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Q9BYJ0 (FGFP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor-binding protein 2

Short name=FGF-BP2
Short name=FGF-binding protein 2
Short name=FGFBP-2
Alternative name(s):
37 kDa killer-specific secretory protein
Short name=Ksp37
HBp17-related protein
Short name=HBp17-RP
Gene names
Name:FGFBP2
Synonyms:KSP37
ORF Names:UNQ425/PRO1065
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secretedextracellular space Ref.1.

Tissue specificity

Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at protein level). Ref.1

Sequence similarities

Belongs to the fibroblast growth factor-binding protein family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   LigandGrowth factor binding
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 223204Fibroblast growth factor-binding protein 2
PRO_0000245860

Amino acid modifications

Disulfide bond43 ↔ 63 By similarity
Disulfide bond72 ↔ 106 By similarity
Disulfide bond81 ↔ 117 By similarity
Disulfide bond206 ↔ 214 By similarity

Natural variations

Natural variant281S → N.
Corresponds to variant rs35496730 [ dbSNP | Ensembl ].
VAR_061171
Natural variant841F → L.
Corresponds to variant rs2286459 [ dbSNP | Ensembl ].
VAR_059287
Natural variant901P → S.
Corresponds to variant rs758329 [ dbSNP | Ensembl ].
VAR_049065

Sequences

Sequence LengthMass (Da)Tools
Q9BYJ0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 792E68933E7929D9

FASTA22324,581
        10         20         30         40         50         60 
MKFVPCLLLV TLSCLGTLGQ APRQKQGSTG EEFHFQTGGR DSCTMRPSSL GQGAGEVWLR 

        70         80         90        100        110        120 
VDCRNTDQTY WCEYRGQPSM CQAFAADPKP YWNQALQELR RLHHACQGAP VLRPSVCREA 

       130        140        150        160        170        180 
GPQAHMQQVT SSLKGSPEPN QQPEAGTPSL RPKATVKLTE ATQLGKDSME ELGKAKPTTR 

       190        200        210        220 
PTAKPTQPGP RPGGNEEAKK KAWEHCWKPF QALCAFLISF FRG 

« Hide

References

« Hide 'large scale' references
[1]"A novel serum protein that is selectively produced by cytotoxic lymphocytes."
Ogawa K., Tanaka K., Ishii A., Nakamura Y., Kondo S., Sugamura K., Takano S., Nakamura M., Nagata K.
J. Immunol. 166:6404-6412(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: Cytotoxic T-cell.
[2]"cDNA encoding a human protein related to FGF-binding protein HBp17 (HBp17-RP)."
Sato J.D., Chapline M.C.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Epidermal carcinoma.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB021123 mRNA. Translation: BAB39770.1.
AF361936 mRNA. Translation: AAK51503.1.
AY358978 mRNA. Translation: AAQ89337.1.
BC025720 mRNA. Translation: AAH25720.1.
RefSeqNP_114156.1. NM_031950.3.
UniGeneHs.98785.

3D structure databases

ProteinModelPortalQ9BYJ0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123799. 1 interaction.
STRING9606.ENSP00000259989.

PTM databases

PhosphoSiteQ9BYJ0.

Polymorphism databases

DMDM74733476.

Proteomic databases

PaxDbQ9BYJ0.
PRIDEQ9BYJ0.

Protocols and materials databases

DNASU83888.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259989; ENSP00000259989; ENSG00000137441.
GeneID83888.
KEGGhsa:83888.
UCSCuc003gon.3. human.

Organism-specific databases

CTD83888.
GeneCardsGC04M015961.
HGNCHGNC:29451. FGFBP2.
HPAHPA039180.
MIM607713. gene.
neXtProtNX_Q9BYJ0.
PharmGKBPA162388435.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46097.
HOGENOMHOG000112575.
HOVERGENHBG081527.
InParanoidQ9BYJ0.
OMAGEEFHFQ.
OrthoDBEOG7P02JZ.
PhylomeDBQ9BYJ0.
TreeFamTF335877.

Gene expression databases

BgeeQ9BYJ0.
CleanExHS_FGFBP2.
GenevestigatorQ9BYJ0.

Family and domain databases

InterProIPR010510. FGF1-bd.
[Graphical view]
PANTHERPTHR15258. PTHR15258. 1 hit.
PfamPF06473. FGF-BP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi83888.
NextBio72965.
PROQ9BYJ0.
SOURCESearch...

Entry information

Entry nameFGFP2_HUMAN
AccessionPrimary (citable) accession number: Q9BYJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM