Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BYJ0

- FGFP2_HUMAN

UniProt

Q9BYJ0 - FGFP2_HUMAN

Protein

Fibroblast growth factor-binding protein 2

Gene

FGFBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Keywords - Ligandi

    Growth factor binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor-binding protein 2
    Short name:
    FGF-BP2
    Short name:
    FGF-binding protein 2
    Short name:
    FGFBP-2
    Alternative name(s):
    37 kDa killer-specific secretory protein
    Short name:
    Ksp37
    HBp17-related protein
    Short name:
    HBp17-RP
    Gene namesi
    Name:FGFBP2
    Synonyms:KSP37
    ORF Names:UNQ425/PRO1065
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:29451. FGFBP2.

    Subcellular locationi

    Secretedextracellular space 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162388435.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 223204Fibroblast growth factor-binding protein 2PRO_0000245860Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 63By similarity
    Disulfide bondi72 ↔ 106By similarity
    Disulfide bondi81 ↔ 117By similarity
    Disulfide bondi206 ↔ 214By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9BYJ0.
    PRIDEiQ9BYJ0.

    PTM databases

    PhosphoSiteiQ9BYJ0.

    Expressioni

    Tissue specificityi

    Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at protein level).1 Publication

    Gene expression databases

    BgeeiQ9BYJ0.
    CleanExiHS_FGFBP2.
    GenevestigatoriQ9BYJ0.

    Organism-specific databases

    HPAiHPA039180.

    Interactioni

    Protein-protein interaction databases

    BioGridi123799. 1 interaction.
    STRINGi9606.ENSP00000259989.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYJ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46097.
    HOGENOMiHOG000112575.
    HOVERGENiHBG081527.
    InParanoidiQ9BYJ0.
    OMAiGEEFHFQ.
    OrthoDBiEOG7P02JZ.
    PhylomeDBiQ9BYJ0.
    TreeFamiTF335877.

    Family and domain databases

    InterProiIPR010510. FGF1-bd.
    [Graphical view]
    PANTHERiPTHR15258. PTHR15258. 1 hit.
    PfamiPF06473. FGF-BP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BYJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFVPCLLLV TLSCLGTLGQ APRQKQGSTG EEFHFQTGGR DSCTMRPSSL    50
    GQGAGEVWLR VDCRNTDQTY WCEYRGQPSM CQAFAADPKP YWNQALQELR 100
    RLHHACQGAP VLRPSVCREA GPQAHMQQVT SSLKGSPEPN QQPEAGTPSL 150
    RPKATVKLTE ATQLGKDSME ELGKAKPTTR PTAKPTQPGP RPGGNEEAKK 200
    KAWEHCWKPF QALCAFLISF FRG 223
    Length:223
    Mass (Da):24,581
    Last modified:June 1, 2001 - v1
    Checksum:i792E68933E7929D9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281S → N.
    Corresponds to variant rs35496730 [ dbSNP | Ensembl ].
    VAR_061171
    Natural varianti84 – 841F → L.
    Corresponds to variant rs2286459 [ dbSNP | Ensembl ].
    VAR_059287
    Natural varianti90 – 901P → S.
    Corresponds to variant rs758329 [ dbSNP | Ensembl ].
    VAR_049065

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB021123 mRNA. Translation: BAB39770.1.
    AF361936 mRNA. Translation: AAK51503.1.
    AY358978 mRNA. Translation: AAQ89337.1.
    BC025720 mRNA. Translation: AAH25720.1.
    CCDSiCCDS3419.1.
    RefSeqiNP_114156.1. NM_031950.3.
    UniGeneiHs.98785.

    Genome annotation databases

    EnsembliENST00000259989; ENSP00000259989; ENSG00000137441.
    GeneIDi83888.
    KEGGihsa:83888.
    UCSCiuc003gon.3. human.

    Polymorphism databases

    DMDMi74733476.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB021123 mRNA. Translation: BAB39770.1 .
    AF361936 mRNA. Translation: AAK51503.1 .
    AY358978 mRNA. Translation: AAQ89337.1 .
    BC025720 mRNA. Translation: AAH25720.1 .
    CCDSi CCDS3419.1.
    RefSeqi NP_114156.1. NM_031950.3.
    UniGenei Hs.98785.

    3D structure databases

    ProteinModelPortali Q9BYJ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123799. 1 interaction.
    STRINGi 9606.ENSP00000259989.

    PTM databases

    PhosphoSitei Q9BYJ0.

    Polymorphism databases

    DMDMi 74733476.

    Proteomic databases

    PaxDbi Q9BYJ0.
    PRIDEi Q9BYJ0.

    Protocols and materials databases

    DNASUi 83888.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259989 ; ENSP00000259989 ; ENSG00000137441 .
    GeneIDi 83888.
    KEGGi hsa:83888.
    UCSCi uc003gon.3. human.

    Organism-specific databases

    CTDi 83888.
    GeneCardsi GC04M015961.
    HGNCi HGNC:29451. FGFBP2.
    HPAi HPA039180.
    MIMi 607713. gene.
    neXtProti NX_Q9BYJ0.
    PharmGKBi PA162388435.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46097.
    HOGENOMi HOG000112575.
    HOVERGENi HBG081527.
    InParanoidi Q9BYJ0.
    OMAi GEEFHFQ.
    OrthoDBi EOG7P02JZ.
    PhylomeDBi Q9BYJ0.
    TreeFami TF335877.

    Miscellaneous databases

    GenomeRNAii 83888.
    NextBioi 72965.
    PROi Q9BYJ0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BYJ0.
    CleanExi HS_FGFBP2.
    Genevestigatori Q9BYJ0.

    Family and domain databases

    InterProi IPR010510. FGF1-bd.
    [Graphical view ]
    PANTHERi PTHR15258. PTHR15258. 1 hit.
    Pfami PF06473. FGF-BP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel serum protein that is selectively produced by cytotoxic lymphocytes."
      Ogawa K., Tanaka K., Ishii A., Nakamura Y., Kondo S., Sugamura K., Takano S., Nakamura M., Nagata K.
      J. Immunol. 166:6404-6412(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Cytotoxic T-cell.
    2. "cDNA encoding a human protein related to FGF-binding protein HBp17 (HBp17-RP)."
      Sato J.D., Chapline M.C.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Epidermal carcinoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiFGFP2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3