Q9BYD3 (RM04_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L4, mitochondrial
Short name=L4mt
Short name=MRP-L4

Gene names

Name:	MRPL4
ORF Names:	CDABP0091, CGI-28

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the ribosomal protein L4P family.
Sequence caution	The sequence AAD27737.1 differs from that shown. Reason: Frameshift at position 128. The sequence AAG02005.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BYD3-1)

Also known as: isoform a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BYD3-2)

Also known as: isoform b;

The sequence of this isoform differs from the canonical sequence as follows:
     248-263: LNVHSMLKHQTLVLTL → EQRAQAPRVRMCRLRC
     264-311: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	39S ribosomal protein L4, mitochondrial		PRO_0000238949
Natural variations
	Alternative sequence	248 – 263	16	LNVHS…LVLTL → EQRAQAPRVRMCRLRC in isoform 2.		VSP_019027
	Alternative sequence	264 – 311	48	Missing in isoform 2.		VSP_019028

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (isoform a) [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 8267C61C42BFCF07	FASTA	311	34,919
	10 20 30 40 50 60 MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK VELPVPTHRR 70 80 90 100 110 120 PVQAWVESLR GFEQERVGLA DLHPDVFATA PRLDILHQVA MWQKNFKRIS YAKTKTRAEV 130 140 150 160 170 180 RGGGRKPWPQ KGTGRARHGS IRSPLWRGGG VAHGPRGPTS YYYMLPMKVR ALGLKVALTV 190 200 210 220 230 240 KLAQDDLHIM DSLELPTGDP QYLTELAHYR RWGDSVLLVD LTHEEMPQSI VEATSRLKTF 250 260 270 280 290 300 NLIPAVGLNV HSMLKHQTLV LTLPTVAFLE DKLLWQDSRY RPLYPFSLPY SDFPRPLPHA 310 TQGPAATPYH C
	Isoform 2 (isoform b) [UniParc]. Checksum: 698CAA74688002FE	FASTA	263	29,502
	10 20 30 40 50 60 MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK VELPVPTHRR 70 80 90 100 110 120 PVQAWVESLR GFEQERVGLA DLHPDVFATA PRLDILHQVA MWQKNFKRIS YAKTKTRAEV 130 140 150 160 170 180 RGGGRKPWPQ KGTGRARHGS IRSPLWRGGG VAHGPRGPTS YYYMLPMKVR ALGLKVALTV 190 200 210 220 230 240 KLAQDDLHIM DSLELPTGDP QYLTELAHYR RWGDSVLLVD LTHEEMPQSI VEATSRLKTF 250 260 NLIPAVGEQR AQAPRVRMCR LRC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria." Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K. J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Lung and Ovary.
[6]	"Pediatric leukemia cDNA sequencing project." Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-311 (ISOFORM 1). Tissue: Leukemia.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB049635 mRNA. Translation: BAB40840.1. AF132962 mRNA. Translation: AAD27737.1. Frameshift. AC011511 Genomic DNA. No translation available. CH471106 Genomic DNA. Translation: EAW84083.1. BC000756 mRNA. Translation: AAH00756.1. BC009858 mRNA. Translation: AAH09858.1. AY007152 mRNA. Translation: AAG02005.1. Different initiation.
IPI	IPI00023334. IPI00107137.
RefSeq	NP_057040.2. NM_015956.2. NP_666499.1. NM_146387.1. NP_666500.1. NM_146388.1.
UniGene	Hs.279652.
3D structure databases
ProteinModelPortal	Q9BYD3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BYD3. 5 interactions.
MINT	MINT-1389069.
STRING	9606.ENSP00000253099.
PTM databases
PhosphoSite	Q9BYD3.
Polymorphism databases
DMDM	74733471.
Proteomic databases
PaxDb	Q9BYD3.
PRIDE	Q9BYD3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000253099; ENSP00000253099; ENSG00000105364. ENST00000307422; ENSP00000306902; ENSG00000105364. ENST00000590669; ENSP00000465143; ENSG00000105364.
GeneID	51073.
KEGG	hsa:51073.
UCSC	uc002mnm.3. human. uc002mno.3. human.
Organism-specific databases
CTD	51073.
GeneCards	GC19P010362.
HGNC	HGNC:14276. MRPL4.
HPA	HPA051261.
MIM	611823. gene.
neXtProt	NX_Q9BYD3.
PharmGKB	PA30971.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0088.
HOGENOM	HOG000248767.
HOVERGEN	HBG083638.
InParanoid	Q9BYD3.
KO	K02926.
OMA	GKAHGPV.
OrthoDB	EOG4XKV7V.
PhylomeDB	Q9BYD3.
Gene expression databases
Bgee	Q9BYD3.
CleanEx	HS_MRPL4.
Genevestigator	Q9BYD3.
GermOnline	ENSG00000105364. Homo sapiens.
Family and domain databases
Gene3D	3.40.1370.10. 1 hit.
InterPro	IPR002136. Ribosomal_L4/L1e. IPR013005. Ribosomal_L4/L1e_bac-type. IPR023574. Ribosomal_L4_dom. [Graphical view]
PANTHER	PTHR10746. PTHR10746. 1 hit.
Pfam	PF00573. Ribosomal_L4. 1 hit. [Graphical view]
SUPFAM	SSF52166. Ribosomal_L4/L1E. 1 hit.
TIGRFAMs	TIGR03953. rplD_bact. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	MRPL4. human.
GenomeRNAi	51073.
NextBio	53691.
SOURCE	Search...

Entry information

Entry name

RM04_HUMAN

Accession

Primary (citable) accession number: Q9BYD3
Secondary accession number(s): A6NNV7 , Q9BW07, Q9H4N2, Q9Y317

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.