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Protein

Gamma-aminobutyric acid receptor-associated protein-like 3

Gene

GABARAPL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy

Enzyme and pathway databases

BioCyciZFISH:G66-33670-MONOMER.
ReactomeiR-HSA-1632852. Macroautophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor-associated protein-like 3
Alternative name(s):
GABA(A) receptor-associated protein-like 3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4069. GABARAPL3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi23766.

Polymorphism and mutation databases

DMDMi44887972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002123761 – 116Gamma-aminobutyric acid receptor-associated protein-like 3Add BLAST116
PropeptideiPRO_0000423073117Removed in mature formBy similarity1

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi116Phosphatidylethanolamine amidated glycineBy similarity1

Post-translational modificationi

The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL3-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei116 – 117Cleavage; by ATG4BBy similarity2

Keywords - PTMi

Lipoprotein

Proteomic databases

PaxDbiQ9BY60.
PeptideAtlasiQ9BY60.
PRIDEiQ9BY60.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000238244.

Interactioni

Subunit structurei

Interacts with GABRG2 and beta-tubulin.By similarity

Protein-protein interaction databases

MINTiMINT-139574.
STRINGi9606.ENSP00000394008.

Structurei

3D structure databases

ProteinModelPortaliQ9BY60.
SMRiQ9BY60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 22Interaction with beta-tubulinBy similarityAdd BLAST22
Regioni36 – 68Interaction with GABRG2By similarityAdd BLAST33

Sequence similaritiesi

Belongs to the ATG8 family.Curated

Phylogenomic databases

eggNOGiKOG1654. Eukaryota.
ENOG4111JAT. LUCA.
HOGENOMiHOG000232034.
HOVERGENiHBG051706.
InParanoidiQ9BY60.
PhylomeDBiQ9BY60.
TreeFamiTF314556.

Family and domain databases

CDDicd01611. GABARAP. 1 hit.
InterProiIPR004241. Atg8-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10969. PTHR10969. 1 hit.
PfamiPF02991. Atg8. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BY60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFQYKEVHP FEYRKKEGEK IRKKYPDRVP LIVEKAPKAR VPDLDRRKYL
60 70 80 90 100
VPSDLTDGQF YLLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDSHE
110
EDDFLYVAYS NESVYGK
Length:117
Mass (Da):13,976
Last modified:June 1, 2001 - v1
Checksum:iA4AA4C7C958AF32D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180519 mRNA. Translation: AAK16237.1.
UniGeneiHs.592014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180519 mRNA. Translation: AAK16237.1.
UniGeneiHs.592014.

3D structure databases

ProteinModelPortaliQ9BY60.
SMRiQ9BY60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-139574.
STRINGi9606.ENSP00000394008.

Polymorphism and mutation databases

DMDMi44887972.

Proteomic databases

PaxDbiQ9BY60.
PeptideAtlasiQ9BY60.
PRIDEiQ9BY60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi23766.
GeneCardsiGABARAPL3.
H-InvDBHIX0038085.
HGNCiHGNC:4069. GABARAPL3.
neXtProtiNX_Q9BY60.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1654. Eukaryota.
ENOG4111JAT. LUCA.
HOGENOMiHOG000232034.
HOVERGENiHBG051706.
InParanoidiQ9BY60.
PhylomeDBiQ9BY60.
TreeFamiTF314556.

Enzyme and pathway databases

BioCyciZFISH:G66-33670-MONOMER.
ReactomeiR-HSA-1632852. Macroautophagy.

Miscellaneous databases

PROiQ9BY60.

Gene expression databases

BgeeiENSG00000238244.

Family and domain databases

CDDicd01611. GABARAP. 1 hit.
InterProiIPR004241. Atg8-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10969. PTHR10969. 1 hit.
PfamiPF02991. Atg8. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGBRL3_HUMAN
AccessioniPrimary (citable) accession number: Q9BY60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.