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Q9BYD9

- ACTT3_HUMAN

UniProt

Q9BYD9 - ACTT3_HUMAN

Protein

Actin-related protein T3

Gene

ACTRT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    SignaLinkiQ9BYD9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin-related protein T3
    Short name:
    ARP-T3
    Alternative name(s):
    Actin-related protein M1
    Gene namesi
    Name:ACTRT3
    Synonyms:ARPM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:24022. ACTRT3.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. cytoskeleton Source: UniProtKB-SubCell
    3. male germ cell nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Actin-related protein T3PRO_0000089142Add
    BLAST

    Proteomic databases

    PaxDbiQ9BYD9.
    PRIDEiQ9BYD9.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    BgeeiQ9BYD9.
    GenevestigatoriQ9BYD9.

    Organism-specific databases

    HPAiHPA035817.
    HPA035818.

    Interactioni

    Subunit structurei

    Interacts with PFN3.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYD9.
    SMRiQ9BYD9. Positions 8-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the actin family.Curated

    Phylogenomic databases

    eggNOGiCOG5277.
    HOGENOMiHOG000233340.
    HOVERGENiHBG003771.
    InParanoidiQ9BYD9.
    OMAiNIVHQRC.
    OrthoDBiEOG708VZV.
    PhylomeDBiQ9BYD9.
    TreeFamiTF337161.

    Family and domain databases

    InterProiIPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    [Graphical view]
    PANTHERiPTHR11937. PTHR11937. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    [Graphical view]
    PRINTSiPR00190. ACTIN.
    SMARTiSM00268. ACTIN. 1 hit.
    [Graphical view]
    PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BYD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHCQLPVVI DNGSGMIKAG VAGCREPQFI YPNIIGRAKG QSRAAQGGLE    50
    LCVGDQAQDW RSSLFISYPV ERGLITSWED MEIMWKHIYD YNLKLKPCDG 100
    PVLITEPALN PLANRQQITE MFFEHLGVPA FYMSIQAVLA LFAAGFTTGL 150
    VLNSGAGVTQ SVPIFEGYCL PHGVQQLDLA GLDLTNYLMV LMKNHGIMLL 200
    SASDRKIVED IKESFCYVAM NYEEEMAKKP DCLEKVYQLP DGKVIQLHDQ 250
    LFSCPEALFS PCHMNLEAPG IDKICFSSIM KCDTGLRNSF FSNIILAGGS 300
    TSFPGLDKRL VKDIAKVAPA NTAVQVIAPP ERKISVWMGG SILASLSAFQ 350
    DMWITAAEFK EVGPNIVHQR CF 372
    Length:372
    Mass (Da):41,008
    Last modified:June 1, 2001 - v1
    Checksum:i56413BCF02AA4794
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781W → C in AAH07289. (PubMed:16641997)Curated
    Sequence conflicti282 – 2821C → R in BAB70906. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti234 – 2341E → K.
    Corresponds to variant rs2068178 [ dbSNP | Ensembl ].
    VAR_055483

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049117 mRNA. Translation: BAB39481.1.
    AK055346 mRNA. Translation: BAB70906.1.
    AC078802 Genomic DNA. No translation available.
    BC007289 mRNA. Translation: AAH07289.1.
    CCDSiCCDS3206.1.
    RefSeqiNP_115876.3. NM_032487.4.
    UniGeneiHs.135411.

    Genome annotation databases

    EnsembliENST00000330368; ENSP00000333037; ENSG00000184378.
    GeneIDi84517.
    KEGGihsa:84517.
    UCSCiuc003ffs.2. human.

    Polymorphism databases

    DMDMi47116738.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049117 mRNA. Translation: BAB39481.1 .
    AK055346 mRNA. Translation: BAB70906.1 .
    AC078802 Genomic DNA. No translation available.
    BC007289 mRNA. Translation: AAH07289.1 .
    CCDSi CCDS3206.1.
    RefSeqi NP_115876.3. NM_032487.4.
    UniGenei Hs.135411.

    3D structure databases

    ProteinModelPortali Q9BYD9.
    SMRi Q9BYD9. Positions 8-372.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 47116738.

    Proteomic databases

    PaxDbi Q9BYD9.
    PRIDEi Q9BYD9.

    Protocols and materials databases

    DNASUi 84517.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330368 ; ENSP00000333037 ; ENSG00000184378 .
    GeneIDi 84517.
    KEGGi hsa:84517.
    UCSCi uc003ffs.2. human.

    Organism-specific databases

    CTDi 84517.
    GeneCardsi GC03M169492.
    HGNCi HGNC:24022. ACTRT3.
    HPAi HPA035817.
    HPA035818.
    MIMi 608534. gene.
    neXtProti NX_Q9BYD9.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5277.
    HOGENOMi HOG000233340.
    HOVERGENi HBG003771.
    InParanoidi Q9BYD9.
    OMAi NIVHQRC.
    OrthoDBi EOG708VZV.
    PhylomeDBi Q9BYD9.
    TreeFami TF337161.

    Enzyme and pathway databases

    SignaLinki Q9BYD9.

    Miscellaneous databases

    GenomeRNAii 84517.
    NextBioi 74326.
    PROi Q9BYD9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BYD9.
    Genevestigatori Q9BYD9.

    Family and domain databases

    InterProi IPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    [Graphical view ]
    PANTHERi PTHR11937. PTHR11937. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    [Graphical view ]
    PRINTSi PR00190. ACTIN.
    SMARTi SM00268. ACTIN. 1 hit.
    [Graphical view ]
    PROSITEi PS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin."
      Harata M., Nishimori K., Hatta S.
      Biochim. Biophys. Acta 1522:130-133(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.

    Entry informationi

    Entry nameiACTT3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYD9
    Secondary accession number(s): Q96IS0, Q96NJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3