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Q9BYG4 (PAR6G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Partitioning defective 6 homolog gamma

Short name=PAR-6 gamma
Alternative name(s):
PAR6D
Gene names
Name:PARD6G
Synonyms:PAR6G
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins By similarity.

Subunit structure

Interacts with PARD3 Probable. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Ref.1 Ref.5

Subcellular location

Cytoplasm. Cell membrane By similarity. Cell junctiontight junction By similarity.

Tissue specificity

Widely expressed, with a higher expression in fetal and adult kidney.

Domain

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases By similarity.

Sequence similarities

Belongs to the PAR6 family.

Contains 1 OPR domain.

Contains 1 PDZ (DHR) domain.

Contains 1 pseudo-CRIB domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BYG4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BYG4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     99-107: EEAERGSLG → DDGALRPGT
     108-376: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Partitioning defective 6 homolog gamma
PRO_0000112518

Regions

Domain18 – 9881OPR
Domain134 – 15118Pseudo-CRIB
Domain158 – 25194PDZ
Region127 – 254128Interaction with PARD3 and CDC42 By similarity

Natural variations

Alternative sequence99 – 1079EEAERGSLG → DDGALRPGT in isoform 2.
VSP_047586
Alternative sequence108 – 376269Missing in isoform 2.
VSP_047587

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: E5A4EF521403CA11

FASTA37640,883
        10         20         30         40         50         60 
MNRSFHKSQT LRFYDCSAVE VKSKFGAEFR RFSLDRHKPG KFEDFYKLVV HTHHISNSDV 

        70         80         90        100        110        120 
TIGYADVHGD LLPINNDDNF CKAVSSANPL LRVFIQKREE AERGSLGAGS LCRRRRALGA 

       130        140        150        160        170        180 
LRDEGPRRRA HLDIGLPRDF RPVSSIIDVD LVPETHRRVR LHRHGCEKPL GFYIRDGASV 

       190        200        210        220        230        240 
RVTPHGLEKV PGIFISRMVP GGLAESTGLL AVNDEVLEVN GIEVAGKTLD QVTDMMIANS 

       250        260        270        280        290        300 
HNLIVTVKPA NQRNNVVRGG RALGSSGPPS DGTAGFVGPP APRVLQNFHP DEAESDEDND 

       310        320        330        340        350        360 
VVIEGTLEPA RPPQTPGAPA GSLSRVNGAG LAQRLQRDLA LDGGLQRLLS SLRADPRHSL 

       370 
ALPPGGVEEH GPAVTL 

« Hide

Isoform 2 [UniParc].

Checksum: 55FF2570EA829289
Show »

FASTA10712,243

References

« Hide 'large scale' references
[1]"Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C."
Noda Y., Takeya R., Ohno S., Naito S., Ito T., Sumimoto H.
Genes Cells 6:107-119(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RAC1; CDC42; PRKCI AND PRKCZ.
Tissue: Neuroblastoma.
[2]"Splicing variants of the cell polarity protein PAR-6."
Noda Y., Kohjima M., Izaki T., Sumimoto H.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[5]"The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42."
Joberty G., Petersen C., Gao L., Macara I.G.
Nat. Cell Biol. 2:531-539(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ARHQ.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB044556 mRNA. Translation: BAB40757.1.
AB178536 mRNA. Translation: BAF92015.1.
AC139100 Genomic DNA. No translation available.
BC060797 mRNA. Translation: AAH60797.1.
RefSeqNP_115899.1. NM_032510.3.
UniGeneHs.654920.

3D structure databases

ProteinModelPortalQ9BYG4.
SMRQ9BYG4. Positions 17-98, 154-251.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124135. 17 interactions.
IntActQ9BYG4. 14 interactions.
MINTMINT-2816681.
STRING9606.ENSP00000343144.

PTM databases

PhosphoSiteQ9BYG4.

Polymorphism databases

DMDM30913175.

Proteomic databases

PaxDbQ9BYG4.
PRIDEQ9BYG4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000353265; ENSP00000343144; ENSG00000178184. [Q9BYG4-1]
ENST00000470488; ENSP00000468735; ENSG00000178184. [Q9BYG4-2]
GeneID84552.
KEGGhsa:84552.
UCSCuc002lny.3. human. [Q9BYG4-1]

Organism-specific databases

CTD84552.
GeneCardsGC18M077915.
H-InvDBHIX0020684.
HGNCHGNC:16076. PARD6G.
HPAHPA047017.
MIM608976. gene.
neXtProtNX_Q9BYG4.
PharmGKBPA32939.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG315424.
HOGENOMHOG000231716.
HOVERGENHBG053509.
InParanoidQ9BYG4.
KOK06093.
OMAFHKSQTL.
OrthoDBEOG73JKWB.
PhylomeDBQ9BYG4.
TreeFamTF312899.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressQ9BYG4.
BgeeQ9BYG4.
CleanExHS_PARD6G.
GenevestigatorQ9BYG4.

Family and domain databases

Gene3D2.30.42.10. 1 hit.
InterProIPR000270. OPR_PB1.
IPR001478. PDZ.
[Graphical view]
PfamPF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84552.
NextBio35465103.
PROQ9BYG4.
SOURCESearch...

Entry information

Entry namePAR6G_HUMAN
AccessionPrimary (citable) accession number: Q9BYG4
Secondary accession number(s): A8QM57
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM