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Q9BYJ4

- TRI34_HUMAN

UniProt

Q9BYJ4 - TRI34_HUMAN

Protein

Tripartite motif-containing protein 34

Gene

TRIM34

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri15 – 6046RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri92 – 13443B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProt
    2. protein trimerization Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 34
    Alternative name(s):
    Interferon-responsive finger protein 1
    RING finger protein 21
    Gene namesi
    Name:TRIM34
    Synonyms:IFP1, RNF21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10063. TRIM34.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35533.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Tripartite motif-containing protein 34PRO_0000056248Add
    BLAST

    Proteomic databases

    MaxQBiQ9BYJ4.
    PaxDbiQ9BYJ4.
    PRIDEiQ9BYJ4.

    PTM databases

    PhosphoSiteiQ9BYJ4.

    Expressioni

    Tissue specificityi

    Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes.1 Publication

    Inductioni

    Isoform 1 is up-regulated by interferons.1 Publication

    Gene expression databases

    BgeeiQ9BYJ4.
    CleanExiHS_TRIM34.
    GenevestigatoriQ9BYJ4.

    Interactioni

    Protein-protein interaction databases

    BioGridi119809. 11 interactions.
    IntActiQ9BYJ4. 6 interactions.
    MINTiMINT-6631709.
    STRINGi9606.ENSP00000346916.

    Structurei

    Secondary structure

    1
    488
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni16 – 194
    Beta strandi29 – 313
    Helixi36 – 394
    Beta strandi47 – 493
    Beta strandi57 – 593
    Helixi67 – 693
    Beta strandi72 – 743

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EGPNMR-A8-79[»]
    ProteinModelPortaliQ9BYJ4.
    SMRiQ9BYJ4. Positions 8-79, 91-133, 287-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BYJ4.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini283 – 488206B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili131 – 239109Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi154 – 1596Poly-Glu
    Compositional biasi206 – 2094Poly-Glu

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri15 – 6046RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri92 – 13443B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG259921.
    HOGENOMiHOG000234134.
    HOVERGENiHBG001357.
    InParanoidiQ9BYJ4.
    KOiK11999.
    OrthoDBiEOG7RJPR6.
    PhylomeDBiQ9BYJ4.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BYJ4-1) [UniParc]FASTAAdd to Basket

    Also known as: Medium

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASKILLNVQ EEVTCPICLE LLTEPLSLDC GHSLCRACIT VSNKEAVTSM    50
    GGKSSCPVCG ISYSFEHLQA NQHLANIVER LKEVKLSPDN GKKRDLCDHH 100
    GEKLLLFCKE DRKVICWLCE RSQEHRGHHT VLTEEVFKEC QEKLQAVLKR 150
    LKKEEEEAEK LEADIREEKT SWKYQVQTER QRIQTEFDQL RSILNNEEQR 200
    ELQRLEEEEK KTLDKFAEAE DELVQQKQLV RELISDVECR SQWSTMELLQ 250
    DMSGIMKWSE IWRLKKPKMV SKKLKTVFHA PDLSRMLQMF RELTAVRCYW 300
    VDVTLNSVNL NLNLVLSEDQ RQVISVPIWP FQCYNYGVLG SQYFSSGKHY 350
    WEVDVSKKTA WILGVYCRTY SRHMKYVVRR CANRQNLYTK YRPLFGYWVI 400
    GLQNKCKYGV FEESLSSDPE VLTLSMAVPP CRVGVFLDYE AGIVSFFNVT 450
    SHGSLIYKFS KCCFSQPVYP YFNPWNCPAP MTLCPPSS 488
    Length:488
    Mass (Da):56,864
    Last modified:November 23, 2004 - v2
    Checksum:iF2D60A16576187A0
    GO
    Isoform 2 (identifier: Q9BYJ4-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         259-270: SEIWRLKKPKMV → CVWVATSGACEL
         271-488: Missing.

    Show »
    Length:270
    Mass (Da):31,338
    Checksum:i7802B9B749E5111F
    GO

    Sequence cautioni

    The sequence BAB17050.1 differs from that shown. Reason: The in vivo relevance of this transcript of the TRIM6 (AC Q9C030) and TRIM34 genes creating a chimeric protein of 842 residues is uncertain.
    The sequence AAG53517.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti349 – 3491H → Y(PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti276 – 2761T → S.
    Corresponds to variant rs6578670 [ dbSNP | Ensembl ].
    VAR_019825
    Natural varianti282 – 2821D → H.
    Corresponds to variant rs3740997 [ dbSNP | Ensembl ].
    VAR_019826
    Natural varianti404 – 4041N → K.
    Corresponds to variant rs16933844 [ dbSNP | Ensembl ].
    VAR_052141

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei259 – 27012SEIWR…KPKMV → CVWVATSGACEL in isoform 2. 1 PublicationVSP_011921Add
    BLAST
    Alternative sequencei271 – 488218Missing in isoform 2. 1 PublicationVSP_011922Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039902 mRNA. Translation: BAB17049.1.
    AB039903 mRNA. Translation: BAB17050.1. Sequence problems.
    AB039904 mRNA. Translation: BAB17051.1.
    AF220143 mRNA. Translation: AAG53516.1.
    AF220144 mRNA. Translation: AAG53517.1. Different initiation.
    AK027876 mRNA. Translation: BAB55424.1.
    CH471064 Genomic DNA. Translation: EAW68778.1.
    CH471064 Genomic DNA. Translation: EAW68780.1.
    AL583914 mRNA. Translation: CAC29498.1.
    CCDSiCCDS31391.1. [Q9BYJ4-1]
    RefSeqiNP_001003827.1. NM_001003827.1. [Q9BYJ4-1]
    NP_067629.2. NM_021616.5. [Q9BYJ4-1]
    NP_569074.2. NM_130390.2.
    UniGeneiHs.729048.

    Genome annotation databases

    EnsembliENST00000429814; ENSP00000402595; ENSG00000258659. [Q9BYJ4-1]
    ENST00000514226; ENSP00000422947; ENSG00000258659. [Q9BYJ4-1]
    GeneIDi53840.
    KEGGihsa:53840.
    UCSCiuc001mbh.3. human. [Q9BYJ4-1]

    Polymorphism databases

    DMDMi55976584.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039902 mRNA. Translation: BAB17049.1 .
    AB039903 mRNA. Translation: BAB17050.1 . Sequence problems.
    AB039904 mRNA. Translation: BAB17051.1 .
    AF220143 mRNA. Translation: AAG53516.1 .
    AF220144 mRNA. Translation: AAG53517.1 . Different initiation.
    AK027876 mRNA. Translation: BAB55424.1 .
    CH471064 Genomic DNA. Translation: EAW68778.1 .
    CH471064 Genomic DNA. Translation: EAW68780.1 .
    AL583914 mRNA. Translation: CAC29498.1 .
    CCDSi CCDS31391.1. [Q9BYJ4-1 ]
    RefSeqi NP_001003827.1. NM_001003827.1. [Q9BYJ4-1 ]
    NP_067629.2. NM_021616.5. [Q9BYJ4-1 ]
    NP_569074.2. NM_130390.2.
    UniGenei Hs.729048.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EGP NMR - A 8-79 [» ]
    ProteinModelPortali Q9BYJ4.
    SMRi Q9BYJ4. Positions 8-79, 91-133, 287-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119809. 11 interactions.
    IntActi Q9BYJ4. 6 interactions.
    MINTi MINT-6631709.
    STRINGi 9606.ENSP00000346916.

    PTM databases

    PhosphoSitei Q9BYJ4.

    Polymorphism databases

    DMDMi 55976584.

    Proteomic databases

    MaxQBi Q9BYJ4.
    PaxDbi Q9BYJ4.
    PRIDEi Q9BYJ4.

    Protocols and materials databases

    DNASUi 53840.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000429814 ; ENSP00000402595 ; ENSG00000258659 . [Q9BYJ4-1 ]
    ENST00000514226 ; ENSP00000422947 ; ENSG00000258659 . [Q9BYJ4-1 ]
    GeneIDi 53840.
    KEGGi hsa:53840.
    UCSCi uc001mbh.3. human. [Q9BYJ4-1 ]

    Organism-specific databases

    CTDi 53840.
    GeneCardsi GC11P005640.
    HGNCi HGNC:10063. TRIM34.
    MIMi 605684. gene.
    neXtProti NX_Q9BYJ4.
    PharmGKBi PA35533.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259921.
    HOGENOMi HOG000234134.
    HOVERGENi HBG001357.
    InParanoidi Q9BYJ4.
    KOi K11999.
    OrthoDBi EOG7RJPR6.
    PhylomeDBi Q9BYJ4.

    Miscellaneous databases

    EvolutionaryTracei Q9BYJ4.
    GenomeRNAii 53840.
    NextBioi 56186.
    PROi Q9BYJ4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BYJ4.
    CleanExi HS_TRIM34.
    Genevestigatori Q9BYJ4.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem."
      Orimo A., Tominaga N., Yoshimura K., Yamauchi Y., Nomura M., Sato M., Nogi Y., Suzuki M., Suzuki H., Ikeda K., Inoue S., Muramatsu M.
      Genomics 69:143-149(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, INDUCTION, TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thyroid.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-488 (ISOFORM 1).
      Tissue: Lymph node.
    6. "Solution structure of the RING-finger domain from human tripartite motif protein 34."
      RIKEN structural genomics initiative (RSGI)
      Submitted (SEP-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 8-79.

    Entry informationi

    Entry nameiTRI34_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYJ4
    Secondary accession number(s): D3DQS7
    , Q9C016, Q9HCR0, Q9HCR1, Q9HCR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3