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Protein

39S ribosomal protein L13, mitochondrial

Gene

MRPL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L13, mitochondrial
Short name:
L13mt
Short name:
MRP-L13
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL13m1 Publication
Gene namesi
Name:MRPL13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000172172.7.
HGNCiHGNC:14278. MRPL13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi28998.
OpenTargetsiENSG00000172172.
PharmGKBiPA30942.

Polymorphism and mutation databases

BioMutaiMRPL13.
DMDMi22257023.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001337932 – 17839S ribosomal protein L13, mitochondrialAdd BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BYD1.
MaxQBiQ9BYD1.
PaxDbiQ9BYD1.
PeptideAtlasiQ9BYD1.
PRIDEiQ9BYD1.
TopDownProteomicsiQ9BYD1.

PTM databases

iPTMnetiQ9BYD1.
PhosphoSitePlusiQ9BYD1.

Expressioni

Gene expression databases

BgeeiENSG00000172172.
CleanExiHS_MRPL13.
ExpressionAtlasiQ9BYD1. baseline and differential.
GenevisibleiQ9BYD1. HS.

Organism-specific databases

HPAiHPA060899.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with OXA1L (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi118817. 101 interactors.
CORUMiQ9BYD1.
IntActiQ9BYD1. 14 interactors.
MINTiMINT-3064087.
STRINGi9606.ENSP00000306548.

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 13Combined sources8
Beta strandi18 – 22Combined sources5
Helixi30 – 40Combined sources11
Turni41 – 43Combined sources3
Turni49 – 51Combined sources3
Beta strandi56 – 60Combined sources5
Helixi62 – 64Combined sources3
Beta strandi66 – 68Combined sources3
Helixi71 – 74Combined sources4
Beta strandi76 – 80Combined sources5
Beta strandi87 – 91Combined sources5
Helixi92 – 98Combined sources7
Helixi102 – 111Combined sources10
Helixi117 – 123Combined sources7
Beta strandi125 – 127Combined sources3
Beta strandi129 – 131Combined sources3
Helixi135 – 140Combined sources6
Turni155 – 157Combined sources3
Helixi160 – 165Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40K1-178[»]
3J9Melectron microscopy3.50K1-178[»]
ProteinModelPortaliQ9BYD1.
SMRiQ9BYD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3203. Eukaryota.
COG0102. LUCA.
GeneTreeiENSGT00390000001515.
HOGENOMiHOG000225288.
HOVERGENiHBG036111.
InParanoidiQ9BYD1.
KOiK02871.
OMAiVLMGKHK.
OrthoDBiEOG091G0QCX.
PhylomeDBiQ9BYD1.
TreeFamiTF312914.

Family and domain databases

CDDicd00392. Ribosomal_L13. 1 hit.
Gene3Di3.90.1180.10. 1 hit.
HAMAPiMF_01366. Ribosomal_L13. 1 hit.
InterProiView protein in InterPro
IPR005822. Ribosomal_L13.
IPR005823. Ribosomal_L13_bac-type.
IPR023563. Ribosomal_L13_CS.
PANTHERiPTHR11545. PTHR11545. 1 hit.
PfamiView protein in Pfam
PF00572. Ribosomal_L13. 1 hit.
PIRSFiPIRSF002181. Ribosomal_L13. 1 hit.
SUPFAMiSSF52161. SSF52161. 1 hit.
TIGRFAMsiTIGR01066. rplM_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00783. RIBOSOMAL_L13. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFSRAPQQ WATFARIWYL LDGKMQPPGK LAAMASIRLQ GLHKPVYHAL
60 70 80 90 100
SDCGDHVVIM NTRHIAFSGN KWEQKVYSSH TGYPGGFRQV TAAQLHLRDP
110 120 130 140 150
VAIVKLAIYG MLPKNLHRRT MMERLHLFPD EYIPEDILKN LVEELPQPRK
160 170
IPKRLDEYTQ EEIDAFPRLW TPPEDYRL
Length:178
Mass (Da):20,692
Last modified:June 1, 2001 - v1
Checksum:iAF4FD524CC234D52
GO

Sequence cautioni

The sequence AAF17202 differs from that shown. Reason: Frameshift at position 160.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049640 mRNA. Translation: BAB40845.1.
AF112214 mRNA. Translation: AAF17202.1. Frameshift.
AK311924 mRNA. Translation: BAG34865.1.
CH471060 Genomic DNA. Translation: EAW92004.1.
BC009190 mRNA. Translation: AAH09190.1.
BC021744 mRNA. Translation: AAH21744.1.
CCDSiCCDS6332.1.
RefSeqiNP_054797.2. NM_014078.5.
UniGeneiHs.333823.

Genome annotation databases

EnsembliENST00000306185; ENSP00000306548; ENSG00000172172.
GeneIDi28998.
KEGGihsa:28998.
UCSCiuc003ypa.4. human.

Similar proteinsi

Entry informationi

Entry nameiRM13_HUMAN
AccessioniPrimary (citable) accession number: Q9BYD1
Secondary accession number(s): B2R4R8, Q9UI04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families