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Q9BY42

- RTF2_HUMAN

UniProt

Q9BY42 - RTF2_HUMAN

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Protein

Protein RTF2 homolog

Gene
RTFDC1, C20orf43, AD-007, CDA05, HSPC164, HSPC169
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RTF2 homolog
Alternative name(s):
Replication termination factor 2 domain-containing protein 1
Gene namesi
Name:RTFDC1
Synonyms:C20orf43
ORF Names:AD-007, CDA05, HSPC164, HSPC169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15890. RTFDC1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25756.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Protein RTF2 homologPRO_0000079427Add
BLAST

Proteomic databases

MaxQBiQ9BY42.
PaxDbiQ9BY42.
PRIDEiQ9BY42.

PTM databases

PhosphoSiteiQ9BY42.

Expressioni

Gene expression databases

ArrayExpressiQ9BY42.
BgeeiQ9BY42.
CleanExiHS_C20orf43.
GenevestigatoriQ9BY42.

Organism-specific databases

HPAiHPA053986.

Interactioni

Protein-protein interaction databases

BioGridi119578. 3 interactions.
IntActiQ9BY42. 2 interactions.
MINTiMINT-3063696.
STRINGi9606.ENSP00000023939.

Structurei

3D structure databases

ProteinModelPortaliQ9BY42.
SMRiQ9BY42. Positions 36-69.

Family & Domainsi

Sequence similaritiesi

Belongs to the rtf2 family.

Phylogenomic databases

eggNOGiNOG307139.
HOVERGENiHBG051164.
InParanoidiQ9BY42.
OrthoDBiEOG7BW0KH.
PhylomeDBiQ9BY42.
TreeFamiTF314621.

Family and domain databases

InterProiIPR006735. DUF602.
IPR027799. Rtf2_RING-finger.
[Graphical view]
PANTHERiPTHR12775. PTHR12775. 1 hit.
PfamiPF04641. Rtf2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BY42-1 [UniParc]FASTAAdd to Basket

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MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEILRRPIVA    50
CELGRLYNKD AVIEFLLDKS AEKALGKAAS HIKSIKNVTE LKLSDNPAWE 100
GDKGNTKGDK HDDLQRARFI CPVVGLEMNG RHRFCFLRCC GCVFSERALK 150
EIKAEVCHTC GAAFQEDDVI MLNGTKEDVD VLKTRMEERR LRAKLEKKTK 200
KPKAAESVSK PDVSEEAPGP SKVKTGKPEE ASLDSREKKT NLAPKSTAMN 250
ESSSGKAGKP PCGATKRSIA DSEESEAYKS LFTTHSSAKR SKEESAHWVT 300
HTSYCF 306
Length:306
Mass (Da):33,887
Last modified:November 30, 2010 - v3
Checksum:i41EBAB29F7D535BF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591T → A.
Corresponds to variant rs6024909 [ dbSNP | Ensembl ].
VAR_028134
Natural varianti171 – 1711M → V.6 Publications
Corresponds to variant rs1059768 [ dbSNP | Ensembl ].
VAR_028135

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891R → G in BAA91193. 1 Publication
Sequence conflicti194 – 1941K → N in AAF17212. 1 Publication
Sequence conflicti194 – 1941K → N in AAK14929. 1 Publication
Sequence conflicti195 – 1951L → R in AAF17212. 1 Publication
Sequence conflicti195 – 1951L → W in AAK14929. 1 Publication
Sequence conflicti199 – 1991T → P in AAF29128. 1 Publication
Sequence conflicti208 – 2081V → A in AAF29128. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117231 mRNA. Translation: AAF17212.1.
AF161513 mRNA. Translation: AAF29128.1.
AF161518 mRNA. Translation: AAF29133.1.
AF212244 mRNA. Translation: AAK14929.1.
AK000481 mRNA. Translation: BAA91193.1.
AL109806 Genomic DNA. Translation: CAC03740.1.
CH471077 Genomic DNA. Translation: EAW75539.1.
CH471077 Genomic DNA. Translation: EAW75540.1.
BC003359 mRNA. Translation: AAH03359.1.
CCDSiCCDS13453.1.
RefSeqiNP_001269964.1. NM_001283035.1.
NP_001269965.1. NM_001283036.1.
NP_001269966.1. NM_001283037.1.
NP_057491.2. NM_016407.4.
UniGeneiHs.517134.

Genome annotation databases

EnsembliENST00000023939; ENSP00000023939; ENSG00000022277.
GeneIDi51507.
KEGGihsa:51507.
UCSCiuc002xxt.2. human.

Polymorphism databases

DMDMi313104242.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117231 mRNA. Translation: AAF17212.1 .
AF161513 mRNA. Translation: AAF29128.1 .
AF161518 mRNA. Translation: AAF29133.1 .
AF212244 mRNA. Translation: AAK14929.1 .
AK000481 mRNA. Translation: BAA91193.1 .
AL109806 Genomic DNA. Translation: CAC03740.1 .
CH471077 Genomic DNA. Translation: EAW75539.1 .
CH471077 Genomic DNA. Translation: EAW75540.1 .
BC003359 mRNA. Translation: AAH03359.1 .
CCDSi CCDS13453.1.
RefSeqi NP_001269964.1. NM_001283035.1.
NP_001269965.1. NM_001283036.1.
NP_001269966.1. NM_001283037.1.
NP_057491.2. NM_016407.4.
UniGenei Hs.517134.

3D structure databases

ProteinModelPortali Q9BY42.
SMRi Q9BY42. Positions 36-69.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119578. 3 interactions.
IntActi Q9BY42. 2 interactions.
MINTi MINT-3063696.
STRINGi 9606.ENSP00000023939.

PTM databases

PhosphoSitei Q9BY42.

Polymorphism databases

DMDMi 313104242.

Proteomic databases

MaxQBi Q9BY42.
PaxDbi Q9BY42.
PRIDEi Q9BY42.

Protocols and materials databases

DNASUi 51507.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000023939 ; ENSP00000023939 ; ENSG00000022277 .
GeneIDi 51507.
KEGGi hsa:51507.
UCSCi uc002xxt.2. human.

Organism-specific databases

CTDi 51507.
GeneCardsi GC20P055045.
H-InvDB HIX0015933.
HGNCi HGNC:15890. RTFDC1.
HPAi HPA053986.
neXtProti NX_Q9BY42.
PharmGKBi PA25756.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307139.
HOVERGENi HBG051164.
InParanoidi Q9BY42.
OrthoDBi EOG7BW0KH.
PhylomeDBi Q9BY42.
TreeFami TF314621.

Miscellaneous databases

ChiTaRSi C20orf43. human.
GeneWikii C20orf43.
GenomeRNAii 51507.
NextBioi 55194.

Gene expression databases

ArrayExpressi Q9BY42.
Bgeei Q9BY42.
CleanExi HS_C20orf43.
Genevestigatori Q9BY42.

Family and domain databases

InterProi IPR006735. DUF602.
IPR027799. Rtf2_RING-finger.
[Graphical view ]
PANTHERi PTHR12775. PTHR12775. 1 hit.
Pfami PF04641. Rtf2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-171.
    Tissue: Adrenal gland.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-171.
    Tissue: Umbilical cord blood.
  3. "A novel gene expressed in human pheochromocytoma."
    Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z., Han Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-171.
    Tissue: Pheochromocytoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-171.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-171.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-171.
    Tissue: Placenta.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRTF2_HUMAN
AccessioniPrimary (citable) accession number: Q9BY42
Secondary accession number(s): E1P5Z9
, Q9BYL7, Q9HCV9, Q9NX29, Q9NZZ8, Q9P002, Q9UHW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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