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Q9BY67

- CADM1_HUMAN

UniProt

Q9BY67 - CADM1_HUMAN

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Protein
Cell adhesion molecule 1
Gene
CADM1, IGSF4, IGSF4A, NECL2, SYNCAM, TSLC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly By similarity. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.By similarity7 Publications

GO - Molecular functioni

  1. PDZ domain binding Source: UniProtKB
  2. protein C-terminus binding Source: UniProtKB
  3. protein binding Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. receptor binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. adherens junction organization Source: Reactome
  2. apoptotic process Source: UniProtKB-KW
  3. bone development Source: Ensembl
  4. brain development Source: Ensembl
  5. calcium-independent cell-cell adhesion Source: Ensembl
  6. cell differentiation Source: UniProtKB-KW
  7. cell junction assembly Source: Reactome
  8. cell recognition Source: UniProtKB
  9. cell-cell junction organization Source: Reactome
  10. detection of stimulus Source: UniProtKB
  11. heterophilic cell-cell adhesion Source: UniProtKB
  12. homophilic cell adhesion Source: UniProtKB
  13. immune system process Source: UniProtKB-KW
  14. liver development Source: Ensembl
  15. positive regulation of cytokine secretion Source: UniProtKB
  16. positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
  17. spermatogenesis Source: UniProtKB-KW
  18. susceptibility to natural killer cell mediated cytotoxicity Source: UniProtKB
  19. synapse assembly Source: Ensembl
  20. unidimensional cell growth Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Apoptosis, Cell adhesion, Differentiation, Immunity, Spermatogenesis

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.
REACT_19268. Nectin/Necl trans heterodimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 1
Alternative name(s):
Immunoglobulin superfamily member 4
Short name:
IgSF4
Nectin-like protein 2
Short name:
NECL-2
Spermatogenic immunoglobulin superfamily
Short name:
SgIgSF
Synaptic cell adhesion molecule
Short name:
SynCAM
Tumor suppressor in lung cancer 1
Short name:
TSLC-1
Gene namesi
Name:CADM1
Synonyms:IGSF4, IGSF4A, NECL2, SYNCAM, TSLC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:5951. CADM1.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Cell junctionsynapse By similarity
Note: Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.By similarity2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini45 – 374330Extracellular Reviewed prediction
Add
BLAST
Transmembranei375 – 39521Helical; Reviewed prediction
Add
BLAST
Topological domaini396 – 44247Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: Ensembl
  2. basolateral plasma membrane Source: UniProtKB
  3. cell-cell junction Source: UniProtKB
  4. dendrite Source: Ensembl
  5. extracellular vesicular exosome Source: UniProt
  6. integral component of membrane Source: UniProtKB-KW
  7. plasma membrane Source: UniProtKB
  8. synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi406 – 4061Y → A: Nearly abolishes EPB41L3 binding. 1 Publication
Mutagenesisi408 – 4081T → A: Strongly reduced affinity for EPB41L3. 1 Publication

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA29764.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4444 Reviewed prediction
Add
BLAST
Chaini45 – 442398Cell adhesion molecule 1
PRO_0000291968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 124 By similarity
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi101 – 1011N-linked (GlcNAc...)3 Publications
Glycosylationi113 – 1131N-linked (GlcNAc...)3 Publications
Glycosylationi165 – 1651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi166 ↔ 220 By similarity
Disulfide bondi267 ↔ 313 By similarity
Glycosylationi301 – 3011N-linked (GlcNAc...); atypical1 Publication
Glycosylationi302 – 3021N-linked (GlcNAc...); atypical1 Publication
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi308 – 3081N-linked (GlcNAc...) Reviewed prediction
Modified residuei434 – 4341Phosphoserine By similarity

Post-translational modificationi

Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9BY67.
PaxDbiQ9BY67.
PRIDEiQ9BY67.

PTM databases

PhosphoSiteiQ9BY67.

Expressioni

Gene expression databases

ArrayExpressiQ9BY67.
BgeeiQ9BY67.
CleanExiHS_CADM1.
GenevestigatoriQ9BY67.

Organism-specific databases

HPAiCAB037266.

Interactioni

Subunit structurei

Homodimer. Interacts with FARP1 By similarity. Interacts with CRTAM. Interacts (via C-terminus) with EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6.6 Publications

Protein-protein interaction databases

BioGridi117218. 3 interactions.
DIPiDIP-57599N.
IntActiQ9BY67. 4 interactions.
MINTiMINT-1184987.
STRINGi9606.ENSP00000329797.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi52 – 554
Beta strandi60 – 689
Beta strandi74 – 774
Beta strandi83 – 864
Beta strandi97 – 1037
Beta strandi106 – 1138
Helixi116 – 1183
Beta strandi120 – 1267
Beta strandi128 – 1303
Beta strandi132 – 14110
Beta strandi405 – 4073

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BINX-ray2.30B400-411[»]
4H5SX-ray1.70B45-144[»]
ProteinModelPortaliQ9BY67.
SMRiQ9BY67. Positions 45-334.

Miscellaneous databases

EvolutionaryTraceiQ9BY67.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 13995Ig-like V-type
Add
BLAST
Domaini144 – 23895Ig-like C2-type 1
Add
BLAST
Domaini243 – 32987Ig-like C2-type 2
Add
BLAST

Domaini

The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.2 Publications

Sequence similaritiesi

Belongs to the nectin family.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG69486.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
KOiK06781.
OMAiEIYTTIT.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ9BY67.
TreeFamiTF334317.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q9BY67-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASVVLPSGS QCAAAAAAAA PPGLRLRLLL LLFSAAALIP TGDGQNLFTK    50
DVTVIEGEVA TISCQVNKSD DSVIQLLNPN RQTIYFRDFR PLKDSRFQLL 100
NFSSSELKVS LTNVSISDEG RYFCQLYTDP PQESYTTITV LVPPRNLMID 150
IQKDTAVEGE EIEVNCTAMA SKPATTIRWF KGNTELKGKS EVEEWSDMYT 200
VTSQLMLKVH KEDDGVPVIC QVEHPAVTGN LQTQRYLEVQ YKPQVHIQMT 250
YPLQGLTREG DALELTCEAI GKPQPVMVTW VRVDDEMPQH AVLSGPNLFI 300
NNLNKTDNGT YRCEASNIVG KAHSDYMLYV YDPPTTIPPP TTTTTTTTTT 350
TTTILTIITD SRAGEEGSIR AVDHAVIGGV VAVVVFAMLC LLIILGRYFA 400
RHKGTYFTHE AKGADDAADA DTAIINAEGG QNNSEEKKEY FI 442
Length:442
Mass (Da):48,509
Last modified:June 26, 2007 - v2
Checksum:iCDEDE1E0C08BDD3A
GO
Isoform 21 Publication (identifier: Q9BY67-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-333: DP → GT
     334-442: Missing.

Show »
Length:333
Mass (Da):36,915
Checksum:iD7C1102F46D08492
GO
Isoform 3 (identifier: Q9BY67-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: T → TDTTATTEPAVHGLTQLPNSAEELDSEDLS

Show »
Length:471
Mass (Da):51,533
Checksum:i322A71AB89E8B21F
GO
Isoform 4 (identifier: Q9BY67-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: T → TDTTATTEPAVH

Show »
Length:453
Mass (Da):49,633
Checksum:i466DC2D374481CFB
GO
Isoform 5 (identifier: Q9BY67-5) [UniParc]FASTAAdd to Basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     333-360: Missing.

Show »
Length:414
Mass (Da):45,624
Checksum:i4C5AB05F34BA714A
GO

Sequence cautioni

The sequence AAI25103.1 differs from that shown. Reason: Frameshift at position 1.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti285 – 2851D → E.
Corresponds to variant rs45525440 [ dbSNP | Ensembl ].
VAR_061309

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei332 – 3332DP → GT in isoform 2. 1 Publication
VSP_052461
Alternative sequencei333 – 36028Missing in isoform 5.
VSP_047405Add
BLAST
Alternative sequencei334 – 442109Missing in isoform 2. 1 Publication
VSP_052462Add
BLAST
Alternative sequencei359 – 3591T → TDTTATTEPAVHGLTQLPNS AEELDSEDLS in isoform 3.
VSP_047406
Alternative sequencei359 – 3591T → TDTTATTEPAVH in isoform 4.
VSP_047407

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131A → V in CCD32613. 1 Publication
Sequence conflicti153 – 1531K → R in AAF69029. 1 Publication
Sequence conflicti333 – 35927PPTTI…LTIIT → TTATTEPAVHGLTQLPNSAE ELDSEDLS in BAC11657. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132811 mRNA. Translation: AAF69029.1.
HE586496 mRNA. Translation: CCD32610.1.
HE586497 mRNA. Translation: CCD32611.1.
HE586498 mRNA. Translation: CCD32612.1.
HE586499 mRNA. Translation: CCD32613.1.
KJ534791 mRNA. Translation: AHW56431.1.
KJ534794 mRNA. Translation: AHW56434.1.
AB094146 mRNA. Translation: BAC66178.1.
AK075502 mRNA. Translation: BAC11657.1.
AP000462 Genomic DNA. No translation available.
AP000465 Genomic DNA. No translation available.
AP003174 Genomic DNA. No translation available.
AP003179 Genomic DNA. No translation available.
AP005020 Genomic DNA. No translation available.
BC125102 mRNA. Translation: AAI25103.1. Frameshift.
CCDSiCCDS53711.1. [Q9BY67-5]
CCDS8373.1. [Q9BY67-1]
RefSeqiNP_001091987.1. NM_001098517.1. [Q9BY67-5]
NP_055148.3. NM_014333.3. [Q9BY67-1]
XP_005271548.1. XM_005271491.2. [Q9BY67-3]
XP_005271549.1. XM_005271492.2. [Q9BY67-4]
XP_005271550.1. XM_005271493.2.
UniGeneiHs.370510.

Genome annotation databases

EnsembliENST00000331581; ENSP00000329797; ENSG00000182985. [Q9BY67-3]
ENST00000452722; ENSP00000395359; ENSG00000182985. [Q9BY67-1]
ENST00000537058; ENSP00000439817; ENSG00000182985. [Q9BY67-4]
ENST00000542447; ENSP00000439176; ENSG00000182985. [Q9BY67-5]
GeneIDi23705.
KEGGihsa:23705.
UCSCiuc001pph.5. human.
uc001ppi.4. human. [Q9BY67-1]
uc001ppj.4. human.
uc001ppl.3. human. [Q9BY67-2]

Polymorphism databases

DMDMi150438862.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132811 mRNA. Translation: AAF69029.1 .
HE586496 mRNA. Translation: CCD32610.1 .
HE586497 mRNA. Translation: CCD32611.1 .
HE586498 mRNA. Translation: CCD32612.1 .
HE586499 mRNA. Translation: CCD32613.1 .
KJ534791 mRNA. Translation: AHW56431.1 .
KJ534794 mRNA. Translation: AHW56434.1 .
AB094146 mRNA. Translation: BAC66178.1 .
AK075502 mRNA. Translation: BAC11657.1 .
AP000462 Genomic DNA. No translation available.
AP000465 Genomic DNA. No translation available.
AP003174 Genomic DNA. No translation available.
AP003179 Genomic DNA. No translation available.
AP005020 Genomic DNA. No translation available.
BC125102 mRNA. Translation: AAI25103.1 . Frameshift.
CCDSi CCDS53711.1. [Q9BY67-5 ]
CCDS8373.1. [Q9BY67-1 ]
RefSeqi NP_001091987.1. NM_001098517.1. [Q9BY67-5 ]
NP_055148.3. NM_014333.3. [Q9BY67-1 ]
XP_005271548.1. XM_005271491.2. [Q9BY67-3 ]
XP_005271549.1. XM_005271492.2. [Q9BY67-4 ]
XP_005271550.1. XM_005271493.2.
UniGenei Hs.370510.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BIN X-ray 2.30 B 400-411 [» ]
4H5S X-ray 1.70 B 45-144 [» ]
ProteinModelPortali Q9BY67.
SMRi Q9BY67. Positions 45-334.
ModBasei Search...

Protein-protein interaction databases

BioGridi 117218. 3 interactions.
DIPi DIP-57599N.
IntActi Q9BY67. 4 interactions.
MINTi MINT-1184987.
STRINGi 9606.ENSP00000329797.

PTM databases

PhosphoSitei Q9BY67.

Polymorphism databases

DMDMi 150438862.

Proteomic databases

MaxQBi Q9BY67.
PaxDbi Q9BY67.
PRIDEi Q9BY67.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331581 ; ENSP00000329797 ; ENSG00000182985 . [Q9BY67-3 ]
ENST00000452722 ; ENSP00000395359 ; ENSG00000182985 . [Q9BY67-1 ]
ENST00000537058 ; ENSP00000439817 ; ENSG00000182985 . [Q9BY67-4 ]
ENST00000542447 ; ENSP00000439176 ; ENSG00000182985 . [Q9BY67-5 ]
GeneIDi 23705.
KEGGi hsa:23705.
UCSCi uc001pph.5. human.
uc001ppi.4. human. [Q9BY67-1 ]
uc001ppj.4. human.
uc001ppl.3. human. [Q9BY67-2 ]

Organism-specific databases

CTDi 23705.
GeneCardsi GC11M115044.
HGNCi HGNC:5951. CADM1.
HPAi CAB037266.
MIMi 605686. gene.
neXtProti NX_Q9BY67.
PharmGKBi PA29764.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG69486.
HOGENOMi HOG000036057.
HOVERGENi HBG057086.
KOi K06781.
OMAi EIYTTIT.
OrthoDBi EOG7PVWPD.
PhylomeDBi Q9BY67.
TreeFami TF334317.

Enzyme and pathway databases

Reactomei REACT_19195. Adherens junctions interactions.
REACT_19268. Nectin/Necl trans heterodimerization.

Miscellaneous databases

ChiTaRSi CADM1. human.
EvolutionaryTracei Q9BY67.
GeneWikii Cell_adhesion_molecule_1.
GenomeRNAii 23705.
NextBioi 35461775.
PROi Q9BY67.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BY67.
Bgeei Q9BY67.
CleanExi HS_CADM1.
Genevestigatori Q9BY67.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane."
    Zhou Y., Du G., Hu X., Yu S., Liu Y., Xu Y., Huang X., Liu J., Yin B., Fan M., Peng X., Qiang B., Yuan J.
    Biochim. Biophys. Acta 1669:142-154(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion."
    Moiseeva E.P., Leyland M.L., Bradding P.
    Cell. Mol. Life Sci. 69:2751-2764(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
    Tissue: Mast cell.
  3. "Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
    Corominas R., Yang X., Lin G.N., Kang S., Shen Y., Ghamsari L., Broly M., Rodriguez M., Tam S., Wanamaker S.A., Fan C., Yi S., Tasan M., Lemmens I., Kuang X., Zhao N., Malhotra D., Michaelson J.J.
    , Vacic V., Calderwood M.A., Roth F.P., Tavernier J., Horvath S., Salehi-Ashtiani K., Korkin D., Sebat J., Hill D.E., Hao T., Vidal M., Iakoucheva L.M.
    Nat. Commun. 5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    Tissue: Fetal brain.
  4. "Cloning of a secretory isoform of SgIGSF/TSLC-1."
    Ito A., Koma Y., Nagano T.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Lung.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  8. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer."
    Yageta M., Kuramochi M., Masuda M., Fukami T., Fukuhara H., Maruyama T., Shibuya M., Murakami Y.
    Cancer Res. 62:5129-5133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EPB41L3.
  10. "The tumor suppressor protein TSLC1 is involved in cell-cell adhesion."
    Masuda M., Yageta M., Fukuhara H., Kuramochi M., Maruyama T., Nomoto A., Murakami Y.
    J. Biol. Chem. 277:31014-31019(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, GLYCOSYLATION.
  11. "The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer."
    Mao X., Seidlitz E., Ghosh K., Murakami Y., Ghosh H.P.
    Cancer Res. 63:7979-7985(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN.
  12. "Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines."
    Fukami T., Fukuhara H., Kuramochi M., Maruyama T., Isogai K., Sakamoto M., Takamoto S., Murakami Y.
    Int. J. Cancer 107:53-59(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISEASE.
  13. "Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma."
    Ito A., Okada M., Uchino K., Wakayama T., Koma Y., Iseki S., Tsubota N., Okita Y., Kitamura Y.
    Lab. Invest. 83:1175-1183(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg."
    Fukuhara H., Masuda M., Yageta M., Fukami T., Kuramochi M., Maruyama T., Kitamura T., Murakami Y.
    Oncogene 22:6160-6165(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MPP3.
  15. "Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth."
    Mao X., Seidlitz E., Truant R., Hitt M., Ghosh H.P.
    Oncogene 23:5632-5642(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN.
  16. "The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM."
    Boles K.S., Barchet W., Diacovo T., Cella M., Colonna M.
    Blood 106:779-786(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CRTAM.
  17. "Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule."
    Galibert L., Diemer G.S., Liu Z., Johnson R.S., Smith J.L., Walzer T., Comeau M.R., Rauch C.T., Wolfson M.F., Sorensen R.A., Van der Vuurst de Vries A.-R., Branstetter D.G., Koelling R.M., Scholler J., Fanslow W.C., Baum P.R., Derry J.M., Yan W.
    J. Biol. Chem. 280:21955-21964(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRTAM.
  18. "The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves."
    Furuno T., Ito A., Koma Y., Watabe K., Yokozaki H., Bienenstock J., Nakanishi M., Kitamura Y.
    J. Immunol. 174:6934-6942(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  19. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-101 AND ASN-113.
    Tissue: Plasma.
  20. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-101 AND ASN-113.
    Tissue: Liver.
  21. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-101; ASN-113; ASN-301 AND ASN-302.
    Tissue: Leukemic T-cell.
  22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  23. "Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B)."
    Busam R.D., Thorsell A.G., Flores A., Hammarstrom M., Persson C., Obrink B., Hallberg B.M.
    J. Biol. Chem. 286:4511-4516(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 400-411 IN COMPLEX WITH EPB41L3, MUTAGENESIS OF TYR-406 AND THR-408, INTERACTION WITH EPB41L3.

Entry informationi

Entry nameiCADM1_HUMAN
AccessioniPrimary (citable) accession number: Q9BY67
Secondary accession number(s): A4FVB5
, F5H0J4, H0YGA7, H1ZZV9, H1ZZW1, H1ZZW2, Q86WB8, Q8N2F4, X5D2C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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