome annotation databases

EnsembliENST00000342427; ENSP00000344308; ENSG00000131061. [Q9BYN7-2]
ENST00000375200; ENSP00000364346; ENSG00000131061. [Q9BYN7-1]
GeneIDi84905.
KEGGihsa:84905.
UCSCiuc002wzx.5. human. [Q9BYN7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050349 Genomic DNA. Translation: CAI21796.2.
CH471077 Genomic DNA. Translation: EAW76295.1.
BC132873 mRNA. Translation: AAI32874.1.
BC144188 mRNA. Translation: AAI44189.1.
BC146811 mRNA. Translation: AAI46812.1.
BC157823 mRNA. Translation: AAI57824.1.
AK027550 mRNA. Translation: BAB55193.1. Different initiation.
CCDSiCCDS13227.1. [Q9BYN7-2]
CCDS74719.1. [Q9BYN7-1]
RefSeqiNP_001269862.1. NM_001282933.1. [Q9BYN7-1]
NP_001269864.1. NM_001282935.1.
NP_116208.3. NM_032819.4. [Q9BYN7-2]
UniGeneiHs.516989.

3D structure databases

ProteinModelPortaliQ9BYN7.
SMRiQ9BYN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124344. 7 interactors.
IntActiQ9BYN7. 11 interactors.
STRINGi9606.ENSP00000344308.

PTM databases

iPTMnetiQ9BYN7.
PhosphoSitePlusiQ9BYN7.

Polymorphism and mutation databases

BioMutaiZNF341.
DMDMi76803837.

Proteomic databases

MaxQBiQ9BYN7.
PaxDbiQ9BYN7.
PeptideAtlasiQ9BYN7.
PRIDEiQ9BYN7.

Protocols and materials databases

DNASUi84905.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342427; ENSP00000344308; ENSG00000131061. [Q9BYN7-2]
ENST00000375200; ENSP00000364346; ENSG00000131061. [Q9BYN7-1]
GeneIDi84905.
KEGGihsa:84905.
UCSCiuc002wzx.5. human. [Q9BYN7-1]

Organism-specific databases

CTDi84905.
GeneCardsiZNF341.
HGNCiHGNC:15992. ZNF341.
HPAiHPA023240.
HPA024607.
HPA067108.
neXtProtiNX_Q9BYN7.
OpenTargetsiENSG00000131061.
PharmGKBiPA38076.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00390000000546.
HOGENOMiHOG000232006.
HOVERGENiHBG056415.
InParanoidiQ9BYN7.
OMAiHTGCSKE.
OrthoDBiEOG091G01QZ.
PhylomeDBiQ9BYN7.
TreeFamiTF333164.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131061-MONOMER.

Miscellaneous databases

ChiTaRSiZNF341. human.
GenomeRNAii84905.
PROiQ9BYN7.

Gene expression databases

BgeeiENSG00000131061.
CleanExiHS_ZNF341.
ExpressionAtlasiQ9BYN7. baseline and differential.
GenevisibleiQ9BYN7. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
3.30.40.10. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN341_HUMAN
AccessioniPrimary (citable) accession number: Q9BYN7
Secondary accession number(s): A2RUF4
, B2RXE5, B7ZM09, Q5JXM8, Q96ST5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: September 27, 2005
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.