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Protein

39S ribosomal protein L4, mitochondrial

Gene

MRPL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L4, mitochondrial
Short name:
L4mt
Short name:
MRP-L4
Gene namesi
Name:MRPL4
ORF Names:CDABP0091, CGI-28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:14276. MRPL4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30971.

Polymorphism and mutation databases

BioMutaiMRPL4.
DMDMi74733471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31131139S ribosomal protein L4, mitochondrialPRO_0000238949Add
BLAST

Proteomic databases

MaxQBiQ9BYD3.
PaxDbiQ9BYD3.
PRIDEiQ9BYD3.

PTM databases

PhosphoSiteiQ9BYD3.

Expressioni

Gene expression databases

BgeeiQ9BYD3.
CleanExiHS_MRPL4.
ExpressionAtlasiQ9BYD3. baseline and differential.
GenevisibleiQ9BYD3. HS.

Organism-specific databases

HPAiHPA051261.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLK2P497603EBI-721368,EBI-750020
TRIM23P364063EBI-721368,EBI-740098

Protein-protein interaction databases

BioGridi119264. 102 interactions.
IntActiQ9BYD3. 8 interactions.
MINTiMINT-1389069.
STRINGi9606.ENSP00000253099.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40F1-311[»]
3J9Melectron microscopy3.50F1-311[»]
ProteinModelPortaliQ9BYD3.
SMRiQ9BYD3. Positions 45-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L4P family.Curated

Phylogenomic databases

eggNOGiCOG0088.
GeneTreeiENSGT00390000014512.
HOGENOMiHOG000248767.
HOVERGENiHBG083638.
InParanoidiQ9BYD3.
KOiK02926.
OMAiVVRSHEH.
PhylomeDBiQ9BYD3.
TreeFamiTF313913.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
HAMAPiMF_01328_B. Ribosomal_L4_B.
InterProiIPR002136. Ribosomal_L4/L1e.
IPR023574. Ribosomal_L4_dom.
IPR013005. Ribosomal_uL4/L1e.
[Graphical view]
PANTHERiPTHR10746. PTHR10746. 1 hit.
PfamiPF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
TIGRFAMsiTIGR03953. rplD_bact. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYD3-1) [UniParc]FASTAAdd to basket

Also known as: isoform a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK
60 70 80 90 100
VELPVPTHRR PVQAWVESLR GFEQERVGLA DLHPDVFATA PRLDILHQVA
110 120 130 140 150
MWQKNFKRIS YAKTKTRAEV RGGGRKPWPQ KGTGRARHGS IRSPLWRGGG
160 170 180 190 200
VAHGPRGPTS YYYMLPMKVR ALGLKVALTV KLAQDDLHIM DSLELPTGDP
210 220 230 240 250
QYLTELAHYR RWGDSVLLVD LTHEEMPQSI VEATSRLKTF NLIPAVGLNV
260 270 280 290 300
HSMLKHQTLV LTLPTVAFLE DKLLWQDSRY RPLYPFSLPY SDFPRPLPHA
310
TQGPAATPYH C
Length:311
Mass (Da):34,919
Last modified:June 1, 2001 - v1
Checksum:i8267C61C42BFCF07
GO
Isoform 2 (identifier: Q9BYD3-2) [UniParc]FASTAAdd to basket

Also known as: isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     248-263: LNVHSMLKHQTLVLTL → EQRAQAPRVRMCRLRC
     264-311: Missing.

Show »
Length:263
Mass (Da):29,502
Checksum:i698CAA74688002FE
GO

Sequence cautioni

The sequence AAD27737.1 differs from that shown. Reason: Frameshift at position 128. Curated
The sequence AAG02005.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei248 – 26316LNVHS…LVLTL → EQRAQAPRVRMCRLRC in isoform 2. 1 PublicationVSP_019027Add
BLAST
Alternative sequencei264 – 31148Missing in isoform 2. 1 PublicationVSP_019028Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049635 mRNA. Translation: BAB40840.1.
AF132962 mRNA. Translation: AAD27737.1. Frameshift.
AC011511 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84083.1.
BC000756 mRNA. Translation: AAH00756.1.
BC009858 mRNA. Translation: AAH09858.1.
AY007152 mRNA. Translation: AAG02005.1. Different initiation.
CCDSiCCDS12230.1. [Q9BYD3-1]
CCDS42499.1. [Q9BYD3-2]
RefSeqiNP_057040.2. NM_015956.2. [Q9BYD3-1]
NP_666499.1. NM_146387.1. [Q9BYD3-1]
NP_666500.1. NM_146388.1. [Q9BYD3-2]
UniGeneiHs.279652.

Genome annotation databases

EnsembliENST00000253099; ENSP00000253099; ENSG00000105364.
ENST00000307422; ENSP00000306902; ENSG00000105364.
ENST00000590669; ENSP00000465143; ENSG00000105364. [Q9BYD3-2]
GeneIDi51073.
KEGGihsa:51073.
UCSCiuc002mnm.3. human. [Q9BYD3-1]
uc002mno.3. human. [Q9BYD3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049635 mRNA. Translation: BAB40840.1.
AF132962 mRNA. Translation: AAD27737.1. Frameshift.
AC011511 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84083.1.
BC000756 mRNA. Translation: AAH00756.1.
BC009858 mRNA. Translation: AAH09858.1.
AY007152 mRNA. Translation: AAG02005.1. Different initiation.
CCDSiCCDS12230.1. [Q9BYD3-1]
CCDS42499.1. [Q9BYD3-2]
RefSeqiNP_057040.2. NM_015956.2. [Q9BYD3-1]
NP_666499.1. NM_146387.1. [Q9BYD3-1]
NP_666500.1. NM_146388.1. [Q9BYD3-2]
UniGeneiHs.279652.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40F1-311[»]
3J9Melectron microscopy3.50F1-311[»]
ProteinModelPortaliQ9BYD3.
SMRiQ9BYD3. Positions 45-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119264. 102 interactions.
IntActiQ9BYD3. 8 interactions.
MINTiMINT-1389069.
STRINGi9606.ENSP00000253099.

PTM databases

PhosphoSiteiQ9BYD3.

Polymorphism and mutation databases

BioMutaiMRPL4.
DMDMi74733471.

Proteomic databases

MaxQBiQ9BYD3.
PaxDbiQ9BYD3.
PRIDEiQ9BYD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253099; ENSP00000253099; ENSG00000105364.
ENST00000307422; ENSP00000306902; ENSG00000105364.
ENST00000590669; ENSP00000465143; ENSG00000105364. [Q9BYD3-2]
GeneIDi51073.
KEGGihsa:51073.
UCSCiuc002mnm.3. human. [Q9BYD3-1]
uc002mno.3. human. [Q9BYD3-2]

Organism-specific databases

CTDi51073.
GeneCardsiGC19P010362.
HGNCiHGNC:14276. MRPL4.
HPAiHPA051261.
MIMi611823. gene.
neXtProtiNX_Q9BYD3.
PharmGKBiPA30971.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0088.
GeneTreeiENSGT00390000014512.
HOGENOMiHOG000248767.
HOVERGENiHBG083638.
InParanoidiQ9BYD3.
KOiK02926.
OMAiVVRSHEH.
PhylomeDBiQ9BYD3.
TreeFamiTF313913.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL4. human.
GeneWikiiMRPL4.
GenomeRNAii51073.
NextBioi53691.
PROiQ9BYD3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BYD3.
CleanExiHS_MRPL4.
ExpressionAtlasiQ9BYD3. baseline and differential.
GenevisibleiQ9BYD3. HS.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
HAMAPiMF_01328_B. Ribosomal_L4_B.
InterProiIPR002136. Ribosomal_L4/L1e.
IPR023574. Ribosomal_L4_dom.
IPR013005. Ribosomal_uL4/L1e.
[Graphical view]
PANTHERiPTHR10746. PTHR10746. 1 hit.
PfamiPF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
TIGRFAMsiTIGR03953. rplD_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung and Ovary.
  6. "Pediatric leukemia cDNA sequencing project."
    Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-311 (ISOFORM 1).
    Tissue: Leukemia.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM04_HUMAN
AccessioniPrimary (citable) accession number: Q9BYD3
Secondary accession number(s): A6NNV7
, Q9BW07, Q9H4N2, Q9Y317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.