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Q9BYD3

- RM04_HUMAN

UniProt

Q9BYD3 - RM04_HUMAN

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Protein

39S ribosomal protein L4, mitochondrial

Gene
MRPL4, CDABP0091, CGI-28
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L4, mitochondrial
Short name:
L4mt
Short name:
MRP-L4
Gene namesi
Name:MRPL4
ORF Names:CDABP0091, CGI-28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:14276. MRPL4.

Subcellular locationi

Mitochondrion By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30971.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31131139S ribosomal protein L4, mitochondrialUniRule annotationPRO_0000238949Add
BLAST

Proteomic databases

MaxQBiQ9BYD3.
PaxDbiQ9BYD3.
PRIDEiQ9BYD3.

PTM databases

PhosphoSiteiQ9BYD3.

Expressioni

Gene expression databases

ArrayExpressiQ9BYD3.
BgeeiQ9BYD3.
CleanExiHS_MRPL4.
GenevestigatoriQ9BYD3.

Organism-specific databases

HPAiHPA051261.

Interactioni

Protein-protein interaction databases

BioGridi119264. 25 interactions.
IntActiQ9BYD3. 6 interactions.
MINTiMINT-1389069.
STRINGi9606.ENSP00000253099.

Structurei

3D structure databases

ProteinModelPortaliQ9BYD3.
SMRiQ9BYD3. Positions 95-263.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0088.
HOGENOMiHOG000248767.
HOVERGENiHBG083638.
InParanoidiQ9BYD3.
KOiK02926.
OMAiILNHECV.
PhylomeDBiQ9BYD3.
TreeFamiTF313913.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
HAMAPiMF_01328_B. Ribosomal_L4_B.
InterProiIPR002136. Ribosomal_L4/L1e.
IPR013005. Ribosomal_L4/L1e_bac-type.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PANTHERiPTHR10746. PTHR10746. 1 hit.
PfamiPF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
TIGRFAMsiTIGR03953. rplD_bact. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BYD3-1) [UniParc]FASTAAdd to Basket

Also known as: isoform a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK    50
VELPVPTHRR PVQAWVESLR GFEQERVGLA DLHPDVFATA PRLDILHQVA 100
MWQKNFKRIS YAKTKTRAEV RGGGRKPWPQ KGTGRARHGS IRSPLWRGGG 150
VAHGPRGPTS YYYMLPMKVR ALGLKVALTV KLAQDDLHIM DSLELPTGDP 200
QYLTELAHYR RWGDSVLLVD LTHEEMPQSI VEATSRLKTF NLIPAVGLNV 250
HSMLKHQTLV LTLPTVAFLE DKLLWQDSRY RPLYPFSLPY SDFPRPLPHA 300
TQGPAATPYH C 311
Length:311
Mass (Da):34,919
Last modified:June 1, 2001 - v1
Checksum:i8267C61C42BFCF07
GO
Isoform 2 (identifier: Q9BYD3-2) [UniParc]FASTAAdd to Basket

Also known as: isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     248-263: LNVHSMLKHQTLVLTL → EQRAQAPRVRMCRLRC
     264-311: Missing.

Show »
Length:263
Mass (Da):29,502
Checksum:i698CAA74688002FE
GO

Sequence cautioni

The sequence AAD27737.1 differs from that shown. Reason: Frameshift at position 128.
The sequence AAG02005.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei248 – 26316LNVHS…LVLTL → EQRAQAPRVRMCRLRC in isoform 2. VSP_019027Add
BLAST
Alternative sequencei264 – 31148Missing in isoform 2. VSP_019028Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049635 mRNA. Translation: BAB40840.1.
AF132962 mRNA. Translation: AAD27737.1. Frameshift.
AC011511 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84083.1.
BC000756 mRNA. Translation: AAH00756.1.
BC009858 mRNA. Translation: AAH09858.1.
AY007152 mRNA. Translation: AAG02005.1. Different initiation.
CCDSiCCDS12230.1. [Q9BYD3-1]
CCDS42499.1. [Q9BYD3-2]
RefSeqiNP_057040.2. NM_015956.2. [Q9BYD3-1]
NP_666499.1. NM_146387.1. [Q9BYD3-1]
NP_666500.1. NM_146388.1. [Q9BYD3-2]
UniGeneiHs.279652.

Genome annotation databases

EnsembliENST00000253099; ENSP00000253099; ENSG00000105364. [Q9BYD3-1]
ENST00000307422; ENSP00000306902; ENSG00000105364. [Q9BYD3-1]
ENST00000590669; ENSP00000465143; ENSG00000105364. [Q9BYD3-2]
GeneIDi51073.
KEGGihsa:51073.
UCSCiuc002mnm.3. human. [Q9BYD3-1]
uc002mno.3. human. [Q9BYD3-2]

Polymorphism databases

DMDMi74733471.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049635 mRNA. Translation: BAB40840.1 .
AF132962 mRNA. Translation: AAD27737.1 . Frameshift.
AC011511 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84083.1 .
BC000756 mRNA. Translation: AAH00756.1 .
BC009858 mRNA. Translation: AAH09858.1 .
AY007152 mRNA. Translation: AAG02005.1 . Different initiation.
CCDSi CCDS12230.1. [Q9BYD3-1 ]
CCDS42499.1. [Q9BYD3-2 ]
RefSeqi NP_057040.2. NM_015956.2. [Q9BYD3-1 ]
NP_666499.1. NM_146387.1. [Q9BYD3-1 ]
NP_666500.1. NM_146388.1. [Q9BYD3-2 ]
UniGenei Hs.279652.

3D structure databases

ProteinModelPortali Q9BYD3.
SMRi Q9BYD3. Positions 95-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119264. 25 interactions.
IntActi Q9BYD3. 6 interactions.
MINTi MINT-1389069.
STRINGi 9606.ENSP00000253099.

PTM databases

PhosphoSitei Q9BYD3.

Polymorphism databases

DMDMi 74733471.

Proteomic databases

MaxQBi Q9BYD3.
PaxDbi Q9BYD3.
PRIDEi Q9BYD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253099 ; ENSP00000253099 ; ENSG00000105364 . [Q9BYD3-1 ]
ENST00000307422 ; ENSP00000306902 ; ENSG00000105364 . [Q9BYD3-1 ]
ENST00000590669 ; ENSP00000465143 ; ENSG00000105364 . [Q9BYD3-2 ]
GeneIDi 51073.
KEGGi hsa:51073.
UCSCi uc002mnm.3. human. [Q9BYD3-1 ]
uc002mno.3. human. [Q9BYD3-2 ]

Organism-specific databases

CTDi 51073.
GeneCardsi GC19P010362.
HGNCi HGNC:14276. MRPL4.
HPAi HPA051261.
MIMi 611823. gene.
neXtProti NX_Q9BYD3.
PharmGKBi PA30971.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0088.
HOGENOMi HOG000248767.
HOVERGENi HBG083638.
InParanoidi Q9BYD3.
KOi K02926.
OMAi ILNHECV.
PhylomeDBi Q9BYD3.
TreeFami TF313913.

Miscellaneous databases

ChiTaRSi MRPL4. human.
GeneWikii MRPL4.
GenomeRNAii 51073.
NextBioi 53691.
PROi Q9BYD3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BYD3.
Bgeei Q9BYD3.
CleanExi HS_MRPL4.
Genevestigatori Q9BYD3.

Family and domain databases

Gene3Di 3.40.1370.10. 1 hit.
HAMAPi MF_01328_B. Ribosomal_L4_B.
InterProi IPR002136. Ribosomal_L4/L1e.
IPR013005. Ribosomal_L4/L1e_bac-type.
IPR023574. Ribosomal_L4_dom.
[Graphical view ]
PANTHERi PTHR10746. PTHR10746. 1 hit.
Pfami PF00573. Ribosomal_L4. 1 hit.
[Graphical view ]
SUPFAMi SSF52166. SSF52166. 1 hit.
TIGRFAMsi TIGR03953. rplD_bact. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung and Ovary.
  6. "Pediatric leukemia cDNA sequencing project."
    Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-311 (ISOFORM 1).
    Tissue: Leukemia.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM04_HUMAN
AccessioniPrimary (citable) accession number: Q9BYD3
Secondary accession number(s): A6NNV7
, Q9BW07, Q9H4N2, Q9Y317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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