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Protein

Sulfiredoxin-1

Gene

SRXN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.2 Publications

Catalytic activityi

Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.

Cofactori

Mg2+By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi98 – 101ATP4

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: GO_Central
  • response to oxidative stress Source: UniProtKB

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDAi1.8.98.2 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfiredoxin-1 (EC:1.8.98.2)
Gene namesi
Name:SRXN1
Synonyms:C20orf139, SRX, SRX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000271303.1
HGNCiHGNC:16132 SRXN1
MIMi617583 gene
neXtProtiNX_Q9BYN0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi99C → S: No effect on association with PRDX1, PRDX2, PRDX3 or PRDX4. 1 Publication1

Organism-specific databases

DisGeNETi140809
OpenTargetsiENSG00000271303
PharmGKBiPA25681

Polymorphism and mutation databases

DMDMi30315944

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114311 – 137Sulfiredoxin-1Add BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11Omega-N-methylarginineCombined sources1
Modified residuei16Omega-N-methylarginineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Disulfide bondi99InterchainBy similarity

Keywords - PTMi

Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9BYN0
MaxQBiQ9BYN0
PaxDbiQ9BYN0
PeptideAtlasiQ9BYN0
PRIDEiQ9BYN0

PTM databases

iPTMnetiQ9BYN0
PhosphoSitePlusiQ9BYN0

Expressioni

Tissue specificityi

Widely expressed with highest levels in kidney, lung, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000271303
CleanExiHS_SRXN1
GenevisibleiQ9BYN0 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRDX1Q068303EBI-15678820,EBI-353193

Protein-protein interaction databases

BioGridi126716, 39 interactors
CORUMiQ9BYN0
DIPiDIP-59836N
IntActiQ9BYN0, 1 interactor
STRINGi9606.ENSP00000371388

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 24Combined sources3
Beta strandi26 – 28Combined sources3
Beta strandi39 – 45Combined sources7
Helixi46 – 48Combined sources3
Helixi59 – 71Combined sources13
Helixi73 – 75Combined sources3
Beta strandi79 – 85Combined sources7
Beta strandi91 – 94Combined sources4
Helixi99 – 107Combined sources9
Beta strandi111 – 120Combined sources10
Helixi122 – 129Combined sources8
Helixi130 – 132Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XW3X-ray1.65A32-137[»]
1XW4X-ray2.00X32-137[»]
1YZSNMR-A17-137[»]
2B6FNMR-A17-137[»]
2RIIX-ray2.60X/Y32-137[»]
3CYIX-ray1.80A32-137[»]
3HY2X-ray2.10X/Y32-137[»]
ProteinModelPortaliQ9BYN0
SMRiQ9BYN0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BYN0

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfiredoxin family.Curated

Phylogenomic databases

eggNOGiKOG3388 Eukaryota
COG5119 LUCA
GeneTreeiENSGT00390000007832
HOGENOMiHOG000231799
HOVERGENiHBG080441
InParanoidiQ9BYN0
KOiK12260
OMAiGGCHRFA
OrthoDBiEOG091G10MM
PhylomeDBiQ9BYN0
TreeFamiTF300230

Family and domain databases

InterProiView protein in InterPro
IPR003115 ParB/Sulfiredoxin_dom
IPR036086 ParB/Sulfiredoxin_sf
IPR016692 Sulfiredoxin
PANTHERiPTHR21348 PTHR21348, 1 hit
PfamiView protein in Pfam
PF02195 ParBc, 1 hit
PIRSFiPIRSF017267 Sulfiredoxin, 1 hit
SMARTiView protein in SMART
SM00470 ParB, 1 hit
SUPFAMiSSF110849 SSF110849, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BYN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRAGGTLG RAGAGRGAPE GPGPSGGAQG GSIHSGRIAA VHNVPLSVLI
60 70 80 90 100
RPLPSVLDPA KVQSLVDTIR EDPDSVPPID VLWIKGAQGG DYFYSFGGCH
110 120 130
RYAAYQQLQR ETIPAKLVQS TLSDLRVYLG ASTPDLQ
Length:137
Mass (Da):14,259
Last modified:April 30, 2003 - v2
Checksum:i44F2C4256E5574D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312054 mRNA Translation: BAG34990.1
AL833944 mRNA Translation: CAD38799.1
AL121758 Genomic DNA No translation available.
BC017001 mRNA Translation: AAH17001.1
BC032604 mRNA Translation: AAH32604.1
BC047707 mRNA Translation: AAH47707.1
CCDSiCCDS13005.1
RefSeqiNP_542763.1, NM_080725.2
UniGeneiHs.516830

Genome annotation databases

EnsembliENST00000381962; ENSP00000371388; ENSG00000271303
GeneIDi140809
KEGGihsa:140809
UCSCiuc002wea.5 human

Similar proteinsi

Entry informationi

Entry nameiSRXN1_HUMAN
AccessioniPrimary (citable) accession number: Q9BYN0
Secondary accession number(s): B2R543, Q8NDM3, Q96AK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: March 28, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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