Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NF-kappa-B inhibitor zeta

Gene

NFKBIZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor zeta
Alternative name(s):
I-kappa-B-zeta
Short name:
IkB-zeta
Short name:
IkappaBzeta
IL-1 inducible nuclear ankyrin-repeat protein
Short name:
INAP
Molecule possessing ankyrin repeats induced by lipopolysaccharide
Short name:
MAIL
Gene namesi
Name:NFKBIZ
Synonyms:IKBZ, INAP, MAIL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144802.11
HGNCiHGNC:29805 NFKBIZ
MIMi608004 gene
neXtProtiNX_Q9BYH8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64332
OpenTargetsiENSG00000144802
PharmGKBiPA134990505

Polymorphism and mutation databases

BioMutaiNFKBIZ
DMDMi74752456

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003235771 – 718NF-kappa-B inhibitor zetaAdd BLAST718

Proteomic databases

MaxQBiQ9BYH8
PaxDbiQ9BYH8
PeptideAtlasiQ9BYH8
PRIDEiQ9BYH8

PTM databases

iPTMnetiQ9BYH8
PhosphoSitePlusiQ9BYH8

Expressioni

Tissue specificityi

Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.1 Publication

Inductioni

By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000144802
CleanExiHS_NFKBIZ
ExpressionAtlasiQ9BYH8 baseline and differential
GenevisibleiQ9BYH8 HS

Organism-specific databases

HPAiHPA010547
HPA075363

Interactioni

Subunit structurei

Interacts with NFKB1/p50. Interacts with RELA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Akirin2B1AXD83EBI-3939694,EBI-10107866From Mus musculus.

Protein-protein interaction databases

BioGridi122139, 4 interactors
IntActiQ9BYH8, 4 interactors
MINTiQ9BYH8
STRINGi9606.ENSP00000325663

Structurei

3D structure databases

ProteinModelPortaliQ9BYH8
SMRiQ9BYH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati443 – 472ANK 1Add BLAST30
Repeati479 – 508ANK 2Add BLAST30
Repeati512 – 541ANK 3Add BLAST30
Repeati551 – 580ANK 4Add BLAST30
Repeati582 – 607ANK 5Add BLAST26
Repeati612 – 641ANK 6Add BLAST30
Repeati648 – 681ANK 7Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni321 – 394Required for transcriptional activityBy similarityAdd BLAST74
Regioni404 – 718Interaction with NFKB1/p50By similarityAdd BLAST315

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi164 – 179Nuclear localization signalBy similarityAdd BLAST16

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00550000074527
HOGENOMiHOG000113023
HOVERGENiHBG059690
InParanoidiQ9BYH8
KOiK14242
OMAiLHIRSHK
OrthoDBiEOG091G06D9
PhylomeDBiQ9BYH8
TreeFamiTF330224

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYH8-1) [UniParc]FASTAAdd to basket
Also known as: MAIL-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIVDKLLDDS RGGEGLRDAA GGCGLMTSPL NLSYFYGASP PAAAPGACDA
60 70 80 90 100
SCSVLGPSAP GSPGSDSSDF SSASSVSSCG AVESRSRGGA RAERQPVEPH
110 120 130 140 150
MGVGRQQRGP FQGVRVKNSV KELLLHIRSH KQKASGQAVD DFKTQGVNIE
160 170 180 190 200
QFRELKNTVS YSGKRKGPDS LSDGPACKRP ALLHSQFLTP PQTPTPGESM
210 220 230 240 250
EDVHLNEPKQ ESSADLLQNI INIKNECSPV SLNTVQVSWL NPVVVPQSSP
260 270 280 290 300
AEQCQDFHGG QVFSPPQKCQ PFQVRGSQQM IDQASLYQYS PQNQHVEQQP
310 320 330 340 350
HYTHKPTLEY SPFPIPPQSP AYEPNLFDGP ESQFCPNQSL VSLLGDQRES
360 370 380 390 400
ENIANPMQTS SSVQQQNDAH LHSFSMMPSS ACEAMVGHEM ASDSSNTSLP
410 420 430 440 450
FSNMGNPMNT TQLGKSLFQW QVEQEESKLA NISQDQFLSK DADGDTFLHI
460 470 480 490 500
AVAQGRRALS YVLARKMNAL HMLDIKEHNG QSAFQVAVAA NQHLIVQDLV
510 520 530 540 550
NIGAQVNTTD CWGRTPLHVC AEKGHSQVLQ AIQKGAVGSN QFVDLEATNY
560 570 580 590 600
DGLTPLHCAV IAHNAVVHEL QRNQQPHSPE VQELLLKNKS LVDTIKCLIQ
610 620 630 640 650
MGAAVEAKDR KSGRTALHLA AEEANLELIR LFLELPSCLS FVNAKAYNGN
660 670 680 690 700
TALHVAASLQ YRLTQLDAVR LLMRKGADPS TRNLENEQPV HLVPDGPVGE
710
QIRRILKGKS IQQRAPPY
Length:718
Mass (Da):78,061
Last modified:June 1, 2001 - v1
Checksum:i5656E00F2507DC7C
GO
Isoform 2 (identifier: Q9BYH8-2) [UniParc]FASTAAdd to basket
Also known as: MAIL-S, Transcription variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Show »
Length:618
Mass (Da):68,245
Checksum:i483EE108DC96AA52
GO
Isoform 3 (identifier: Q9BYH8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-358: Missing.

Show »
Length:596
Mass (Da):64,298
Checksum:iFB69A4BAF8B33318
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti567V → F in BAC03746 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039547307T → S. Corresponds to variant dbSNP:rs3821727Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0320221 – 100Missing in isoform 2. 3 PublicationsAdd BLAST100
Alternative sequenceiVSP_032023237 – 358Missing in isoform 3. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037925 mRNA Translation: BAB40337.1
AF548362 mRNA Translation: AAN40698.1
DQ224339 mRNA Translation: ABB02425.1
AK054787 mRNA Translation: BAG51424.1
AK091782 mRNA Translation: BAC03746.1
CH471052 Genomic DNA Translation: EAW79771.1
CH471052 Genomic DNA Translation: EAW79772.1
BC060800 mRNA Translation: AAH60800.1
CCDSiCCDS2946.1 [Q9BYH8-1]
CCDS43123.1 [Q9BYH8-2]
RefSeqiNP_001005474.1, NM_001005474.2 [Q9BYH8-2]
NP_113607.1, NM_031419.3 [Q9BYH8-1]
UniGeneiHs.319171

Genome annotation databases

EnsembliENST00000326151; ENSP00000325593; ENSG00000144802 [Q9BYH8-3]
ENST00000326172; ENSP00000325663; ENSG00000144802 [Q9BYH8-1]
ENST00000394054; ENSP00000377618; ENSG00000144802 [Q9BYH8-2]
GeneIDi64332
KEGGihsa:64332
UCSCiuc003dvo.4 human [Q9BYH8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIKBZ_HUMAN
AccessioniPrimary (citable) accession number: Q9BYH8
Secondary accession number(s): B3KNR2
, D3DN54, Q8IUL4, Q8NAZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health