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Protein

Partitioning defective 6 homolog gamma

Gene

PARD6G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective 6 homolog gamma
Short name:
PAR-6 gamma
Alternative name(s):
PAR6D
Gene namesi
Name:PARD6G
Synonyms:PAR6G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000178184.15
HGNCiHGNC:16076 PARD6G
MIMi608976 gene
neXtProtiNX_Q9BYG4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi84552
OpenTargetsiENSG00000178184
PharmGKBiPA32939

Polymorphism and mutation databases

BioMutaiPARD6G
DMDMi30913175

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125181 – 376Partitioning defective 6 homolog gammaAdd BLAST376

Proteomic databases

EPDiQ9BYG4
MaxQBiQ9BYG4
PaxDbiQ9BYG4
PeptideAtlasiQ9BYG4
PRIDEiQ9BYG4

PTM databases

iPTMnetiQ9BYG4
PhosphoSitePlusiQ9BYG4

Expressioni

Tissue specificityi

Widely expressed, with a higher expression in fetal and adult kidney.

Gene expression databases

BgeeiENSG00000178184
CleanExiHS_PARD6G
ExpressionAtlasiQ9BYG4 baseline and differential
GenevisibleiQ9BYG4 HS

Organism-specific databases

HPAiHPA047017

Interactioni

Subunit structurei

Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ.Curated2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124135, 18 interactors
IntActiQ9BYG4, 14 interactors
MINTiQ9BYG4
STRINGi9606.ENSP00000343144

Structurei

3D structure databases

ProteinModelPortaliQ9BYG4
SMRiQ9BYG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 98PB1PROSITE-ProRule annotationAdd BLAST81
Domaini134 – 151Pseudo-CRIBAdd BLAST18
Domaini158 – 251PDZPROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 254Interaction with PARD3 and CDC42By similarityAdd BLAST128

Domaini

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.By similarity

Sequence similaritiesi

Belongs to the PAR6 family.Curated

Phylogenomic databases

eggNOGiKOG3606 Eukaryota
ENOG410XRJ3 LUCA
GeneTreeiENSGT00390000005255
HOGENOMiHOG000231716
HOVERGENiHBG053509
InParanoidiQ9BYG4
KOiK06093
OMAiISMPHDF
OrthoDBiEOG091G0FFH
PhylomeDBiQ9BYG4
TreeFamiTF312899

Family and domain databases

CDDicd06403 PB1_Par6, 1 hit
InterProiView protein in InterPro
IPR034874 PAR-6_G
IPR000270 PB1_dom
IPR034868 PB1_Par6
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR14102:SF3 PTHR14102:SF3, 1 hit
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50106 PDZ, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRSFHKSQT LRFYDCSAVE VKSKFGAEFR RFSLDRHKPG KFEDFYKLVV
60 70 80 90 100
HTHHISNSDV TIGYADVHGD LLPINNDDNF CKAVSSANPL LRVFIQKREE
110 120 130 140 150
AERGSLGAGS LCRRRRALGA LRDEGPRRRA HLDIGLPRDF RPVSSIIDVD
160 170 180 190 200
LVPETHRRVR LHRHGCEKPL GFYIRDGASV RVTPHGLEKV PGIFISRMVP
210 220 230 240 250
GGLAESTGLL AVNDEVLEVN GIEVAGKTLD QVTDMMIANS HNLIVTVKPA
260 270 280 290 300
NQRNNVVRGG RALGSSGPPS DGTAGFVGPP APRVLQNFHP DEAESDEDND
310 320 330 340 350
VVIEGTLEPA RPPQTPGAPA GSLSRVNGAG LAQRLQRDLA LDGGLQRLLS
360 370
SLRADPRHSL ALPPGGVEEH GPAVTL
Length:376
Mass (Da):40,883
Last modified:June 1, 2001 - v1
Checksum:iE5A4EF521403CA11
GO
Isoform 2 (identifier: Q9BYG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-107: EEAERGSLG → DDGALRPGT
     108-376: Missing.

Show »
Length:107
Mass (Da):12,243
Checksum:i55FF2570EA829289
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04758699 – 107EEAERGSLG → DDGALRPGT in isoform 2. 1 Publication9
Alternative sequenceiVSP_047587108 – 376Missing in isoform 2. 1 PublicationAdd BLAST269

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044556 mRNA Translation: BAB40757.1
AB178536 mRNA Translation: BAF92015.1
AC139100 Genomic DNA No translation available.
BC060797 mRNA Translation: AAH60797.1
CCDSiCCDS12022.1 [Q9BYG4-1]
RefSeqiNP_115899.1, NM_032510.3 [Q9BYG4-1]
UniGeneiHs.654920

Genome annotation databases

EnsembliENST00000353265; ENSP00000343144; ENSG00000178184 [Q9BYG4-1]
ENST00000470488; ENSP00000468735; ENSG00000178184 [Q9BYG4-2]
GeneIDi84552
KEGGihsa:84552
UCSCiuc002lny.4 human [Q9BYG4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPAR6G_HUMAN
AccessioniPrimary (citable) accession number: Q9BYG4
Secondary accession number(s): A8QM57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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