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Protein

Partitioning defective 6 homolog gamma

Gene

PARD6G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178184-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Partitioning defective 6 homolog gamma
Short name:
PAR-6 gamma
Alternative name(s):
PAR6D
Gene namesi
Name:PARD6G
Synonyms:PAR6G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:16076. PARD6G.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi84552.
OpenTargetsiENSG00000178184.
PharmGKBiPA32939.

Polymorphism and mutation databases

BioMutaiPARD6G.
DMDMi30913175.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125181 – 376Partitioning defective 6 homolog gammaAdd BLAST376

Proteomic databases

EPDiQ9BYG4.
MaxQBiQ9BYG4.
PaxDbiQ9BYG4.
PeptideAtlasiQ9BYG4.
PRIDEiQ9BYG4.

PTM databases

iPTMnetiQ9BYG4.
PhosphoSitePlusiQ9BYG4.

Expressioni

Tissue specificityi

Widely expressed, with a higher expression in fetal and adult kidney.

Gene expression databases

BgeeiENSG00000178184.
CleanExiHS_PARD6G.
ExpressionAtlasiQ9BYG4. baseline and differential.
GenevisibleiQ9BYG4. HS.

Organism-specific databases

HPAiHPA047017.

Interactioni

Subunit structurei

Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ.Curated2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC42P609535EBI-295417,EBI-81752
MARK2Q7KZI72EBI-295417,EBI-516560
MARK4Q96L342EBI-295417,EBI-302319
PARD3Q8TEW03EBI-295417,EBI-81968
PRKCIP417435EBI-295417,EBI-286199
PRKCZQ055133EBI-295417,EBI-295351
RAC1P630002EBI-295417,EBI-413628
YWHAHQ049172EBI-295417,EBI-306940

Protein-protein interaction databases

BioGridi124135. 18 interactors.
IntActiQ9BYG4. 14 interactors.
MINTiMINT-2816681.
STRINGi9606.ENSP00000343144.

Structurei

3D structure databases

ProteinModelPortaliQ9BYG4.
SMRiQ9BYG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 98PB1PROSITE-ProRule annotationAdd BLAST81
Domaini134 – 151Pseudo-CRIBAdd BLAST18
Domaini158 – 251PDZPROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 254Interaction with PARD3 and CDC42By similarityAdd BLAST128

Domaini

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.By similarity

Sequence similaritiesi

Belongs to the PAR6 family.Curated
Contains 1 PB1 domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 pseudo-CRIB domain.Curated

Phylogenomic databases

eggNOGiKOG3606. Eukaryota.
ENOG410XRJ3. LUCA.
GeneTreeiENSGT00390000005255.
HOGENOMiHOG000231716.
HOVERGENiHBG053509.
InParanoidiQ9BYG4.
KOiK06093.
OMAiHRHGCEK.
OrthoDBiEOG091G0FFH.
PhylomeDBiQ9BYG4.
TreeFamiTF312899.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR000270. PB1_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRSFHKSQT LRFYDCSAVE VKSKFGAEFR RFSLDRHKPG KFEDFYKLVV
60 70 80 90 100
HTHHISNSDV TIGYADVHGD LLPINNDDNF CKAVSSANPL LRVFIQKREE
110 120 130 140 150
AERGSLGAGS LCRRRRALGA LRDEGPRRRA HLDIGLPRDF RPVSSIIDVD
160 170 180 190 200
LVPETHRRVR LHRHGCEKPL GFYIRDGASV RVTPHGLEKV PGIFISRMVP
210 220 230 240 250
GGLAESTGLL AVNDEVLEVN GIEVAGKTLD QVTDMMIANS HNLIVTVKPA
260 270 280 290 300
NQRNNVVRGG RALGSSGPPS DGTAGFVGPP APRVLQNFHP DEAESDEDND
310 320 330 340 350
VVIEGTLEPA RPPQTPGAPA GSLSRVNGAG LAQRLQRDLA LDGGLQRLLS
360 370
SLRADPRHSL ALPPGGVEEH GPAVTL
Length:376
Mass (Da):40,883
Last modified:June 1, 2001 - v1
Checksum:iE5A4EF521403CA11
GO
Isoform 2 (identifier: Q9BYG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-107: EEAERGSLG → DDGALRPGT
     108-376: Missing.

Show »
Length:107
Mass (Da):12,243
Checksum:i55FF2570EA829289
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04758699 – 107EEAERGSLG → DDGALRPGT in isoform 2. 1 Publication9
Alternative sequenceiVSP_047587108 – 376Missing in isoform 2. 1 PublicationAdd BLAST269

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044556 mRNA. Translation: BAB40757.1.
AB178536 mRNA. Translation: BAF92015.1.
AC139100 Genomic DNA. No translation available.
BC060797 mRNA. Translation: AAH60797.1.
CCDSiCCDS12022.1. [Q9BYG4-1]
RefSeqiNP_115899.1. NM_032510.3. [Q9BYG4-1]
UniGeneiHs.654920.

Genome annotation databases

EnsembliENST00000353265; ENSP00000343144; ENSG00000178184. [Q9BYG4-1]
ENST00000470488; ENSP00000468735; ENSG00000178184. [Q9BYG4-2]
GeneIDi84552.
KEGGihsa:84552.
UCSCiuc002lny.4. human. [Q9BYG4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044556 mRNA. Translation: BAB40757.1.
AB178536 mRNA. Translation: BAF92015.1.
AC139100 Genomic DNA. No translation available.
BC060797 mRNA. Translation: AAH60797.1.
CCDSiCCDS12022.1. [Q9BYG4-1]
RefSeqiNP_115899.1. NM_032510.3. [Q9BYG4-1]
UniGeneiHs.654920.

3D structure databases

ProteinModelPortaliQ9BYG4.
SMRiQ9BYG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124135. 18 interactors.
IntActiQ9BYG4. 14 interactors.
MINTiMINT-2816681.
STRINGi9606.ENSP00000343144.

PTM databases

iPTMnetiQ9BYG4.
PhosphoSitePlusiQ9BYG4.

Polymorphism and mutation databases

BioMutaiPARD6G.
DMDMi30913175.

Proteomic databases

EPDiQ9BYG4.
MaxQBiQ9BYG4.
PaxDbiQ9BYG4.
PeptideAtlasiQ9BYG4.
PRIDEiQ9BYG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353265; ENSP00000343144; ENSG00000178184. [Q9BYG4-1]
ENST00000470488; ENSP00000468735; ENSG00000178184. [Q9BYG4-2]
GeneIDi84552.
KEGGihsa:84552.
UCSCiuc002lny.4. human. [Q9BYG4-1]

Organism-specific databases

CTDi84552.
DisGeNETi84552.
GeneCardsiPARD6G.
H-InvDBHIX0020684.
HGNCiHGNC:16076. PARD6G.
HPAiHPA047017.
MIMi608976. gene.
neXtProtiNX_Q9BYG4.
OpenTargetsiENSG00000178184.
PharmGKBiPA32939.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3606. Eukaryota.
ENOG410XRJ3. LUCA.
GeneTreeiENSGT00390000005255.
HOGENOMiHOG000231716.
HOVERGENiHBG053509.
InParanoidiQ9BYG4.
KOiK06093.
OMAiHRHGCEK.
OrthoDBiEOG091G0FFH.
PhylomeDBiQ9BYG4.
TreeFamiTF312899.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178184-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Miscellaneous databases

GenomeRNAii84552.
PROiQ9BYG4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178184.
CleanExiHS_PARD6G.
ExpressionAtlasiQ9BYG4. baseline and differential.
GenevisibleiQ9BYG4. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR000270. PB1_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAR6G_HUMAN
AccessioniPrimary (citable) accession number: Q9BYG4
Secondary accession number(s): A8QM57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.