Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

39S ribosomal protein L20, mitochondrial

Gene

MRPL20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • rRNA binding Source: InterPro
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L20, mitochondrial
Short name:
L20mt
Short name:
MRP-L20
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL20m1 Publication
Gene namesi
Name:MRPL20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000242485.5.
HGNCiHGNC:14478. MRPL20.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000242485.
PharmGKBiPA30950.

Polymorphism and mutation databases

BioMutaiMRPL20.
DMDMi74752447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 9MitochondrionBy similarity9
ChainiPRO_000024827910 – 14939S ribosomal protein L20, mitochondrialAdd BLAST140

Proteomic databases

EPDiQ9BYC9.
MaxQBiQ9BYC9.
PaxDbiQ9BYC9.
PeptideAtlasiQ9BYC9.
PRIDEiQ9BYC9.

PTM databases

iPTMnetiQ9BYC9.
PhosphoSitePlusiQ9BYC9.
SwissPalmiQ9BYC9.

Expressioni

Gene expression databases

BgeeiENSG00000242485.
CleanExiHS_MRPL20.
ExpressionAtlasiQ9BYC9. baseline and differential.
GenevisibleiQ9BYC9. HS.

Organism-specific databases

HPAiHPA047074.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with OXA1L (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi120374. 50 interactors.
CORUMiQ9BYC9.
IntActiQ9BYC9. 18 interactors.
MINTiMINT-1419302.
STRINGi9606.ENSP00000341082.

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 28Combined sources12
Helixi33 – 36Combined sources4
Helixi39 – 77Combined sources39
Turni78 – 80Combined sources3
Helixi83 – 93Combined sources11
Helixi99 – 108Combined sources10
Helixi110 – 132Combined sources23
Beta strandi133 – 135Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40R1-149[»]
3J9Melectron microscopy3.50R1-149[»]
5OOLelectron microscopy3.06R1-149[»]
5OOMelectron microscopy3.03R1-149[»]
ProteinModelPortaliQ9BYC9.
SMRiQ9BYC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4707. Eukaryota.
COG0292. LUCA.
GeneTreeiENSGT00390000015823.
HOGENOMiHOG000035046.
HOVERGENiHBG058971.
InParanoidiQ9BYC9.
KOiK02887.
OMAiDLAMNHP.
OrthoDBiEOG091G0Q0P.
PhylomeDBiQ9BYC9.
TreeFamiTF324702.

Family and domain databases

CDDicd07026. Ribosomal_L20. 1 hit.
Gene3Di1.10.1900.20. 1 hit.
InterProiView protein in InterPro
IPR005813. Ribosomal_L20.
IPR035566. Ribosomal_protein_L20_C-ter.
PANTHERiPTHR10986. PTHR10986. 1 hit.
PfamiView protein in Pfam
PF00453. Ribosomal_L20. 1 hit.
PRINTSiPR00062. RIBOSOMALL20.
SUPFAMiSSF74731. SSF74731. 1 hit.
TIGRFAMsiTIGR01032. rplT_bact. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFLTAQLWL RNRVTDRYFR IQEVLKHARH FRGRKNRCYR LAVRTVIRAF
60 70 80 90 100
VKCTKARYLK KKNMRTLWIN RITAASQEHG LKYPALIGNL VKCQVELNRK
110 120 130 140
VLADLAIYEP KTFKSLAALA SRRRHEGFAA ALGDGKEPEG IFSRVVQYH
Length:149
Mass (Da):17,443
Last modified:June 1, 2001 - v1
Checksum:i53AD05B3BBD9AE6B
GO
Isoform 2 (identifier: Q9BYC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-149: CQVELNRKVL...GIFSRVVQYH → VWVSMWVPLK...VSMLSVVSIW

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):18,099
Checksum:iDCB0C378CF4DF3B1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05608493 – 149CQVEL…VVQYH → VWVSMWVPLKFWTSAETIMR GVVVLPVVPANQEAEARGSL ETDFWAVVCYADGVSMLSVV SIW in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049644 mRNA. Translation: BAB40849.1.
AK301440 mRNA. Translation: BAH13482.1.
AK315794 mRNA. Translation: BAG38138.1.
AL391244 Genomic DNA. No translation available.
CH471183 Genomic DNA. Translation: EAW56207.1.
BC009515 mRNA. Translation: AAH09515.1.
BC014316 mRNA. Translation: AAH14316.1.
BC059945 mRNA. Translation: AAH59945.1.
CCDSiCCDS26.1. [Q9BYC9-1]
RefSeqiNP_060441.2. NM_017971.3. [Q9BYC9-1]
UniGeneiHs.182698.

Genome annotation databases

EnsembliENST00000344843; ENSP00000341082; ENSG00000242485. [Q9BYC9-1]
ENST00000482352; ENSP00000460924; ENSG00000242485. [Q9BYC9-2]
GeneIDi55052.
KEGGihsa:55052.
UCSCiuc001afo.5. human. [Q9BYC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRM20_HUMAN
AccessioniPrimary (citable) accession number: Q9BYC9
Secondary accession number(s): B2RE41, B7Z746
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families