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Q9BYD3

- RM04_HUMAN

UniProt

Q9BYD3 - RM04_HUMAN

Protein

39S ribosomal protein L4, mitochondrial

Gene

MRPL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L4, mitochondrial
    Short name:
    L4mt
    Short name:
    MRP-L4
    Gene namesi
    Name:MRPL4
    ORF Names:CDABP0091, CGI-28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:14276. MRPL4.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30971.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 31131139S ribosomal protein L4, mitochondrialPRO_0000238949Add
    BLAST

    Proteomic databases

    MaxQBiQ9BYD3.
    PaxDbiQ9BYD3.
    PRIDEiQ9BYD3.

    PTM databases

    PhosphoSiteiQ9BYD3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BYD3.
    BgeeiQ9BYD3.
    CleanExiHS_MRPL4.
    GenevestigatoriQ9BYD3.

    Organism-specific databases

    HPAiHPA051261.

    Interactioni

    Protein-protein interaction databases

    BioGridi119264. 25 interactions.
    IntActiQ9BYD3. 6 interactions.
    MINTiMINT-1389069.
    STRINGi9606.ENSP00000253099.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYD3.
    SMRiQ9BYD3. Positions 95-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L4P family.Curated

    Phylogenomic databases

    eggNOGiCOG0088.
    HOGENOMiHOG000248767.
    HOVERGENiHBG083638.
    InParanoidiQ9BYD3.
    KOiK02926.
    OMAiILNHECV.
    PhylomeDBiQ9BYD3.
    TreeFamiTF313913.

    Family and domain databases

    Gene3Di3.40.1370.10. 1 hit.
    HAMAPiMF_01328_B. Ribosomal_L4_B.
    InterProiIPR002136. Ribosomal_L4/L1e.
    IPR013005. Ribosomal_L4/L1e_bac-type.
    IPR023574. Ribosomal_L4_dom.
    [Graphical view]
    PANTHERiPTHR10746. PTHR10746. 1 hit.
    PfamiPF00573. Ribosomal_L4. 1 hit.
    [Graphical view]
    SUPFAMiSSF52166. SSF52166. 1 hit.
    TIGRFAMsiTIGR03953. rplD_bact. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BYD3-1) [UniParc]FASTAAdd to Basket

    Also known as: isoform a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK    50
    VELPVPTHRR PVQAWVESLR GFEQERVGLA DLHPDVFATA PRLDILHQVA 100
    MWQKNFKRIS YAKTKTRAEV RGGGRKPWPQ KGTGRARHGS IRSPLWRGGG 150
    VAHGPRGPTS YYYMLPMKVR ALGLKVALTV KLAQDDLHIM DSLELPTGDP 200
    QYLTELAHYR RWGDSVLLVD LTHEEMPQSI VEATSRLKTF NLIPAVGLNV 250
    HSMLKHQTLV LTLPTVAFLE DKLLWQDSRY RPLYPFSLPY SDFPRPLPHA 300
    TQGPAATPYH C 311
    Length:311
    Mass (Da):34,919
    Last modified:June 1, 2001 - v1
    Checksum:i8267C61C42BFCF07
    GO
    Isoform 2 (identifier: Q9BYD3-2) [UniParc]FASTAAdd to Basket

    Also known as: isoform b

    The sequence of this isoform differs from the canonical sequence as follows:
         248-263: LNVHSMLKHQTLVLTL → EQRAQAPRVRMCRLRC
         264-311: Missing.

    Show »
    Length:263
    Mass (Da):29,502
    Checksum:i698CAA74688002FE
    GO

    Sequence cautioni

    The sequence AAD27737.1 differs from that shown. Reason: Frameshift at position 128.
    The sequence AAG02005.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei248 – 26316LNVHS…LVLTL → EQRAQAPRVRMCRLRC in isoform 2. 1 PublicationVSP_019027Add
    BLAST
    Alternative sequencei264 – 31148Missing in isoform 2. 1 PublicationVSP_019028Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049635 mRNA. Translation: BAB40840.1.
    AF132962 mRNA. Translation: AAD27737.1. Frameshift.
    AC011511 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84083.1.
    BC000756 mRNA. Translation: AAH00756.1.
    BC009858 mRNA. Translation: AAH09858.1.
    AY007152 mRNA. Translation: AAG02005.1. Different initiation.
    CCDSiCCDS12230.1. [Q9BYD3-1]
    CCDS42499.1. [Q9BYD3-2]
    RefSeqiNP_057040.2. NM_015956.2. [Q9BYD3-1]
    NP_666499.1. NM_146387.1. [Q9BYD3-1]
    NP_666500.1. NM_146388.1. [Q9BYD3-2]
    UniGeneiHs.279652.

    Genome annotation databases

    EnsembliENST00000253099; ENSP00000253099; ENSG00000105364. [Q9BYD3-1]
    ENST00000307422; ENSP00000306902; ENSG00000105364. [Q9BYD3-1]
    ENST00000590669; ENSP00000465143; ENSG00000105364. [Q9BYD3-2]
    GeneIDi51073.
    KEGGihsa:51073.
    UCSCiuc002mnm.3. human. [Q9BYD3-1]
    uc002mno.3. human. [Q9BYD3-2]

    Polymorphism databases

    DMDMi74733471.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049635 mRNA. Translation: BAB40840.1 .
    AF132962 mRNA. Translation: AAD27737.1 . Frameshift.
    AC011511 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84083.1 .
    BC000756 mRNA. Translation: AAH00756.1 .
    BC009858 mRNA. Translation: AAH09858.1 .
    AY007152 mRNA. Translation: AAG02005.1 . Different initiation.
    CCDSi CCDS12230.1. [Q9BYD3-1 ]
    CCDS42499.1. [Q9BYD3-2 ]
    RefSeqi NP_057040.2. NM_015956.2. [Q9BYD3-1 ]
    NP_666499.1. NM_146387.1. [Q9BYD3-1 ]
    NP_666500.1. NM_146388.1. [Q9BYD3-2 ]
    UniGenei Hs.279652.

    3D structure databases

    ProteinModelPortali Q9BYD3.
    SMRi Q9BYD3. Positions 95-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119264. 25 interactions.
    IntActi Q9BYD3. 6 interactions.
    MINTi MINT-1389069.
    STRINGi 9606.ENSP00000253099.

    PTM databases

    PhosphoSitei Q9BYD3.

    Polymorphism databases

    DMDMi 74733471.

    Proteomic databases

    MaxQBi Q9BYD3.
    PaxDbi Q9BYD3.
    PRIDEi Q9BYD3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253099 ; ENSP00000253099 ; ENSG00000105364 . [Q9BYD3-1 ]
    ENST00000307422 ; ENSP00000306902 ; ENSG00000105364 . [Q9BYD3-1 ]
    ENST00000590669 ; ENSP00000465143 ; ENSG00000105364 . [Q9BYD3-2 ]
    GeneIDi 51073.
    KEGGi hsa:51073.
    UCSCi uc002mnm.3. human. [Q9BYD3-1 ]
    uc002mno.3. human. [Q9BYD3-2 ]

    Organism-specific databases

    CTDi 51073.
    GeneCardsi GC19P010362.
    HGNCi HGNC:14276. MRPL4.
    HPAi HPA051261.
    MIMi 611823. gene.
    neXtProti NX_Q9BYD3.
    PharmGKBi PA30971.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0088.
    HOGENOMi HOG000248767.
    HOVERGENi HBG083638.
    InParanoidi Q9BYD3.
    KOi K02926.
    OMAi ILNHECV.
    PhylomeDBi Q9BYD3.
    TreeFami TF313913.

    Miscellaneous databases

    ChiTaRSi MRPL4. human.
    GeneWikii MRPL4.
    GenomeRNAii 51073.
    NextBioi 53691.
    PROi Q9BYD3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BYD3.
    Bgeei Q9BYD3.
    CleanExi HS_MRPL4.
    Genevestigatori Q9BYD3.

    Family and domain databases

    Gene3Di 3.40.1370.10. 1 hit.
    HAMAPi MF_01328_B. Ribosomal_L4_B.
    InterProi IPR002136. Ribosomal_L4/L1e.
    IPR013005. Ribosomal_L4/L1e_bac-type.
    IPR023574. Ribosomal_L4_dom.
    [Graphical view ]
    PANTHERi PTHR10746. PTHR10746. 1 hit.
    Pfami PF00573. Ribosomal_L4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52166. SSF52166. 1 hit.
    TIGRFAMsi TIGR03953. rplD_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung and Ovary.
    6. "Pediatric leukemia cDNA sequencing project."
      Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-311 (ISOFORM 1).
      Tissue: Leukemia.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM04_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYD3
    Secondary accession number(s): A6NNV7
    , Q9BW07, Q9H4N2, Q9Y317
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3