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Protein

Uncharacterized protein KIAA1671

Gene

KIAA1671

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA1671
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:29345. KIAA1671.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165378342.

Polymorphism and mutation databases

BioMutaiKIAA1671.
DMDMi147647261.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18061806Uncharacterized protein KIAA1671PRO_0000287145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521PhosphoserineCombined sources
Modified residuei56 – 561PhosphoserineCombined sources
Modified residuei79 – 791PhosphoserineCombined sources
Modified residuei87 – 871PhosphoserineCombined sources
Modified residuei88 – 881PhosphoserineCombined sources
Modified residuei92 – 921PhosphoserineCombined sources
Modified residuei128 – 1281PhosphoserineCombined sources
Modified residuei244 – 2441PhosphoserineCombined sources
Modified residuei284 – 2841PhosphoserineCombined sources
Modified residuei366 – 3661PhosphoserineCombined sources
Modified residuei378 – 3781PhosphothreonineCombined sources
Modified residuei384 – 3841PhosphoserineCombined sources
Modified residuei404 – 4041PhosphoserineCombined sources
Modified residuei458 – 4581PhosphoserineCombined sources
Modified residuei508 – 5081PhosphoserineCombined sources
Modified residuei600 – 6001PhosphothreonineCombined sources
Modified residuei749 – 7491PhosphoserineCombined sources
Modified residuei969 – 9691PhosphoserineCombined sources
Modified residuei981 – 9811PhosphoserineCombined sources
Modified residuei1059 – 10591PhosphothreonineCombined sources
Modified residuei1063 – 10631PhosphoserineCombined sources
Modified residuei1154 – 11541PhosphoserineCombined sources
Modified residuei1163 – 11631PhosphothreonineCombined sources
Modified residuei1179 – 11791PhosphothreonineCombined sources
Modified residuei1185 – 11851PhosphothreonineCombined sources
Modified residuei1224 – 12241PhosphoserineCombined sources
Modified residuei1226 – 12261PhosphothreonineCombined sources
Modified residuei1366 – 13661PhosphoserineCombined sources
Modified residuei1441 – 14411PhosphoserineCombined sources
Modified residuei1488 – 14881PhosphoserineCombined sources
Modified residuei1506 – 15061PhosphoserineCombined sources
Modified residuei1555 – 15551PhosphoserineCombined sources
Modified residuei1662 – 16621PhosphoserineCombined sources
Modified residuei1701 – 17011PhosphoserineCombined sources
Modified residuei1757 – 17571PhosphoserineCombined sources
Modified residuei1760 – 17601PhosphoserineCombined sources
Modified residuei1786 – 17861PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BY89.
MaxQBiQ9BY89.
PaxDbiQ9BY89.
PeptideAtlasiQ9BY89.
PRIDEiQ9BY89.

PTM databases

iPTMnetiQ9BY89.
PhosphoSiteiQ9BY89.
SwissPalmiQ9BY89.

Expressioni

Gene expression databases

BgeeiENSG00000197077.
GenevisibleiQ9BY89. HS.

Organism-specific databases

HPAiHPA018135.

Interactioni

Protein-protein interaction databases

BioGridi124506. 44 interactions.
IntActiQ9BY89. 27 interactions.
STRINGi9606.ENSP00000351207.

Structurei

3D structure databases

ProteinModelPortaliQ9BY89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFQ8. Eukaryota.
ENOG4111YBN. LUCA.
GeneTreeiENSGT00730000111235.
HOGENOMiHOG000113173.
HOVERGENiHBG100622.
InParanoidiQ9BY89.
OMAiPKATFFA.
OrthoDBiEOG091G008E.
PhylomeDBiQ9BY89.
TreeFamiTF336029.

Family and domain databases

InterProiIPR032764. Tankyrase-bd_C.
[Graphical view]
PfamiPF15327. Tankyrase_bdg_C. 1 hit.
[Graphical view]
SMARTiSM01319. Tankyrase_bdg_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BY89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRVEVGSI TPLTAVPGLG EMGKEETLTR TYFLQAGEAS GAPPARILEA
60 70 80 90 100
KSPLRSPARL LPLPRLAPKP FSKEQDVKSP VPSLRPSSTG PSPSGGLSEE
110 120 130 140 150
PAAKDLDNRM PGLVGQEVGS GEGPRTSSPL FNKAVFLRPS SSTMILFETT
160 170 180 190 200
KSGPALGKAV SEGAEEAKLG VSGSRPEVAA KPALPTQKPA GTLPRSAPLS
210 220 230 240 250
QDTKPPVPQE EAGQDHPPSK ASSVEDTARP LVEPRPRLKR RPVSAIFTES
260 270 280 290 300
IQPQKPGPGA AATVGKVPPT PPEKTWVRKP RPLSMDLTAR FENKEALLRK
310 320 330 340 350
VADEGSGPTA GDMAGLERPR AASKLDRDCL VKAEAPLHDP DLDFLEVAKK
360 370 380 390 400
IRERKEKMLS KPEMGSPRAL VGGSSGVTPS NDQSPWEEKA KLDPEPEKAA
410 420 430 440 450
ESPSPRLGRG LELAEVKSRV ADGEAAAGGE WASRRSVRKC ISLFREDSTL
460 470 480 490 500
ALAVGSESPL ATPASPSAAP EPEKGVVSVQ ERIRGWTAES SEAKPEVRRR
510 520 530 540 550
TFQARPLSAD LTKLFSSSAS SNEVKYEKSA ELSGEFPKEP REKQKEGHSL
560 570 580 590 600
DGACIPRSPW KPGTLRDKSR QTEQKVSSNQ DPDSCRGGSS VEAPCPSDVT
610 620 630 640 650
PEDDRSFQTV WATVFEHHVE RHTVADQSGR CLSTTPPGDM AHARVSEPRP
660 670 680 690 700
RPEMGSWLGR DPPDMTKLKK ENSRGFDNPE TEKLGPTTLL NGELRPYHTP
710 720 730 740 750
LRDKYPLSEN HNNNTFLKHL ENPPTSQRIE PRYDIVHAVG ERVHSEAISP
760 770 780 790 800
APEEKAVTLR SLRSWLSLKD RQLSQEVTPA DLECGLEGQA GSVQRASLIW
810 820 830 840 850
EARGMPEASG PKFGGNCPFP KWTGGAVVSS HKATVAVSEE HCAPGATSVR
860 870 880 890 900
AIKAAIWESQ HEGPEGARSK PGVGARGPPQ GCPLDPLSRA TNGPSDSQAR
910 920 930 940 950
THPDAFAVQK GPFIVAAREG DPGPAQVPQP AVRMRKAGAM DQRMDRWRRR
960 970 980 990 1000
TLPPNVKFDT FSSLVPEDSP HVGHRRTDYV SPTASALRKP QLSHYRVETQ
1010 1020 1030 1040 1050
EVNPGASRDQ TSPAVKQGSP VEPKATFFAV TYQIPNTQKA KGVVLSGAES
1060 1070 1080 1090 1100
LLEHSRKITP PSSPHSLTST LVSLGHEEAL EMAGSKNWMK GREHENASIL
1110 1120 1130 1140 1150
KTLKPTDRPS SLGAWSLDPF NGRIIDVDAL WSHRGSEDGP RPQSNWKESA
1160 1170 1180 1190 1200
NKMSPSGGAP QTTPTLRSRP KDLPVRRKTD VISDTFPGKI RDGYRSSVLD
1210 1220 1230 1240 1250
IDALMAEYQE LSLKVPGEAQ ERRSPTVEPS TLPRERPVQL GGVEQRRRSL
1260 1270 1280 1290 1300
KEMPDTGGLW KPASSAEINH SFTPGLGKQL AETLETAMGT KSSPPFWALP
1310 1320 1330 1340 1350
PSAPSERYPG GSPIPADPRK KTGFAEDDRK AFASKHHVAK CQNYLAESKP
1360 1370 1380 1390 1400
SGREDPGSGV RVSPKSPPTD QKKGTPRKST GRGEEDSVAQ WGDHPRDCGR
1410 1420 1430 1440 1450
VPLDIKRAYS EKGPPANIRE GLSIMHEARE RRREQPKGRP SLTGENLEAK
1460 1470 1480 1490 1500
MGPCWWESGT GDSHKVLPRD LEKEDAPQEK ERPLQQVSPV ASVPWRSHSF
1510 1520 1530 1540 1550
CKDRRSGPFV DQLKQCFSRQ PTEPKDTDTL VHEAGSQYGT WTEQCQSGES
1560 1570 1580 1590 1600
LATESPDSSA TSTRKQPPSS RLSSLSSQTE PTSAGDQYDC SRDQRSTSVD
1610 1620 1630 1640 1650
HSSTDLESTD GMEGPPPPDA CPEKRVDDFS FIDQTSVLDS SALKTRVQLS
1660 1670 1680 1690 1700
KRSRRRAPIS HSLRRSRFSE SESRSPLEDE TDNTWMFKDS TEEKSPRKEE
1710 1720 1730 1740 1750
SDEEETASKA ERTPVSHPQR MPAFPGMDPA VLKAQLHKRP EVDSPGETPS
1760 1770 1780 1790 1800
WAPQPKSPKS PFQPGVLGSR VLPSSMDKDE RSDEPSPQWL KELKSKKRQS

LYENQV
Length:1,806
Mass (Da):196,711
Last modified:May 15, 2007 - v2
Checksum:i5120F319DCE33F5D
GO
Isoform 2 (identifier: Q9BY89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1493: Missing.
     1494-1510: PWRSHSFCKDRRSGPFV → MEYYYCPSLLKLLRYLW

Show »
Length:313
Mass (Da):35,295
Checksum:i5E4E6CD131F5A3A8
GO

Sequence cautioni

The sequence BAB33341 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti644 – 6441R → L in AAI71801 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 14931493Missing in isoform 2. 1 PublicationVSP_025337Add
BLAST
Alternative sequencei1494 – 151017PWRSH…SGPFV → MEYYYCPSLLKLLRYLW in isoform 2. 1 PublicationVSP_025338Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051458 mRNA. Translation: BAB33341.1. Different initiation.
AL022323, Z99916 Genomic DNA. Translation: CAI17936.1.
Z99916, AL022323 Genomic DNA. Translation: CAI17930.1.
AL022323, Z99916 Genomic DNA. Translation: CAQ07889.1.
Z99916, AL022323 Genomic DNA. Translation: CAQ10804.1.
CH471095 Genomic DNA. Translation: EAW59684.1.
BC171801 mRNA. Translation: AAI71801.1.
CCDSiCCDS46676.1. [Q9BY89-1]
RefSeqiNP_001138678.1. NM_001145206.1. [Q9BY89-1]
XP_005261850.1. XM_005261793.2. [Q9BY89-1]
XP_005261851.1. XM_005261794.4. [Q9BY89-1]
XP_006724409.1. XM_006724346.2. [Q9BY89-1]
UniGeneiHs.419171.

Genome annotation databases

EnsembliENST00000358431; ENSP00000351207; ENSG00000197077. [Q9BY89-1]
ENST00000401395; ENSP00000385377; ENSG00000197077. [Q9BY89-2]
ENST00000406486; ENSP00000385152; ENSG00000197077. [Q9BY89-1]
GeneIDi85379.
KEGGihsa:85379.
UCSCiuc003abl.4. human. [Q9BY89-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051458 mRNA. Translation: BAB33341.1. Different initiation.
AL022323, Z99916 Genomic DNA. Translation: CAI17936.1.
Z99916, AL022323 Genomic DNA. Translation: CAI17930.1.
AL022323, Z99916 Genomic DNA. Translation: CAQ07889.1.
Z99916, AL022323 Genomic DNA. Translation: CAQ10804.1.
CH471095 Genomic DNA. Translation: EAW59684.1.
BC171801 mRNA. Translation: AAI71801.1.
CCDSiCCDS46676.1. [Q9BY89-1]
RefSeqiNP_001138678.1. NM_001145206.1. [Q9BY89-1]
XP_005261850.1. XM_005261793.2. [Q9BY89-1]
XP_005261851.1. XM_005261794.4. [Q9BY89-1]
XP_006724409.1. XM_006724346.2. [Q9BY89-1]
UniGeneiHs.419171.

3D structure databases

ProteinModelPortaliQ9BY89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124506. 44 interactions.
IntActiQ9BY89. 27 interactions.
STRINGi9606.ENSP00000351207.

PTM databases

iPTMnetiQ9BY89.
PhosphoSiteiQ9BY89.
SwissPalmiQ9BY89.

Polymorphism and mutation databases

BioMutaiKIAA1671.
DMDMi147647261.

Proteomic databases

EPDiQ9BY89.
MaxQBiQ9BY89.
PaxDbiQ9BY89.
PeptideAtlasiQ9BY89.
PRIDEiQ9BY89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358431; ENSP00000351207; ENSG00000197077. [Q9BY89-1]
ENST00000401395; ENSP00000385377; ENSG00000197077. [Q9BY89-2]
ENST00000406486; ENSP00000385152; ENSG00000197077. [Q9BY89-1]
GeneIDi85379.
KEGGihsa:85379.
UCSCiuc003abl.4. human. [Q9BY89-1]

Organism-specific databases

CTDi85379.
GeneCardsiKIAA1671.
HGNCiHGNC:29345. KIAA1671.
HPAiHPA018135.
neXtProtiNX_Q9BY89.
PharmGKBiPA165378342.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFQ8. Eukaryota.
ENOG4111YBN. LUCA.
GeneTreeiENSGT00730000111235.
HOGENOMiHOG000113173.
HOVERGENiHBG100622.
InParanoidiQ9BY89.
OMAiPKATFFA.
OrthoDBiEOG091G008E.
PhylomeDBiQ9BY89.
TreeFamiTF336029.

Miscellaneous databases

ChiTaRSiKIAA1671. human.
GenomeRNAii85379.
PROiQ9BY89.

Gene expression databases

BgeeiENSG00000197077.
GenevisibleiQ9BY89. HS.

Family and domain databases

InterProiIPR032764. Tankyrase-bd_C.
[Graphical view]
PfamiPF15327. Tankyrase_bdg_C. 1 hit.
[Graphical view]
SMARTiSM01319. Tankyrase_bdg_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1671_HUMAN
AccessioniPrimary (citable) accession number: Q9BY89
Secondary accession number(s): B0QYF2, B7ZW08, Q5THZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against KIAA1671 are present in sera from patients with breast cancer who developed several autoantibodies.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.