ID   Q9BY69_HUMAN            Unreviewed;       489 AA.
AC   Q9BY69;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   24-JAN-2024, entry version 105.
DE   SubName: Full=Interferon-gamma receptor {ECO:0000313|EMBL:AAK30623.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAK30623.1};
RN   [1] {ECO:0000313|EMBL:AAK30623.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:AAK30623.1};
RX   PubMed=11139207; DOI=10.1128/CDLI.8.1.133-137.2001;
RA   Allende L.M., Lopez-Goyanes A., Paz-Artal E., Corell A., Garcia-Perez M.A.,
RA   Varela P., Scarpellini A., Negreira S., Palenque E., Arnaiz-Villena A.;
RT   "A point mutation in a domain of gamma interferon receptor 1 provokes
RT   severe immunodeficiency.";
RL   Clin. Diagn. Lab. Immunol. 8:133-137(2001).
CC   -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC       {ECO:0000256|ARBA:ARBA00005399}.
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DR   EMBL; AF056979; AAK30623.1; -; mRNA.
DR   AlphaFoldDB; Q9BY69; -.
DR   PeptideAtlas; Q9BY69; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019955; F:cytokine binding; IEA:InterPro.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   GO; GO:0060333; P:type II interferon-mediated signaling pathway; IEA:InterPro.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR021126; IFN_gamma_rc_D2_pox/mammal.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008355; Interferon_gamma_rcpt_asu.
DR   PANTHER; PTHR20859:SF5; INTERFERON GAMMA RECEPTOR 1; 1.
DR   PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR   Pfam; PF07140; IFNGR1_D2; 1.
DR   Pfam; PF20634; IFNGR1_transm; 1.
DR   Pfam; PF01108; Tissue_fac; 1.
DR   PRINTS; PR01777; INTERFERONGR.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:AAK30623.1};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..489
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004327335"
FT   TRANSMEM        247..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          21..112
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|Pfam:PF01108"
FT   DOMAIN          132..240
FT                   /note="Interferon gamma receptor D2"
FT                   /evidence="ECO:0000259|Pfam:PF07140"
FT   REGION          329..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..401
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..433
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   489 AA;  54362 MW;  8BF38D9AA34FC30A CRC64;
     MALLFLLPLV MQGVSRAEMG TADLGPSSVP TPTNVTIESY NMNPIVYWEY QIMPQVPVFT
     VEGKNYGVKN SEWIDACINI SHHYCNISDH VGDPSNSLWV RVKARVGQKE SAYAKSEEFA
     VCRDGKIGPP KLDIRKEEKQ IMIDIFHPSV FVNGDEQEVD YDPETTCYIR VYNVYVRMNG
     SEIQYKILTQ KEDDCDEIQC QLAIPVSSLN SQYCVSAEGV LHVWGVTTEK SKEVCITIFN
     SSIKGSLWIP VVAALLLFLV LSLVFICFYI KKINPLKEKS IILPKSLISV VRSATLETKP
     ESKYVSLITS YQPFSLEKEV VCEEPLSPAT VPGMHTEDNP GKVEHTEELS SITEVVTTEE
     NIPDVVPGSH LTPIERESSS PLSSNQSEPG SIALNSYHSR NCSESDHSRN GFDTDSSCLE
     SHSSLSDSEF PPNNKGEIKT EGQELITVIK APTSFGYDKP HVLVDLLVDD SGKESLIGYR
     PTEDSKEFS
//