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Protein

Sulfiredoxin-1

Gene

SRXN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.2 Publications

Catalytic activityi

Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.

Cofactori

Mg2+By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi98 – 1014ATP

GO - Molecular functioni

GO - Biological processi

  • response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDAi1.8.98.2. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfiredoxin-1 (EC:1.8.98.2)
Gene namesi
Name:SRXN1
Synonyms:C20orf139, SRX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16132. SRXN1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi99 – 991C → S: No effect on association with PRDX1, PRDX2, PRDX3 or PRDX4. 1 Publication

Organism-specific databases

PharmGKBiPA25681.

Polymorphism and mutation databases

DMDMi30315944.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Sulfiredoxin-1PRO_0000211431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321PhosphoserineCombined sources
Disulfide bondi99 – 99InterchainBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ9BYN0.
MaxQBiQ9BYN0.
PaxDbiQ9BYN0.
PeptideAtlasiQ9BYN0.
PRIDEiQ9BYN0.

PTM databases

iPTMnetiQ9BYN0.
PhosphoSiteiQ9BYN0.

Expressioni

Tissue specificityi

Widely expressed with highest levels in kidney, lung, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000271303.
CleanExiHS_SRXN1.
GenevisibleiQ9BYN0. HS.

Interactioni

Protein-protein interaction databases

BioGridi126716. 39 interactions.
DIPiDIP-59836N.
MINTiMINT-4714272.
STRINGi9606.ENSP00000371388.

Structurei

Secondary structure

1
137
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 243Combined sources
Beta strandi26 – 283Combined sources
Beta strandi39 – 457Combined sources
Helixi46 – 483Combined sources
Helixi59 – 7113Combined sources
Helixi73 – 753Combined sources
Beta strandi79 – 857Combined sources
Beta strandi91 – 944Combined sources
Helixi99 – 1079Combined sources
Beta strandi111 – 12010Combined sources
Helixi122 – 1298Combined sources
Helixi130 – 1323Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XW3X-ray1.65A32-137[»]
1XW4X-ray2.00X32-137[»]
1YZSNMR-A17-137[»]
2B6FNMR-A17-137[»]
2RIIX-ray2.60X/Y32-137[»]
3CYIX-ray1.80A32-137[»]
3HY2X-ray2.10X/Y32-137[»]
ProteinModelPortaliQ9BYN0.
SMRiQ9BYN0. Positions 17-137.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BYN0.

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfiredoxin family.Curated

Phylogenomic databases

eggNOGiKOG3388. Eukaryota.
COG5119. LUCA.
GeneTreeiENSGT00390000007832.
HOGENOMiHOG000231799.
HOVERGENiHBG080441.
InParanoidiQ9BYN0.
KOiK12260.
OMAiCHRFEAY.
OrthoDBiEOG091G10MM.
PhylomeDBiQ9BYN0.
TreeFamiTF300230.

Family and domain databases

InterProiIPR003115. ParB/Sulfiredoxin_dom.
IPR016692. Sulfiredoxin.
[Graphical view]
PANTHERiPTHR21348. PTHR21348. 1 hit.
PfamiPF02195. ParBc. 1 hit.
[Graphical view]
PIRSFiPIRSF017267. Sulfiredoxin. 1 hit.
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BYN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRAGGTLG RAGAGRGAPE GPGPSGGAQG GSIHSGRIAA VHNVPLSVLI
60 70 80 90 100
RPLPSVLDPA KVQSLVDTIR EDPDSVPPID VLWIKGAQGG DYFYSFGGCH
110 120 130
RYAAYQQLQR ETIPAKLVQS TLSDLRVYLG ASTPDLQ
Length:137
Mass (Da):14,259
Last modified:April 30, 2003 - v2
Checksum:i44F2C4256E5574D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312054 mRNA. Translation: BAG34990.1.
AL833944 mRNA. Translation: CAD38799.1.
AL121758 Genomic DNA. Translation: CAI23005.1.
BC017001 mRNA. Translation: AAH17001.1.
BC032604 mRNA. Translation: AAH32604.1.
BC047707 mRNA. Translation: AAH47707.1.
CCDSiCCDS13005.1.
RefSeqiNP_542763.1. NM_080725.2.
UniGeneiHs.516830.

Genome annotation databases

EnsembliENST00000381962; ENSP00000371388; ENSG00000271303.
GeneIDi140809.
KEGGihsa:140809.
UCSCiuc002wea.5. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312054 mRNA. Translation: BAG34990.1.
AL833944 mRNA. Translation: CAD38799.1.
AL121758 Genomic DNA. Translation: CAI23005.1.
BC017001 mRNA. Translation: AAH17001.1.
BC032604 mRNA. Translation: AAH32604.1.
BC047707 mRNA. Translation: AAH47707.1.
CCDSiCCDS13005.1.
RefSeqiNP_542763.1. NM_080725.2.
UniGeneiHs.516830.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XW3X-ray1.65A32-137[»]
1XW4X-ray2.00X32-137[»]
1YZSNMR-A17-137[»]
2B6FNMR-A17-137[»]
2RIIX-ray2.60X/Y32-137[»]
3CYIX-ray1.80A32-137[»]
3HY2X-ray2.10X/Y32-137[»]
ProteinModelPortaliQ9BYN0.
SMRiQ9BYN0. Positions 17-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126716. 39 interactions.
DIPiDIP-59836N.
MINTiMINT-4714272.
STRINGi9606.ENSP00000371388.

PTM databases

iPTMnetiQ9BYN0.
PhosphoSiteiQ9BYN0.

Polymorphism and mutation databases

DMDMi30315944.

Proteomic databases

EPDiQ9BYN0.
MaxQBiQ9BYN0.
PaxDbiQ9BYN0.
PeptideAtlasiQ9BYN0.
PRIDEiQ9BYN0.

Protocols and materials databases

DNASUi140809.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381962; ENSP00000371388; ENSG00000271303.
GeneIDi140809.
KEGGihsa:140809.
UCSCiuc002wea.5. human.

Organism-specific databases

CTDi140809.
GeneCardsiSRXN1.
HGNCiHGNC:16132. SRXN1.
neXtProtiNX_Q9BYN0.
PharmGKBiPA25681.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3388. Eukaryota.
COG5119. LUCA.
GeneTreeiENSGT00390000007832.
HOGENOMiHOG000231799.
HOVERGENiHBG080441.
InParanoidiQ9BYN0.
KOiK12260.
OMAiCHRFEAY.
OrthoDBiEOG091G10MM.
PhylomeDBiQ9BYN0.
TreeFamiTF300230.

Enzyme and pathway databases

BRENDAi1.8.98.2. 2681.

Miscellaneous databases

ChiTaRSiSRXN1. human.
EvolutionaryTraceiQ9BYN0.
GeneWikiiSRXN1.
GenomeRNAii140809.
PROiQ9BYN0.

Gene expression databases

BgeeiENSG00000271303.
CleanExiHS_SRXN1.
GenevisibleiQ9BYN0. HS.

Family and domain databases

InterProiIPR003115. ParB/Sulfiredoxin_dom.
IPR016692. Sulfiredoxin.
[Graphical view]
PANTHERiPTHR21348. PTHR21348. 1 hit.
PfamiPF02195. ParBc. 1 hit.
[Graphical view]
PIRSFiPIRSF017267. Sulfiredoxin. 1 hit.
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSRXN1_HUMAN
AccessioniPrimary (citable) accession number: Q9BYN0
Secondary accession number(s): B2R543, Q8NDM3, Q96AK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: September 7, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.