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Q9BYD3 (RM04_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L4, mitochondrial

Short name=L4mt
Short name=MRP-L4
Gene names
Name:MRPL4
ORF Names:CDABP0091, CGI-28
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion By similarity HAMAP-Rule MF_01328_B.

Sequence similarities

Belongs to the ribosomal protein L4P family.

Sequence caution

The sequence AAD27737.1 differs from that shown. Reason: Frameshift at position 128.

The sequence AAG02005.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BYD3-1)

Also known as: isoform a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BYD3-2)

Also known as: isoform b;

The sequence of this isoform differs from the canonical sequence as follows:
     248-263: LNVHSMLKHQTLVLTL → EQRAQAPRVRMCRLRC
     264-311: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 31131139S ribosomal protein L4, mitochondrial HAMAP-Rule MF_01328_B
PRO_0000238949

Natural variations

Alternative sequence248 – 26316LNVHS…LVLTL → EQRAQAPRVRMCRLRC in isoform 2.
VSP_019027
Alternative sequence264 – 31148Missing in isoform 2.
VSP_019028

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (isoform a) [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 8267C61C42BFCF07

FASTA31134,919
        10         20         30         40         50         60 
MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK VELPVPTHRR 

        70         80         90        100        110        120 
PVQAWVESLR GFEQERVGLA DLHPDVFATA PRLDILHQVA MWQKNFKRIS YAKTKTRAEV 

       130        140        150        160        170        180 
RGGGRKPWPQ KGTGRARHGS IRSPLWRGGG VAHGPRGPTS YYYMLPMKVR ALGLKVALTV 

       190        200        210        220        230        240 
KLAQDDLHIM DSLELPTGDP QYLTELAHYR RWGDSVLLVD LTHEEMPQSI VEATSRLKTF 

       250        260        270        280        290        300 
NLIPAVGLNV HSMLKHQTLV LTLPTVAFLE DKLLWQDSRY RPLYPFSLPY SDFPRPLPHA 

       310 
TQGPAATPYH C 

« Hide

Isoform 2 (isoform b) [UniParc].

Checksum: 698CAA74688002FE
Show »

FASTA26329,502

References

« Hide 'large scale' references
[1]"Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Lung and Ovary.
[6]"Pediatric leukemia cDNA sequencing project."
Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-311 (ISOFORM 1).
Tissue: Leukemia.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB049635 mRNA. Translation: BAB40840.1.
AF132962 mRNA. Translation: AAD27737.1. Frameshift.
AC011511 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84083.1.
BC000756 mRNA. Translation: AAH00756.1.
BC009858 mRNA. Translation: AAH09858.1.
AY007152 mRNA. Translation: AAG02005.1. Different initiation.
CCDSCCDS12230.1. [Q9BYD3-1]
CCDS42499.1. [Q9BYD3-2]
RefSeqNP_057040.2. NM_015956.2. [Q9BYD3-1]
NP_666499.1. NM_146387.1. [Q9BYD3-1]
NP_666500.1. NM_146388.1. [Q9BYD3-2]
UniGeneHs.279652.

3D structure databases

ProteinModelPortalQ9BYD3.
SMRQ9BYD3. Positions 95-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119264. 25 interactions.
IntActQ9BYD3. 6 interactions.
MINTMINT-1389069.
STRING9606.ENSP00000253099.

PTM databases

PhosphoSiteQ9BYD3.

Polymorphism databases

DMDM74733471.

Proteomic databases

MaxQBQ9BYD3.
PaxDbQ9BYD3.
PRIDEQ9BYD3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253099; ENSP00000253099; ENSG00000105364. [Q9BYD3-1]
ENST00000307422; ENSP00000306902; ENSG00000105364. [Q9BYD3-1]
ENST00000590669; ENSP00000465143; ENSG00000105364. [Q9BYD3-2]
GeneID51073.
KEGGhsa:51073.
UCSCuc002mnm.3. human. [Q9BYD3-1]
uc002mno.3. human. [Q9BYD3-2]

Organism-specific databases

CTD51073.
GeneCardsGC19P010362.
HGNCHGNC:14276. MRPL4.
HPAHPA051261.
MIM611823. gene.
neXtProtNX_Q9BYD3.
PharmGKBPA30971.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0088.
HOGENOMHOG000248767.
HOVERGENHBG083638.
InParanoidQ9BYD3.
KOK02926.
OMAILNHECV.
PhylomeDBQ9BYD3.
TreeFamTF313913.

Gene expression databases

ArrayExpressQ9BYD3.
BgeeQ9BYD3.
CleanExHS_MRPL4.
GenevestigatorQ9BYD3.

Family and domain databases

Gene3D3.40.1370.10. 1 hit.
HAMAPMF_01328_B. Ribosomal_L4_B.
InterProIPR002136. Ribosomal_L4/L1e.
IPR013005. Ribosomal_L4/L1e_bac-type.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PANTHERPTHR10746. PTHR10746. 1 hit.
PfamPF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMSSF52166. SSF52166. 1 hit.
TIGRFAMsTIGR03953. rplD_bact. 1 hit.
ProtoNetSearch...

Other

ChiTaRSMRPL4. human.
GeneWikiMRPL4.
GenomeRNAi51073.
NextBio53691.
PROQ9BYD3.
SOURCESearch...

Entry information

Entry nameRM04_HUMAN
AccessionPrimary (citable) accession number: Q9BYD3
Secondary accession number(s): A6NNV7 expand/collapse secondary AC list , Q9BW07, Q9H4N2, Q9Y317
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM