Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Helicase with zinc finger domain 2

Gene

HELZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri40 – 6425C2H2-type; atypicalAdd
BLAST
Nucleotide bindingi544 – 5518ATPSequence analysis
Nucleotide bindingi2174 – 21818ATPSequence analysis

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • helicase activity Source: UniProtKB-KW
  • ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1368082. RORA activates gene expression.
R-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
R-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.
R-HSA-2426168. Activation of gene expression by SREBF (SREBP).
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
R-HSA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
R-HSA-400253. Circadian Clock.

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase with zinc finger domain 2
Alternative name(s):
ATP-dependent helicase PRIC285
Helicase with zinc finger 2, transcriptional coactivator
PPAR-alpha-interacting complex protein 285
PPAR-gamma DNA-binding domain-interacting protein 1
Short name:
PDIP1
Short name:
PPAR-gamma DBD-interacting protein 1
Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC:3.6.4.-)
Gene namesi
Name:HELZ2
Synonyms:KIAA1769, PRIC285
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:30021. HELZ2.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiHELZ2.
DMDMi317373591.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26492649Helicase with zinc finger domain 2PRO_0000058561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1006 – 10061PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BYK8.
MaxQBiQ9BYK8.
PaxDbiQ9BYK8.
PeptideAtlasiQ9BYK8.
PRIDEiQ9BYK8.

PTM databases

iPTMnetiQ9BYK8.
PhosphoSiteiQ9BYK8.

Expressioni

Tissue specificityi

Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood and placenta.1 Publication

Gene expression databases

BgeeiENSG00000130589.
GenevisibleiQ9BYK8. HS.

Organism-specific databases

HPAiHPA051267.

Interactioni

Subunit structurei

Interacts with PPARA (via DNA-binding domain) and PPARG; the interaction stimulates the transcriptional activity of PPARA and PPARG. Interacts with THRAP3; the interaction is direct and HELZ2 and THRAP3 synergistically enhance the transcriptional activity of PPARG. It is probably part of the peroxisome proliferator activated receptor alpha interacting complex (PRIC).2 Publications

Protein-protein interaction databases

BioGridi124528. 10 interactions.
IntActiQ9BYK8. 1 interaction.
STRINGi9606.ENSP00000417401.

Structurei

3D structure databases

ProteinModelPortaliQ9BYK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni563 – 1059497Interaction with THRAP3Add
BLAST
Regioni2135 – 2649515Interaction with THRAP3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi667 – 6704DEAA box
Motifi1075 – 10795LXXLL motif 1
Motifi1118 – 11225LXXLL motif 2
Motifi1173 – 11775LXXLL motif 3
Motifi2012 – 20165LXXLL motif 4
Motifi2229 – 22335LXXLL motif 5

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi968 – 105992Ala-richAdd
BLAST

Domaini

Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG.1 Publication

Sequence similaritiesi

Belongs to the DNA2/NAM7 helicase family.Curated
Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri40 – 6425C2H2-type; atypicalAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1804. Eukaryota.
KOG2102. Eukaryota.
COG0557. LUCA.
COG1112. LUCA.
GeneTreeiENSGT00800000124068.
HOGENOMiHOG000231856.
HOVERGENiHBG080465.
InParanoidiQ9BYK8.
OMAiPRHPQHY.
OrthoDBiEOG091G01CH.
PhylomeDBiQ9BYK8.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR031191. HELZ2.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR022966. RNase_II/R_CS.
[Graphical view]
PANTHERiPTHR10887:SF376. PTHR10887:SF376. 3 hits.
SUPFAMiSSF50249. SSF50249. 4 hits.
SSF52540. SSF52540. 4 hits.
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYK8-1) [UniParc]FASTAAdd to basket
Also known as: PDIP1-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVWEAEQLG GLQRGDLLTP PAPDGDGRTA PLGQPPGAQL YCPACLVTCH
60 70 80 90 100
SQEAFENHCA SSEHAQMVAF DQALPWEHRS PPPGLSKFEL CPKPDLCEYG
110 120 130 140 150
DACTKAHSAQ ELQEWVRRTQ AVELRGQAAW QDGLVPYQER LLAEYQRSSS
160 170 180 190 200
EVLVLAETLD GVRVTCNQPL MYQAQERKTQ YSWTFAVHSE EPLLHVALLK
210 220 230 240 250
QEPGADFSLV APGLPPGRLY ARGERFRVPS STADFQVGVR VQAASFGTFE
260 270 280 290 300
QWVVFDFGRR PVLLQKLGLQ LGQGRRPGPC RNLALGHPEE MERWHTGNRH
310 320 330 340 350
VVPGVERTAE QTALMAKYKG PALALEFNRS SVASGPISPT NYRQRMHQFL
360 370 380 390 400
YEEEAAQQQL VAKLTLRGQV FLKTALQTPA LNMLFAPPGA LYAEVPVPSS
410 420 430 440 450
LMPDTDQGFL LGRAVSTALV APVPAPDNTV FEVRLERRAS SEQALWLLLP
460 470 480 490 500
ARCCLALGLQ PEARLVLEVQ FQIDPMTFRL WHQAVDTLPE EQLVVPDLPT
510 520 530 540 550
CALPRPWSVP PLRRGNRKQE LAVALIAGWG PGDGRRVPPL LIYGPFGTGK
560 570 580 590 600
TYTLAMASLE VIRRPETKVL ICTHTNSAAD IYIREYFHSH VSGGHPEATP
610 620 630 640 650
LRVMYTDRPL SQTDPVTLQY CCLTDDRQAF RPPTRAELAR HRVVVTTTSQ
660 670 680 690 700
ARELRVPVGF FSHILIDEAA QMLECEALTP LAYASHGTRL VLAGDHMQVT
710 720 730 740 750
PRLFSVARAR AAEHTLLHRL FLCYQQETHE VARQSRLVFH ENYRCTDAIV
760 770 780 790 800
SFISRHFYVA KGNPIHARGK VPPHPRHYPL MFCHVAGSPD RDMSMASWLN
810 820 830 840 850
LAEIAQVVEK VQEAYNTWPS CWGGREQRCI CVVSHGAQVS ALRQELRRRD
860 870 880 890 900
LGQVSVGSFE ILPGRQFRVV VLSTVHTCQS LLSPGALAPE FFTDARVLNT
910 920 930 940 950
VLTRAQSQLV VVGDAVALCS FGACGKLWES FIRECVERHS VCPEGLSMEQ
960 970 980 990 1000
VEQGVAQRRR WPPRGTQAGA AGNWEAAPEP VGDLAEEQAA VVTAMVKAEP
1010 1020 1030 1040 1050
GDEALSPASR DITATTAQTE AAAAPAGDAV KEDVVPGACA AGAAAAAGVE
1060 1070 1080 1090 1100
STEAEDAEAD FWPWDGELNA DDAILRELLD ESQKVMVTVG EDGLLDTVAR
1110 1120 1130 1140 1150
PESLQQARLY ENLPPAALRK LLHAEPERYR HCSFVPETFE RASAIPLDDA
1160 1170 1180 1190 1200
SSGPIQVRGR LDCGMAFAGD EVLVQLLSGD KAPEGRLRGR VLGVLKRKRH
1210 1220 1230 1240 1250
ELAFVCRMDT WDPRIMVPIN GSVTKIFVAE LKDPSQVPIY SLRKGRLQRV
1260 1270 1280 1290 1300
GLERLTAEAR HSRLFWVQIV LWRQGFYYPL GIVREVLPEA STWEQGLRIL
1310 1320 1330 1340 1350
GLEYSLRVPP SDQATITKVL QKYHTELGRV AGRREDCRAF LTFTVDPQGA
1360 1370 1380 1390 1400
CNLDDALSVR DLGPRCEVAV HITDVASFVP RDGVLDVEAR RQGAAFYAPG
1410 1420 1430 1440 1450
REPVPMLPAS LCQDVLSLLP GRDRLAISLF LTMEKASGQL KSLRFAPSVV
1460 1470 1480 1490 1500
QSDRQLSYEE AEEVIRQHPG AGRELPARLD SVDACVVAAC YFSRLLRRHR
1510 1520 1530 1540 1550
LRSDCFYEQP DEDGTLGFRA AHIMVKEYMI QFNRLVAEFL VGSECTRTVT
1560 1570 1580 1590 1600
PLRWQPAPRS QQLKALCEKH GDRVPLSLHL GHHLHGGGGS PPDTRLHLLA
1610 1620 1630 1640 1650
SLWKQVQFAA RTQDYEQMVD LVTTDDMHPF LAPAGRDLRK ALERSAFGRC
1660 1670 1680 1690 1700
ARGHQQQGGH YSLQVDWYTW ATSPIRRYLD VVLQRQILLA LGHGGSAYSA
1710 1720 1730 1740 1750
RDIDGLCQAF SLQHALAQSY QRRARSLHLA VQLKAQPLDK LGFVVDVEAG
1760 1770 1780 1790 1800
SRCFRLLFPS NRETLPDPCP VPYGSLQLAE HPHALAGRPG LRLLWRRRVY
1810 1820 1830 1840 1850
SAQGSSPPLP LPGTVPDPHT LAVETALWKQ LLELVELQRW PEAAALIQEK
1860 1870 1880 1890 1900
GEASQRRELV QVQRSHCGHF LEVARELGSG DTLQVQLGTS LQHGFLVPSP
1910 1920 1930 1940 1950
QLWTVAPGFS LCLEHVERPG DCFSGRVYRA PRDRYRDVDE YACVWEPFCA
1960 1970 1980 1990 2000
LESATGAVAE NDSVTLQHLS VSWEASRTPQ GQLQGAFRLE AAFLEENCAD
2010 2020 2030 2040 2050
INFSCCYLCI RLEGLPAPTA SPRPGPSSLG PGLNVDPGTY TWVAHGQTQD
2060 2070 2080 2090 2100
WDQERRADRQ EAPRRVHLFV HHMGMEKVPE EVLRPGTLFT VELLPKQLPD
2110 2120 2130 2140 2150
LRKEEAVRGL EEASPLVTSI ALGRPVPQPL CRVIPSRFLE RQTYNIPGGR
2160 2170 2180 2190 2200
HKLNPSQNVA VREALEKPFT VIQGPPGTGK TIVGLHIVFW FHKSNQEQVQ
2210 2220 2230 2240 2250
PGGPPRGEKR LGGPCILYCG PSNKSVDVLA GLLLRRMELK PLRVYSEQAE
2260 2270 2280 2290 2300
ASEFPVPRVG SRKLLRKSPR EGRPNQSLRS ITLHHRIRQA PNPYSSEIKA
2310 2320 2330 2340 2350
FDTRLQRGEL FSREDLVWYK KVLWEARKFE LDRHEVILCT CSCAASASLK
2360 2370 2380 2390 2400
ILDVRQILVD EAGMATEPET LIPLVQFPQA EKVVLLGDHK QLRPVVKNER
2410 2420 2430 2440 2450
LQNLGLDRSL FERYHEDAHM LDTQYRMHEG ICAFPSVAFY KSKLKTWQGL
2460 2470 2480 2490 2500
RRPPSVLGHA GKESCPVIFG HVQGHERSLL VSTDEGNENS KANLEEVAEV
2510 2520 2530 2540 2550
VRITKQLTLG RTVEPQDIAV LTPYNAQASE ISKALRREGI AGVAVSSITK
2560 2570 2580 2590 2600
SQGSEWRYVL VSTVRTCAKS DLDQRPTKSW LKKFLGFVVD PNQVNVAVTR
2610 2620 2630 2640
AQEGLCLIGD HLLLRCCPLW RSLLDFCEAQ QTLVPAGQVR VCRRPTMPS
Note: More abundantly expressed than isoform 2.
Length:2,649
Mass (Da):294,651
Last modified:January 11, 2011 - v6
Checksum:i419573D5AEE700D7
GO
Isoform 2 (identifier: Q9BYK8-2) [UniParc]FASTAAdd to basket
Also known as: PDIP1-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-569: Missing.
     570-576: LICTHTN → MSSSPSR

Show »
Length:2,080
Mass (Da):231,670
Checksum:i35FB7F42FC6B1032
GO
Isoform 3 (identifier: Q9BYK8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-535: Missing.
     536-576: RVPPLLIYGP...TKVLICTHTN → LTSDSQTRAV...KKPMSSSPSR

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:2,114
Mass (Da):235,048
Checksum:i715DEB33785A56D3
GO

Sequence cautioni

The sequence BAB70969 differs from that shown. Reason: Frameshift at position 2206. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961V → A in BAE46995 (PubMed:16239304).Curated
Sequence conflicti327 – 3293FNR → SNH in BAE46995 (PubMed:16239304).Curated
Sequence conflicti442 – 4421E → G in BAE46995 (PubMed:16239304).Curated
Sequence conflicti836 – 8361G → D in BAE46995 (PubMed:16239304).Curated
Sequence conflicti1873 – 18731V → A in BAE46995 (PubMed:16239304).Curated
Sequence conflicti2203 – 22031G → S in BAE46995 (PubMed:16239304).Curated
Sequence conflicti2383 – 23831V → A in BAE46995 (PubMed:16239304).Curated
Sequence conflicti2626 – 26261F → L in BAE46995 (PubMed:16239304).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti788 – 7881S → N.3 Publications
Corresponds to variant rs438363 [ dbSNP | Ensembl ].
VAR_015597
Natural varianti1123 – 11231H → R.3 Publications
Corresponds to variant rs310632 [ dbSNP | Ensembl ].
VAR_015598
Natural varianti1152 – 11521S → L.
Corresponds to variant rs35817585 [ dbSNP | Ensembl ].
VAR_047038
Natural varianti1308 – 13081V → L.
Corresponds to variant rs310631 [ dbSNP | Ensembl ].
VAR_047039
Natural varianti1381 – 13811R → K.
Corresponds to variant rs3810487 [ dbSNP | Ensembl ].
VAR_047040
Natural varianti1821 – 18211L → R.
Corresponds to variant rs3810486 [ dbSNP | Ensembl ].
VAR_047041
Natural varianti1889 – 18891T → A.
Corresponds to variant rs34980032 [ dbSNP | Ensembl ].
VAR_047042
Natural varianti2016 – 20161P → L.3 Publications
Corresponds to variant rs3810485 [ dbSNP | Ensembl ].
VAR_015599
Natural varianti2049 – 20491Q → E.3 Publications
Corresponds to variant rs3810483 [ dbSNP | Ensembl ].
VAR_015600
Natural varianti2170 – 21701T → M.
Corresponds to variant rs3810481 [ dbSNP | Ensembl ].
VAR_047043

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 569569Missing in isoform 2. 2 PublicationsVSP_007297Add
BLAST
Alternative sequencei1 – 535535Missing in isoform 3. CuratedVSP_017377Add
BLAST
Alternative sequencei536 – 57641RVPPL…CTHTN → LTSDSQTRAVLRGSSAGHTV GALADSTEAPSKKPMSSSPS R in isoform 3. CuratedVSP_017378Add
BLAST
Alternative sequencei570 – 5767LICTHTN → MSSSPSR in isoform 2. 2 PublicationsVSP_007298

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF517673 mRNA. Translation: AAM74197.1.
AB201715 mRNA. Translation: BAE46995.1.
AB051556 mRNA. Translation: BAB21860.2.
AL121829 Genomic DNA. Translation: CAI95749.1.
AK074171 mRNA. Translation: BAB84997.1.
AK055611 mRNA. Translation: BAB70969.1. Frameshift.
CCDSiCCDS13527.1. [Q9BYK8-2]
CCDS33508.1. [Q9BYK8-1]
RefSeqiNP_001032412.2. NM_001037335.2. [Q9BYK8-1]
NP_208384.3. NM_033405.3. [Q9BYK8-2]
UniGeneiHs.517180.

Genome annotation databases

EnsembliENST00000427522; ENSP00000393257; ENSG00000130589. [Q9BYK8-2]
ENST00000467148; ENSP00000417401; ENSG00000130589. [Q9BYK8-1]
GeneIDi85441.
KEGGihsa:85441.
UCSCiuc002yfl.2. human. [Q9BYK8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF517673 mRNA. Translation: AAM74197.1.
AB201715 mRNA. Translation: BAE46995.1.
AB051556 mRNA. Translation: BAB21860.2.
AL121829 Genomic DNA. Translation: CAI95749.1.
AK074171 mRNA. Translation: BAB84997.1.
AK055611 mRNA. Translation: BAB70969.1. Frameshift.
CCDSiCCDS13527.1. [Q9BYK8-2]
CCDS33508.1. [Q9BYK8-1]
RefSeqiNP_001032412.2. NM_001037335.2. [Q9BYK8-1]
NP_208384.3. NM_033405.3. [Q9BYK8-2]
UniGeneiHs.517180.

3D structure databases

ProteinModelPortaliQ9BYK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124528. 10 interactions.
IntActiQ9BYK8. 1 interaction.
STRINGi9606.ENSP00000417401.

PTM databases

iPTMnetiQ9BYK8.
PhosphoSiteiQ9BYK8.

Polymorphism and mutation databases

BioMutaiHELZ2.
DMDMi317373591.

Proteomic databases

EPDiQ9BYK8.
MaxQBiQ9BYK8.
PaxDbiQ9BYK8.
PeptideAtlasiQ9BYK8.
PRIDEiQ9BYK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427522; ENSP00000393257; ENSG00000130589. [Q9BYK8-2]
ENST00000467148; ENSP00000417401; ENSG00000130589. [Q9BYK8-1]
GeneIDi85441.
KEGGihsa:85441.
UCSCiuc002yfl.2. human. [Q9BYK8-1]

Organism-specific databases

CTDi85441.
GeneCardsiHELZ2.
HGNCiHGNC:30021. HELZ2.
HPAiHPA051267.
MIMi611265. gene.
neXtProtiNX_Q9BYK8.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1804. Eukaryota.
KOG2102. Eukaryota.
COG0557. LUCA.
COG1112. LUCA.
GeneTreeiENSGT00800000124068.
HOGENOMiHOG000231856.
HOVERGENiHBG080465.
InParanoidiQ9BYK8.
OMAiPRHPQHY.
OrthoDBiEOG091G01CH.
PhylomeDBiQ9BYK8.

Enzyme and pathway databases

ReactomeiR-HSA-1368082. RORA activates gene expression.
R-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
R-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.
R-HSA-2426168. Activation of gene expression by SREBF (SREBP).
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
R-HSA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
R-HSA-400253. Circadian Clock.

Miscellaneous databases

GeneWikiiPRIC285.
GenomeRNAii85441.
PROiQ9BYK8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130589.
GenevisibleiQ9BYK8. HS.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR031191. HELZ2.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR022966. RNase_II/R_CS.
[Graphical view]
PANTHERiPTHR10887:SF376. PTHR10887:SF376. 3 hits.
SUPFAMiSSF50249. SSF50249. 4 hits.
SSF52540. SSF52540. 4 hits.
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHELZ2_HUMAN
AccessioniPrimary (citable) accession number: Q9BYK8
Secondary accession number(s): Q3C2G2
, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: January 11, 2011
Last modified: September 7, 2016
This is version 158 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PubMed:12189208 experiments have been carried out partly in rat and partly in human.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.