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Protein

UDP-glucuronosyltransferase 2B28

Gene

UGT2B28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.1 Publication

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.1 Publication

GO - Molecular functioni

GO - Biological processi

  • metabolic process Source: UniProtKB
  • xenobiotic metabolic process Source: UniProtKB

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-156588. Glucuronidation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B28 (EC:2.4.1.17)
Short name:
UDPGT 2B28
Gene namesi
Name:UGT2B28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000135226.16.
HGNCiHGNC:13479. UGT2B28.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei495 – 517HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi54490.
OpenTargetsiENSG00000135226.
PharmGKBiPA37779.

Chemistry databases

ChEMBLiCHEMBL6189.

Polymorphism and mutation databases

BioMutaiUGT2B28.
DMDMi20140759.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003604625 – 529UDP-glucuronosyltransferase 2B28Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9BY64.
PaxDbiQ9BY64.
PeptideAtlasiQ9BY64.
PRIDEiQ9BY64.

PTM databases

iPTMnetiQ9BY64.
PhosphoSitePlusiQ9BY64.

Expressioni

Tissue specificityi

Expressed in the liver, breast and kidney.1 Publication

Gene expression databases

BgeeiENSG00000135226.
CleanExiHS_UGT2B28.
GenevisibleiQ9BY64. HS.

Organism-specific databases

HPAiHPA045108.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334276.

Structurei

3D structure databases

ProteinModelPortaliQ9BY64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ9BY64.
KOiK00699.
OMAiASIKMCE.
PhylomeDBiQ9BY64.
TreeFamiTF315472.

Family and domain databases

InterProiView protein in InterPro
IPR002213. UDP_glucos_trans.
IPR035595. UDP_glycos_trans_CS.
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiView protein in Pfam
PF00201. UDPGT. 1 hit.
PROSITEiView protein in PROSITE
PS00375. UDPGT. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BY64-1) [UniParc]FASTAAdd to basket
Also known as: I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALKWTSVLL LIHLGCYFSS GSCGKVLVWT GEYSHWMNMK TILKELVQRG
60 70 80 90 100
HEVTVLASSA SILFDPNDAF TLKLEVYPTS LTKTEFENII MQQVKRWSDI
110 120 130 140 150
QKDSFWLYFS QEQEILWEFH DIFRNFCKDV VSNKKVMKKL QESRFDIIFA
160 170 180 190 200
DAFFPCGELL AALLNIPFVY SLCFTPGYTI ERHSGGLIFP PSYIPVVMSK
210 220 230 240 250
LSDQMTFMER VKNMIYVLYF DFWFQMCDMK KWDQFYSEVL GRPTTLFETM
260 270 280 290 300
GKADIWLMRN SWSFQFPHPF LPNIDFVGGL HCKPAKPLPK EMEEFVQSSG
310 320 330 340 350
ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN
360 370 380 390 400
TRLYKWIPQN DLLGLPKTRA FITHGGANGI YEAIYHGIPM VGIPLFWDQP
410 420 430 440 450
DNIAHMKAKG AAVRLDFHTM SSTDLLNALK TVINDPSYKE NVMKLSIIQH
460 470 480 490 500
DQPVKPLHRA VFWIEFVMCH KGAKHLRVAA RDLTWFQYHS LDVIGFLLAC
510 520
VATVIFVVTK FCLFCFWKFA RKGKKGKRD
Length:529
Mass (Da):60,906
Last modified:June 1, 2001 - v1
Checksum:i8C75277E964690C1
GO
Isoform 2 (identifier: Q9BY64-2) [UniParc]FASTAAdd to basket
Also known as: II

The sequence of this isoform differs from the canonical sequence as follows:
     335-335: V → I
     336-529: Missing.

Show »
Length:335
Mass (Da):38,743
Checksum:iD136BAE9B6A34539
GO

Sequence cautioni

Q9BY64: The sequence AAK31809 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173C → R in BAG70270 (PubMed:19054851).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059847365L → H1 PublicationCorresponds to variant dbSNP:rs4235127Ensembl.1
Natural variantiVAR_060661447I → R1 PublicationCorresponds to variant dbSNP:rs6843900Ensembl.1
Natural variantiVAR_060662458H → D1 PublicationCorresponds to variant dbSNP:rs6828191Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006710335V → I in isoform 2. 1 Publication1
Alternative sequenceiVSP_006711336 – 529Missing in isoform 2. 1 PublicationAdd BLAST194

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177272 mRNA. Translation: AAK31807.1.
AF177273 mRNA. Translation: AAK31808.1.
AF177274 mRNA. Translation: AAK31809.1. Sequence problems.
AB451456 mRNA. Translation: BAG70270.1.
CCDSiCCDS3528.1. [Q9BY64-1]
CCDS56330.1. [Q9BY64-2]
RefSeqiNP_001193933.1. NM_001207004.1. [Q9BY64-2]
NP_444267.1. NM_053039.1. [Q9BY64-1]
UniGeneiHs.653154.

Genome annotation databases

EnsembliENST00000335568; ENSP00000334276; ENSG00000135226. [Q9BY64-1]
ENST00000511240; ENSP00000427399; ENSG00000135226. [Q9BY64-2]
GeneIDi54490.
KEGGihsa:54490.
UCSCiuc003hej.3. human. [Q9BY64-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUDB28_HUMAN
AccessioniPrimary (citable) accession number: Q9BY64
Secondary accession number(s): B5BUM0, Q9BY62, Q9BY63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families