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Unreviewed, UniProtKB/TrEMBL Q9BYG6 (Q9BYG6_HUMAN)

Last modified January 19, 2010. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    SMAD4 EMBL BAB40977.1
Gene names
Name: SMAD4 EMBL BAB40977.1
OrganismHomo sapiens (Human) EMBL BAB40977.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length436 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation Spearmint SPM003619
   Cellular componentNucleus Spearmint SPM003619
Gene Ontology (GO)
   Biological processanterior/posterior pattern formation

Inferred from electronic annotation. Source: Compara

branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Compara

gastrulation with mouth forming second

Inferred from electronic annotation. Source: Compara

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Compara

neuron fate commitment

Inferred from electronic annotation. Source: Compara

palate development

Inferred from electronic annotation. Source: Compara

positive regulation of SMAD protein nuclear translocation

Inferred from electronic annotation. Source: Compara

positive regulation of epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Compara

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Compara

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Compara

regulation of binding

Inferred from electronic annotation. Source: Compara

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular componenttranscription factor complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionSMAD binding

Inferred from electronic annotation. Source: Compara

collagen binding

Inferred from electronic annotation. Source: Compara

transcription activator activity

Inferred from electronic annotation. Source: Compara

transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue4361 EMBL BAB40977.1

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Sequences

Sequence LengthMass (Da)Tools
Q9BYG6-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 60BADB8004C8C8F3

FASTA43648,085
        10         20         30         40         50         60 
MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA 

        70         80         90        100        110        120 
ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD 

       130        140        150        160        170        180 
LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPSSMMVKD EYVHDFEGQP SLSTEGHSIQ 

       190        200        210        220        230        240 
TIQHPPSNRA STETYSTPAL LAPSESNATS TANFPNIPVA STSQPASILG GSHSEGLLQI 

       250        260        270        280        290        300 
ASGPQPGQQQ NGFTGQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPMPPHPGH 

       310        320        330        340        350        360 
YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV DGYVDPSGGD 

       370        380        390        400        410        420 
RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR CLSDHAVFVQ SYYLDREAGR 

       430 
APGDAVHKIY PSAYIK

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References

[1]"Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus."
Yanaihara N., Kohno T., Takakura S., Takei K., Otsuka A., Sunaga N., Takahashi M., Yamazaki M., Tashiro H., Fukuzumi Y., Fujimori Y., Hagiwara K., Tanaka T., Yokota J.
Genomics 72:169-179(2001) [PubMed: 11401430] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB043547 Genomic DNA. Translation: BAB40977.1.
IPIIPI00013404.
UniGeneHs.75862

3D structure databases

HSSPHSSP built from PDB template 1DD1 based on UniProtKB Q13485.
SMRQ9BYG6. Positions 19-138, 285-436.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9BYG6.

Genome annotation databases

EnsemblENST00000342988; ENSP00000341551; ENSG00000141646; Homo sapiens. [Genome view]
ENST00000398417; ENSP00000381452; ENSG00000141646; Homo sapiens. [Genome view]

Organism-specific databases

HGNCHGNC:6770. SMAD4.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9BYG6.

Gene expression databases

ArrayExpressQ9BYG6.
BgeeQ9BYG6.

Family and domain databases

InterProIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
Gene3DG3DSA:3.90.520.10. MAD_MH1. 1 hit.
G3DSA:2.60.200.10. MH2_Dwarfin-type. 1 hit.
PANTHERPTHR13703. Dwarfin. 1 hit.
PfamPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
PROSITEPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameQ9BYG6_HUMAN
AccessionPrimary (citable) accession number: Q9BYG6
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: January 19, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information