Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein subunit beta-like protein 1

Gene

GNB1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • intracellular signal transduction Source: UniProtKB
  • social behavior Source: Ensembl

Enzyme and pathway databases

SignaLinkiQ9BYB4

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-like protein 1
Short name:
G protein subunit beta-like protein 1
Alternative name(s):
DGCRK3
WD repeat-containing protein 14
WD40 repeat-containing protein deleted in VCFS
Short name:
WDVCF
Gene namesi
Name:GNB1L
Synonyms:GY2, KIAA1645, WDR14
ORF Names:FKSG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000185838.13
HGNCiHGNC:4397 GNB1L
MIMi610778 gene
neXtProtiNX_Q9BYB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi54584
OpenTargetsiENSG00000185838
PharmGKBiPA28777

Polymorphism and mutation databases

BioMutaiGNB1L
DMDMi27151507

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510081 – 327Guanine nucleotide-binding protein subunit beta-like protein 1Add BLAST327

Proteomic databases

EPDiQ9BYB4
MaxQBiQ9BYB4
PaxDbiQ9BYB4
PeptideAtlasiQ9BYB4
PRIDEiQ9BYB4
ProteomicsDBi79608
79609 [Q9BYB4-2]

PTM databases

iPTMnetiQ9BYB4
PhosphoSitePlusiQ9BYB4

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in heart, liver, skeletal muscle, kidney, spleen, thymus and pancreas. Detected at low levels in lung, placenta and brain.

Gene expression databases

BgeeiENSG00000185838
CleanExiHS_GNB1L
ExpressionAtlasiQ9BYB4 baseline and differential
GenevisibleiQ9BYB4 HS

Organism-specific databases

HPAiHPA034627
HPA034628

Interactioni

Protein-protein interaction databases

BioGridi120061, 29 interactors
IntActiQ9BYB4, 5 interactors
MINTiQ9BYB4
STRINGi9606.ENSP00000331313

Structurei

3D structure databases

ProteinModelPortaliQ9BYB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati16 – 54WD 1Add BLAST39
Repeati58 – 97WD 2Add BLAST40
Repeati103 – 145WD 3Add BLAST43
Repeati153 – 195WD 4Add BLAST43
Repeati200 – 237WD 5Add BLAST38
Repeati242 – 282WD 6Add BLAST41
Repeati286 – 323WD 7Add BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 12Poly-Pro9

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0322 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00390000018606
HOGENOMiHOG000007056
HOVERGENiHBG051745
InParanoidiQ9BYB4
OMAiLAVLKWH
OrthoDBiEOG091G0HHK
PhylomeDBiQ9BYB4
TreeFamiTF344050

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BYB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAPCPPPPP DPQFVLRGTQ SPVHALHFCE GAQAQGRPLL FSGSQSGLVH
60 70 80 90 100
IWSLQTRRAV TTLDGHGGQC VTWLQTLPQG RQLLSQGRDL KLCLWDLAEG
110 120 130 140 150
RSAVVDSVCL ESVGFCRSSI LAGGQPRWTL AVPGRGSDEV QILEMPSKTS
160 170 180 190 200
VCALKPKADA KLGMPMCLRL WQADCSSRPL LLAGYEDGSV VLWDVSEQKV
210 220 230 240 250
CSRIACHEEP VMDLDFDSQK ARGISGSAGK ALAVWSLDWQ QALQVRGTHE
260 270 280 290 300
LTNPGIAEVT IRPDRKILAT AGWDHRIRVF HWRTMQPLAV LAFHSAAVQC
310 320
VAFTADGLLA AGSKDQRISL WSLYPRA
Length:327
Mass (Da):35,618
Last modified:December 13, 2002 - v2
Checksum:i1A2FEAE50AF57A60
GO
Isoform 2 (identifier: Q9BYB4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-212: VM → GL
     213-327: Missing.

Note: No experimental confirmation available.
Show »
Length:212
Mass (Da):22,896
Checksum:i7E10D4702139F9BC
GO

Sequence cautioni

The sequence BAB33315 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05339430E → K. Corresponds to variant dbSNP:rs35178436Ensembl.1
Natural variantiVAR_05339537R → H. Corresponds to variant dbSNP:rs5748449Ensembl.1
Natural variantiVAR_024698239W → G. Corresponds to variant dbSNP:rs2073770Ensembl.1
Natural variantiVAR_035882296A → T in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs61758989Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006767211 – 212VM → GL in isoform 2. 1 Publication2
Alternative sequenceiVSP_006768213 – 327Missing in isoform 2. 1 PublicationAdd BLAST115

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238328 mRNA Translation: AAG36826.1
AF301895 mRNA Translation: AAG53933.1
AY007378 mRNA Translation: AAG12162.1
AB049212 Genomic DNA Translation: BAB68408.1
AB051432 mRNA Translation: BAB33315.1 Different initiation.
CR456496 mRNA Translation: CAG30382.1
BC012060 mRNA Translation: AAH12060.1
CCDSiCCDS13768.1 [Q9BYB4-1]
RefSeqiNP_443730.1, NM_053004.2 [Q9BYB4-1]
UniGeneiHs.105642

Genome annotation databases

EnsembliENST00000329517; ENSP00000331313; ENSG00000185838 [Q9BYB4-1]
ENST00000403325; ENSP00000385154; ENSG00000185838 [Q9BYB4-1]
ENST00000405009; ENSP00000384626; ENSG00000185838 [Q9BYB4-2]
GeneIDi54584
KEGGihsa:54584
UCSCiuc002zqf.2 human [Q9BYB4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGNB1L_HUMAN
AccessioniPrimary (citable) accession number: Q9BYB4
Secondary accession number(s): Q9H2S2, Q9H4M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: December 13, 2002
Last modified: June 20, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health