Q9BYG4 (PAR6G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Partitioning defective 6 homolog gamma
Short name=PAR-6 gamma

Alternative name(s):
PAR6D

Gene names

Name:	PARD6G
Synonyms:	PAR6G

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins By similarity.
Subunit structure	Interacts with PARD3 Probable. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Ref.1 Ref.3
Subcellular location	Cytoplasm. Cell membrane By similarity. Cell junction › tight junction By similarity.
Tissue specificity	Widely expressed, with a higher expression in fetal and adult kidney.
Domain	The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases By similarity.
Sequence similarities	Belongs to the PAR6 family. Contains 1 OPR domain. Contains 1 PDZ (DHR) domain. Contains 1 pseudo-CRIB domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cell junction Cell membrane Cytoplasm Membrane Tight junction
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW tight junction assembly Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome protein complex Inferred from electronic annotation. Source: Compara tight junction Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC42	P60953	5	EBI-295417,EBI-81752
MARK2	Q7KZI7	2	EBI-295417,EBI-516560
MARK4	Q96L34	2	EBI-295417,EBI-302319
PARD3	Q8TEW0	3	EBI-295417,EBI-81968
PRKCI	P41743	5	EBI-295417,EBI-286199
RAC1	P63000	2	EBI-295417,EBI-413628
YWHAH	Q04917	2	EBI-295417,EBI-306940

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Partitioning defective 6 homolog gamma		PRO_0000112518
Regions
	Domain	18 – 98	81	OPR
	Domain	134 – 151	18	Pseudo-CRIB
	Domain	158 – 251	94	PDZ
	Region	127 – 254	128	Interaction with PARD3 and CDC42 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9BYG4 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: E5A4EF521403CA11	FASTA	376	40,883
	10 20 30 40 50 60 MNRSFHKSQT LRFYDCSAVE VKSKFGAEFR RFSLDRHKPG KFEDFYKLVV HTHHISNSDV 70 80 90 100 110 120 TIGYADVHGD LLPINNDDNF CKAVSSANPL LRVFIQKREE AERGSLGAGS LCRRRRALGA 130 140 150 160 170 180 LRDEGPRRRA HLDIGLPRDF RPVSSIIDVD LVPETHRRVR LHRHGCEKPL GFYIRDGASV 190 200 210 220 230 240 RVTPHGLEKV PGIFISRMVP GGLAESTGLL AVNDEVLEVN GIEVAGKTLD QVTDMMIANS 250 260 270 280 290 300 HNLIVTVKPA NQRNNVVRGG RALGSSGPPS DGTAGFVGPP APRVLQNFHP DEAESDEDND 310 320 330 340 350 360 VVIEGTLEPA RPPQTPGAPA GSLSRVNGAG LAQRLQRDLA LDGGLQRLLS SLRADPRHSL 370 ALPPGGVEEH GPAVTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C." Noda Y., Takeya R., Ohno S., Naito S., Ito T., Sumimoto H. Genes Cells 6:107-119(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RAC1; CDC42; PRKCI AND PRKCZ. Tissue: Neuroblastoma.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42." Joberty G., Petersen C., Gao L., Macara I.G. Nat. Cell Biol. 2:531-539(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ARHQ.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB044556 mRNA. Translation: BAB40757.1. BC060797 mRNA. Translation: AAH60797.1.
IPI	IPI00032555.
RefSeq	NP_115899.1. NM_032510.3.
UniGene	Hs.654920.
3D structure databases
ProteinModelPortal	Q9BYG4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BYG4. 13 interactions.
MINT	MINT-2816681.
STRING	9606.ENSP00000343144.
PTM databases
PhosphoSite	Q9BYG4.
Polymorphism databases
DMDM	30913175.
Proteomic databases
PaxDb	Q9BYG4.
PRIDE	Q9BYG4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000353265; ENSP00000343144; ENSG00000178184.
GeneID	84552.
KEGG	hsa:84552.
UCSC	uc002lny.3. human.
Organism-specific databases
CTD	84552.
GeneCards	GC18M077915.
H-InvDB	HIX0020684.
HGNC	HGNC:16076. PARD6G.
HPA	HPA047017.
MIM	608976. gene.
neXtProt	NX_Q9BYG4.
PharmGKB	PA32939.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG315424.
HOGENOM	HOG000231716.
HOVERGEN	HBG053509.
InParanoid	Q9BYG4.
KO	K06093.
OMA	FHKSQTL.
OrthoDB	EOG4PC9S9.
PhylomeDB	Q9BYG4.
Enzyme and pathway databases
Reactome	REACT_111155. Cell-Cell communication.
Gene expression databases
ArrayExpress	Q9BYG4.
Bgee	Q9BYG4.
CleanEx	HS_PARD6G.
Genevestigator	Q9BYG4.
GermOnline	ENSG00000178184. Homo sapiens.
Family and domain databases
InterPro	IPR000270. OPR_PB1. IPR001478. PDZ. [Graphical view]
Pfam	PF00564. PB1. 1 hit. PF00595. PDZ. 1 hit. [Graphical view]
SMART	SM00666. PB1. 1 hit. SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit.
PROSITE	PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84552.
NextBio	74431.
SOURCE	Search...

Entry information

Entry name

PAR6G_HUMAN

Accession

Primary (citable) accession number: Q9BYG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2003
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.