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Protein

Peroxisomal trans-2-enoyl-CoA reductase

Gene

PECR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity.

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.1 Publication

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 47NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • receptor binding Source: UniProtKB
  • trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB

GO - Biological processi

  • cellular lipid metabolic process Source: Reactome
  • fatty acid biosynthetic process Source: UniProtKB-UniPathway
  • oxidation-reduction process Source: UniProtKB
  • phytol metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS03889-MONOMER.
ZFISH:HS03889-MONOMER.
BRENDAi1.3.1.38. 2681.
ReactomeiR-HSA-390918. Peroxisomal lipid metabolism.
UniPathwayiUPA00094.

Chemistry databases

SwissLipidsiSLP:000001094.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal trans-2-enoyl-CoA reductase (EC:1.3.1.38)
Short name:
TERP
Alternative name(s):
2,4-dienoyl-CoA reductase-related protein
Short name:
DCR-RP
HPDHase
Short chain dehydrogenase/reductase family 29C member 1
pVI-ARL
Gene namesi
Name:PECR
Synonyms:SDR29C1
ORF Names:PRO1004
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:18281. PECR.

Subcellular locationi

GO - Cellular componenti

  • intracellular membrane-bounded organelle Source: HPA
  • mitochondrion Source: Ensembl
  • peroxisomal membrane Source: UniProtKB
  • peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi303Missing : Abolishes localization to peroxisomes. 1 Publication1

Organism-specific databases

DisGeNETi55825.
OpenTargetsiENSG00000115425.
PharmGKBiPA134967510.

Chemistry databases

DrugBankiDB00173. Adenine.

Polymorphism and mutation databases

BioMutaiPECR.
DMDMi62287123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000547402 – 303Peroxisomal trans-2-enoyl-CoA reductaseAdd BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32N6-succinyllysineBy similarity1
Modified residuei49PhosphoserineCombined sources1
Modified residuei179PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BY49.
MaxQBiQ9BY49.
PaxDbiQ9BY49.
PeptideAtlasiQ9BY49.
PRIDEiQ9BY49.

PTM databases

iPTMnetiQ9BY49.
PhosphoSitePlusiQ9BY49.

Expressioni

Inductioni

Not induced by IR.1 Publication

Gene expression databases

BgeeiENSG00000115425.
CleanExiHS_PECR.
ExpressionAtlasiQ9BY49. baseline and differential.
GenevisibleiQ9BY49. HS.

Organism-specific databases

HPAiHPA021593.
HPA022539.

Interactioni

Subunit structurei

Interacts with PEX5, probably required to target it into peroxisomes.2 Publications

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120932. 11 interactors.
IntActiQ9BY49. 1 interactor.
STRINGi9606.ENSP00000265322.

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni13 – 18Combined sources6
Beta strandi20 – 24Combined sources5
Turni25 – 27Combined sources3
Helixi29 – 40Combined sources12
Beta strandi44 – 50Combined sources7
Helixi52 – 64Combined sources13
Beta strandi74 – 78Combined sources5
Helixi84 – 98Combined sources15
Beta strandi103 – 106Combined sources4
Helixi116 – 118Combined sources3
Helixi121 – 131Combined sources11
Helixi133 – 145Combined sources13
Helixi147 – 150Combined sources4
Beta strandi152 – 157Combined sources6
Helixi169 – 188Combined sources20
Helixi190 – 192Combined sources3
Beta strandi194 – 201Combined sources8
Helixi208 – 210Combined sources3
Helixi214 – 221Combined sources8
Helixi224 – 227Combined sources4
Helixi237 – 247Combined sources11
Helixi249 – 251Combined sources3
Beta strandi258 – 262Combined sources5
Helixi265 – 267Combined sources3
Helixi288 – 302Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YXMX-ray1.90A/B/C/D1-303[»]
ProteinModelPortaliQ9BY49.
SMRiQ9BY49.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BY49.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi301 – 303Microbody targeting signal3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105268.
InParanoidiQ9BY49.
KOiK07753.
OMAiFEGSFQK.
OrthoDBiEOG091G0GO6.
PhylomeDBiQ9BY49.
TreeFamiTF315256.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BY49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASWAKGRSY LAPGLLQGQV AIVTGGATGI GKAIVKELLE LGSNVVIASR
60 70 80 90 100
KLERLKSAAD ELQANLPPTK QARVIPIQCN IRNEEEVNNL VKSTLDTFGK
110 120 130 140 150
INFLVNNGGG QFLSPAEHIS SKGWHAVLET NLTGTFYMCK AVYSSWMKEH
160 170 180 190 200
GGSIVNIIVP TKAGFPLAVH SGAARAGVYN LTKSLALEWA CSGIRINCVA
210 220 230 240 250
PGVIYSQTAV ENYGSWGQSF FEGSFQKIPA KRIGVPEEVS SVVCFLLSPA
260 270 280 290 300
ASFITGQSVD VDGGRSLYTH SYEVPDHDNW PKGAGDLSVV KKMKETFKEK

AKL
Length:303
Mass (Da):32,544
Last modified:March 29, 2005 - v2
Checksum:iBCCE6AB89F58382C
GO
Isoform 2 (identifier: Q9BY49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Show »
Length:157
Mass (Da):16,834
Checksum:i8215EB7A51D81D48
GO

Sequence cautioni

The sequence AAF69798 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22I → F in CAB89810 (PubMed:11669066).Curated1
Sequence conflicti129E → R in CAB89810 (PubMed:11669066).Curated1
Sequence conflicti135T → S in CAB89810 (PubMed:11669066).Curated1
Sequence conflicti248S → P in CAG33426 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021535149E → K.Corresponds to variant rs1429148dbSNPEnsembl.1
Natural variantiVAR_021536297F → L.Corresponds to variant rs9288513dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0132601 – 146Missing in isoform 2. 2 PublicationsAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF232009 mRNA. Translation: AAF69798.1. Different initiation.
AJ250303 mRNA. Translation: CAB89810.1.
AF212234 mRNA. Translation: AAK14920.1.
AF119841 mRNA. Translation: AAF69595.1.
CR457145 mRNA. Translation: CAG33426.1.
AK315795 mRNA. Translation: BAG38139.1.
AC010686 Genomic DNA. Translation: AAY14657.1.
BC002529 mRNA. Translation: AAH02529.1.
CCDSiCCDS33375.1. [Q9BY49-1]
RefSeqiNP_060911.2. NM_018441.5. [Q9BY49-1]
XP_011509780.1. XM_011511478.2. [Q9BY49-2]
UniGeneiHs.281680.

Genome annotation databases

EnsembliENST00000265322; ENSP00000265322; ENSG00000115425. [Q9BY49-1]
GeneIDi55825.
KEGGihsa:55825.
UCSCiuc002vft.4. human. [Q9BY49-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF232009 mRNA. Translation: AAF69798.1. Different initiation.
AJ250303 mRNA. Translation: CAB89810.1.
AF212234 mRNA. Translation: AAK14920.1.
AF119841 mRNA. Translation: AAF69595.1.
CR457145 mRNA. Translation: CAG33426.1.
AK315795 mRNA. Translation: BAG38139.1.
AC010686 Genomic DNA. Translation: AAY14657.1.
BC002529 mRNA. Translation: AAH02529.1.
CCDSiCCDS33375.1. [Q9BY49-1]
RefSeqiNP_060911.2. NM_018441.5. [Q9BY49-1]
XP_011509780.1. XM_011511478.2. [Q9BY49-2]
UniGeneiHs.281680.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YXMX-ray1.90A/B/C/D1-303[»]
ProteinModelPortaliQ9BY49.
SMRiQ9BY49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120932. 11 interactors.
IntActiQ9BY49. 1 interactor.
STRINGi9606.ENSP00000265322.

Chemistry databases

DrugBankiDB00173. Adenine.
SwissLipidsiSLP:000001094.

PTM databases

iPTMnetiQ9BY49.
PhosphoSitePlusiQ9BY49.

Polymorphism and mutation databases

BioMutaiPECR.
DMDMi62287123.

Proteomic databases

EPDiQ9BY49.
MaxQBiQ9BY49.
PaxDbiQ9BY49.
PeptideAtlasiQ9BY49.
PRIDEiQ9BY49.

Protocols and materials databases

DNASUi55825.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265322; ENSP00000265322; ENSG00000115425. [Q9BY49-1]
GeneIDi55825.
KEGGihsa:55825.
UCSCiuc002vft.4. human. [Q9BY49-1]

Organism-specific databases

CTDi55825.
DisGeNETi55825.
GeneCardsiPECR.
HGNCiHGNC:18281. PECR.
HPAiHPA021593.
HPA022539.
MIMi605843. gene.
neXtProtiNX_Q9BY49.
OpenTargetsiENSG00000115425.
PharmGKBiPA134967510.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105268.
InParanoidiQ9BY49.
KOiK07753.
OMAiFEGSFQK.
OrthoDBiEOG091G0GO6.
PhylomeDBiQ9BY49.
TreeFamiTF315256.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciMetaCyc:HS03889-MONOMER.
ZFISH:HS03889-MONOMER.
BRENDAi1.3.1.38. 2681.
ReactomeiR-HSA-390918. Peroxisomal lipid metabolism.

Miscellaneous databases

EvolutionaryTraceiQ9BY49.
GeneWikiiPECR.
GenomeRNAii55825.
PROiQ9BY49.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115425.
CleanExiHS_PECR.
ExpressionAtlasiQ9BY49. baseline and differential.
GenevisibleiQ9BY49. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPECR_HUMAN
AccessioniPrimary (citable) accession number: Q9BY49
Secondary accession number(s): B2RE42
, Q53TC4, Q6IAK9, Q9NRD4, Q9NY60, Q9P1A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.