Q9BY71 (LRRC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-rich repeat-containing protein 3

Gene names

Name:	LRRC3
Synonyms:	C21orf102, LRRC3A
ORF Names:	UNQ9233/PRO31982

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Widely expressed; detected in testis, lung, small intestine, breast, brain, heart, bone marrow, placenta, colon, fetal brain, liver, fetal liver, thymus, salivary gland, spinal cord, spleen, trachea and adrenal gland.
Sequence similarities	Belongs to the LRRC3 family. Contains 4 LRR (leucine-rich) repeats. Contains 1 LRRNT domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	2	EBI-1761329,EBI-389883

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Chain	33 – 257	225	Leucine-rich repeat-containing protein 3		PRO_0000021618
Regions
	Transmembrane	205 – 225	21	Helical; Potential
	Domain	33 – 64	32	LRRNT
	Repeat	65 – 86	22	LRR 1
	Repeat	89 – 110	22	LRR 2
	Repeat	114 – 135	22	LRR 3
	Repeat	136 – 157	22	LRR 4

Sequences

	Sequence		Length	Mass (Da)
	Q9BY71 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: C668FAACF5E68148	FASTA	257	28,108
	10 20 30 40 50 60 MGTVRPPRPS LLLVSTRESC LFLLFCLHLG AACPQPCRCP DHAGAVAVFC SLRGLQEVPE 70 80 90 100 110 120 DIPANTVLLK LDANKISHLP DGAFQHLHRL RELDLSHNAI EAIGSATFAG LAGGLRLLDL 130 140 150 160 170 180 SYNRIQRIPK DALGKLSAKI RLSHNPLHCE CALQEALWEL KLDPDSVDEI ACHTSVQEEF 190 200 210 220 230 240 VGKPLVQALD AGASLCSVPH RTTDVAMLVT MFGWFAMVIA YVVYYVRHNQ EDARRHLEYL 250 KSLPSAPASK DPIGPGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel leucine-rich repeat-containing gene LRRC3 on the human chromosome 21." Hahn Y., Park H.-S., Kim Y.S. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Nineteen additional unpredicted transcripts from human chromosome 21." Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B., Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S., Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E. Genomics 79:824-832(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB058646 mRNA. Translation: BAB40229.1. AY061857 mRNA. Translation: AAL35741.1. AY358120 mRNA. Translation: AAQ88487.1. BC119648 mRNA. Translation: AAI19649.1. BC119649 mRNA. Translation: AAI19650.1.
IPI	IPI00008377.
RefSeq	NP_112153.1. NM_030891.3.
UniGene	Hs.326579.
3D structure databases
ProteinModelPortal	Q9BY71.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BY71. 1 interaction.
MINT	MINT-7242320.
STRING	9606.ENSP00000291592.
PTM databases
PhosphoSite	Q9BY71.
Polymorphism databases
DMDM	18202742.
Proteomic databases
PaxDb	Q9BY71.
PRIDE	Q9BY71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000291592; ENSP00000291592; ENSG00000160233.
GeneID	81543.
KEGG	hsa:81543.
UCSC	uc002zfa.3. human.
Organism-specific databases
CTD	81543.
GeneCards	GC21P045875.
HGNC	HGNC:14965. LRRC3.
HPA	HPA017975.
neXtProt	NX_Q9BY71.
PharmGKB	PA30462.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG318731.
HOGENOM	HOG000073532.
HOVERGEN	HBG052349.
InParanoid	Q9BY71.
OMA	HCECALQ.
OrthoDB	EOG48PMM1.
PhylomeDB	Q9BY71.
Gene expression databases
Bgee	Q9BY71.
CleanEx	HS_LRRC3.
Genevestigator	Q9BY71.
GermOnline	ENSG00000160233. Homo sapiens.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
Pfam	PF00560. LRR_1. 1 hit. PF01462. LRRNT. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	81543.
NextBio	71777.

Entry information

Entry name

LRRC3_HUMAN

Accession

Primary (citable) accession number: Q9BY71
Secondary accession number(s): Q0VDJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.