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Protein

39S ribosomal protein L32, mitochondrial

Gene

MRPL32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. mitochondrial translation Source: Reactome
  2. mitochondrial translational elongation Source: Reactome
  3. mitochondrial translational initiation Source: Reactome
  4. mitochondrial translational termination Source: Reactome
  5. organelle organization Source: Reactome
  6. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L32, mitochondrial
Short name:
L32mt
Short name:
MRP-L32
Gene namesi
Name:MRPL32
ORF Names:HSPC283
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14035. MRPL32.

Subcellular locationi

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 18839S ribosomal protein L32, mitochondrialPRO_0000030513
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiQ9BYC8.
PaxDbiQ9BYC8.
PRIDEiQ9BYC8.

PTM databases

PhosphoSiteiQ9BYC8.

Expressioni

Gene expression databases

BgeeiQ9BYC8.
CleanExiHS_MRPL32.
ExpressionAtlasiQ9BYC8. baseline and differential.
GenevestigatoriQ9BYC8.

Organism-specific databases

HPAiHPA048965.

Interactioni

Protein-protein interaction databases

BioGridi122368. 37 interactions.
IntActiQ9BYC8. 1 interaction.
MINTiMINT-6781284.
STRINGi9606.ENSP00000223324.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4001-188[»]
ProteinModelPortaliQ9BYC8.
SMRiQ9BYC8. Positions 79-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L32P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG297873.
GeneTreeiENSGT00390000014996.
HOGENOMiHOG000252980.
HOVERGENiHBG036112.
InParanoidiQ9BYC8.
KOiK02911.
OMAiVPPWPAA.
OrthoDBiEOG7C2R2G.
PhylomeDBiQ9BYC8.
TreeFamiTF106139.

Family and domain databases

InterProiIPR002677. Ribosomal_L32p.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF01783. Ribosomal_L32p. 1 hit.
[Graphical view]
SUPFAMiSSF57829. SSF57829. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BYC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAMLVLVV SPWSAARGVL RNYWERLLRK LPQSRPGFPS PPWGPALAVQ
60 70 80 90 100
GPAMFTEPAN DTSGSKENSS LLDSIFWMAA PKNRRTIEVN RCRRRNPQKL
110 120 130 140 150
IKVKNNIDVC PECGHLKQKH VLCAYCYEKV CKETAEIRRQ IGKQEGGPFK
160 170 180
APTIETVVLY TGETPSEQDQ GKRIIERDRK RPSWFTQN
Length:188
Mass (Da):21,405
Last modified:May 31, 2001 - v1
Checksum:i60164AD910AE3EFD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 4333SPWSA…PSPPW → RRGLRPGECFETTGSDCYGS FRRAGRAFPVLRGV (Ref. 3) CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049649 mRNA. Translation: BAB40854.1.
BC013147 mRNA. Translation: AAH13147.1.
AF161401 mRNA. Translation: AAF28961.1.
AB051343 Genomic DNA. Translation: BAB54933.1.
CCDSiCCDS5468.1.
RefSeqiNP_114109.1. NM_031903.2.
UniGeneiHs.50252.

Genome annotation databases

EnsembliENST00000223324; ENSP00000223324; ENSG00000106591.
GeneIDi64983.
KEGGihsa:64983.
UCSCiuc003tia.3. human.

Polymorphism databases

DMDMi22001923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049649 mRNA. Translation: BAB40854.1.
BC013147 mRNA. Translation: AAH13147.1.
AF161401 mRNA. Translation: AAF28961.1.
AB051343 Genomic DNA. Translation: BAB54933.1.
CCDSiCCDS5468.1.
RefSeqiNP_114109.1. NM_031903.2.
UniGeneiHs.50252.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4001-188[»]
ProteinModelPortaliQ9BYC8.
SMRiQ9BYC8. Positions 79-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122368. 37 interactions.
IntActiQ9BYC8. 1 interaction.
MINTiMINT-6781284.
STRINGi9606.ENSP00000223324.

PTM databases

PhosphoSiteiQ9BYC8.

Polymorphism databases

DMDMi22001923.

Proteomic databases

MaxQBiQ9BYC8.
PaxDbiQ9BYC8.
PRIDEiQ9BYC8.

Protocols and materials databases

DNASUi64983.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223324; ENSP00000223324; ENSG00000106591.
GeneIDi64983.
KEGGihsa:64983.
UCSCiuc003tia.3. human.

Organism-specific databases

CTDi64983.
GeneCardsiGC07P042971.
HGNCiHGNC:14035. MRPL32.
HPAiHPA048965.
MIMi611839. gene.
neXtProtiNX_Q9BYC8.
PharmGKBiPA30963.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG297873.
GeneTreeiENSGT00390000014996.
HOGENOMiHOG000252980.
HOVERGENiHBG036112.
InParanoidiQ9BYC8.
KOiK02911.
OMAiVPPWPAA.
OrthoDBiEOG7C2R2G.
PhylomeDBiQ9BYC8.
TreeFamiTF106139.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL32. human.
GeneWikiiMRPL32.
GenomeRNAii64983.
NextBioi67176.
PROiQ9BYC8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BYC8.
CleanExiHS_MRPL32.
ExpressionAtlasiQ9BYC8. baseline and differential.
GenevestigatoriQ9BYC8.

Family and domain databases

InterProiIPR002677. Ribosomal_L32p.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF01783. Ribosomal_L32p. 1 hit.
[Graphical view]
SUPFAMiSSF57829. SSF57829. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  3. "Human partial CDS from CD34+ stem cells."
    Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-188.
    Tissue: Umbilical cord blood.
  4. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-126.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM32_HUMAN
AccessioniPrimary (citable) accession number: Q9BYC8
Secondary accession number(s): Q96Q68, Q9P098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2002
Last sequence update: May 31, 2001
Last modified: March 31, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.