Q9BYJ0 (FGFP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor-binding protein 2
Short name=FGF-BP2
Short name=FGF-binding protein 2
Short name=FGFBP-2

Alternative name(s):
37 kDa killer-specific secretory protein
Short name=Ksp37
HBp17-related protein
Short name=HBp17-RP

Gene names

Name:	FGFBP2
Synonyms:	KSP37
ORF Names:	UNQ425/PRO1065

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted › extracellular space Ref.1.
Tissue specificity	Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at protein level). Ref.1
Sequence similarities	Belongs to the fibroblast growth factor-binding protein family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Growth factor binding
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 223	204	Fibroblast growth factor-binding protein 2		PRO_0000245860
Amino acid modifications
	Disulfide bond	43 ↔ 63		By similarity
	Disulfide bond	72 ↔ 106		By similarity
	Disulfide bond	81 ↔ 117		By similarity
	Disulfide bond	206 ↔ 214		By similarity
Natural variations
	Natural variant	28	1	S → N. Corresponds to variant rs35496730 [ dbSNP | Ensembl ].		VAR_061171
	Natural variant	84	1	F → L. Corresponds to variant rs2286459 [ dbSNP | Ensembl ].		VAR_059287
	Natural variant	90	1	P → S. Corresponds to variant rs758329 [ dbSNP | Ensembl ].		VAR_049065

Sequences

	Sequence		Length	Mass (Da)
	Q9BYJ0 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 792E68933E7929D9	FASTA	223	24,581
	10 20 30 40 50 60 MKFVPCLLLV TLSCLGTLGQ APRQKQGSTG EEFHFQTGGR DSCTMRPSSL GQGAGEVWLR 70 80 90 100 110 120 VDCRNTDQTY WCEYRGQPSM CQAFAADPKP YWNQALQELR RLHHACQGAP VLRPSVCREA 130 140 150 160 170 180 GPQAHMQQVT SSLKGSPEPN QQPEAGTPSL RPKATVKLTE ATQLGKDSME ELGKAKPTTR 190 200 210 220 PTAKPTQPGP RPGGNEEAKK KAWEHCWKPF QALCAFLISF FRG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel serum protein that is selectively produced by cytotoxic lymphocytes." Ogawa K., Tanaka K., Ishii A., Nakamura Y., Kondo S., Sugamura K., Takano S., Nakamura M., Nagata K. J. Immunol. 166:6404-6412(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Cytotoxic T-cell.
[2]	"cDNA encoding a human protein related to FGF-binding protein HBp17 (HBp17-RP)." Sato J.D., Chapline M.C. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epidermal carcinoma.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB021123 mRNA. Translation: BAB39770.1. AF361936 mRNA. Translation: AAK51503.1. AY358978 mRNA. Translation: AAQ89337.1. BC025720 mRNA. Translation: AAH25720.1.
IPI	IPI00011194.
RefSeq	NP_114156.1. NM_031950.3.
UniGene	Hs.98785.
3D structure databases
ProteinModelPortal	Q9BYJ0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000259989.
PTM databases
PhosphoSite	Q9BYJ0.
Polymorphism databases
DMDM	74733476.
Proteomic databases
PaxDb	Q9BYJ0.
PRIDE	Q9BYJ0.
Protocols and materials databases
DNASU	83888.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259989; ENSP00000259989; ENSG00000137441.
GeneID	83888.
KEGG	hsa:83888.
UCSC	uc003gon.3. human.
Organism-specific databases
CTD	83888.
GeneCards	GC04M015961.
HGNC	HGNC:29451. FGFBP2.
HPA	HPA039180.
MIM	607713. gene.
neXtProt	NX_Q9BYJ0.
PharmGKB	PA162388435.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46097.
HOGENOM	HOG000112575.
HOVERGEN	HBG081527.
InParanoid	Q9BYJ0.
OMA	CEYRGQP.
OrthoDB	EOG4SN1PW.
PhylomeDB	Q9BYJ0.
Gene expression databases
Bgee	Q9BYJ0.
CleanEx	HS_FGFBP2.
Genevestigator	Q9BYJ0.
GermOnline	ENSG00000137441. Homo sapiens.
Family and domain databases
InterPro	IPR010510. FGF1-bd. [Graphical view]
PANTHER	PTHR15258. PTHR15258. 1 hit.
Pfam	PF06473. FGF-BP1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83888.
NextBio	72965.
SOURCE	Search...

Entry information

Entry name

FGFP2_HUMAN

Accession

Primary (citable) accession number: Q9BYJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.