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Protein

Actin-related protein T3

Gene

ACTRT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ9BYD9.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein T3
Short name:
ARP-T3
Alternative name(s):
Actin-related protein M1
Gene namesi
Name:ACTRT3
Synonyms:ARPM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24022. ACTRT3.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. cytoskeleton Source: UniProtKB-SubCell
  3. male germ cell nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Actin-related protein T3PRO_0000089142Add
BLAST

Proteomic databases

PaxDbiQ9BYD9.
PRIDEiQ9BYD9.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ9BYD9.
GenevestigatoriQ9BYD9.

Organism-specific databases

HPAiHPA035817.
HPA035818.

Interactioni

Subunit structurei

Interacts with PFN3.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9BYD9.
SMRiQ9BYD9. Positions 8-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiCOG5277.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ9BYD9.
OMAiNIVHQRC.
OrthoDBiEOG708VZV.
PhylomeDBiQ9BYD9.
TreeFamiTF337161.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR030068. ARP-T3.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF159. PTHR11937:SF159. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BYD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHCQLPVVI DNGSGMIKAG VAGCREPQFI YPNIIGRAKG QSRAAQGGLE
60 70 80 90 100
LCVGDQAQDW RSSLFISYPV ERGLITSWED MEIMWKHIYD YNLKLKPCDG
110 120 130 140 150
PVLITEPALN PLANRQQITE MFFEHLGVPA FYMSIQAVLA LFAAGFTTGL
160 170 180 190 200
VLNSGAGVTQ SVPIFEGYCL PHGVQQLDLA GLDLTNYLMV LMKNHGIMLL
210 220 230 240 250
SASDRKIVED IKESFCYVAM NYEEEMAKKP DCLEKVYQLP DGKVIQLHDQ
260 270 280 290 300
LFSCPEALFS PCHMNLEAPG IDKICFSSIM KCDTGLRNSF FSNIILAGGS
310 320 330 340 350
TSFPGLDKRL VKDIAKVAPA NTAVQVIAPP ERKISVWMGG SILASLSAFQ
360 370
DMWITAAEFK EVGPNIVHQR CF
Length:372
Mass (Da):41,008
Last modified:June 1, 2001 - v1
Checksum:i56413BCF02AA4794
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781W → C in AAH07289 (PubMed:16641997).Curated
Sequence conflicti282 – 2821C → R in BAB70906 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341E → K.
Corresponds to variant rs2068178 [ dbSNP | Ensembl ].
VAR_055483

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049117 mRNA. Translation: BAB39481.1.
AK055346 mRNA. Translation: BAB70906.1.
AC078802 Genomic DNA. No translation available.
BC007289 mRNA. Translation: AAH07289.1.
CCDSiCCDS3206.1.
RefSeqiNP_115876.3. NM_032487.4.
UniGeneiHs.135411.

Genome annotation databases

EnsembliENST00000330368; ENSP00000333037; ENSG00000184378.
GeneIDi84517.
KEGGihsa:84517.
UCSCiuc003ffs.2. human.

Polymorphism databases

DMDMi47116738.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049117 mRNA. Translation: BAB39481.1.
AK055346 mRNA. Translation: BAB70906.1.
AC078802 Genomic DNA. No translation available.
BC007289 mRNA. Translation: AAH07289.1.
CCDSiCCDS3206.1.
RefSeqiNP_115876.3. NM_032487.4.
UniGeneiHs.135411.

3D structure databases

ProteinModelPortaliQ9BYD9.
SMRiQ9BYD9. Positions 8-372.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism databases

DMDMi47116738.

Proteomic databases

PaxDbiQ9BYD9.
PRIDEiQ9BYD9.

Protocols and materials databases

DNASUi84517.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330368; ENSP00000333037; ENSG00000184378.
GeneIDi84517.
KEGGihsa:84517.
UCSCiuc003ffs.2. human.

Organism-specific databases

CTDi84517.
GeneCardsiGC03M169497.
HGNCiHGNC:24022. ACTRT3.
HPAiHPA035817.
HPA035818.
MIMi608534. gene.
neXtProtiNX_Q9BYD9.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5277.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ9BYD9.
OMAiNIVHQRC.
OrthoDBiEOG708VZV.
PhylomeDBiQ9BYD9.
TreeFamiTF337161.

Enzyme and pathway databases

SignaLinkiQ9BYD9.

Miscellaneous databases

GenomeRNAii84517.
NextBioi74326.
PROiQ9BYD9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BYD9.
GenevestigatoriQ9BYD9.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR030068. ARP-T3.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF159. PTHR11937:SF159. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin."
    Harata M., Nishimori K., Hatta S.
    Biochim. Biophys. Acta 1522:130-133(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiACTT3_HUMAN
AccessioniPrimary (citable) accession number: Q9BYD9
Secondary accession number(s): Q96IS0, Q96NJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.