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Protein

39S ribosomal protein L1, mitochondrial

Gene

MRPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • box H/ACA snoRNA binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L1, mitochondrial
Short name:
L1mt
Short name:
MRP-L1
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL1m1 Publication
Gene namesi
Name:MRPL1
ORF Names:BM-022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:14275. MRPL1.

Subcellular locationi

  • Mitochondrion By similarity1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi65008.
OpenTargetsiENSG00000169288.
PharmGKBiPA30938.

Polymorphism and mutation databases

BioMutaiMRPL1.
DMDMi239938694.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 50MitochondrionSequence analysisAdd BLAST50
ChainiPRO_000025244051 – 32539S ribosomal protein L1, mitochondrialAdd BLAST275

Proteomic databases

EPDiQ9BYD6.
MaxQBiQ9BYD6.
PaxDbiQ9BYD6.
PeptideAtlasiQ9BYD6.
PRIDEiQ9BYD6.

PTM databases

iPTMnetiQ9BYD6.
PhosphoSitePlusiQ9BYD6.
SwissPalmiQ9BYD6.

Expressioni

Gene expression databases

BgeeiENSG00000169288.
CleanExiHS_MRPL1.
ExpressionAtlasiQ9BYD6. baseline and differential.
GenevisibleiQ9BYD6. HS.

Organism-specific databases

HPAiHPA043656.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:11279069). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GOPCQ9HD263EBI-5325394,EBI-349832

Protein-protein interaction databases

BioGridi122371. 85 interactors.
IntActiQ9BYD6. 59 interactors.
STRINGi9606.ENSP00000315017.

Structurei

3D structure databases

ProteinModelPortaliQ9BYD6.
SMRiQ9BYD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1569. Eukaryota.
COG0081. LUCA.
GeneTreeiENSGT00390000003587.
HOVERGENiHBG061212.
InParanoidiQ9BYD6.
KOiK02863.
OMAiVDNFQRM.
OrthoDBiEOG091G0CV1.
PhylomeDBiQ9BYD6.
TreeFamiTF314989.

Family and domain databases

CDDicd00403. Ribosomal_L1. 1 hit.
InterProiView protein in InterPro
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR005879. Ribosomal_L1_mit.
PfamiView protein in Pfam
PF00687. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01170. rplA_mito. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVRCMGR ALIHHQRHSL SKMVYQTSLC SCSVNIRVPN RHFAAATKSA
60 70 80 90 100
KKTKKGAKEK TPDEKKDEIE KIKAYPYMEG EPEDDVYLKR LYPRQIYEVE
110 120 130 140 150
KAVHLLKKFQ ILDFTSPKQS VYLDLTLDMA LGKKKNVEPF TSVLSLPYPF
160 170 180 190 200
ASEINKVAVF TENASEVKIA EENGAAFAGG TSLIQKIWDD EIVADFYVAV
210 220 230 240 250
PEIMPELNRL RKKLNKKYPK LSRNSIGRDI PKMLELFKNG HEIKVDEERE
260 270 280 290 300
NFLQTKIATL DMSSDQIAAN LQAVINEVCR HRPLNLGPFV VRAFLRSSTS
310 320
EGLLLKIDPL LPKEVKNEES EKEDA
Length:325
Mass (Da):36,909
Last modified:June 16, 2009 - v2
Checksum:iEB53BEE59065B682
GO

Sequence cautioni

The sequence AAF87327 differs from that shown. Reason: Frameshift at positions 4, 6, 19, 123, 139 and 147.Curated
The sequence AAF87327 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH14356 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH15109 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH32595 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAY41057 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB15005 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB40180 differs from that shown. Reason: Frameshift at position 20.Curated
The sequence BAB40180 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85D → N in BAB15005 (PubMed:14702039).Curated1
Sequence conflicti229D → H in CAG33472 (PubMed:15489334).Curated1
Sequence conflicti265D → G in BAB15005 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02786547T → K1 PublicationCorresponds to variant dbSNP:rs17851275Ensembl.1
Natural variantiVAR_027866177F → S1 PublicationCorresponds to variant dbSNP:rs17855456Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212225 mRNA. Translation: AAF87327.1. Sequence problems.
AC112225 Genomic DNA. Translation: AAY41057.1. Sequence problems.
AC114801 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05820.1.
BC014356 mRNA. Translation: AAH14356.1. Different initiation.
BC015109 mRNA. Translation: AAH15109.1. Different initiation.
BC032595 mRNA. Translation: AAH32595.1. Different initiation.
AB049474 mRNA. Translation: BAB40180.1. Sequence problems.
CR457191 mRNA. Translation: CAG33472.1.
AK024791 mRNA. Translation: BAB15005.1. Different initiation.
CCDSiCCDS3583.2.
RefSeqiNP_064621.3. NM_020236.3.
XP_011530500.1. XM_011532198.2.
XP_011530501.1. XM_011532199.1.
UniGeneiHs.532019.

Genome annotation databases

EnsembliENST00000315567; ENSP00000315017; ENSG00000169288.
GeneIDi65008.
KEGGihsa:65008.
UCSCiuc003hku.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM01_HUMAN
AccessioniPrimary (citable) accession number: Q9BYD6
Secondary accession number(s): A6NG03
, Q4W5B8, Q6IAG4, Q96BW3, Q9H793, Q9NRL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 16, 2009
Last modified: August 30, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families