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Q9BYJ0

- FGFP2_HUMAN

UniProt

Q9BYJ0 - FGFP2_HUMAN

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Protein

Fibroblast growth factor-binding protein 2

Gene

FGFBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Keywords - Ligandi

Growth factor binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor-binding protein 2
Short name:
FGF-BP2
Short name:
FGF-binding protein 2
Short name:
FGFBP-2
Alternative name(s):
37 kDa killer-specific secretory protein
Short name:
Ksp37
HBp17-related protein
Short name:
HBp17-RP
Gene namesi
Name:FGFBP2
Synonyms:KSP37
ORF Names:UNQ425/PRO1065
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:29451. FGFBP2.

Subcellular locationi

Secretedextracellular space 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 223204Fibroblast growth factor-binding protein 2PRO_0000245860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 63By similarity
Disulfide bondi72 ↔ 106By similarity
Disulfide bondi81 ↔ 117By similarity
Disulfide bondi206 ↔ 214By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9BYJ0.
PRIDEiQ9BYJ0.

PTM databases

PhosphoSiteiQ9BYJ0.

Expressioni

Tissue specificityi

Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at protein level).1 Publication

Gene expression databases

BgeeiQ9BYJ0.
CleanExiHS_FGFBP2.
GenevestigatoriQ9BYJ0.

Organism-specific databases

HPAiHPA039180.

Interactioni

Protein-protein interaction databases

BioGridi123799. 1 interaction.
STRINGi9606.ENSP00000259989.

Structurei

3D structure databases

ProteinModelPortaliQ9BYJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46097.
GeneTreeiENSGT00730000111501.
HOGENOMiHOG000112575.
HOVERGENiHBG081527.
InParanoidiQ9BYJ0.
OMAiGEEFHFQ.
OrthoDBiEOG7P02JZ.
PhylomeDBiQ9BYJ0.
TreeFamiTF335877.

Family and domain databases

InterProiIPR010510. FGF1-bd.
[Graphical view]
PANTHERiPTHR15258. PTHR15258. 1 hit.
PfamiPF06473. FGF-BP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYJ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFVPCLLLV TLSCLGTLGQ APRQKQGSTG EEFHFQTGGR DSCTMRPSSL
60 70 80 90 100
GQGAGEVWLR VDCRNTDQTY WCEYRGQPSM CQAFAADPKP YWNQALQELR
110 120 130 140 150
RLHHACQGAP VLRPSVCREA GPQAHMQQVT SSLKGSPEPN QQPEAGTPSL
160 170 180 190 200
RPKATVKLTE ATQLGKDSME ELGKAKPTTR PTAKPTQPGP RPGGNEEAKK
210 220
KAWEHCWKPF QALCAFLISF FRG
Length:223
Mass (Da):24,581
Last modified:June 1, 2001 - v1
Checksum:i792E68933E7929D9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281S → N.
Corresponds to variant rs35496730 [ dbSNP | Ensembl ].
VAR_061171
Natural varianti84 – 841F → L.
Corresponds to variant rs2286459 [ dbSNP | Ensembl ].
VAR_059287
Natural varianti90 – 901P → S.
Corresponds to variant rs758329 [ dbSNP | Ensembl ].
VAR_049065

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021123 mRNA. Translation: BAB39770.1.
AF361936 mRNA. Translation: AAK51503.1.
AY358978 mRNA. Translation: AAQ89337.1.
BC025720 mRNA. Translation: AAH25720.1.
CCDSiCCDS3419.1.
RefSeqiNP_114156.1. NM_031950.3.
UniGeneiHs.98785.

Genome annotation databases

EnsembliENST00000259989; ENSP00000259989; ENSG00000137441.
GeneIDi83888.
KEGGihsa:83888.
UCSCiuc003gon.3. human.

Polymorphism databases

DMDMi74733476.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021123 mRNA. Translation: BAB39770.1 .
AF361936 mRNA. Translation: AAK51503.1 .
AY358978 mRNA. Translation: AAQ89337.1 .
BC025720 mRNA. Translation: AAH25720.1 .
CCDSi CCDS3419.1.
RefSeqi NP_114156.1. NM_031950.3.
UniGenei Hs.98785.

3D structure databases

ProteinModelPortali Q9BYJ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123799. 1 interaction.
STRINGi 9606.ENSP00000259989.

PTM databases

PhosphoSitei Q9BYJ0.

Polymorphism databases

DMDMi 74733476.

Proteomic databases

PaxDbi Q9BYJ0.
PRIDEi Q9BYJ0.

Protocols and materials databases

DNASUi 83888.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259989 ; ENSP00000259989 ; ENSG00000137441 .
GeneIDi 83888.
KEGGi hsa:83888.
UCSCi uc003gon.3. human.

Organism-specific databases

CTDi 83888.
GeneCardsi GC04M015961.
HGNCi HGNC:29451. FGFBP2.
HPAi HPA039180.
MIMi 607713. gene.
neXtProti NX_Q9BYJ0.
PharmGKBi PA162388435.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46097.
GeneTreei ENSGT00730000111501.
HOGENOMi HOG000112575.
HOVERGENi HBG081527.
InParanoidi Q9BYJ0.
OMAi GEEFHFQ.
OrthoDBi EOG7P02JZ.
PhylomeDBi Q9BYJ0.
TreeFami TF335877.

Miscellaneous databases

GenomeRNAii 83888.
NextBioi 72965.
PROi Q9BYJ0.
SOURCEi Search...

Gene expression databases

Bgeei Q9BYJ0.
CleanExi HS_FGFBP2.
Genevestigatori Q9BYJ0.

Family and domain databases

InterProi IPR010510. FGF1-bd.
[Graphical view ]
PANTHERi PTHR15258. PTHR15258. 1 hit.
Pfami PF06473. FGF-BP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel serum protein that is selectively produced by cytotoxic lymphocytes."
    Ogawa K., Tanaka K., Ishii A., Nakamura Y., Kondo S., Sugamura K., Takano S., Nakamura M., Nagata K.
    J. Immunol. 166:6404-6412(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Cytotoxic T-cell.
  2. "cDNA encoding a human protein related to FGF-binding protein HBp17 (HBp17-RP)."
    Sato J.D., Chapline M.C.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epidermal carcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiFGFP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BYJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3