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Q9BYD6

- RM01_HUMAN

UniProt

Q9BYD6 - RM01_HUMAN

Protein

39S ribosomal protein L1, mitochondrial

Gene

MRPL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L1, mitochondrial
    Short name:
    L1mt
    Short name:
    MRP-L1
    Gene namesi
    Name:MRPL1
    ORF Names:BM-022
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:14275. MRPL1.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. large ribosomal subunit Source: InterPro
    2. mitochondrion Source: HPA
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30938.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5050MitochondrionSequence AnalysisAdd
    BLAST
    Chaini51 – 32527539S ribosomal protein L1, mitochondrialPRO_0000252440Add
    BLAST

    Proteomic databases

    MaxQBiQ9BYD6.
    PaxDbiQ9BYD6.
    PRIDEiQ9BYD6.

    PTM databases

    PhosphoSiteiQ9BYD6.

    Expressioni

    Gene expression databases

    BgeeiQ9BYD6.
    CleanExiHS_MRPL1.
    GenevestigatoriQ9BYD6.

    Organism-specific databases

    HPAiHPA043656.
    HPA050405.

    Interactioni

    Protein-protein interaction databases

    BioGridi122371. 19 interactions.
    IntActiQ9BYD6. 2 interactions.
    STRINGi9606.ENSP00000315017.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYD6.
    SMRiQ9BYD6. Positions 88-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L1P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG271882.
    HOVERGENiHBG061212.
    InParanoidiQ9BYD6.
    KOiK02863.
    OMAiKSYPFME.
    OrthoDBiEOG73BVDN.
    PhylomeDBiQ9BYD6.
    TreeFamiTF314989.

    Family and domain databases

    Gene3Di3.30.190.20. 2 hits.
    3.40.50.790. 1 hit.
    InterProiIPR023674. Ribosomal_L1-like.
    IPR016094. Ribosomal_L1_2-a/b-sand.
    IPR016095. Ribosomal_L1_3-a/b-sand.
    IPR024663. Ribosomal_L1_chr.
    IPR005879. Ribosomal_L1_mit.
    [Graphical view]
    PfamiPF13003. MRL1. 1 hit.
    [Graphical view]
    SUPFAMiSSF56808. SSF56808. 1 hit.
    TIGRFAMsiTIGR01170. rplA_mito. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BYD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAVRCMGR ALIHHQRHSL SKMVYQTSLC SCSVNIRVPN RHFAAATKSA    50
    KKTKKGAKEK TPDEKKDEIE KIKAYPYMEG EPEDDVYLKR LYPRQIYEVE 100
    KAVHLLKKFQ ILDFTSPKQS VYLDLTLDMA LGKKKNVEPF TSVLSLPYPF 150
    ASEINKVAVF TENASEVKIA EENGAAFAGG TSLIQKIWDD EIVADFYVAV 200
    PEIMPELNRL RKKLNKKYPK LSRNSIGRDI PKMLELFKNG HEIKVDEERE 250
    NFLQTKIATL DMSSDQIAAN LQAVINEVCR HRPLNLGPFV VRAFLRSSTS 300
    EGLLLKIDPL LPKEVKNEES EKEDA 325
    Length:325
    Mass (Da):36,909
    Last modified:June 16, 2009 - v2
    Checksum:iEB53BEE59065B682
    GO

    Sequence cautioni

    The sequence AAF87327.1 differs from that shown. Reason: Frameshift at positions 4, 6, 19, 123, 139 and 147.
    The sequence BAB40180.1 differs from that shown. Reason: Frameshift at position 20.
    The sequence AAF87327.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH14356.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH15109.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH32595.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB15005.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB40180.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAY41057.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851D → N in BAB15005. (PubMed:14702039)Curated
    Sequence conflicti229 – 2291D → H in CAG33472. (PubMed:15489334)Curated
    Sequence conflicti265 – 2651D → G in BAB15005. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471T → K.1 Publication
    Corresponds to variant rs17851275 [ dbSNP | Ensembl ].
    VAR_027865
    Natural varianti177 – 1771F → S.1 Publication
    Corresponds to variant rs17855456 [ dbSNP | Ensembl ].
    VAR_027866

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212225 mRNA. Translation: AAF87327.1. Sequence problems.
    AC112225 Genomic DNA. Translation: AAY41057.1. Sequence problems.
    AC114801 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05820.1.
    BC014356 mRNA. Translation: AAH14356.1. Different initiation.
    BC015109 mRNA. Translation: AAH15109.1. Different initiation.
    BC032595 mRNA. Translation: AAH32595.1. Different initiation.
    AB049474 mRNA. Translation: BAB40180.1. Sequence problems.
    CR457191 mRNA. Translation: CAG33472.1.
    AK024791 mRNA. Translation: BAB15005.1. Different initiation.
    CCDSiCCDS3583.2.
    RefSeqiNP_064621.3. NM_020236.3.
    UniGeneiHs.532019.

    Genome annotation databases

    EnsembliENST00000315567; ENSP00000315017; ENSG00000169288.
    GeneIDi65008.
    KEGGihsa:65008.
    UCSCiuc003hku.2. human.

    Polymorphism databases

    DMDMi239938694.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212225 mRNA. Translation: AAF87327.1 . Sequence problems.
    AC112225 Genomic DNA. Translation: AAY41057.1 . Sequence problems.
    AC114801 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05820.1 .
    BC014356 mRNA. Translation: AAH14356.1 . Different initiation.
    BC015109 mRNA. Translation: AAH15109.1 . Different initiation.
    BC032595 mRNA. Translation: AAH32595.1 . Different initiation.
    AB049474 mRNA. Translation: BAB40180.1 . Sequence problems.
    CR457191 mRNA. Translation: CAG33472.1 .
    AK024791 mRNA. Translation: BAB15005.1 . Different initiation.
    CCDSi CCDS3583.2.
    RefSeqi NP_064621.3. NM_020236.3.
    UniGenei Hs.532019.

    3D structure databases

    ProteinModelPortali Q9BYD6.
    SMRi Q9BYD6. Positions 88-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122371. 19 interactions.
    IntActi Q9BYD6. 2 interactions.
    STRINGi 9606.ENSP00000315017.

    PTM databases

    PhosphoSitei Q9BYD6.

    Polymorphism databases

    DMDMi 239938694.

    Proteomic databases

    MaxQBi Q9BYD6.
    PaxDbi Q9BYD6.
    PRIDEi Q9BYD6.

    Protocols and materials databases

    DNASUi 65008.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315567 ; ENSP00000315017 ; ENSG00000169288 .
    GeneIDi 65008.
    KEGGi hsa:65008.
    UCSCi uc003hku.2. human.

    Organism-specific databases

    CTDi 65008.
    GeneCardsi GC04P078694.
    HGNCi HGNC:14275. MRPL1.
    HPAi HPA043656.
    HPA050405.
    MIMi 611821. gene.
    neXtProti NX_Q9BYD6.
    PharmGKBi PA30938.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271882.
    HOVERGENi HBG061212.
    InParanoidi Q9BYD6.
    KOi K02863.
    OMAi KSYPFME.
    OrthoDBi EOG73BVDN.
    PhylomeDBi Q9BYD6.
    TreeFami TF314989.

    Miscellaneous databases

    GeneWikii MRPL1.
    GenomeRNAii 65008.
    NextBioi 67192.
    PROi Q9BYD6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BYD6.
    CleanExi HS_MRPL1.
    Genevestigatori Q9BYD6.

    Family and domain databases

    Gene3Di 3.30.190.20. 2 hits.
    3.40.50.790. 1 hit.
    InterProi IPR023674. Ribosomal_L1-like.
    IPR016094. Ribosomal_L1_2-a/b-sand.
    IPR016095. Ribosomal_L1_3-a/b-sand.
    IPR024663. Ribosomal_L1_chr.
    IPR005879. Ribosomal_L1_mit.
    [Graphical view ]
    Pfami PF13003. MRL1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56808. SSF56808. 1 hit.
    TIGRFAMsi TIGR01170. rplA_mito. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene expressed in human bone marrow."
      Zhao M., Song H., Li N., Peng Y., Han Z., Chen Z.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LYS-47 AND SER-177.
      Tissue: Bone marrow and Skin.
    5. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-325, SUBCELLULAR LOCATION.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-325.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-325.
      Tissue: Coronary artery.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM01_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYD6
    Secondary accession number(s): A6NG03
    , Q4W5B8, Q6IAG4, Q96BW3, Q9H793, Q9NRL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3