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Q9BYG4

- PAR6G_HUMAN

UniProt

Q9BYG4 - PAR6G_HUMAN

Protein

Partitioning defective 6 homolog gamma

Gene

PARD6G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell-cell junction organization Source: Reactome
    2. cell cycle Source: UniProtKB-KW
    3. cell division Source: UniProtKB-KW
    4. cell junction assembly Source: Reactome
    5. tight junction assembly Source: Reactome

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_19373. Tight junction interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Partitioning defective 6 homolog gamma
    Short name:
    PAR-6 gamma
    Alternative name(s):
    PAR6D
    Gene namesi
    Name:PARD6G
    Synonyms:PAR6G
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:16076. PARD6G.

    Subcellular locationi

    Cytoplasm. Cell membrane By similarity. Cell junctiontight junction By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. plasma membrane Source: Reactome
    3. protein complex Source: Ensembl
    4. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32939.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Partitioning defective 6 homolog gammaPRO_0000112518Add
    BLAST

    Proteomic databases

    PaxDbiQ9BYG4.
    PRIDEiQ9BYG4.

    PTM databases

    PhosphoSiteiQ9BYG4.

    Expressioni

    Tissue specificityi

    Widely expressed, with a higher expression in fetal and adult kidney.

    Gene expression databases

    ArrayExpressiQ9BYG4.
    BgeeiQ9BYG4.
    CleanExiHS_PARD6G.
    GenevestigatoriQ9BYG4.

    Organism-specific databases

    HPAiHPA047017.

    Interactioni

    Subunit structurei

    Interacts with PARD3 Probable. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ.2 PublicationsCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC42P609535EBI-295417,EBI-81752
    MARK2Q7KZI72EBI-295417,EBI-516560
    MARK4Q96L342EBI-295417,EBI-302319
    PARD3Q8TEW03EBI-295417,EBI-81968
    PRKCIP417435EBI-295417,EBI-286199
    PRKCZQ055132EBI-295417,EBI-295351
    RAC1P630002EBI-295417,EBI-413628
    YWHAHQ049172EBI-295417,EBI-306940

    Protein-protein interaction databases

    BioGridi124135. 17 interactions.
    IntActiQ9BYG4. 14 interactions.
    MINTiMINT-2816681.
    STRINGi9606.ENSP00000343144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYG4.
    SMRiQ9BYG4. Positions 17-98, 154-251.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 9881OPRAdd
    BLAST
    Domaini134 – 15118Pseudo-CRIBAdd
    BLAST
    Domaini158 – 25194PDZPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 254128Interaction with PARD3 and CDC42By similarityAdd
    BLAST

    Domaini

    The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.By similarity

    Sequence similaritiesi

    Belongs to the PAR6 family.Curated
    Contains 1 OPR domain.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 pseudo-CRIB domain.Curated

    Phylogenomic databases

    eggNOGiNOG315424.
    HOGENOMiHOG000231716.
    HOVERGENiHBG053509.
    InParanoidiQ9BYG4.
    KOiK06093.
    OMAiFHKSQTL.
    OrthoDBiEOG73JKWB.
    PhylomeDBiQ9BYG4.
    TreeFamiTF312899.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR000270. OPR_PB1.
    IPR001478. PDZ.
    [Graphical view]
    PfamiPF00564. PB1. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00666. PB1. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BYG4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNRSFHKSQT LRFYDCSAVE VKSKFGAEFR RFSLDRHKPG KFEDFYKLVV    50
    HTHHISNSDV TIGYADVHGD LLPINNDDNF CKAVSSANPL LRVFIQKREE 100
    AERGSLGAGS LCRRRRALGA LRDEGPRRRA HLDIGLPRDF RPVSSIIDVD 150
    LVPETHRRVR LHRHGCEKPL GFYIRDGASV RVTPHGLEKV PGIFISRMVP 200
    GGLAESTGLL AVNDEVLEVN GIEVAGKTLD QVTDMMIANS HNLIVTVKPA 250
    NQRNNVVRGG RALGSSGPPS DGTAGFVGPP APRVLQNFHP DEAESDEDND 300
    VVIEGTLEPA RPPQTPGAPA GSLSRVNGAG LAQRLQRDLA LDGGLQRLLS 350
    SLRADPRHSL ALPPGGVEEH GPAVTL 376
    Length:376
    Mass (Da):40,883
    Last modified:June 1, 2001 - v1
    Checksum:iE5A4EF521403CA11
    GO
    Isoform 2 (identifier: Q9BYG4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         99-107: EEAERGSLG → DDGALRPGT
         108-376: Missing.

    Show »
    Length:107
    Mass (Da):12,243
    Checksum:i55FF2570EA829289
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei99 – 1079EEAERGSLG → DDGALRPGT in isoform 2. 1 PublicationVSP_047586
    Alternative sequencei108 – 376269Missing in isoform 2. 1 PublicationVSP_047587Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044556 mRNA. Translation: BAB40757.1.
    AB178536 mRNA. Translation: BAF92015.1.
    AC139100 Genomic DNA. No translation available.
    BC060797 mRNA. Translation: AAH60797.1.
    CCDSiCCDS12022.1. [Q9BYG4-1]
    RefSeqiNP_115899.1. NM_032510.3. [Q9BYG4-1]
    UniGeneiHs.654920.

    Genome annotation databases

    EnsembliENST00000353265; ENSP00000343144; ENSG00000178184. [Q9BYG4-1]
    ENST00000470488; ENSP00000468735; ENSG00000178184. [Q9BYG4-2]
    GeneIDi84552.
    KEGGihsa:84552.
    UCSCiuc002lny.3. human. [Q9BYG4-1]

    Polymorphism databases

    DMDMi30913175.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB044556 mRNA. Translation: BAB40757.1 .
    AB178536 mRNA. Translation: BAF92015.1 .
    AC139100 Genomic DNA. No translation available.
    BC060797 mRNA. Translation: AAH60797.1 .
    CCDSi CCDS12022.1. [Q9BYG4-1 ]
    RefSeqi NP_115899.1. NM_032510.3. [Q9BYG4-1 ]
    UniGenei Hs.654920.

    3D structure databases

    ProteinModelPortali Q9BYG4.
    SMRi Q9BYG4. Positions 17-98, 154-251.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124135. 17 interactions.
    IntActi Q9BYG4. 14 interactions.
    MINTi MINT-2816681.
    STRINGi 9606.ENSP00000343144.

    PTM databases

    PhosphoSitei Q9BYG4.

    Polymorphism databases

    DMDMi 30913175.

    Proteomic databases

    PaxDbi Q9BYG4.
    PRIDEi Q9BYG4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000353265 ; ENSP00000343144 ; ENSG00000178184 . [Q9BYG4-1 ]
    ENST00000470488 ; ENSP00000468735 ; ENSG00000178184 . [Q9BYG4-2 ]
    GeneIDi 84552.
    KEGGi hsa:84552.
    UCSCi uc002lny.3. human. [Q9BYG4-1 ]

    Organism-specific databases

    CTDi 84552.
    GeneCardsi GC18M077915.
    H-InvDB HIX0020684.
    HGNCi HGNC:16076. PARD6G.
    HPAi HPA047017.
    MIMi 608976. gene.
    neXtProti NX_Q9BYG4.
    PharmGKBi PA32939.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315424.
    HOGENOMi HOG000231716.
    HOVERGENi HBG053509.
    InParanoidi Q9BYG4.
    KOi K06093.
    OMAi FHKSQTL.
    OrthoDBi EOG73JKWB.
    PhylomeDBi Q9BYG4.
    TreeFami TF312899.

    Enzyme and pathway databases

    Reactomei REACT_19373. Tight junction interactions.

    Miscellaneous databases

    GenomeRNAii 84552.
    NextBioi 35465103.
    PROi Q9BYG4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BYG4.
    Bgeei Q9BYG4.
    CleanExi HS_PARD6G.
    Genevestigatori Q9BYG4.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR000270. OPR_PB1.
    IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00564. PB1. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00666. PB1. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C."
      Noda Y., Takeya R., Ohno S., Naito S., Ito T., Sumimoto H.
      Genes Cells 6:107-119(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RAC1; CDC42; PRKCI AND PRKCZ.
      Tissue: Neuroblastoma.
    2. "Splicing variants of the cell polarity protein PAR-6."
      Noda Y., Kohjima M., Izaki T., Sumimoto H.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    5. "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42."
      Joberty G., Petersen C., Gao L., Macara I.G.
      Nat. Cell Biol. 2:531-539(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARHQ.

    Entry informationi

    Entry nameiPAR6G_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYG4
    Secondary accession number(s): A8QM57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3