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Q9BYJ4 (TRI34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 34
Alternative name(s):
Interferon-responsive finger protein 1
RING finger protein 21
Gene names
Name:TRIM34
Synonyms:IFP1, RNF21
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes. Ref.1

Induction

Isoform 1 is up-regulated by interferons. Ref.1

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence AAG53517.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB17050.1 differs from that shown. Reason: The biological existence and relevance of this transcript that contains the product of both TRIM6 (AC Q9C030) and TRIM34 genes creating a chimeric protein of 842 residues is uncertain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BYJ4-1)

Also known as: Medium;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BYJ4-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     259-270: SEIWRLKKPKMV → CVWVATSGACEL
     271-488: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Tripartite motif-containing protein 34
PRO_0000056248

Regions

Domain283 – 488206B30.2/SPRY
Zinc finger15 – 6046RING-type
Zinc finger92 – 13443B box-type
Coiled coil131 – 239109 Potential
Compositional bias154 – 1596Poly-Glu
Compositional bias206 – 2094Poly-Glu

Natural variations

Alternative sequence259 – 27012SEIWR…KPKMV → CVWVATSGACEL in isoform 2.
VSP_011921
Alternative sequence271 – 488218Missing in isoform 2.
VSP_011922
Natural variant2761T → S.
Corresponds to variant rs6578670 [ dbSNP | Ensembl ].
VAR_019825
Natural variant2821D → H.
Corresponds to variant rs3740997 [ dbSNP | Ensembl ].
VAR_019826
Natural variant4041N → K.
Corresponds to variant rs16933844 [ dbSNP | Ensembl ].
VAR_052141

Experimental info

Sequence conflict3491H → Y Ref.5

Secondary structure

............... 488
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Medium) [UniParc].

Last modified November 23, 2004. Version 2.
Checksum: F2D60A16576187A0

FASTA48856,864
        10         20         30         40         50         60 
MASKILLNVQ EEVTCPICLE LLTEPLSLDC GHSLCRACIT VSNKEAVTSM GGKSSCPVCG 

        70         80         90        100        110        120 
ISYSFEHLQA NQHLANIVER LKEVKLSPDN GKKRDLCDHH GEKLLLFCKE DRKVICWLCE 

       130        140        150        160        170        180 
RSQEHRGHHT VLTEEVFKEC QEKLQAVLKR LKKEEEEAEK LEADIREEKT SWKYQVQTER 

       190        200        210        220        230        240 
QRIQTEFDQL RSILNNEEQR ELQRLEEEEK KTLDKFAEAE DELVQQKQLV RELISDVECR 

       250        260        270        280        290        300 
SQWSTMELLQ DMSGIMKWSE IWRLKKPKMV SKKLKTVFHA PDLSRMLQMF RELTAVRCYW 

       310        320        330        340        350        360 
VDVTLNSVNL NLNLVLSEDQ RQVISVPIWP FQCYNYGVLG SQYFSSGKHY WEVDVSKKTA 

       370        380        390        400        410        420 
WILGVYCRTY SRHMKYVVRR CANRQNLYTK YRPLFGYWVI GLQNKCKYGV FEESLSSDPE 

       430        440        450        460        470        480 
VLTLSMAVPP CRVGVFLDYE AGIVSFFNVT SHGSLIYKFS KCCFSQPVYP YFNPWNCPAP 


MTLCPPSS 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 7802B9B749E5111F
Show »

FASTA27031,338

References

« Hide 'large scale' references
[1]"Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem."
Orimo A., Tominaga N., Yoshimura K., Yamauchi Y., Nomura M., Sato M., Nogi Y., Suzuki M., Suzuki H., Ikeda K., Inoue S., Muramatsu M.
Genomics 69:143-149(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, INDUCTION, TISSUE SPECIFICITY.
[2]"The tripartite motif family identifies cell compartments."
Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A.
EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Thyroid.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-488 (ISOFORM 1).
Tissue: Lymph node.
[6]"Solution structure of the RING-finger domain from human tripartite motif protein 34."
RIKEN structural genomics initiative (RSGI)
Submitted (SEP-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 8-79.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB039902 mRNA. Translation: BAB17049.1.
AB039903 mRNA. Translation: BAB17050.1. Sequence problems.
AB039904 mRNA. Translation: BAB17051.1.
AF220143 mRNA. Translation: AAG53516.1.
AF220144 mRNA. Translation: AAG53517.1. Different initiation.
AK027876 mRNA. Translation: BAB55424.1.
CH471064 Genomic DNA. Translation: EAW68778.1.
CH471064 Genomic DNA. Translation: EAW68780.1.
AL583914 mRNA. Translation: CAC29498.1.
CCDSCCDS31391.1. [Q9BYJ4-1]
RefSeqNP_001003827.1. NM_001003827.1. [Q9BYJ4-1]
NP_067629.2. NM_021616.5. [Q9BYJ4-1]
NP_569074.2. NM_130390.2.
UniGeneHs.729048.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2EGPNMR-A8-79[»]
ProteinModelPortalQ9BYJ4.
SMRQ9BYJ4. Positions 8-79, 91-133, 287-484.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119809. 11 interactions.
IntActQ9BYJ4. 6 interactions.
MINTMINT-6631709.
STRING9606.ENSP00000346916.

PTM databases

PhosphoSiteQ9BYJ4.

Polymorphism databases

DMDM55976584.

Proteomic databases

MaxQBQ9BYJ4.
PaxDbQ9BYJ4.
PRIDEQ9BYJ4.

Protocols and materials databases

DNASU53840.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000429814; ENSP00000402595; ENSG00000258659. [Q9BYJ4-1]
ENST00000514226; ENSP00000422947; ENSG00000258659. [Q9BYJ4-1]
GeneID53840.
KEGGhsa:53840.
UCSCuc001mbh.3. human. [Q9BYJ4-1]

Organism-specific databases

CTD53840.
GeneCardsGC11P005640.
HGNCHGNC:10063. TRIM34.
MIM605684. gene.
neXtProtNX_Q9BYJ4.
PharmGKBPA35533.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG259921.
HOGENOMHOG000234134.
HOVERGENHBG001357.
InParanoidQ9BYJ4.
KOK11999.
OrthoDBEOG7RJPR6.
PhylomeDBQ9BYJ4.

Gene expression databases

BgeeQ9BYJ4.
CleanExHS_TRIM34.
GenevestigatorQ9BYJ4.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9BYJ4.
GenomeRNAi53840.
NextBio56186.
PROQ9BYJ4.
SOURCESearch...

Entry information

Entry nameTRI34_HUMAN
AccessionPrimary (citable) accession number: Q9BYJ4
Secondary accession number(s): D3DQS7 expand/collapse secondary AC list , Q9C016, Q9HCR0, Q9HCR1, Q9HCR2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM