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Protein

Tripartite motif-containing protein 34

Gene

TRIM34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as antiviral protein and may contribute to the defense against retroviral infections.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 60RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri92 – 134B box-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 34
Alternative name(s):
Interferon-responsive finger protein 1
RING finger protein 21
Gene namesi
Name:TRIM34
Synonyms:IFP1, RNF21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:10063. TRIM34.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi121R → E: Reduced association with TRIM5. 1 Publication1

Organism-specific databases

DisGeNETi53840.
OpenTargetsiENSG00000258659.
PharmGKBiPA35533.

Polymorphism and mutation databases

BioMutaiTRIM34.
DMDMi55976584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562481 – 488Tripartite motif-containing protein 34Add BLAST488

Proteomic databases

EPDiQ9BYJ4.
MaxQBiQ9BYJ4.
PaxDbiQ9BYJ4.
PeptideAtlasiQ9BYJ4.
PRIDEiQ9BYJ4.

PTM databases

iPTMnetiQ9BYJ4.
PhosphoSitePlusiQ9BYJ4.

Expressioni

Tissue specificityi

Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes.1 Publication

Inductioni

Isoform 1 is up-regulated by interferons.1 Publication

Gene expression databases

CleanExiHS_TRIM34.
GenevisibleiQ9BYJ4. HS.

Interactioni

Subunit structurei

Homotrimer. Interacts (via the B30.2/SPRY domain) with HIV-1 capsid complexes (PubMed:17156811). Interacts (via B-box and SPRY domain) with TRIM5 (PubMed:21680743, PubMed:17156811).2 Publications

Protein-protein interaction databases

BioGridi119809. 9 interactors.
IntActiQ9BYJ4. 6 interactors.
MINTiMINT-6631709.
STRINGi9606.ENSP00000402595.

Structurei

Secondary structure

1488
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni16 – 19Combined sources4
Beta strandi29 – 31Combined sources3
Helixi36 – 39Combined sources4
Beta strandi47 – 49Combined sources3
Beta strandi57 – 59Combined sources3
Helixi67 – 69Combined sources3
Beta strandi72 – 74Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EGPNMR-A8-79[»]
ProteinModelPortaliQ9BYJ4.
SMRiQ9BYJ4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BYJ4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini283 – 488B30.2/SPRYPROSITE-ProRule annotationAdd BLAST206

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili131 – 239Sequence analysisAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 159Poly-Glu6
Compositional biasi206 – 209Poly-Glu4

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 60RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri92 – 134B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234134.
HOVERGENiHBG001357.
InParanoidiQ9BYJ4.
KOiK11999.
OrthoDBiEOG091G04O8.
PhylomeDBiQ9BYJ4.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYJ4-1) [UniParc]FASTAAdd to basket
Also known as: Medium

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKILLNVQ EEVTCPICLE LLTEPLSLDC GHSLCRACIT VSNKEAVTSM
60 70 80 90 100
GGKSSCPVCG ISYSFEHLQA NQHLANIVER LKEVKLSPDN GKKRDLCDHH
110 120 130 140 150
GEKLLLFCKE DRKVICWLCE RSQEHRGHHT VLTEEVFKEC QEKLQAVLKR
160 170 180 190 200
LKKEEEEAEK LEADIREEKT SWKYQVQTER QRIQTEFDQL RSILNNEEQR
210 220 230 240 250
ELQRLEEEEK KTLDKFAEAE DELVQQKQLV RELISDVECR SQWSTMELLQ
260 270 280 290 300
DMSGIMKWSE IWRLKKPKMV SKKLKTVFHA PDLSRMLQMF RELTAVRCYW
310 320 330 340 350
VDVTLNSVNL NLNLVLSEDQ RQVISVPIWP FQCYNYGVLG SQYFSSGKHY
360 370 380 390 400
WEVDVSKKTA WILGVYCRTY SRHMKYVVRR CANRQNLYTK YRPLFGYWVI
410 420 430 440 450
GLQNKCKYGV FEESLSSDPE VLTLSMAVPP CRVGVFLDYE AGIVSFFNVT
460 470 480
SHGSLIYKFS KCCFSQPVYP YFNPWNCPAP MTLCPPSS
Length:488
Mass (Da):56,864
Last modified:November 23, 2004 - v2
Checksum:iF2D60A16576187A0
GO
Isoform 2 (identifier: Q9BYJ4-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     259-270: SEIWRLKKPKMV → CVWVATSGACEL
     271-488: Missing.

Show »
Length:270
Mass (Da):31,338
Checksum:i7802B9B749E5111F
GO

Sequence cautioni

The sequence AAG53517 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB17050 differs from that shown. The in vivo relevance of this transcript of the TRIM6 (AC Q9C030) and TRIM34 genes creating a chimeric protein of 842 residues is uncertain.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti349H → Y (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019825276T → S.Corresponds to variant rs6578670dbSNPEnsembl.1
Natural variantiVAR_019826282D → H.Corresponds to variant rs3740997dbSNPEnsembl.1
Natural variantiVAR_052141404N → K.Corresponds to variant rs16933844dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011921259 – 270SEIWR…KPKMV → CVWVATSGACEL in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_011922271 – 488Missing in isoform 2. 1 PublicationAdd BLAST218

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039902 mRNA. Translation: BAB17049.1.
AB039903 mRNA. Translation: BAB17050.1. Sequence problems.
AB039904 mRNA. Translation: BAB17051.1.
AF220143 mRNA. Translation: AAG53516.1.
AF220144 mRNA. Translation: AAG53517.1. Different initiation.
AK027876 mRNA. Translation: BAB55424.1.
CH471064 Genomic DNA. Translation: EAW68778.1.
CH471064 Genomic DNA. Translation: EAW68780.1.
AL583914 mRNA. Translation: CAC29498.1.
CCDSiCCDS31391.1. [Q9BYJ4-1]
RefSeqiNP_001003827.1. NM_001003827.1. [Q9BYJ4-1]
NP_067629.2. NM_021616.5. [Q9BYJ4-1]
NP_569074.2. NM_130390.2.
UniGeneiHs.729048.

Genome annotation databases

EnsembliENST00000429814; ENSP00000402595; ENSG00000258659. [Q9BYJ4-1]
ENST00000514226; ENSP00000422947; ENSG00000258659. [Q9BYJ4-1]
GeneIDi53840.
KEGGihsa:53840.
UCSCiuc001mbh.4. human. [Q9BYJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039902 mRNA. Translation: BAB17049.1.
AB039903 mRNA. Translation: BAB17050.1. Sequence problems.
AB039904 mRNA. Translation: BAB17051.1.
AF220143 mRNA. Translation: AAG53516.1.
AF220144 mRNA. Translation: AAG53517.1. Different initiation.
AK027876 mRNA. Translation: BAB55424.1.
CH471064 Genomic DNA. Translation: EAW68778.1.
CH471064 Genomic DNA. Translation: EAW68780.1.
AL583914 mRNA. Translation: CAC29498.1.
CCDSiCCDS31391.1. [Q9BYJ4-1]
RefSeqiNP_001003827.1. NM_001003827.1. [Q9BYJ4-1]
NP_067629.2. NM_021616.5. [Q9BYJ4-1]
NP_569074.2. NM_130390.2.
UniGeneiHs.729048.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EGPNMR-A8-79[»]
ProteinModelPortaliQ9BYJ4.
SMRiQ9BYJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119809. 9 interactors.
IntActiQ9BYJ4. 6 interactors.
MINTiMINT-6631709.
STRINGi9606.ENSP00000402595.

PTM databases

iPTMnetiQ9BYJ4.
PhosphoSitePlusiQ9BYJ4.

Polymorphism and mutation databases

BioMutaiTRIM34.
DMDMi55976584.

Proteomic databases

EPDiQ9BYJ4.
MaxQBiQ9BYJ4.
PaxDbiQ9BYJ4.
PeptideAtlasiQ9BYJ4.
PRIDEiQ9BYJ4.

Protocols and materials databases

DNASUi53840.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000429814; ENSP00000402595; ENSG00000258659. [Q9BYJ4-1]
ENST00000514226; ENSP00000422947; ENSG00000258659. [Q9BYJ4-1]
GeneIDi53840.
KEGGihsa:53840.
UCSCiuc001mbh.4. human. [Q9BYJ4-1]

Organism-specific databases

CTDi53840.
DisGeNETi53840.
GeneCardsiTRIM34.
HGNCiHGNC:10063. TRIM34.
MIMi605684. gene.
neXtProtiNX_Q9BYJ4.
OpenTargetsiENSG00000258659.
PharmGKBiPA35533.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234134.
HOVERGENiHBG001357.
InParanoidiQ9BYJ4.
KOiK11999.
OrthoDBiEOG091G04O8.
PhylomeDBiQ9BYJ4.

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

EvolutionaryTraceiQ9BYJ4.
GenomeRNAii53840.
PROiQ9BYJ4.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TRIM34.
GenevisibleiQ9BYJ4. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI34_HUMAN
AccessioniPrimary (citable) accession number: Q9BYJ4
Secondary accession number(s): D3DQS7
, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.