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Q9BYC9

- RM20_HUMAN

UniProt

Q9BYC9 - RM20_HUMAN

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Protein

39S ribosomal protein L20, mitochondrial

Gene

MRPL20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. rRNA binding Source: InterPro
  3. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L20, mitochondrial
Short name:
L20mt
Short name:
MRP-L20
Gene namesi
Name:MRPL20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14478. MRPL20.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30950.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4545MitochondrionSequence AnalysisAdd
BLAST
Chaini46 – 14910439S ribosomal protein L20, mitochondrialPRO_0000248279Add
BLAST

Proteomic databases

MaxQBiQ9BYC9.
PaxDbiQ9BYC9.
PeptideAtlasiQ9BYC9.
PRIDEiQ9BYC9.

PTM databases

PhosphoSiteiQ9BYC9.

Expressioni

Gene expression databases

BgeeiQ9BYC9.
CleanExiHS_MRPL20.
ExpressionAtlasiQ9BYC9. baseline and differential.
GenevestigatoriQ9BYC9.

Organism-specific databases

HPAiHPA047074.

Interactioni

Subunit structurei

Interacts with OXA1L.By similarity

Protein-protein interaction databases

BioGridi120374. 27 interactions.
IntActiQ9BYC9. 12 interactions.
MINTiMINT-1419302.
STRINGi9606.ENSP00000341082.

Structurei

3D structure databases

ProteinModelPortaliQ9BYC9.
SMRiQ9BYC9. Positions 10-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L20P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0292.
GeneTreeiENSGT00390000015823.
HOGENOMiHOG000035046.
HOVERGENiHBG058971.
InParanoidiQ9BYC9.
KOiK02887.
OMAiINAEARN.
OrthoDBiEOG7PZS00.
PhylomeDBiQ9BYC9.
TreeFamiTF324702.

Family and domain databases

InterProiIPR005813. Ribosomal_L20.
[Graphical view]
PANTHERiPTHR10986. PTHR10986. 1 hit.
PfamiPF00453. Ribosomal_L20. 1 hit.
[Graphical view]
PRINTSiPR00062. RIBOSOMALL20.
TIGRFAMsiTIGR01032. rplT_bact. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BYC9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFLTAQLWL RNRVTDRYFR IQEVLKHARH FRGRKNRCYR LAVRTVIRAF
60 70 80 90 100
VKCTKARYLK KKNMRTLWIN RITAASQEHG LKYPALIGNL VKCQVELNRK
110 120 130 140
VLADLAIYEP KTFKSLAALA SRRRHEGFAA ALGDGKEPEG IFSRVVQYH
Length:149
Mass (Da):17,443
Last modified:June 1, 2001 - v1
Checksum:i53AD05B3BBD9AE6B
GO
Isoform 2 (identifier: Q9BYC9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-149: CQVELNRKVL...GIFSRVVQYH → VWVSMWVPLK...VSMLSVVSIW

Note: No experimental confirmation available.

Show »
Length:155
Mass (Da):18,099
Checksum:iDCB0C378CF4DF3B1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei93 – 14957CQVEL…VVQYH → VWVSMWVPLKFWTSAETIMR GVVVLPVVPANQEAEARGSL ETDFWAVVCYADGVSMLSVV SIW in isoform 2. 1 PublicationVSP_056084Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049644 mRNA. Translation: BAB40849.1.
AK301440 mRNA. Translation: BAH13482.1.
AK315794 mRNA. Translation: BAG38138.1.
AL391244 Genomic DNA. Translation: CAI22658.1.
CH471183 Genomic DNA. Translation: EAW56207.1.
BC009515 mRNA. Translation: AAH09515.1.
BC014316 mRNA. Translation: AAH14316.1.
BC059945 mRNA. Translation: AAH59945.1.
CCDSiCCDS26.1. [Q9BYC9-1]
RefSeqiNP_060441.2. NM_017971.3. [Q9BYC9-1]
XP_005244824.1. XM_005244767.1. [Q9BYC9-2]
UniGeneiHs.182698.

Genome annotation databases

EnsembliENST00000344843; ENSP00000341082; ENSG00000242485. [Q9BYC9-1]
ENST00000482352; ENSP00000460924; ENSG00000242485. [Q9BYC9-2]
GeneIDi55052.
KEGGihsa:55052.
UCSCiuc001afo.4. human. [Q9BYC9-1]

Polymorphism databases

DMDMi74752447.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049644 mRNA. Translation: BAB40849.1 .
AK301440 mRNA. Translation: BAH13482.1 .
AK315794 mRNA. Translation: BAG38138.1 .
AL391244 Genomic DNA. Translation: CAI22658.1 .
CH471183 Genomic DNA. Translation: EAW56207.1 .
BC009515 mRNA. Translation: AAH09515.1 .
BC014316 mRNA. Translation: AAH14316.1 .
BC059945 mRNA. Translation: AAH59945.1 .
CCDSi CCDS26.1. [Q9BYC9-1 ]
RefSeqi NP_060441.2. NM_017971.3. [Q9BYC9-1 ]
XP_005244824.1. XM_005244767.1. [Q9BYC9-2 ]
UniGenei Hs.182698.

3D structure databases

ProteinModelPortali Q9BYC9.
SMRi Q9BYC9. Positions 10-124.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120374. 27 interactions.
IntActi Q9BYC9. 12 interactions.
MINTi MINT-1419302.
STRINGi 9606.ENSP00000341082.

PTM databases

PhosphoSitei Q9BYC9.

Polymorphism databases

DMDMi 74752447.

Proteomic databases

MaxQBi Q9BYC9.
PaxDbi Q9BYC9.
PeptideAtlasi Q9BYC9.
PRIDEi Q9BYC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344843 ; ENSP00000341082 ; ENSG00000242485 . [Q9BYC9-1 ]
ENST00000482352 ; ENSP00000460924 ; ENSG00000242485 . [Q9BYC9-2 ]
GeneIDi 55052.
KEGGi hsa:55052.
UCSCi uc001afo.4. human. [Q9BYC9-1 ]

Organism-specific databases

CTDi 55052.
GeneCardsi GC01M001329.
H-InvDB HIX0000027.
HGNCi HGNC:14478. MRPL20.
HPAi HPA047074.
MIMi 611833. gene.
neXtProti NX_Q9BYC9.
PharmGKBi PA30950.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0292.
GeneTreei ENSGT00390000015823.
HOGENOMi HOG000035046.
HOVERGENi HBG058971.
InParanoidi Q9BYC9.
KOi K02887.
OMAi INAEARN.
OrthoDBi EOG7PZS00.
PhylomeDBi Q9BYC9.
TreeFami TF324702.

Enzyme and pathway databases

Reactomei REACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

GeneWikii MRPL20.
GenomeRNAii 55052.
NextBioi 35480142.
PROi Q9BYC9.
SOURCEi Search...

Gene expression databases

Bgeei Q9BYC9.
CleanExi HS_MRPL20.
ExpressionAtlasi Q9BYC9. baseline and differential.
Genevestigatori Q9BYC9.

Family and domain databases

InterProi IPR005813. Ribosomal_L20.
[Graphical view ]
PANTHERi PTHR10986. PTHR10986. 1 hit.
Pfami PF00453. Ribosomal_L20. 1 hit.
[Graphical view ]
PRINTSi PR00062. RIBOSOMALL20.
TIGRFAMsi TIGR01032. rplT_bact. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Synovium and Uterus.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow, Lymph and Mammary gland.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM20_HUMAN
AccessioniPrimary (citable) accession number: Q9BYC9
Secondary accession number(s): B2RE41, B7Z746
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3