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Protein

Gamma-aminobutyric acid receptor-associated protein-like 3

Gene

GABARAPL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processAutophagy

Enzyme and pathway databases

ReactomeiR-HSA-1632852. Macroautophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor-associated protein-like 3
Alternative name(s):
GABA(A) receptor-associated protein-like 3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4069. GABARAPL3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi44887972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002123761 – 116Gamma-aminobutyric acid receptor-associated protein-like 3Add BLAST116
PropeptideiPRO_0000423073117Removed in mature formBy similarity1

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi116Phosphatidylethanolamine amidated glycineBy similarity1

Post-translational modificationi

The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL3-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei116 – 117Cleavage; by ATG4BBy similarity2

Keywords - PTMi

Lipoprotein

Proteomic databases

PaxDbiQ9BY60.
PRIDEiQ9BY60.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine.1 Publication

Organism-specific databases

HPAiHPA065883.

Interactioni

Subunit structurei

Interacts with GABRG2 and beta-tubulin.By similarity

Protein-protein interaction databases

MINTiMINT-139574.
STRINGi9606.ENSP00000394008.

Structurei

3D structure databases

ProteinModelPortaliQ9BY60.
SMRiQ9BY60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 22Interaction with beta-tubulinBy similarityAdd BLAST22
Regioni36 – 68Interaction with GABRG2By similarityAdd BLAST33

Sequence similaritiesi

Belongs to the ATG8 family.Curated

Phylogenomic databases

eggNOGiKOG1654. Eukaryota.
ENOG4111JAT. LUCA.
HOGENOMiHOG000232034.
HOVERGENiHBG051706.
InParanoidiQ9BY60.
PhylomeDBiQ9BY60.
TreeFamiTF314556.

Family and domain databases

CDDicd01611. GABARAP. 1 hit.
InterProiView protein in InterPro
IPR004241. Atg8-like.
IPR029071. Ubiquitin-like_domsf.
PANTHERiPTHR10969. PTHR10969. 1 hit.
PfamiView protein in Pfam
PF02991. Atg8. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BY60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFQYKEVHP FEYRKKEGEK IRKKYPDRVP LIVEKAPKAR VPDLDRRKYL
60 70 80 90 100
VPSDLTDGQF YLLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDSHE
110
EDDFLYVAYS NESVYGK
Length:117
Mass (Da):13,976
Last modified:June 1, 2001 - v1
Checksum:iA4AA4C7C958AF32D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180519 mRNA. Translation: AAK16237.1.
UniGeneiHs.592014.

Similar proteinsi

Entry informationi

Entry nameiGBRL3_HUMAN
AccessioniPrimary (citable) accession number: Q9BY60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families