Q9BY60 (GBRL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor-associated protein-like 3

Alternative name(s):
GABA(A) receptor-associated protein-like 3

Gene names

Name:

GABARAPL3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Interacts with GABRG2 and beta-tubulin By similarity.
Subcellular location	Cytoplasm › cytoskeleton Probable.
Tissue specificity	Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. Ref.1
Sequence similarities	Belongs to the MAP1 LC3 family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara cell body Inferred from electronic annotation. Source: Compara dendrite cytoplasm Inferred from electronic annotation. Source: Compara dendrite membrane Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	Gamma-aminobutyric acid receptor-associated protein-like 3		PRO_0000212376
Regions
	Region	1 – 22	22	Interaction with beta-tubulin By similarity
	Region	36 – 68	33	Interaction with GABRG2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9BY60 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: A4AA4C7C958AF32D	FASTA	117	13,976
	10 20 30 40 50 60 MKFQYKEVHP FEYRKKEGEK IRKKYPDRVP LIVEKAPKAR VPDLDRRKYL VPSDLTDGQF 70 80 90 100 110 YLLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDSHE EDDFLYVAYS NESVYGK

References

[1]

"Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein." Xin Y., Yu L., Chen Z., Zheng L., Fu Q., Jiang J., Zhang P., Gong R., Zhao S. Genomics 74:408-413(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF180519 mRNA. Translation: AAK16237.1.
IPI	IPI00000252.
UniGene	Hs.592014.
3D structure databases
ProteinModelPortal	Q9BY60.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000266458.
Polymorphism databases
DMDM	44887972.
Proteomic databases
PaxDb	Q9BY60.
PRIDE	Q9BY60.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000412799; ENSP00000394008; ENSG00000238244.
Organism-specific databases
GeneCards	GC15M090893.
H-InvDB	HIX0038085.
HGNC	HGNC:4069. GABARAPL3.
neXtProt	NX_Q9BY60.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG263746.
HOGENOM	HOG000232034.
HOVERGEN	HBG051706.
InParanoid	Q9BY60.
OMA	EDSHEED.
OrthoDB	EOG47SSGT.
Gene expression databases
Bgee	Q9BY60.
Genevestigator	Q9BY60.
GermOnline	ENSG00000173683. Homo sapiens.
Family and domain databases
InterPro	IPR004241. Atg8_ubiquitin-like. [Graphical view]
PANTHER	PTHR10969. PTHR10969. 1 hit.
Pfam	PF02991. Atg8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GBRL3_HUMAN

Accession

Primary (citable) accession number: Q9BY60

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.