Q9BYH1 (SE6L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Seizure 6-like protein

Gene names

Name:	SEZ6L
Synonyms:	KIAA0927
ORF Names:	UNQ2542/PRO6094

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1024 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May contribute to specialized endoplasmic reticulum functions in neurons By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Widely expressed, including adult and fetal brains and lungs. Not expressed in all lung cancer cell lines.
Sequence similarities	Belongs to the SEZ6 family. Contains 3 CUB domains. Contains 5 Sushi (CCP/SCR) domains.
Sequence caution	The sequence BAA76771.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Sushi Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 4 (identifier: Q9BYH1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9BYH1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-227: Missing.
     868-944: Missing.
     1016-1024: ETREYEVSI → GTQKV

Isoform 2 (identifier: Q9BYH1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-227: Missing.
     943-943: Missing.
     1016-1024: ETREYEVSI → GTQKV

Isoform 3 (identifier: Q9BYH1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     803-867: IMYCTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGSSLLTCYSRETGTPIWTSRLPHCVS → T
     933-943: Missing.

Isoform 5 (identifier: Q9BYH1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     867-943: SEESLACDNP...QDSFEHALEV → L

Isoform 6 (identifier: Q9BYH1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     943-943: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

28

Potential

Chain

29 – 1024

996

Seizure 6-like protein

PRO_0000022323

Regions

Topological domain

29 – 958

930

Extracellular Potential

Transmembrane

959 – 979

21

Helical; Potential

Topological domain

980 – 1024

45

Cytoplasmic Potential

Domain

281 – 389

109

CUB 1

Domain

391 – 450

60

Sushi 1

Domain

452 – 562

111

CUB 2

Domain

565 – 626

62

Sushi 2

Domain

628 – 739

112

CUB 3

Domain

743 – 802

60

Sushi 3

Domain

804 – 867

64

Sushi 4

Domain

871 – 932

62

Sushi 5

Amino acid modifications

Glycosylation

311

1

N-linked (GlcNAc...) Potential

Glycosylation

328

1

N-linked (GlcNAc...) Potential

Glycosylation

350

1

N-linked (GlcNAc...) Potential

Glycosylation

435

1

N-linked (GlcNAc...) Potential

Glycosylation

458

1

N-linked (GlcNAc...) Potential

Glycosylation

474

1

N-linked (GlcNAc...) Potential

Glycosylation

514

1

N-linked (GlcNAc...) Potential

Glycosylation

576

1

N-linked (GlcNAc...) Potential

Glycosylation

618

1

N-linked (GlcNAc...) Potential

Glycosylation

674

1

N-linked (GlcNAc...) Potential

Glycosylation

742

1

N-linked (GlcNAc...) Potential

Disulfide bond

281 ↔ 308

By similarity

Disulfide bond

393 ↔ 433

By similarity

Disulfide bond

419 ↔ 448

By similarity

Disulfide bond

567 ↔ 609

By similarity

Disulfide bond

594 ↔ 624

By similarity

Disulfide bond

745 ↔ 787

By similarity

Disulfide bond

773 ↔ 800

By similarity

Disulfide bond

806 ↔ 848

By similarity

Disulfide bond

834 ↔ 865

By similarity

Disulfide bond

873 ↔ 915

By similarity

Disulfide bond

901 ↔ 930

By similarity

Natural variations

Alternative sequence

1 – 227

227

Missing in isoform 1 and isoform 2.

VSP_003976

Alternative sequence

803 – 867

65

IMYCT…PHCVS → T in isoform 3.

VSP_003981

Alternative sequence

867 – 943

77

SEESL…HALEV → L in isoform 5.

VSP_013022

Alternative sequence

868 – 944

77

Missing in isoform 1.

VSP_003977

Alternative sequence

933 – 943

11

Missing in isoform 3.

VSP_003978

Alternative sequence

943

1

Missing in isoform 2 and isoform 6.

VSP_003979

Alternative sequence

1016 – 1024

9

ETREYEVSI → GTQKV in isoform 1 and isoform 2.

VSP_003980

Natural variant

52

1

P → L.
Corresponds to variant rs6004989 [ dbSNP | Ensembl ].

VAR_043338

Natural variant

185

1

W → L.
Corresponds to variant rs137203 [ dbSNP | Ensembl ].

VAR_024348

Natural variant

430

1

M → I. Ref.7
Corresponds to variant rs663048 [ dbSNP | Ensembl ].

VAR_020330

Natural variant

671

1

Q → H.
Corresponds to variant rs586542 [ dbSNP | Ensembl ].

VAR_043339

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

1024

Helix Strand Turn

Details...

Beta strand

759 – 762

4

Beta strand

768 – 771

4

Beta strand

778 – 780

3

Beta strand

784 – 787

4

Beta strand

793 – 795

3

Beta strand

799 – 801

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 4 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: CBC0679E22C23B6E	FASTA	1,024	111,782
	10 20 30 40 50 60 MPAARPPAAG LRGISLFLAL LLGSPAAALE RDALPEGDAS PLGPYLLPSG APERGSPGKE 70 80 90 100 110 120 HPEERVVTAP PSSSQSAEVL GELVLDGTAP SAHHDIPALS PLLPEEARPK HALPPKKKLP 130 140 150 160 170 180 SLKQVNSARK QLRPKATSAA TVQRAGSQPA SQGLDLLSSS TEKPGPPGDP DPIVASEEAS 190 200 210 220 230 240 EVPLWLDRKE SAVPTTPAPL QISPFTSQPY VAHTLPQRPE PGEPGPDMAQ EAPQEDTSPM 250 260 270 280 290 300 ALMDKGENEL TGSASEESQE TTTSTIITTT VITTEQAPAL CSVSFSNPEG YIDSSDYPLL 310 320 330 340 350 360 PLNNFLECTY NVTVYTGYGV ELQVKSVNLS DGELLSIRGV DGPTLTVLAN QTLLVEGQVI 370 380 390 400 410 420 RSPTNTISVY FRTFQDDGLG TFQLHYQAFM LSCNFPRRPD SGDVTVMDLH SGGVAHFHCH 430 440 450 460 470 480 LGYELQGAKM LTCINASKPH WSSQEPICSA PCGGAVHNAT IGRVLSPSYP ENTNGSQFCI 490 500 510 520 530 540 WTIEAPEGQK LHLHFERLLL HDKDRMTVHS GQTNKSALLY DSLQTESVPF EGLLSEGNTI 550 560 570 580 590 600 RIEFTSDQAR AASTFNIRFE AFEKGHCYEP YIQNGNFTTS DPTYNIGTIV EFTCDPGHSL 610 620 630 640 650 660 EQGPAIIECI NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYVE GEDCIWKIHV 670 680 690 700 710 720 GEEKRIFLDI QFLNLSNSDI LTIYDGDEVM PHILGQYLGN SGPQKLYSST PDLTIQFHSD 730 740 750 760 770 780 PAGLIFGKGQ GFIMNYIEVS RNDSCSDLPE IQNGWKTTSH TELVRGARIT YQCDPGYDIV 790 800 810 820 830 840 GSDTLTCQWD LSWSSDPPFC EKIMYCTDPG EVDHSTRLIS DPVLLVGTTI QYTCNPGFVL 850 860 870 880 890 900 EGSSLLTCYS RETGTPIWTS RLPHCVSEES LACDNPGLPE NGYQILYKRL YLPGESLTFM 910 920 930 940 950 960 CYEGFELMGE VTIRCILGQP SHWNGPLPVC KVNQDSFEHA LEVAEAAAET SLEGGNMALA 970 980 990 1000 1010 1020 IFIPVLIISL LLGGAYIYIT RCRYYSNLRL PLMYSHPYSQ ITVETEFDNP IYETGETREY EVSI
	Isoform 1 [UniParc]. Checksum: 2D7EB9BFA5255AE6	FASTA	716	79,048
	10 20 30 40 50 60 MAQEAPQEDT SPMALMDKGE NELTGSASEE SQETTTSTII TTTVITTEQA PALCSVSFSN 70 80 90 100 110 120 PEGYIDSSDY PLLPLNNFLE CTYNVTVYTG YGVELQVKSV NLSDGELLSI RGVDGPTLTV 130 140 150 160 170 180 LANQTLLVEG QVIRSPTNTI SVYFRTFQDD GLGTFQLHYQ AFMLSCNFPR RPDSGDVTVM 190 200 210 220 230 240 DLHSGGVAHF HCHLGYELQG AKMLTCINAS KPHWSSQEPI CSAPCGGAVH NATIGRVLSP 250 260 270 280 290 300 SYPENTNGSQ FCIWTIEAPE GQKLHLHFER LLLHDKDRMT VHSGQTNKSA LLYDSLQTES 310 320 330 340 350 360 VPFEGLLSEG NTIRIEFTSD QARAASTFNI RFEAFEKGHC YEPYIQNGNF TTSDPTYNIG 370 380 390 400 410 420 TIVEFTCDPG HSLEQGPAII ECINVRDPYW NDTEPLCRAM CGGELSAVAG VVLSPNWPEP 430 440 450 460 470 480 YVEGEDCIWK IHVGEEKRIF LDIQFLNLSN SDILTIYDGD EVMPHILGQY LGNSGPQKLY 490 500 510 520 530 540 SSTPDLTIQF HSDPAGLIFG KGQGFIMNYI EVSRNDSCSD LPEIQNGWKT TSHTELVRGA 550 560 570 580 590 600 RITYQCDPGY DIVGSDTLTC QWDLSWSSDP PFCEKIMYCT DPGEVDHSTR LISDPVLLVG 610 620 630 640 650 660 TTIQYTCNPG FVLEGSSLLT CYSRETGTPI WTSRLPHCVS EAAAETSLEG GNMALAIFIP 670 680 690 700 710 VLIISLLLGG AYIYITRCRY YSNLRLPLMY SHPYSQITVE TEFDNPIYET GGTQKV
	Isoform 2 [UniParc]. Checksum: 06B56E639B87C01A	FASTA	792	87,593
	10 20 30 40 50 60 MAQEAPQEDT SPMALMDKGE NELTGSASEE SQETTTSTII TTTVITTEQA PALCSVSFSN 70 80 90 100 110 120 PEGYIDSSDY PLLPLNNFLE CTYNVTVYTG YGVELQVKSV NLSDGELLSI RGVDGPTLTV 130 140 150 160 170 180 LANQTLLVEG QVIRSPTNTI SVYFRTFQDD GLGTFQLHYQ AFMLSCNFPR RPDSGDVTVM 190 200 210 220 230 240 DLHSGGVAHF HCHLGYELQG AKMLTCINAS KPHWSSQEPI CSAPCGGAVH NATIGRVLSP 250 260 270 280 290 300 SYPENTNGSQ FCIWTIEAPE GQKLHLHFER LLLHDKDRMT VHSGQTNKSA LLYDSLQTES 310 320 330 340 350 360 VPFEGLLSEG NTIRIEFTSD QARAASTFNI RFEAFEKGHC YEPYIQNGNF TTSDPTYNIG 370 380 390 400 410 420 TIVEFTCDPG HSLEQGPAII ECINVRDPYW NDTEPLCRAM CGGELSAVAG VVLSPNWPEP 430 440 450 460 470 480 YVEGEDCIWK IHVGEEKRIF LDIQFLNLSN SDILTIYDGD EVMPHILGQY LGNSGPQKLY 490 500 510 520 530 540 SSTPDLTIQF HSDPAGLIFG KGQGFIMNYI EVSRNDSCSD LPEIQNGWKT TSHTELVRGA 550 560 570 580 590 600 RITYQCDPGY DIVGSDTLTC QWDLSWSSDP PFCEKIMYCT DPGEVDHSTR LISDPVLLVG 610 620 630 640 650 660 TTIQYTCNPG FVLEGSSLLT CYSRETGTPI WTSRLPHCVS EESLACDNPG LPENGYQILY 670 680 690 700 710 720 KRLYLPGESL TFMCYEGFEL MGEVTIRCIL GQPSHWNGPL PVCKVNQDSF EHALEAEAAA 730 740 750 760 770 780 ETSLEGGNMA LAIFIPVLII SLLLGGAYIY ITRCRYYSNL RLPLMYSHPY SQITVETEFD 790 NPIYETGGTQ KV
	Isoform 3 [UniParc]. Checksum: 64FACD9450B3F6F3	FASTA	949	103,497
	10 20 30 40 50 60 MPAARPPAAG LRGISLFLAL LLGSPAAALE RDALPEGDAS PLGPYLLPSG APERGSPGKE 70 80 90 100 110 120 HPEERVVTAP PSSSQSAEVL GELVLDGTAP SAHHDIPALS PLLPEEARPK HALPPKKKLP 130 140 150 160 170 180 SLKQVNSARK QLRPKATSAA TVQRAGSQPA SQGLDLLSSS TEKPGPPGDP DPIVASEEAS 190 200 210 220 230 240 EVPLWLDRKE SAVPTTPAPL QISPFTSQPY VAHTLPQRPE PGEPGPDMAQ EAPQEDTSPM 250 260 270 280 290 300 ALMDKGENEL TGSASEESQE TTTSTIITTT VITTEQAPAL CSVSFSNPEG YIDSSDYPLL 310 320 330 340 350 360 PLNNFLECTY NVTVYTGYGV ELQVKSVNLS DGELLSIRGV DGPTLTVLAN QTLLVEGQVI 370 380 390 400 410 420 RSPTNTISVY FRTFQDDGLG TFQLHYQAFM LSCNFPRRPD SGDVTVMDLH SGGVAHFHCH 430 440 450 460 470 480 LGYELQGAKM LTCINASKPH WSSQEPICSA PCGGAVHNAT IGRVLSPSYP ENTNGSQFCI 490 500 510 520 530 540 WTIEAPEGQK LHLHFERLLL HDKDRMTVHS GQTNKSALLY DSLQTESVPF EGLLSEGNTI 550 560 570 580 590 600 RIEFTSDQAR AASTFNIRFE AFEKGHCYEP YIQNGNFTTS DPTYNIGTIV EFTCDPGHSL 610 620 630 640 650 660 EQGPAIIECI NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYVE GEDCIWKIHV 670 680 690 700 710 720 GEEKRIFLDI QFLNLSNSDI LTIYDGDEVM PHILGQYLGN SGPQKLYSST PDLTIQFHSD 730 740 750 760 770 780 PAGLIFGKGQ GFIMNYIEVS RNDSCSDLPE IQNGWKTTSH TELVRGARIT YQCDPGYDIV 790 800 810 820 830 840 GSDTLTCQWD LSWSSDPPFC EKTEESLACD NPGLPENGYQ ILYKRLYLPG ESLTFMCYEG 850 860 870 880 890 900 FELMGEVTIR CILGQPSHWN GPLPVCKVAE AAAETSLEGG NMALAIFIPV LIISLLLGGA 910 920 930 940 YIYITRCRYY SNLRLPLMYS HPYSQITVET EFDNPIYETG ETREYEVSI
	Isoform 5 [UniParc]. Checksum: AC7FE35AA8986926	FASTA	948	103,234
	10 20 30 40 50 60 MPAARPPAAG LRGISLFLAL LLGSPAAALE RDALPEGDAS PLGPYLLPSG APERGSPGKE 70 80 90 100 110 120 HPEERVVTAP PSSSQSAEVL GELVLDGTAP SAHHDIPALS PLLPEEARPK HALPPKKKLP 130 140 150 160 170 180 SLKQVNSARK QLRPKATSAA TVQRAGSQPA SQGLDLLSSS TEKPGPPGDP DPIVASEEAS 190 200 210 220 230 240 EVPLWLDRKE SAVPTTPAPL QISPFTSQPY VAHTLPQRPE PGEPGPDMAQ EAPQEDTSPM 250 260 270 280 290 300 ALMDKGENEL TGSASEESQE TTTSTIITTT VITTEQAPAL CSVSFSNPEG YIDSSDYPLL 310 320 330 340 350 360 PLNNFLECTY NVTVYTGYGV ELQVKSVNLS DGELLSIRGV DGPTLTVLAN QTLLVEGQVI 370 380 390 400 410 420 RSPTNTISVY FRTFQDDGLG TFQLHYQAFM LSCNFPRRPD SGDVTVMDLH SGGVAHFHCH 430 440 450 460 470 480 LGYELQGAKM LTCINASKPH WSSQEPICSA PCGGAVHNAT IGRVLSPSYP ENTNGSQFCI 490 500 510 520 530 540 WTIEAPEGQK LHLHFERLLL HDKDRMTVHS GQTNKSALLY DSLQTESVPF EGLLSEGNTI 550 560 570 580 590 600 RIEFTSDQAR AASTFNIRFE AFEKGHCYEP YIQNGNFTTS DPTYNIGTIV EFTCDPGHSL 610 620 630 640 650 660 EQGPAIIECI NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYVE GEDCIWKIHV 670 680 690 700 710 720 GEEKRIFLDI QFLNLSNSDI LTIYDGDEVM PHILGQYLGN SGPQKLYSST PDLTIQFHSD 730 740 750 760 770 780 PAGLIFGKGQ GFIMNYIEVS RNDSCSDLPE IQNGWKTTSH TELVRGARIT YQCDPGYDIV 790 800 810 820 830 840 GSDTLTCQWD LSWSSDPPFC EKIMYCTDPG EVDHSTRLIS DPVLLVGTTI QYTCNPGFVL 850 860 870 880 890 900 EGSSLLTCYS RETGTPIWTS RLPHCVLAEA AAETSLEGGN MALAIFIPVL IISLLLGGAY 910 920 930 940 IYITRCRYYS NLRLPLMYSH PYSQITVETE FDNPIYETGE TREYEVSI
	Isoform 6 [UniParc]. Checksum: F944A3C541880D3A	FASTA	1,023	111,683
	10 20 30 40 50 60 MPAARPPAAG LRGISLFLAL LLGSPAAALE RDALPEGDAS PLGPYLLPSG APERGSPGKE 70 80 90 100 110 120 HPEERVVTAP PSSSQSAEVL GELVLDGTAP SAHHDIPALS PLLPEEARPK HALPPKKKLP 130 140 150 160 170 180 SLKQVNSARK QLRPKATSAA TVQRAGSQPA SQGLDLLSSS TEKPGPPGDP DPIVASEEAS 190 200 210 220 230 240 EVPLWLDRKE SAVPTTPAPL QISPFTSQPY VAHTLPQRPE PGEPGPDMAQ EAPQEDTSPM 250 260 270 280 290 300 ALMDKGENEL TGSASEESQE TTTSTIITTT VITTEQAPAL CSVSFSNPEG YIDSSDYPLL 310 320 330 340 350 360 PLNNFLECTY NVTVYTGYGV ELQVKSVNLS DGELLSIRGV DGPTLTVLAN QTLLVEGQVI 370 380 390 400 410 420 RSPTNTISVY FRTFQDDGLG TFQLHYQAFM LSCNFPRRPD SGDVTVMDLH SGGVAHFHCH 430 440 450 460 470 480 LGYELQGAKM LTCINASKPH WSSQEPICSA PCGGAVHNAT IGRVLSPSYP ENTNGSQFCI 490 500 510 520 530 540 WTIEAPEGQK LHLHFERLLL HDKDRMTVHS GQTNKSALLY DSLQTESVPF EGLLSEGNTI 550 560 570 580 590 600 RIEFTSDQAR AASTFNIRFE AFEKGHCYEP YIQNGNFTTS DPTYNIGTIV EFTCDPGHSL 610 620 630 640 650 660 EQGPAIIECI NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYVE GEDCIWKIHV 670 680 690 700 710 720 GEEKRIFLDI QFLNLSNSDI LTIYDGDEVM PHILGQYLGN SGPQKLYSST PDLTIQFHSD 730 740 750 760 770 780 PAGLIFGKGQ GFIMNYIEVS RNDSCSDLPE IQNGWKTTSH TELVRGARIT YQCDPGYDIV 790 800 810 820 830 840 GSDTLTCQWD LSWSSDPPFC EKIMYCTDPG EVDHSTRLIS DPVLLVGTTI QYTCNPGFVL 850 860 870 880 890 900 EGSSLLTCYS RETGTPIWTS RLPHCVSEES LACDNPGLPE NGYQILYKRL YLPGESLTFM 910 920 930 940 950 960 CYEGFELMGE VTIRCILGQP SHWNGPLPVC KVNQDSFEHA LEAEAAAETS LEGGNMALAI 970 980 990 1000 1010 1020 FIPVLIISLL LGGAYIYITR CRYYSNLRLP LMYSHPYSQI TVETEFDNPI YETGETREYE VSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line." Nishioka M., Kohno T., Takahashi M., Niki T., Yamada T., Sone S., Yokota J. Oncogene 19:6251-6260(2000) [PubMed: 11175339] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[3]	"Reevaluating human gene annotation: a second-generation analysis of chromosome 22." Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I. Genome Res. 13:27-36(2003) [PubMed: 12529303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Fetal brain.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
[5]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[6]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-430. Tissue: Brain.
[8]	"A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer." Suzuki H., Gabrielson E., Chen W., Anbazhagan R., Van Engeland M., Weijenberg M.P., Herman J.G., Baylin S.B. Nat. Genet. 31:141-149(2002) [PubMed: 11992124] [Abstract] Cited for: GENE EXPRESSION REGULATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB041736 mRNA. Translation: BAB40970.1.
AB023144 mRNA. Translation: BAA76771.2. Different initiation.
AL035545 mRNA. Translation: CAB37431.1.
AL050253 mRNA. Translation: CAB43355.1.
AY358405 mRNA. Translation: AAQ88771.1.
CR456574 mRNA. Translation: CAG30460.1.
AL022337, AL023513, AL078460 Genomic DNA. Translation: CAI17997.1.
AL078460, AL022337, AL023513 Genomic DNA. Translation: CAI20266.1.
AL023513, AL022337, AL078460 Genomic DNA. Translation: CAI19980.1.
AL023513, AL022337, AL078460 Genomic DNA. Translation: CAQ08922.1.
AL023513, AL022337, AL078460 Genomic DNA. Translation: CAQ08923.1.
AL078460, AL022337, AL023513 Genomic DNA. Translation: CAQ08975.1.
AL078460, AL022337, AL023513 Genomic DNA. Translation: CAQ08976.1.
AL022337, AL023513, AL078460 Genomic DNA. Translation: CAQ10786.1.
AL022337, AL023513, AL078460 Genomic DNA. Translation: CAQ10787.1.
BC126115 mRNA. Translation: AAI26116.1.

IPI

IPI00157417.
IPI00163788.
IPI00220333.
IPI00220334.
IPI00554736.
IPI00879665.

RefSeq

NP_001171702.1. NM_001184773.1.
NP_001171703.1. NM_001184774.1.
NP_001171704.1. NM_001184775.1.
NP_001171705.1. NM_001184776.1.
NP_001171706.1. NM_001184777.1.
NP_066938.2. NM_021115.4.

UniGene

Hs.194766.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YRA	NMR	-	A	745-802	[»]

ProteinModelPortal

Q9BYH1.

SMR

Q9BYH1. Positions 280-933.

ModBase

Search...

Protein-protein interaction databases

STRING

Q9BYH1.

Polymorphism databases

DMDM

22002000.

Proteomic databases

PRIDE

Q9BYH1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000248933; ENSP00000248933; ENSG00000100095.

GeneID

23544.

KEGG

hsa:23544.

UCSC

uc003acb.1. human.
uc003acd.1. human.
uc003ace.1. human.
uc003acf.1. human.
uc010gvc.1. human.

Organism-specific databases

CTD

23544.

GeneCards

GC22P026565.

H-InvDB

HIX0016322.

HGNC

HGNC:10763. SEZ6L.

MIM

607021. gene.

neXtProt

NX_Q9BYH1.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG14999.

GeneTree

ENSGT00600000084043.

HOVERGEN

HBG057885.

InParanoid

Q9BYH1.

OMA

MTVHSGQ.

PhylomeDB

Q9BYH1.

Gene expression databases

ArrayExpress

Q9BYH1.

Bgee

Q9BYH1.

Genevestigator

Q9BYH1.

GermOnline

ENSG00000100095. Homo sapiens.

Family and domain databases

InterPro

IPR016060. Complement_control_module.
IPR000859. CUB.
IPR000436. Sushi_SCR_CCP.
[Graphical view]

Gene3D

G3DSA:2.10.70.10. Complement_control_module. 5 hits.
G3DSA:2.60.120.290. CUB. 3 hits.

Pfam

PF00431. CUB. 3 hits.
PF00084. Sushi. 5 hits.
[Graphical view]

SMART

SM00032. CCP. 5 hits.
SM00042. CUB. 3 hits.
[Graphical view]

SUPFAM

SSF57535. Complement_control_module. 5 hits.
SSF49854. CUB. 3 hits.

PROSITE

PS01180. CUB. 3 hits.
PS50923. SUSHI. 5 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

46072.

SOURCE

Search...

Entry information

Entry name

SE6L1_HUMAN

Accession

Primary (citable) accession number: Q9BYH1
Secondary accession number(s): A0AUW7 , B0QYG4, B0QYG5, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.