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Q9BYJ4

- TRI34_HUMAN

UniProt

Q9BYJ4 - TRI34_HUMAN

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Protein

Tripartite motif-containing protein 34

Gene

TRIM34

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 6046RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 13443B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProt
  2. protein trimerization Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 34
Alternative name(s):
Interferon-responsive finger protein 1
RING finger protein 21
Gene namesi
Name:TRIM34
Synonyms:IFP1, RNF21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:10063. TRIM34.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35533.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Tripartite motif-containing protein 34PRO_0000056248Add
BLAST

Proteomic databases

MaxQBiQ9BYJ4.
PaxDbiQ9BYJ4.
PRIDEiQ9BYJ4.

PTM databases

PhosphoSiteiQ9BYJ4.

Expressioni

Tissue specificityi

Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes.1 Publication

Inductioni

Isoform 1 is up-regulated by interferons.1 Publication

Gene expression databases

BgeeiQ9BYJ4.
CleanExiHS_TRIM34.
GenevestigatoriQ9BYJ4.

Interactioni

Protein-protein interaction databases

BioGridi119809. 11 interactions.
IntActiQ9BYJ4. 6 interactions.
MINTiMINT-6631709.
STRINGi9606.ENSP00000346916.

Structurei

Secondary structure

1
488
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni16 – 194
Beta strandi29 – 313
Helixi36 – 394
Beta strandi47 – 493
Beta strandi57 – 593
Helixi67 – 693
Beta strandi72 – 743

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EGPNMR-A8-79[»]
ProteinModelPortaliQ9BYJ4.
SMRiQ9BYJ4. Positions 8-79, 91-133, 292-485.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BYJ4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini283 – 488206B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili131 – 239109Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi154 – 1596Poly-Glu
Compositional biasi206 – 2094Poly-Glu

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 6046RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 13443B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG259921.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234134.
HOVERGENiHBG001357.
InParanoidiQ9BYJ4.
KOiK11999.
OrthoDBiEOG7RJPR6.
PhylomeDBiQ9BYJ4.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BYJ4) [UniParc]FASTAAdd to Basket

Also known as: Medium

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKILLNVQ EEVTCPICLE LLTEPLSLDC GHSLCRACIT VSNKEAVTSM
60 70 80 90 100
GGKSSCPVCG ISYSFEHLQA NQHLANIVER LKEVKLSPDN GKKRDLCDHH
110 120 130 140 150
GEKLLLFCKE DRKVICWLCE RSQEHRGHHT VLTEEVFKEC QEKLQAVLKR
160 170 180 190 200
LKKEEEEAEK LEADIREEKT SWKYQVQTER QRIQTEFDQL RSILNNEEQR
210 220 230 240 250
ELQRLEEEEK KTLDKFAEAE DELVQQKQLV RELISDVECR SQWSTMELLQ
260 270 280 290 300
DMSGIMKWSE IWRLKKPKMV SKKLKTVFHA PDLSRMLQMF RELTAVRCYW
310 320 330 340 350
VDVTLNSVNL NLNLVLSEDQ RQVISVPIWP FQCYNYGVLG SQYFSSGKHY
360 370 380 390 400
WEVDVSKKTA WILGVYCRTY SRHMKYVVRR CANRQNLYTK YRPLFGYWVI
410 420 430 440 450
GLQNKCKYGV FEESLSSDPE VLTLSMAVPP CRVGVFLDYE AGIVSFFNVT
460 470 480
SHGSLIYKFS KCCFSQPVYP YFNPWNCPAP MTLCPPSS
Length:488
Mass (Da):56,864
Last modified:November 23, 2004 - v2
Checksum:iF2D60A16576187A0
GO
Isoform 2 (identifier: Q9BYJ4-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     259-270: SEIWRLKKPKMV → CVWVATSGACEL
     271-488: Missing.

Show »
Length:270
Mass (Da):31,338
Checksum:i7802B9B749E5111F
GO

Sequence cautioni

The sequence BAB17050.1 differs from that shown. Reason: The in vivo relevance of this transcript of the TRIM6 (AC Q9C030) and TRIM34 genes creating a chimeric protein of 842 residues is uncertain.
The sequence AAG53517.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti349 – 3491H → Y(PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti276 – 2761T → S.
Corresponds to variant rs6578670 [ dbSNP | Ensembl ].
VAR_019825
Natural varianti282 – 2821D → H.
Corresponds to variant rs3740997 [ dbSNP | Ensembl ].
VAR_019826
Natural varianti404 – 4041N → K.
Corresponds to variant rs16933844 [ dbSNP | Ensembl ].
VAR_052141

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei259 – 27012SEIWR…KPKMV → CVWVATSGACEL in isoform 2. 1 PublicationVSP_011921Add
BLAST
Alternative sequencei271 – 488218Missing in isoform 2. 1 PublicationVSP_011922Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039902 mRNA. Translation: BAB17049.1.
AB039903 mRNA. Translation: BAB17050.1. Sequence problems.
AB039904 mRNA. Translation: BAB17051.1.
AF220143 mRNA. Translation: AAG53516.1.
AF220144 mRNA. Translation: AAG53517.1. Different initiation.
AK027876 mRNA. Translation: BAB55424.1.
CH471064 Genomic DNA. Translation: EAW68778.1.
CH471064 Genomic DNA. Translation: EAW68780.1.
AL583914 mRNA. Translation: CAC29498.1.
CCDSiCCDS31391.1. [Q9BYJ4-1]
RefSeqiNP_001003827.1. NM_001003827.1. [Q9BYJ4-1]
NP_067629.2. NM_021616.5. [Q9BYJ4-1]
NP_569074.2. NM_130390.2.
UniGeneiHs.729048.

Genome annotation databases

EnsembliENST00000429814; ENSP00000402595; ENSG00000258659. [Q9BYJ4-1]
ENST00000514226; ENSP00000422947; ENSG00000258659. [Q9BYJ4-1]
GeneIDi53840.
KEGGihsa:53840.
UCSCiuc001mbh.3. human. [Q9BYJ4-1]

Polymorphism databases

DMDMi55976584.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039902 mRNA. Translation: BAB17049.1 .
AB039903 mRNA. Translation: BAB17050.1 . Sequence problems.
AB039904 mRNA. Translation: BAB17051.1 .
AF220143 mRNA. Translation: AAG53516.1 .
AF220144 mRNA. Translation: AAG53517.1 . Different initiation.
AK027876 mRNA. Translation: BAB55424.1 .
CH471064 Genomic DNA. Translation: EAW68778.1 .
CH471064 Genomic DNA. Translation: EAW68780.1 .
AL583914 mRNA. Translation: CAC29498.1 .
CCDSi CCDS31391.1. [Q9BYJ4-1 ]
RefSeqi NP_001003827.1. NM_001003827.1. [Q9BYJ4-1 ]
NP_067629.2. NM_021616.5. [Q9BYJ4-1 ]
NP_569074.2. NM_130390.2.
UniGenei Hs.729048.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EGP NMR - A 8-79 [» ]
ProteinModelPortali Q9BYJ4.
SMRi Q9BYJ4. Positions 8-79, 91-133, 292-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119809. 11 interactions.
IntActi Q9BYJ4. 6 interactions.
MINTi MINT-6631709.
STRINGi 9606.ENSP00000346916.

PTM databases

PhosphoSitei Q9BYJ4.

Polymorphism databases

DMDMi 55976584.

Proteomic databases

MaxQBi Q9BYJ4.
PaxDbi Q9BYJ4.
PRIDEi Q9BYJ4.

Protocols and materials databases

DNASUi 53840.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000429814 ; ENSP00000402595 ; ENSG00000258659 . [Q9BYJ4-1 ]
ENST00000514226 ; ENSP00000422947 ; ENSG00000258659 . [Q9BYJ4-1 ]
GeneIDi 53840.
KEGGi hsa:53840.
UCSCi uc001mbh.3. human. [Q9BYJ4-1 ]

Organism-specific databases

CTDi 53840.
GeneCardsi GC11P005640.
HGNCi HGNC:10063. TRIM34.
MIMi 605684. gene.
neXtProti NX_Q9BYJ4.
PharmGKBi PA35533.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259921.
GeneTreei ENSGT00760000118893.
HOGENOMi HOG000234134.
HOVERGENi HBG001357.
InParanoidi Q9BYJ4.
KOi K11999.
OrthoDBi EOG7RJPR6.
PhylomeDBi Q9BYJ4.

Miscellaneous databases

EvolutionaryTracei Q9BYJ4.
GenomeRNAii 53840.
NextBioi 56186.
PROi Q9BYJ4.
SOURCEi Search...

Gene expression databases

Bgeei Q9BYJ4.
CleanExi HS_TRIM34.
Genevestigatori Q9BYJ4.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem."
    Orimo A., Tominaga N., Yoshimura K., Yamauchi Y., Nomura M., Sato M., Nogi Y., Suzuki M., Suzuki H., Ikeda K., Inoue S., Muramatsu M.
    Genomics 69:143-149(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, INDUCTION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thyroid.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-488 (ISOFORM 1).
    Tissue: Lymph node.
  6. "Solution structure of the RING-finger domain from human tripartite motif protein 34."
    RIKEN structural genomics initiative (RSGI)
    Submitted (SEP-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 8-79.

Entry informationi

Entry nameiTRI34_HUMAN
AccessioniPrimary (citable) accession number: Q9BYJ4
Secondary accession number(s): D3DQS7
, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3