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Q9BYD6 (RM01_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L1, mitochondrial

Short name=L1mt
Short name=MRP-L1
Gene names
Name:MRPL1
ORF Names:BM-022
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion Ref.5.

Sequence similarities

Belongs to the ribosomal protein L1P family.

Sequence caution

The sequence AAF87327.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAF87327.1 differs from that shown. Reason: Frameshift at positions 4, 6, 19, 123, 139 and 147.

The sequence AAH14356.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH15109.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH32595.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAY41057.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAB15005.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB40180.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB40180.1 differs from that shown. Reason: Frameshift at position 20.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityPolymorphism
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlarge ribosomal subunit

Inferred from electronic annotation. Source: InterPro

mitochondrion

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay. Source: HPA

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 5050Mitochondrion Potential
Chain51 – 32527539S ribosomal protein L1, mitochondrial
PRO_0000252440

Natural variations

Natural variant471T → K. Ref.4
Corresponds to variant rs17851275 [ dbSNP | Ensembl ].
VAR_027865
Natural variant1771F → S. Ref.4
Corresponds to variant rs17855456 [ dbSNP | Ensembl ].
VAR_027866

Experimental info

Sequence conflict851D → N in BAB15005. Ref.7
Sequence conflict2291D → H in CAG33472. Ref.4
Sequence conflict2651D → G in BAB15005. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Q9BYD6 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: EB53BEE59065B682

FASTA32536,909
        10         20         30         40         50         60 
MAAAVRCMGR ALIHHQRHSL SKMVYQTSLC SCSVNIRVPN RHFAAATKSA KKTKKGAKEK 

        70         80         90        100        110        120 
TPDEKKDEIE KIKAYPYMEG EPEDDVYLKR LYPRQIYEVE KAVHLLKKFQ ILDFTSPKQS 

       130        140        150        160        170        180 
VYLDLTLDMA LGKKKNVEPF TSVLSLPYPF ASEINKVAVF TENASEVKIA EENGAAFAGG 

       190        200        210        220        230        240 
TSLIQKIWDD EIVADFYVAV PEIMPELNRL RKKLNKKYPK LSRNSIGRDI PKMLELFKNG 

       250        260        270        280        290        300 
HEIKVDEERE NFLQTKIATL DMSSDQIAAN LQAVINEVCR HRPLNLGPFV VRAFLRSSTS 

       310        320 
EGLLLKIDPL LPKEVKNEES EKEDA 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene expressed in human bone marrow."
Zhao M., Song H., Li N., Peng Y., Han Z., Chen Z.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LYS-47 AND SER-177.
Tissue: Bone marrow and Skin.
[5]"Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-325, SUBCELLULAR LOCATION.
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-325.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-325.
Tissue: Coronary artery.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF212225 mRNA. Translation: AAF87327.1. Sequence problems.
AC112225 Genomic DNA. Translation: AAY41057.1. Sequence problems.
AC114801 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05820.1.
BC014356 mRNA. Translation: AAH14356.1. Different initiation.
BC015109 mRNA. Translation: AAH15109.1. Different initiation.
BC032595 mRNA. Translation: AAH32595.1. Different initiation.
AB049474 mRNA. Translation: BAB40180.1. Sequence problems.
CR457191 mRNA. Translation: CAG33472.1.
AK024791 mRNA. Translation: BAB15005.1. Different initiation.
RefSeqNP_064621.3. NM_020236.3.
UniGeneHs.532019.

3D structure databases

ProteinModelPortalQ9BYD6.
SMRQ9BYD6. Positions 88-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122371. 19 interactions.
IntActQ9BYD6. 2 interactions.
STRING9606.ENSP00000315017.

PTM databases

PhosphoSiteQ9BYD6.

Polymorphism databases

DMDM239938694.

Proteomic databases

PaxDbQ9BYD6.
PRIDEQ9BYD6.

Protocols and materials databases

DNASU65008.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315567; ENSP00000315017; ENSG00000169288.
GeneID65008.
KEGGhsa:65008.
UCSCuc003hku.2. human.

Organism-specific databases

CTD65008.
GeneCardsGC04P078694.
HGNCHGNC:14275. MRPL1.
HPAHPA043656.
HPA050405.
MIM611821. gene.
neXtProtNX_Q9BYD6.
PharmGKBPA30938.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG271882.
HOVERGENHBG061212.
InParanoidQ9BYD6.
KOK02863.
OMAKSYPFME.
OrthoDBEOG73BVDN.
PhylomeDBQ9BYD6.
TreeFamTF314989.

Gene expression databases

BgeeQ9BYD6.
CleanExHS_MRPL1.
GenevestigatorQ9BYD6.

Family and domain databases

Gene3D3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
InterProIPR023674. Ribosomal_L1-like.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR024663. Ribosomal_L1_chr.
IPR005879. Ribosomal_L1_mit.
[Graphical view]
PfamPF13003. MRL1. 1 hit.
[Graphical view]
SUPFAMSSF56808. SSF56808. 1 hit.
TIGRFAMsTIGR01170. rplA_mito. 1 hit.
ProtoNetSearch...

Other

GeneWikiMRPL1.
GenomeRNAi65008.
NextBio67192.
PROQ9BYD6.
SOURCESearch...

Entry information

Entry nameRM01_HUMAN
AccessionPrimary (citable) accession number: Q9BYD6
Secondary accession number(s): A6NG03 expand/collapse secondary AC list , Q4W5B8, Q6IAG4, Q96BW3, Q9H793, Q9NRL5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 16, 2009
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM