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Protein

Signal peptidase complex catalytic subunit SEC11C

Gene

SEC11C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-HSA-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
R-HSA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Protein family/group databases

MEROPSiS26.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11C (EC:3.4.21.89)
Alternative name(s):
Microsomal signal peptidase 21 kDa subunit
Short name:
SPase 21 kDa subunit
SEC11 homolog C
SEC11-like protein 3
SPC21
Gene namesi
Name:SEC11C
Synonyms:SEC11L3, SPC21, SPCS4C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:23400. SEC11C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini49 – 192LumenalSequence analysisAdd BLAST144

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi90701.
OpenTargetsiENSG00000166562.
PharmGKBiPA162402587.

Polymorphism and mutation databases

BioMutaiSEC11C.
DMDMi17368701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095481 – 192Signal peptidase complex catalytic subunit SEC11CAdd BLAST192

Proteomic databases

EPDiQ9BY50.
MaxQBiQ9BY50.
PaxDbiQ9BY50.
PeptideAtlasiQ9BY50.
PRIDEiQ9BY50.

PTM databases

iPTMnetiQ9BY50.
PhosphoSitePlusiQ9BY50.

Expressioni

Gene expression databases

BgeeiENSG00000166562.
CleanExiHS_SEC11C.
ExpressionAtlasiQ9BY50. baseline and differential.
GenevisibleiQ9BY50. HS.

Organism-specific databases

HPAiHPA026816.
HPA047533.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

BioGridi124756. 18 interactors.
IntActiQ9BY50. 5 interactors.
STRINGi9606.ENSP00000468633.

Structurei

3D structure databases

ProteinModelPortaliQ9BY50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00390000015600.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiQ9BY50.
KOiK13280.
OMAiWKGLIVI.
OrthoDBiEOG091G0X3D.
PhylomeDBiQ9BY50.

Family and domain databases

InterProiView protein in InterPro
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiView protein in Pfam
PF00717. Peptidase_S24. 1 hit.
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiView protein in PROSITE
PS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BY50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAGAVGAH LPASGLDIFG DLKKMNKRQL YYQVLNFAMI VSSALMIWKG
60 70 80 90 100
LIVLTGSESP IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE
110 120 130 140 150
GRDIPIVHRV IKVHEKDNGD IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV
160 170 180 190
VGRARGFLPY VGMVTIIMND YPKFKYALLA VMGAYVLLKR ES
Length:192
Mass (Da):21,542
Last modified:January 23, 2007 - v3
Checksum:i74FBC5F765791D9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212233 mRNA. Translation: AAK14919.1.
AK314107 mRNA. Translation: BAG36800.1.
CH471096 Genomic DNA. Translation: EAW63090.1.
BC009703 mRNA. Translation: AAH09703.1.
CCDSiCCDS11970.1.
RefSeqiNP_150596.1. NM_033280.3.
UniGeneiHs.45107.
Hs.690840.

Genome annotation databases

EnsembliENST00000587834; ENSP00000468633; ENSG00000166562.
GeneIDi90701.
KEGGihsa:90701.
UCSCiuc002lht.4. human.

Similar proteinsi

Entry informationi

Entry nameiSC11C_HUMAN
AccessioniPrimary (citable) accession number: Q9BY50
Secondary accession number(s): B2RAA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families