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Q9BYG5

- PAR6B_HUMAN

UniProt

Q9BYG5 - PAR6B_HUMAN

Protein

Partitioning defective 6 homolog beta

Gene

PARD6B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. axonogenesis Source: UniProtKB
    2. cell-cell junction assembly Source: UniProtKB
    3. cell-cell junction organization Source: Reactome
    4. cell cycle Source: UniProtKB-KW
    5. cell division Source: UniProtKB-KW
    6. cell junction assembly Source: Reactome
    7. establishment or maintenance of cell polarity Source: UniProtKB
    8. protein complex assembly Source: UniProtKB
    9. regulation of cell migration Source: UniProtKB
    10. tight junction assembly Source: Reactome

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_19373. Tight junction interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Partitioning defective 6 homolog beta
    Short name:
    PAR-6 beta
    Short name:
    PAR-6B
    Gene namesi
    Name:PARD6B
    Synonyms:PAR6B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16245. PARD6B.

    Subcellular locationi

    Cytoplasm. Cell membrane By similarity. Cell junctiontight junction By similarity

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. cell cortex Source: Ensembl
    3. cytoplasm Source: HPA
    4. cytosol Source: Reactome
    5. extracellular vesicular exosome Source: UniProt
    6. nucleus Source: Ensembl
    7. plasma membrane Source: UniProtKB
    8. protein complex Source: Ensembl
    9. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32938.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Partitioning defective 6 homolog betaPRO_0000112516Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei11 – 111Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BYG5.
    PaxDbiQ9BYG5.
    PRIDEiQ9BYG5.

    PTM databases

    PhosphoSiteiQ9BYG5.

    Expressioni

    Tissue specificityi

    Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.

    Gene expression databases

    ArrayExpressiQ9BYG5.
    BgeeiQ9BYG5.
    CleanExiHS_PARD6B.
    GenevestigatoriQ9BYG5.

    Organism-specific databases

    HPAiHPA013376.

    Interactioni

    Subunit structurei

    Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 By similarity. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC42P609537EBI-295391,EBI-81752
    PARD3Q8TEW04EBI-295391,EBI-81968
    PNMA1Q8ND902EBI-295391,EBI-302345
    PRKCIP417439EBI-295391,EBI-286199
    PRKCZQ055133EBI-295391,EBI-295351
    RAC1P630003EBI-295391,EBI-413628
    YWHAHQ049172EBI-295391,EBI-306940

    Protein-protein interaction databases

    BioGridi124145. 16 interactions.
    IntActiQ9BYG5. 12 interactions.
    MINTiMINT-5001972.
    STRINGi9606.ENSP00000360672.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYG5.
    SMRiQ9BYG5. Positions 17-96, 131-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 9681OPRAdd
    BLAST
    Domaini133 – 15018Pseudo-CRIBAdd
    BLAST
    Domaini157 – 25094PDZPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni126 – 253128Interaction with PARD3 and CDC42By similarityAdd
    BLAST

    Domaini

    The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
    The PDZ domain mediates interaction with MPP5.By similarity

    Sequence similaritiesi

    Belongs to the PAR6 family.Curated
    Contains 1 OPR domain.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 pseudo-CRIB domain.Curated

    Phylogenomic databases

    eggNOGiNOG315424.
    HOGENOMiHOG000231716.
    HOVERGENiHBG053509.
    InParanoidiQ9BYG5.
    KOiK06093.
    OMAiEPQQIPK.
    OrthoDBiEOG73JKWB.
    PhylomeDBiQ9BYG5.
    TreeFamiTF312899.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR000270. OPR_PB1.
    IPR001478. PDZ.
    [Graphical view]
    PfamiPF00564. PB1. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00666. PB1. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BYG5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNRSHRHGAG SGCLGTMEVK SKFGAEFRRF SLERSKPGKF EEFYGLLQHV    50
    HKIPNVDVLV GYADIHGDLL PINNDDNYHK AVSTANPLLR IFIQKKEEAD 100
    YSAFGTDTLI KKKNVLTNVL RPDNHRKKPH IVISMPQDFR PVSSIIDVDI 150
    LPETHRRVRL YKYGTEKPLG FYIRDGSSVR VTPHGLEKVP GIFISRLVPG 200
    GLAQSTGLLA VNDEVLEVNG IEVSGKSLDQ VTDMMIANSR NLIITVRPAN 250
    QRNNVVRNSR TSGSSGQSTD NSLLGYPQQI EPSFEPEDED SEEDDIIIED 300
    NGVPQQIPKA VPNTESLESL TQIELSFESG QNGFIPSNEV SLAAIASSSN 350
    TEFETHAPDQ KLLEEDGTII TL 372
    Length:372
    Mass (Da):41,182
    Last modified:June 1, 2001 - v1
    Checksum:i79B5392D72B15BDC
    GO
    Isoform 2 (identifier: Q9BYG5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         97-113: EEADYSAFGTDTLIKKK → GCVLEHSKNNVRMPCLK
         114-370: Missing.

    Show »
    Length:115
    Mass (Da):12,989
    Checksum:i65666757F08F7157
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei97 – 11317EEADY…LIKKK → GCVLEHSKNNVRMPCLK in isoform 2. 1 PublicationVSP_053311Add
    BLAST
    Alternative sequencei114 – 370257Missing in isoform 2. 1 PublicationVSP_053312Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044555 mRNA. Translation: BAB40756.1.
    AB178534 mRNA. Translation: BAF92013.1.
    AL031680 Genomic DNA. Translation: CAB44747.3.
    BC060847 mRNA. Translation: AAH60847.1.
    CCDSiCCDS33485.1. [Q9BYG5-1]
    RefSeqiNP_115910.1. NM_032521.2. [Q9BYG5-1]
    UniGeneiHs.589848.

    Genome annotation databases

    EnsembliENST00000371610; ENSP00000360672; ENSG00000124171. [Q9BYG5-1]
    ENST00000396039; ENSP00000379354; ENSG00000124171. [Q9BYG5-2]
    GeneIDi84612.
    KEGGihsa:84612.
    UCSCiuc002xvo.3. human. [Q9BYG5-1]

    Polymorphism databases

    DMDMi30913176.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044555 mRNA. Translation: BAB40756.1 .
    AB178534 mRNA. Translation: BAF92013.1 .
    AL031680 Genomic DNA. Translation: CAB44747.3 .
    BC060847 mRNA. Translation: AAH60847.1 .
    CCDSi CCDS33485.1. [Q9BYG5-1 ]
    RefSeqi NP_115910.1. NM_032521.2. [Q9BYG5-1 ]
    UniGenei Hs.589848.

    3D structure databases

    ProteinModelPortali Q9BYG5.
    SMRi Q9BYG5. Positions 17-96, 131-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124145. 16 interactions.
    IntActi Q9BYG5. 12 interactions.
    MINTi MINT-5001972.
    STRINGi 9606.ENSP00000360672.

    PTM databases

    PhosphoSitei Q9BYG5.

    Polymorphism databases

    DMDMi 30913176.

    Proteomic databases

    MaxQBi Q9BYG5.
    PaxDbi Q9BYG5.
    PRIDEi Q9BYG5.

    Protocols and materials databases

    DNASUi 84612.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371610 ; ENSP00000360672 ; ENSG00000124171 . [Q9BYG5-1 ]
    ENST00000396039 ; ENSP00000379354 ; ENSG00000124171 . [Q9BYG5-2 ]
    GeneIDi 84612.
    KEGGi hsa:84612.
    UCSCi uc002xvo.3. human. [Q9BYG5-1 ]

    Organism-specific databases

    CTDi 84612.
    GeneCardsi GC20P049348.
    HGNCi HGNC:16245. PARD6B.
    HPAi HPA013376.
    MIMi 608975. gene.
    neXtProti NX_Q9BYG5.
    PharmGKBi PA32938.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315424.
    HOGENOMi HOG000231716.
    HOVERGENi HBG053509.
    InParanoidi Q9BYG5.
    KOi K06093.
    OMAi EPQQIPK.
    OrthoDBi EOG73JKWB.
    PhylomeDBi Q9BYG5.
    TreeFami TF312899.

    Enzyme and pathway databases

    Reactomei REACT_19373. Tight junction interactions.

    Miscellaneous databases

    GeneWikii PARD6B.
    GenomeRNAii 84612.
    NextBioi 35460691.
    PROi Q9BYG5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BYG5.
    Bgeei Q9BYG5.
    CleanExi HS_PARD6B.
    Genevestigatori Q9BYG5.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR000270. OPR_PB1.
    IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00564. PB1. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00666. PB1. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C."
      Noda Y., Takeya R., Ohno S., Naito S., Ito T., Sumimoto H.
      Genes Cells 6:107-119(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH PRKCI; PRKCZ; RAC1 AND CDC42.
      Tissue: Neuroblastoma.
    2. "Splicing variants of the cell polarity protein PAR-6."
      Noda Y., Kohjima M., Izaki T., Sumimoto H.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    5. "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties."
      Gao L., Macara I.G., Joberty G.
      Gene 294:99-107(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ALS2CR19 AND PARD3.
    6. "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity."
      Yamanaka T., Horikoshi Y., Sugiyama Y., Ishiyama C., Suzuki A., Hirose T., Iwamatsu A., Shinohara A., Ohno S.
      Curr. Biol. 13:734-743(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LLGL1 AND PRKCI.
    7. "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity."
      Liu X.F., Ishida H., Raziuddin R., Miki T.
      Mol. Cell. Biol. 24:6665-6675(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ECT2.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPAR6B_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYG5
    Secondary accession number(s): A2A2A7, Q9Y510
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3