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Protein

Leucine-rich repeat-containing protein 3

Gene

LRRC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160233-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 3
Gene namesi
Name:LRRC3
Synonyms:C21orf102, LRRC3A
ORF Names:UNQ9233/PRO31982
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:14965. LRRC3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160233.
PharmGKBiPA30462.

Polymorphism and mutation databases

BioMutaiLRRC3.
DMDMi18202742.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000002161833 – 257Leucine-rich repeat-containing protein 3Add BLAST225

Proteomic databases

PaxDbiQ9BY71.
PRIDEiQ9BY71.

PTM databases

iPTMnetiQ9BY71.
PhosphoSitePlusiQ9BY71.

Expressioni

Tissue specificityi

Widely expressed; detected in testis, lung, small intestine, breast, brain, heart, bone marrow, placenta, colon, fetal brain, liver, fetal liver, thymus, salivary gland, spinal cord, spleen, trachea and adrenal gland.

Gene expression databases

BgeeiENSG00000160233.
CleanExiHS_LRRC3.
GenevisibleiQ9BY71. HS.

Organism-specific databases

HPAiHPA017975.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1761329,EBI-389883

Protein-protein interaction databases

BioGridi123511. 8 interactors.
IntActiQ9BY71. 1 interactor.
STRINGi9606.ENSP00000291592.

Structurei

3D structure databases

ProteinModelPortaliQ9BY71.
SMRiQ9BY71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 64LRRNTAdd BLAST32
Repeati65 – 86LRR 1Add BLAST22
Repeati89 – 110LRR 2Add BLAST22
Repeati114 – 135LRR 3Add BLAST22
Repeati136 – 157LRR 4Add BLAST22

Sequence similaritiesi

Belongs to the LRRC3 family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4237. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000003913.
HOGENOMiHOG000073532.
HOVERGENiHBG052349.
InParanoidiQ9BY71.
OMAiLHCECAL.
OrthoDBiEOG091G0FKZ.
PhylomeDBiQ9BY71.
TreeFamiTF327070.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BY71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTVRPPRPS LLLVSTRESC LFLLFCLHLG AACPQPCRCP DHAGAVAVFC
60 70 80 90 100
SLRGLQEVPE DIPANTVLLK LDANKISHLP DGAFQHLHRL RELDLSHNAI
110 120 130 140 150
EAIGSATFAG LAGGLRLLDL SYNRIQRIPK DALGKLSAKI RLSHNPLHCE
160 170 180 190 200
CALQEALWEL KLDPDSVDEI ACHTSVQEEF VGKPLVQALD AGASLCSVPH
210 220 230 240 250
RTTDVAMLVT MFGWFAMVIA YVVYYVRHNQ EDARRHLEYL KSLPSAPASK

DPIGPGP
Length:257
Mass (Da):28,108
Last modified:June 1, 2001 - v1
Checksum:iC668FAACF5E68148
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058646 mRNA. Translation: BAB40229.1.
AY061857 mRNA. Translation: AAL35741.1.
AY358120 mRNA. Translation: AAQ88487.1.
BC119648 mRNA. Translation: AAI19649.1.
BC119649 mRNA. Translation: AAI19650.1.
CCDSiCCDS13711.1.
RefSeqiNP_112153.1. NM_030891.4.
UniGeneiHs.326579.

Genome annotation databases

EnsembliENST00000291592; ENSP00000291592; ENSG00000160233.
GeneIDi81543.
KEGGihsa:81543.
UCSCiuc002zfa.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058646 mRNA. Translation: BAB40229.1.
AY061857 mRNA. Translation: AAL35741.1.
AY358120 mRNA. Translation: AAQ88487.1.
BC119648 mRNA. Translation: AAI19649.1.
BC119649 mRNA. Translation: AAI19650.1.
CCDSiCCDS13711.1.
RefSeqiNP_112153.1. NM_030891.4.
UniGeneiHs.326579.

3D structure databases

ProteinModelPortaliQ9BY71.
SMRiQ9BY71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123511. 8 interactors.
IntActiQ9BY71. 1 interactor.
STRINGi9606.ENSP00000291592.

PTM databases

iPTMnetiQ9BY71.
PhosphoSitePlusiQ9BY71.

Polymorphism and mutation databases

BioMutaiLRRC3.
DMDMi18202742.

Proteomic databases

PaxDbiQ9BY71.
PRIDEiQ9BY71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291592; ENSP00000291592; ENSG00000160233.
GeneIDi81543.
KEGGihsa:81543.
UCSCiuc002zfa.4. human.

Organism-specific databases

CTDi81543.
GeneCardsiLRRC3.
HGNCiHGNC:14965. LRRC3.
HPAiHPA017975.
neXtProtiNX_Q9BY71.
OpenTargetsiENSG00000160233.
PharmGKBiPA30462.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4237. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000003913.
HOGENOMiHOG000073532.
HOVERGENiHBG052349.
InParanoidiQ9BY71.
OMAiLHCECAL.
OrthoDBiEOG091G0FKZ.
PhylomeDBiQ9BY71.
TreeFamiTF327070.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160233-MONOMER.

Miscellaneous databases

GenomeRNAii81543.
PROiQ9BY71.

Gene expression databases

BgeeiENSG00000160233.
CleanExiHS_LRRC3.
GenevisibleiQ9BY71. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRC3_HUMAN
AccessioniPrimary (citable) accession number: Q9BY71
Secondary accession number(s): Q0VDJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.