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Protein

Polycomb group RING finger protein 6

Gene

PCGF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 173RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9BYE7.

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 6
Alternative name(s):
Mel18 and Bmi1-like RING finger
RING finger protein 134
Gene namesi
Name:PCGF6
Synonyms:MBLR, RNF134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:21156. PCGF6.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • PcG protein complex Source: UniProtKB
  • PRC1 complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30S → A: Abolishes phosphorylation. 1 Publication1
Mutagenesisi57S → A: Does not abolish phosphorylation. 1 Publication1
Mutagenesisi59S → A: Does not abolish phosphorylation. 1 Publication1
Mutagenesisi69S → A: Does not abolish phosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi84108.
OpenTargetsiENSG00000156374.
PharmGKBiPA134887110.

Polymorphism and mutation databases

BioMutaiPCGF6.
DMDMi116242703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559891 – 350Polycomb group RING finger protein 6Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30Phosphoserine1 Publication1
Modified residuei115PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BYE7.
MaxQBiQ9BYE7.
PaxDbiQ9BYE7.
PeptideAtlasiQ9BYE7.
PRIDEiQ9BYE7.

PTM databases

iPTMnetiQ9BYE7.
PhosphoSitePlusiQ9BYE7.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000156374.
CleanExiHS_PCGF6.
GenevisibleiQ9BYE7. HS.

Organism-specific databases

HPAiHPA054086.

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CBX4O00257-32EBI-1048026,EBI-4392727
CBX7O959313EBI-1048026,EBI-3923843
CBX8Q9HC523EBI-1048026,EBI-712912
RING1Q065873EBI-1048026,EBI-752313
RNF2Q994964EBI-1048026,EBI-722416

Protein-protein interaction databases

BioGridi123896. 71 interactors.
DIPiDIP-50946N.
IntActiQ9BYE7. 48 interactors.
STRINGi9606.ENSP00000358862.

Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi130 – 132Combined sources3
Turni135 – 137Combined sources3
Beta strandi148 – 150Combined sources3
Helixi156 – 165Combined sources10
Turni170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DJBNMR-A124-182[»]
ProteinModelPortaliQ9BYE7.
SMRiQ9BYE7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BYE7.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili72 – 110Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 66Pro-richAdd BLAST45
Compositional biasi63 – 120Glu-richAdd BLAST58

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 173RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ9BYE7.
KOiK11470.
OMAiIGANEDT.
OrthoDBiEOG091G0EC9.
PhylomeDBiQ9BYE7.
TreeFamiTF324206.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR029071. Ubiquitin-rel_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGVAVVTAG SVGAAKTEGA AALPPPPPVS PPALTPAPAA GEEGPAPLSE
60 70 80 90 100
TGAPGCSGSR PPELEPERSL GRFRGRFEDE DEELEEEEEL EEEEEEEEED
110 120 130 140 150
MSHFSLRLEG GRQDSEDEEE RLINLSELTP YILCSICKGY LIDATTITEC
160 170 180 190 200
LHTFCKSCIV RHFYYSNRCP KCNIVVHQTQ PLYNIRLDRQ LQDIVYKLVI
210 220 230 240 250
NLEEREKKQM HDFYKERGLE VPKPAVPQPV PSSKGRSKKV LESVFRIPPE
260 270 280 290 300
LDMSLLLEFI GANEGTGHFK PLEKKFVRVS GEATIGHVEK FLRRKMGLDP
310 320 330 340 350
ACQVDIICGD HLLEQYQTLR EIRRAIGDAA MQDGLLVLHY GLVVSPLKIT
Length:350
Mass (Da):39,047
Last modified:October 17, 2006 - v2
Checksum:i05977FE6F14972DE
GO
Isoform 3 (identifier: Q9BYE7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-186: R → S
     187-261: Missing.

Show »
Length:275
Mass (Da):30,249
Checksum:iFA50B97D5A39281B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257L → P in BAF83368 (PubMed:14702039).Curated1
Sequence conflicti261G → S in AAH07602 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05431223L → LPP.2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042007186R → S in isoform 3. 1 Publication1
Alternative sequenceiVSP_042008187 – 261Missing in isoform 3. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047006 mRNA. Translation: BAB40779.1.
AK027885 mRNA. No translation available.
AK290679 mRNA. Translation: BAF83368.1.
AL591408 Genomic DNA. Translation: CAI16745.1.
AL591408 Genomic DNA. Translation: CAI16746.1.
BC007602 mRNA. Translation: AAH07602.1.
BC010235 mRNA. Translation: AAH10235.1.
CCDSiCCDS31275.1. [Q9BYE7-1]
CCDS7546.1. [Q9BYE7-3]
RefSeqiNP_001011663.1. NM_001011663.1. [Q9BYE7-1]
NP_115530.2. NM_032154.3. [Q9BYE7-3]
UniGeneiHs.335808.

Genome annotation databases

EnsembliENST00000337211; ENSP00000338845; ENSG00000156374. [Q9BYE7-3]
ENST00000369847; ENSP00000358862; ENSG00000156374. [Q9BYE7-1]
GeneIDi84108.
KEGGihsa:84108.
UCSCiuc001kwt.3. human. [Q9BYE7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047006 mRNA. Translation: BAB40779.1.
AK027885 mRNA. No translation available.
AK290679 mRNA. Translation: BAF83368.1.
AL591408 Genomic DNA. Translation: CAI16745.1.
AL591408 Genomic DNA. Translation: CAI16746.1.
BC007602 mRNA. Translation: AAH07602.1.
BC010235 mRNA. Translation: AAH10235.1.
CCDSiCCDS31275.1. [Q9BYE7-1]
CCDS7546.1. [Q9BYE7-3]
RefSeqiNP_001011663.1. NM_001011663.1. [Q9BYE7-1]
NP_115530.2. NM_032154.3. [Q9BYE7-3]
UniGeneiHs.335808.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DJBNMR-A124-182[»]
ProteinModelPortaliQ9BYE7.
SMRiQ9BYE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123896. 71 interactors.
DIPiDIP-50946N.
IntActiQ9BYE7. 48 interactors.
STRINGi9606.ENSP00000358862.

PTM databases

iPTMnetiQ9BYE7.
PhosphoSitePlusiQ9BYE7.

Polymorphism and mutation databases

BioMutaiPCGF6.
DMDMi116242703.

Proteomic databases

EPDiQ9BYE7.
MaxQBiQ9BYE7.
PaxDbiQ9BYE7.
PeptideAtlasiQ9BYE7.
PRIDEiQ9BYE7.

Protocols and materials databases

DNASUi84108.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337211; ENSP00000338845; ENSG00000156374. [Q9BYE7-3]
ENST00000369847; ENSP00000358862; ENSG00000156374. [Q9BYE7-1]
GeneIDi84108.
KEGGihsa:84108.
UCSCiuc001kwt.3. human. [Q9BYE7-1]

Organism-specific databases

CTDi84108.
DisGeNETi84108.
GeneCardsiPCGF6.
H-InvDBHIX0014963.
HGNCiHGNC:21156. PCGF6.
HPAiHPA054086.
MIMi607816. gene.
neXtProtiNX_Q9BYE7.
OpenTargetsiENSG00000156374.
PharmGKBiPA134887110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ9BYE7.
KOiK11470.
OMAiIGANEDT.
OrthoDBiEOG091G0EC9.
PhylomeDBiQ9BYE7.
TreeFamiTF324206.

Enzyme and pathway databases

SIGNORiQ9BYE7.

Miscellaneous databases

ChiTaRSiPCGF6. human.
EvolutionaryTraceiQ9BYE7.
GeneWikiiPCGF6.
GenomeRNAii84108.
PROiQ9BYE7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156374.
CleanExiHS_PCGF6.
GenevisibleiQ9BYE7. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR029071. Ubiquitin-rel_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCGF6_HUMAN
AccessioniPrimary (citable) accession number: Q9BYE7
Secondary accession number(s): A8K3R4
, Q5SYD1, Q5SYD6, Q96ID9, Q96SJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.