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Protein

RING finger protein 26

Gene

RNF26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri380 – 422RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

  • zinc ion binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173456-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 26
Gene namesi
Name:RNF26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14646. RNF26.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei147 – 169HelicalSequence analysisAdd BLAST23
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79102.
OpenTargetsiENSG00000173456.
PharmGKBiPA34430.

Polymorphism and mutation databases

BioMutaiRNF26.
DMDMi20139692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560681 – 433RING finger protein 26Add BLAST433

Proteomic databases

EPDiQ9BY78.
PaxDbiQ9BY78.
PeptideAtlasiQ9BY78.
PRIDEiQ9BY78.

PTM databases

iPTMnetiQ9BY78.
PhosphoSitePlusiQ9BY78.

Expressioni

Tissue specificityi

Ubiquitous. Up-regulated in several cancer cell lines.

Gene expression databases

BgeeiENSG00000173456.
CleanExiHS_RNF26.
GenevisibleiQ9BY78. HS.

Organism-specific databases

HPAiHPA027620.

Interactioni

Protein-protein interaction databases

BioGridi122549. 27 interactors.
IntActiQ9BY78. 9 interactors.
STRINGi9606.ENSP00000312439.

Structurei

3D structure databases

ProteinModelPortaliQ9BY78.
SMRiQ9BY78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri380 – 422RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITZ8. Eukaryota.
ENOG410XVCP. LUCA.
GeneTreeiENSGT00390000016584.
HOGENOMiHOG000136849.
HOVERGENiHBG054207.
InParanoidiQ9BY78.
KOiK15693.
OMAiCRRGILQ.
OrthoDBiEOG091G195F.
PhylomeDBiQ9BY78.
TreeFamiTF331813.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BY78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAVYLVVNG LGLVLDVLTL VLDLNFLLVS SLLASLAWLL AFVYNLPHTV
60 70 80 90 100
LTSLLHLGRG VLLSLLALIE AVVRFTCGGL QALCTLLYSC CSGLESLKLL
110 120 130 140 150
GHLASHGALR SREILHRGVL NVVSSGHALL RQACDICAIA MSLVAYVINS
160 170 180 190 200
LVNICLIGTQ NLFSLVLALW DAVTGPLWRM TDVVAAFLAH ISSSAVAMAI
210 220 230 240 250
LLWTPCQLAL ELLASAARLL ASFVLVNLTG LVLLACVLAV TVTVLHPDFT
260 270 280 290 300
LRLATQALSQ LHARPSYHRL REDVMRLSRL ALGSEAWRRV WSRSLQLASW
310 320 330 340 350
PNRGGAPGAP QGDPMRVFSV RTRRQDTLPE AGRRSEAEEE EARTIRVTPV
360 370 380 390 400
RGRERLNEEE PPGGQDPWKL LKEQEERKKC VICQDQSKTV LLLPCRHLCL
410 420 430
CQACTEILMR HPVYHRNCPL CRRGILQTLN VYL
Length:433
Mass (Da):47,737
Last modified:June 1, 2001 - v1
Checksum:iC23E36A66C3677E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055622 mRNA. Translation: BAB40955.1.
AK075379 mRNA. Translation: BAC11580.1.
CH471065 Genomic DNA. Translation: EAW67479.1.
BC000058 mRNA. Translation: AAH00058.1.
BC007534 mRNA. Translation: AAH07534.1.
CCDSiCCDS8419.1.
PIRiJC7678.
RefSeqiNP_114404.1. NM_032015.4.
UniGeneiHs.524084.
Hs.744159.
Hs.745522.

Genome annotation databases

EnsembliENST00000311413; ENSP00000312439; ENSG00000173456.
GeneIDi79102.
KEGGihsa:79102.
UCSCiuc001pwh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055622 mRNA. Translation: BAB40955.1.
AK075379 mRNA. Translation: BAC11580.1.
CH471065 Genomic DNA. Translation: EAW67479.1.
BC000058 mRNA. Translation: AAH00058.1.
BC007534 mRNA. Translation: AAH07534.1.
CCDSiCCDS8419.1.
PIRiJC7678.
RefSeqiNP_114404.1. NM_032015.4.
UniGeneiHs.524084.
Hs.744159.
Hs.745522.

3D structure databases

ProteinModelPortaliQ9BY78.
SMRiQ9BY78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122549. 27 interactors.
IntActiQ9BY78. 9 interactors.
STRINGi9606.ENSP00000312439.

PTM databases

iPTMnetiQ9BY78.
PhosphoSitePlusiQ9BY78.

Polymorphism and mutation databases

BioMutaiRNF26.
DMDMi20139692.

Proteomic databases

EPDiQ9BY78.
PaxDbiQ9BY78.
PeptideAtlasiQ9BY78.
PRIDEiQ9BY78.

Protocols and materials databases

DNASUi79102.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311413; ENSP00000312439; ENSG00000173456.
GeneIDi79102.
KEGGihsa:79102.
UCSCiuc001pwh.4. human.

Organism-specific databases

CTDi79102.
DisGeNETi79102.
GeneCardsiRNF26.
H-InvDBHIX0171332.
HGNCiHGNC:14646. RNF26.
HPAiHPA027620.
MIMi606130. gene.
neXtProtiNX_Q9BY78.
OpenTargetsiENSG00000173456.
PharmGKBiPA34430.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITZ8. Eukaryota.
ENOG410XVCP. LUCA.
GeneTreeiENSGT00390000016584.
HOGENOMiHOG000136849.
HOVERGENiHBG054207.
InParanoidiQ9BY78.
KOiK15693.
OMAiCRRGILQ.
OrthoDBiEOG091G195F.
PhylomeDBiQ9BY78.
TreeFamiTF331813.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173456-MONOMER.

Miscellaneous databases

ChiTaRSiRNF26. human.
GenomeRNAii79102.
PROiQ9BY78.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173456.
CleanExiHS_RNF26.
GenevisibleiQ9BY78. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNF26_HUMAN
AccessioniPrimary (citable) accession number: Q9BY78
Secondary accession number(s): Q542Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.