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Q9BYC9

- RM20_HUMAN

UniProt

Q9BYC9 - RM20_HUMAN

Protein

39S ribosomal protein L20, mitochondrial

Gene

MRPL20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. rRNA binding Source: InterPro
    4. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L20, mitochondrial
    Short name:
    L20mt
    Short name:
    MRP-L20
    Gene namesi
    Name:MRPL20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14478. MRPL20.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrial ribosome Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30950.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4545MitochondrionSequence AnalysisAdd
    BLAST
    Chaini46 – 14910439S ribosomal protein L20, mitochondrialPRO_0000248279Add
    BLAST

    Proteomic databases

    MaxQBiQ9BYC9.
    PaxDbiQ9BYC9.
    PeptideAtlasiQ9BYC9.
    PRIDEiQ9BYC9.

    PTM databases

    PhosphoSiteiQ9BYC9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BYC9.
    BgeeiQ9BYC9.
    CleanExiHS_MRPL20.
    GenevestigatoriQ9BYC9.

    Organism-specific databases

    HPAiHPA047074.

    Interactioni

    Subunit structurei

    Interacts with OXA1L.By similarity

    Protein-protein interaction databases

    BioGridi120374. 16 interactions.
    IntActiQ9BYC9. 12 interactions.
    MINTiMINT-1419302.
    STRINGi9606.ENSP00000341082.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BYC9.
    SMRiQ9BYC9. Positions 10-124.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L20P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0292.
    HOGENOMiHOG000035046.
    HOVERGENiHBG058971.
    InParanoidiQ9BYC9.
    KOiK02887.
    OMAiINAEARN.
    OrthoDBiEOG7PZS00.
    PhylomeDBiQ9BYC9.
    TreeFamiTF324702.

    Family and domain databases

    InterProiIPR005813. Ribosomal_L20.
    [Graphical view]
    PANTHERiPTHR10986. PTHR10986. 1 hit.
    PfamiPF00453. Ribosomal_L20. 1 hit.
    [Graphical view]
    PRINTSiPR00062. RIBOSOMALL20.
    TIGRFAMsiTIGR01032. rplT_bact. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BYC9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVFLTAQLWL RNRVTDRYFR IQEVLKHARH FRGRKNRCYR LAVRTVIRAF    50
    VKCTKARYLK KKNMRTLWIN RITAASQEHG LKYPALIGNL VKCQVELNRK 100
    VLADLAIYEP KTFKSLAALA SRRRHEGFAA ALGDGKEPEG IFSRVVQYH 149
    Length:149
    Mass (Da):17,443
    Last modified:June 1, 2001 - v1
    Checksum:i53AD05B3BBD9AE6B
    GO
    Isoform 2 (identifier: Q9BYC9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         93-149: CQVELNRKVL...GIFSRVVQYH → VWVSMWVPLK...VSMLSVVSIW

    Note: No experimental confirmation available.

    Show »
    Length:155
    Mass (Da):18,099
    Checksum:iDCB0C378CF4DF3B1
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei93 – 14957CQVEL…VVQYH → VWVSMWVPLKFWTSAETIMR GVVVLPVVPANQEAEARGSL ETDFWAVVCYADGVSMLSVV SIW in isoform 2. 1 PublicationVSP_056084Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049644 mRNA. Translation: BAB40849.1.
    AK301440 mRNA. Translation: BAH13482.1.
    AK315794 mRNA. Translation: BAG38138.1.
    AL391244 Genomic DNA. Translation: CAI22658.1.
    CH471183 Genomic DNA. Translation: EAW56207.1.
    BC009515 mRNA. Translation: AAH09515.1.
    BC014316 mRNA. Translation: AAH14316.1.
    BC059945 mRNA. Translation: AAH59945.1.
    CCDSiCCDS26.1.
    RefSeqiNP_060441.2. NM_017971.3.
    XP_005244824.1. XM_005244767.1.
    UniGeneiHs.182698.

    Genome annotation databases

    EnsembliENST00000344843; ENSP00000341082; ENSG00000242485.
    ENST00000482352; ENSP00000460924; ENSG00000242485.
    GeneIDi55052.
    KEGGihsa:55052.
    UCSCiuc001afo.4. human.

    Polymorphism databases

    DMDMi74752447.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049644 mRNA. Translation: BAB40849.1 .
    AK301440 mRNA. Translation: BAH13482.1 .
    AK315794 mRNA. Translation: BAG38138.1 .
    AL391244 Genomic DNA. Translation: CAI22658.1 .
    CH471183 Genomic DNA. Translation: EAW56207.1 .
    BC009515 mRNA. Translation: AAH09515.1 .
    BC014316 mRNA. Translation: AAH14316.1 .
    BC059945 mRNA. Translation: AAH59945.1 .
    CCDSi CCDS26.1.
    RefSeqi NP_060441.2. NM_017971.3.
    XP_005244824.1. XM_005244767.1.
    UniGenei Hs.182698.

    3D structure databases

    ProteinModelPortali Q9BYC9.
    SMRi Q9BYC9. Positions 10-124.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120374. 16 interactions.
    IntActi Q9BYC9. 12 interactions.
    MINTi MINT-1419302.
    STRINGi 9606.ENSP00000341082.

    PTM databases

    PhosphoSitei Q9BYC9.

    Polymorphism databases

    DMDMi 74752447.

    Proteomic databases

    MaxQBi Q9BYC9.
    PaxDbi Q9BYC9.
    PeptideAtlasi Q9BYC9.
    PRIDEi Q9BYC9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344843 ; ENSP00000341082 ; ENSG00000242485 .
    ENST00000482352 ; ENSP00000460924 ; ENSG00000242485 .
    GeneIDi 55052.
    KEGGi hsa:55052.
    UCSCi uc001afo.4. human.

    Organism-specific databases

    CTDi 55052.
    GeneCardsi GC01M001329.
    H-InvDB HIX0000027.
    HGNCi HGNC:14478. MRPL20.
    HPAi HPA047074.
    MIMi 611833. gene.
    neXtProti NX_Q9BYC9.
    PharmGKBi PA30950.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0292.
    HOGENOMi HOG000035046.
    HOVERGENi HBG058971.
    InParanoidi Q9BYC9.
    KOi K02887.
    OMAi INAEARN.
    OrthoDBi EOG7PZS00.
    PhylomeDBi Q9BYC9.
    TreeFami TF324702.

    Miscellaneous databases

    GeneWikii MRPL20.
    GenomeRNAii 55052.
    NextBioi 58521.
    PROi Q9BYC9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BYC9.
    Bgeei Q9BYC9.
    CleanExi HS_MRPL20.
    Genevestigatori Q9BYC9.

    Family and domain databases

    InterProi IPR005813. Ribosomal_L20.
    [Graphical view ]
    PANTHERi PTHR10986. PTHR10986. 1 hit.
    Pfami PF00453. Ribosomal_L20. 1 hit.
    [Graphical view ]
    PRINTSi PR00062. RIBOSOMALL20.
    TIGRFAMsi TIGR01032. rplT_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Synovium and Uterus.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow, Lymph and Mammary gland.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM20_HUMAN
    AccessioniPrimary (citable) accession number: Q9BYC9
    Secondary accession number(s): B2RE41, B7Z746
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3