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Protein

Protein RTF2 homolog

Gene

RTFDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RTF2 homolog
Alternative name(s):
Replication termination factor 2 domain-containing protein 1
Gene namesi
Name:RTFDC1
Synonyms:C20orf43
ORF Names:AD-007, CDA05, HSPC164, HSPC169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000022277.12
HGNCiHGNC:15890 RTFDC1
neXtProtiNX_Q9BY42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000022277
PharmGKBiPA25756

Polymorphism and mutation databases

BioMutaiRTFDC1
DMDMi313104242

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794271 – 306Protein RTF2 homologAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BY42
MaxQBiQ9BY42
PaxDbiQ9BY42
PeptideAtlasiQ9BY42
PRIDEiQ9BY42

PTM databases

iPTMnetiQ9BY42
PhosphoSitePlusiQ9BY42

Expressioni

Gene expression databases

BgeeiENSG00000022277
CleanExiHS_C20orf43
ExpressionAtlasiQ9BY42 baseline and differential
GenevisibleiQ9BY42 HS

Organism-specific databases

HPAiHPA053986

Interactioni

Protein-protein interaction databases

BioGridi119578, 20 interactors
IntActiQ9BY42, 7 interactors
MINTiQ9BY42
STRINGi9606.ENSP00000023939

Structurei

3D structure databases

ProteinModelPortaliQ9BY42
SMRiQ9BY42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rtf2 family.Curated

Phylogenomic databases

eggNOGiKOG3113 Eukaryota
ENOG41113CN LUCA
GeneTreeiENSGT00390000010923
HOVERGENiHBG051164
InParanoidiQ9BY42
PhylomeDBiQ9BY42
TreeFamiTF314621

Family and domain databases

InterProiView protein in InterPro
IPR006735 Rtf2
IPR027799 Rtf2_RING-finger
PANTHERiPTHR12775 PTHR12775, 1 hit
PfamiView protein in Pfam
PF04641 Rtf2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BY42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEILRRPIVA
60 70 80 90 100
CELGRLYNKD AVIEFLLDKS AEKALGKAAS HIKSIKNVTE LKLSDNPAWE
110 120 130 140 150
GDKGNTKGDK HDDLQRARFI CPVVGLEMNG RHRFCFLRCC GCVFSERALK
160 170 180 190 200
EIKAEVCHTC GAAFQEDDVI MLNGTKEDVD VLKTRMEERR LRAKLEKKTK
210 220 230 240 250
KPKAAESVSK PDVSEEAPGP SKVKTGKPEE ASLDSREKKT NLAPKSTAMN
260 270 280 290 300
ESSSGKAGKP PCGATKRSIA DSEESEAYKS LFTTHSSAKR SKEESAHWVT

HTSYCF
Length:306
Mass (Da):33,887
Last modified:November 30, 2010 - v3
Checksum:i41EBAB29F7D535BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189R → G in BAA91193 (PubMed:14702039).Curated1
Sequence conflicti194K → N in AAF17212 (PubMed:10931946).Curated1
Sequence conflicti194K → N in AAK14929 (Ref. 3) Curated1
Sequence conflicti195L → R in AAF17212 (PubMed:10931946).Curated1
Sequence conflicti195L → W in AAK14929 (Ref. 3) Curated1
Sequence conflicti199T → P in AAF29128 (PubMed:11042152).Curated1
Sequence conflicti208V → A in AAF29128 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028134159T → A. Corresponds to variant dbSNP:rs6024909Ensembl.1
Natural variantiVAR_028135171M → V6 PublicationsCorresponds to variant dbSNP:rs1059768Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117231 mRNA Translation: AAF17212.1
AF161513 mRNA Translation: AAF29128.1
AF161518 mRNA Translation: AAF29133.1
AF212244 mRNA Translation: AAK14929.1
AK000481 mRNA Translation: BAA91193.1
AL109806 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75539.1
CH471077 Genomic DNA Translation: EAW75540.1
BC003359 mRNA Translation: AAH03359.1
CCDSiCCDS13453.1
RefSeqiNP_001269964.1, NM_001283035.1
NP_001269965.1, NM_001283036.1
NP_001269966.1, NM_001283037.1
NP_057491.2, NM_016407.4
UniGeneiHs.517134

Genome annotation databases

EnsembliENST00000357348; ENSP00000349906; ENSG00000022277
GeneIDi51507
KEGGihsa:51507
UCSCiuc002xxt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRTF2_HUMAN
AccessioniPrimary (citable) accession number: Q9BY42
Secondary accession number(s): E1P5Z9
, Q9BYL7, Q9HCV9, Q9NX29, Q9NZZ8, Q9P002, Q9UHW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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