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Protein

39S ribosomal protein L1, mitochondrial

Gene

MRPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. mitochondrial translation Source: Reactome
  2. mitochondrial translational elongation Source: Reactome
  3. mitochondrial translational initiation Source: Reactome
  4. mitochondrial translational termination Source: Reactome
  5. organelle organization Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L1, mitochondrial
Short name:
L1mt
Short name:
MRP-L1
Gene namesi
Name:MRPL1
ORF Names:BM-022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:14275. MRPL1.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrion Source: HPA
  4. nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5050MitochondrionSequence AnalysisAdd
BLAST
Chaini51 – 32527539S ribosomal protein L1, mitochondrialPRO_0000252440Add
BLAST

Proteomic databases

MaxQBiQ9BYD6.
PaxDbiQ9BYD6.
PRIDEiQ9BYD6.

PTM databases

PhosphoSiteiQ9BYD6.

Expressioni

Gene expression databases

BgeeiQ9BYD6.
CleanExiHS_MRPL1.
GenevestigatoriQ9BYD6.

Organism-specific databases

HPAiHPA043656.
HPA050405.

Interactioni

Protein-protein interaction databases

BioGridi122371. 28 interactions.
IntActiQ9BYD6. 2 interactions.
STRINGi9606.ENSP00000315017.

Structurei

3D structure databases

ProteinModelPortaliQ9BYD6.
SMRiQ9BYD6. Positions 88-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L1P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG271882.
GeneTreeiENSGT00390000003587.
HOVERGENiHBG061212.
InParanoidiQ9BYD6.
KOiK02863.
OMAiKSYPFME.
OrthoDBiEOG73BVDN.
PhylomeDBiQ9BYD6.
TreeFamiTF314989.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
InterProiIPR023674. Ribosomal_L1-like.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR024663. Ribosomal_L1_chr.
IPR005879. Ribosomal_L1_mit.
[Graphical view]
PfamiPF13003. MRL1. 1 hit.
[Graphical view]
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01170. rplA_mito. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVRCMGR ALIHHQRHSL SKMVYQTSLC SCSVNIRVPN RHFAAATKSA
60 70 80 90 100
KKTKKGAKEK TPDEKKDEIE KIKAYPYMEG EPEDDVYLKR LYPRQIYEVE
110 120 130 140 150
KAVHLLKKFQ ILDFTSPKQS VYLDLTLDMA LGKKKNVEPF TSVLSLPYPF
160 170 180 190 200
ASEINKVAVF TENASEVKIA EENGAAFAGG TSLIQKIWDD EIVADFYVAV
210 220 230 240 250
PEIMPELNRL RKKLNKKYPK LSRNSIGRDI PKMLELFKNG HEIKVDEERE
260 270 280 290 300
NFLQTKIATL DMSSDQIAAN LQAVINEVCR HRPLNLGPFV VRAFLRSSTS
310 320
EGLLLKIDPL LPKEVKNEES EKEDA
Length:325
Mass (Da):36,909
Last modified:June 15, 2009 - v2
Checksum:iEB53BEE59065B682
GO

Sequence cautioni

The sequence AAF87327.1 differs from that shown. Reason: Frameshift at positions 4, 6, 19, 123, 139 and 147. Curated
The sequence AAF87327.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH14356.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH15109.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH32595.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAY41057.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAB15005.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB40180.1 differs from that shown. Reason: Frameshift at position 20. Curated
The sequence BAB40180.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851D → N in BAB15005 (PubMed:14702039).Curated
Sequence conflicti229 – 2291D → H in CAG33472 (PubMed:15489334).Curated
Sequence conflicti265 – 2651D → G in BAB15005 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471T → K.1 Publication
Corresponds to variant rs17851275 [ dbSNP | Ensembl ].
VAR_027865
Natural varianti177 – 1771F → S.1 Publication
Corresponds to variant rs17855456 [ dbSNP | Ensembl ].
VAR_027866

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212225 mRNA. Translation: AAF87327.1. Sequence problems.
AC112225 Genomic DNA. Translation: AAY41057.1. Sequence problems.
AC114801 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05820.1.
BC014356 mRNA. Translation: AAH14356.1. Different initiation.
BC015109 mRNA. Translation: AAH15109.1. Different initiation.
BC032595 mRNA. Translation: AAH32595.1. Different initiation.
AB049474 mRNA. Translation: BAB40180.1. Sequence problems.
CR457191 mRNA. Translation: CAG33472.1.
AK024791 mRNA. Translation: BAB15005.1. Different initiation.
CCDSiCCDS3583.2.
RefSeqiNP_064621.3. NM_020236.3.
UniGeneiHs.532019.

Genome annotation databases

EnsembliENST00000315567; ENSP00000315017; ENSG00000169288.
GeneIDi65008.
KEGGihsa:65008.
UCSCiuc003hku.2. human.

Polymorphism databases

DMDMi239938694.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212225 mRNA. Translation: AAF87327.1. Sequence problems.
AC112225 Genomic DNA. Translation: AAY41057.1. Sequence problems.
AC114801 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05820.1.
BC014356 mRNA. Translation: AAH14356.1. Different initiation.
BC015109 mRNA. Translation: AAH15109.1. Different initiation.
BC032595 mRNA. Translation: AAH32595.1. Different initiation.
AB049474 mRNA. Translation: BAB40180.1. Sequence problems.
CR457191 mRNA. Translation: CAG33472.1.
AK024791 mRNA. Translation: BAB15005.1. Different initiation.
CCDSiCCDS3583.2.
RefSeqiNP_064621.3. NM_020236.3.
UniGeneiHs.532019.

3D structure databases

ProteinModelPortaliQ9BYD6.
SMRiQ9BYD6. Positions 88-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122371. 28 interactions.
IntActiQ9BYD6. 2 interactions.
STRINGi9606.ENSP00000315017.

PTM databases

PhosphoSiteiQ9BYD6.

Polymorphism databases

DMDMi239938694.

Proteomic databases

MaxQBiQ9BYD6.
PaxDbiQ9BYD6.
PRIDEiQ9BYD6.

Protocols and materials databases

DNASUi65008.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315567; ENSP00000315017; ENSG00000169288.
GeneIDi65008.
KEGGihsa:65008.
UCSCiuc003hku.2. human.

Organism-specific databases

CTDi65008.
GeneCardsiGC04P078694.
HGNCiHGNC:14275. MRPL1.
HPAiHPA043656.
HPA050405.
MIMi611821. gene.
neXtProtiNX_Q9BYD6.
PharmGKBiPA30938.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG271882.
GeneTreeiENSGT00390000003587.
HOVERGENiHBG061212.
InParanoidiQ9BYD6.
KOiK02863.
OMAiKSYPFME.
OrthoDBiEOG73BVDN.
PhylomeDBiQ9BYD6.
TreeFamiTF314989.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

GeneWikiiMRPL1.
GenomeRNAii65008.
NextBioi67192.
PROiQ9BYD6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BYD6.
CleanExiHS_MRPL1.
GenevestigatoriQ9BYD6.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
InterProiIPR023674. Ribosomal_L1-like.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR024663. Ribosomal_L1_chr.
IPR005879. Ribosomal_L1_mit.
[Graphical view]
PfamiPF13003. MRL1. 1 hit.
[Graphical view]
SUPFAMiSSF56808. SSF56808. 1 hit.
TIGRFAMsiTIGR01170. rplA_mito. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene expressed in human bone marrow."
    Zhao M., Song H., Li N., Peng Y., Han Z., Chen Z.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LYS-47 AND SER-177.
    Tissue: Bone marrow and Skin.
  5. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-325, SUBCELLULAR LOCATION.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-325.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-325.
    Tissue: Coronary artery.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM01_HUMAN
AccessioniPrimary (citable) accession number: Q9BYD6
Secondary accession number(s): A6NG03
, Q4W5B8, Q6IAG4, Q96BW3, Q9H793, Q9NRL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 16, 2006
Last sequence update: June 15, 2009
Last modified: March 31, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.