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Q9BY50

- SC11C_HUMAN

UniProt

Q9BY50 - SC11C_HUMAN

Protein

Signal peptidase complex catalytic subunit SEC11C

Gene

SEC11C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

    Catalytic activityi

    Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681By similarity

    GO - Molecular functioni

    1. serine-type peptidase activity Source: InterPro

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. regulation of insulin secretion Source: Reactome
    4. signal peptide processing Source: InterPro
    5. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    6. translation Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Protease

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_19189. Synthesis, secretion, and deacylation of Ghrelin.
    REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
    REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

    Protein family/group databases

    MEROPSiS26.010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal peptidase complex catalytic subunit SEC11C (EC:3.4.21.89)
    Alternative name(s):
    Microsomal signal peptidase 21 kDa subunit
    Short name:
    SPase 21 kDa subunit
    SEC11 homolog C
    SEC11-like protein 3
    SPC21
    Gene namesi
    Name:SEC11C
    Synonyms:SEC11L3, SPC21, SPCS4C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:23400. SEC11C.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162402587.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 192191Signal peptidase complex catalytic subunit SEC11CPRO_0000109548Add
    BLAST

    Proteomic databases

    MaxQBiQ9BY50.
    PaxDbiQ9BY50.
    PeptideAtlasiQ9BY50.
    PRIDEiQ9BY50.

    PTM databases

    PhosphoSiteiQ9BY50.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BY50.
    BgeeiQ9BY50.
    CleanExiHS_SEC11C.
    GenevestigatoriQ9BY50.

    Organism-specific databases

    HPAiHPA026816.

    Interactioni

    Subunit structurei

    Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

    Protein-protein interaction databases

    BioGridi124756. 1 interaction.
    IntActiQ9BY50. 2 interactions.
    STRINGi9606.ENSP00000299714.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BY50.
    SMRiQ9BY50. Positions 62-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 2827CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini49 – 192144LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4820Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S26B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0681.
    HOGENOMiHOG000111516.
    HOVERGENiHBG057279.
    InParanoidiQ9BY50.
    KOiK13280.
    OMAiEAYAWEN.
    OrthoDBiEOG7V4B0P.
    PhylomeDBiQ9BY50.

    Family and domain databases

    Gene3Di2.10.109.10. 1 hit.
    InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR001733. Peptidase_S26B.
    [Graphical view]
    PANTHERiPTHR10806. PTHR10806. 1 hit.
    PfamiPF00717. Peptidase_S24. 1 hit.
    [Graphical view]
    PRINTSiPR00728. SIGNALPTASE.
    SUPFAMiSSF51306. SSF51306. 1 hit.
    TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
    PROSITEiPS00501. SPASE_I_1. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BY50-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRAGAVGAH LPASGLDIFG DLKKMNKRQL YYQVLNFAMI VSSALMIWKG    50
    LIVLTGSESP IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE 100
    GRDIPIVHRV IKVHEKDNGD IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV 150
    VGRARGFLPY VGMVTIIMND YPKFKYALLA VMGAYVLLKR ES 192
    Length:192
    Mass (Da):21,542
    Last modified:January 23, 2007 - v3
    Checksum:i74FBC5F765791D9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212233 mRNA. Translation: AAK14919.1.
    AK314107 mRNA. Translation: BAG36800.1.
    CH471096 Genomic DNA. Translation: EAW63090.1.
    BC009703 mRNA. Translation: AAH09703.1.
    CCDSiCCDS11970.1.
    RefSeqiNP_150596.1. NM_033280.2.
    UniGeneiHs.45107.

    Genome annotation databases

    EnsembliENST00000587834; ENSP00000468633; ENSG00000166562.
    GeneIDi90701.
    KEGGihsa:90701.
    UCSCiuc002lht.3. human.

    Polymorphism databases

    DMDMi17368701.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212233 mRNA. Translation: AAK14919.1 .
    AK314107 mRNA. Translation: BAG36800.1 .
    CH471096 Genomic DNA. Translation: EAW63090.1 .
    BC009703 mRNA. Translation: AAH09703.1 .
    CCDSi CCDS11970.1.
    RefSeqi NP_150596.1. NM_033280.2.
    UniGenei Hs.45107.

    3D structure databases

    ProteinModelPortali Q9BY50.
    SMRi Q9BY50. Positions 62-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124756. 1 interaction.
    IntActi Q9BY50. 2 interactions.
    STRINGi 9606.ENSP00000299714.

    Protein family/group databases

    MEROPSi S26.010.

    PTM databases

    PhosphoSitei Q9BY50.

    Polymorphism databases

    DMDMi 17368701.

    Proteomic databases

    MaxQBi Q9BY50.
    PaxDbi Q9BY50.
    PeptideAtlasi Q9BY50.
    PRIDEi Q9BY50.

    Protocols and materials databases

    DNASUi 90701.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000587834 ; ENSP00000468633 ; ENSG00000166562 .
    GeneIDi 90701.
    KEGGi hsa:90701.
    UCSCi uc002lht.3. human.

    Organism-specific databases

    CTDi 90701.
    GeneCardsi GC18P056807.
    HGNCi HGNC:23400. SEC11C.
    HPAi HPA026816.
    neXtProti NX_Q9BY50.
    PharmGKBi PA162402587.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0681.
    HOGENOMi HOG000111516.
    HOVERGENi HBG057279.
    InParanoidi Q9BY50.
    KOi K13280.
    OMAi EAYAWEN.
    OrthoDBi EOG7V4B0P.
    PhylomeDBi Q9BY50.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_19189. Synthesis, secretion, and deacylation of Ghrelin.
    REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
    REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

    Miscellaneous databases

    GenomeRNAii 90701.
    NextBioi 76939.
    PROi Q9BY50.

    Gene expression databases

    ArrayExpressi Q9BY50.
    Bgeei Q9BY50.
    CleanExi HS_SEC11C.
    Genevestigatori Q9BY50.

    Family and domain databases

    Gene3Di 2.10.109.10. 1 hit.
    InterProi IPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR001733. Peptidase_S26B.
    [Graphical view ]
    PANTHERi PTHR10806. PTHR10806. 1 hit.
    Pfami PF00717. Peptidase_S24. 1 hit.
    [Graphical view ]
    PRINTSi PR00728. SIGNALPTASE.
    SUPFAMi SSF51306. SSF51306. 1 hit.
    TIGRFAMsi TIGR02228. sigpep_I_arch. 1 hit.
    PROSITEi PS00501. SPASE_I_1. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene expressed in human liver cancer tissue."
      Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver cancer.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSC11C_HUMAN
    AccessioniPrimary (citable) accession number: Q9BY50
    Secondary accession number(s): B2RAA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3