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Q9BYD9 (ACTT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Actin-related protein T3

Short name=ARP-T3
Alternative name(s):
Actin-related protein M1
Gene names
Name:ACTRT3
Synonyms:ARPM1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Interacts with PFN3 By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity. Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

Ubiquitously expressed. Ref.1

Sequence similarities

Belongs to the actin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Nucleus
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

male germ cell nucleus

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Actin-related protein T3
PRO_0000089142

Natural variations

Natural variant2341E → K.
Corresponds to variant rs2068178 [ dbSNP | Ensembl ].
VAR_055483

Experimental info

Sequence conflict781W → C in AAH07289. Ref.3
Sequence conflict2821C → R in BAB70906. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9BYD9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 56413BCF02AA4794

FASTA37241,008
        10         20         30         40         50         60 
MNHCQLPVVI DNGSGMIKAG VAGCREPQFI YPNIIGRAKG QSRAAQGGLE LCVGDQAQDW 

        70         80         90        100        110        120 
RSSLFISYPV ERGLITSWED MEIMWKHIYD YNLKLKPCDG PVLITEPALN PLANRQQITE 

       130        140        150        160        170        180 
MFFEHLGVPA FYMSIQAVLA LFAAGFTTGL VLNSGAGVTQ SVPIFEGYCL PHGVQQLDLA 

       190        200        210        220        230        240 
GLDLTNYLMV LMKNHGIMLL SASDRKIVED IKESFCYVAM NYEEEMAKKP DCLEKVYQLP 

       250        260        270        280        290        300 
DGKVIQLHDQ LFSCPEALFS PCHMNLEAPG IDKICFSSIM KCDTGLRNSF FSNIILAGGS 

       310        320        330        340        350        360 
TSFPGLDKRL VKDIAKVAPA NTAVQVIAPP ERKISVWMGG SILASLSAFQ DMWITAAEFK 

       370 
EVGPNIVHQR CF 

« Hide

References

« Hide 'large scale' references
[1]"Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin."
Harata M., Nishimori K., Hatta S.
Biochim. Biophys. Acta 1522:130-133(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB049117 mRNA. Translation: BAB39481.1.
AK055346 mRNA. Translation: BAB70906.1.
AC078802 Genomic DNA. No translation available.
BC007289 mRNA. Translation: AAH07289.1.
CCDSCCDS3206.1.
RefSeqNP_115876.3. NM_032487.4.
UniGeneHs.135411.

3D structure databases

ProteinModelPortalQ9BYD9.
SMRQ9BYD9. Positions 8-372.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM47116738.

Proteomic databases

PaxDbQ9BYD9.
PRIDEQ9BYD9.

Protocols and materials databases

DNASU84517.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330368; ENSP00000333037; ENSG00000184378.
GeneID84517.
KEGGhsa:84517.
UCSCuc003ffs.2. human.

Organism-specific databases

CTD84517.
GeneCardsGC03M169492.
HGNCHGNC:24022. ACTRT3.
HPAHPA035817.
HPA035818.
MIM608534. gene.
neXtProtNX_Q9BYD9.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5277.
HOGENOMHOG000233340.
HOVERGENHBG003771.
InParanoidQ9BYD9.
OMANIVHQRC.
OrthoDBEOG708VZV.
PhylomeDBQ9BYD9.
TreeFamTF337161.

Enzyme and pathway databases

SignaLinkQ9BYD9.

Gene expression databases

BgeeQ9BYD9.
GenevestigatorQ9BYD9.

Family and domain databases

InterProIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
[Graphical view]
PANTHERPTHR11937. PTHR11937. 1 hit.
PfamPF00022. Actin. 1 hit.
[Graphical view]
PRINTSPR00190. ACTIN.
SMARTSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84517.
NextBio74326.
PROQ9BYD9.
SOURCESearch...

Entry information

Entry nameACTT3_HUMAN
AccessionPrimary (citable) accession number: Q9BYD9
Secondary accession number(s): Q96IS0, Q96NJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM