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Q9BY42 (RTF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein RTF2 homolog
Alternative name(s):
Replication termination factor 2 domain-containing protein 1
Gene names
Name:RTFDC1
Synonyms:C20orf43
ORF Names:AD-007, CDA05, HSPC164, HSPC169
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the rtf2 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Protein RTF2 homolog
PRO_0000079427

Natural variations

Natural variant1591T → A.
Corresponds to variant rs6024909 [ dbSNP | Ensembl ].
VAR_028134
Natural variant1711M → V. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6 Ref.7
Corresponds to variant rs1059768 [ dbSNP | Ensembl ].
VAR_028135

Experimental info

Sequence conflict1891R → G in BAA91193. Ref.4
Sequence conflict1941K → N in AAF17212. Ref.1
Sequence conflict1941K → N in AAK14929. Ref.3
Sequence conflict1951L → R in AAF17212. Ref.1
Sequence conflict1951L → W in AAK14929. Ref.3
Sequence conflict1991T → P in AAF29128. Ref.2
Sequence conflict2081V → A in AAF29128. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9BY42 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: 41EBAB29F7D535BF

FASTA30633,887
        10         20         30         40         50         60 
MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEILRRPIVA CELGRLYNKD 

        70         80         90        100        110        120 
AVIEFLLDKS AEKALGKAAS HIKSIKNVTE LKLSDNPAWE GDKGNTKGDK HDDLQRARFI 

       130        140        150        160        170        180 
CPVVGLEMNG RHRFCFLRCC GCVFSERALK EIKAEVCHTC GAAFQEDDVI MLNGTKEDVD 

       190        200        210        220        230        240 
VLKTRMEERR LRAKLEKKTK KPKAAESVSK PDVSEEAPGP SKVKTGKPEE ASLDSREKKT 

       250        260        270        280        290        300 
NLAPKSTAMN ESSSGKAGKP PCGATKRSIA DSEESEAYKS LFTTHSSAKR SKEESAHWVT 


HTSYCF 

« Hide

References

[1]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-171.
Tissue: Adrenal gland.
[2]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-171.
Tissue: Umbilical cord blood.
[3]"A novel gene expressed in human pheochromocytoma."
Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z., Han Z.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-171.
Tissue: Pheochromocytoma.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-171.
[5]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-171.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-171.
Tissue: Placenta.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF117231 mRNA. Translation: AAF17212.1.
AF161513 mRNA. Translation: AAF29128.1.
AF161518 mRNA. Translation: AAF29133.1.
AF212244 mRNA. Translation: AAK14929.1.
AK000481 mRNA. Translation: BAA91193.1.
AL109806 Genomic DNA. Translation: CAC03740.1.
CH471077 Genomic DNA. Translation: EAW75539.1.
CH471077 Genomic DNA. Translation: EAW75540.1.
BC003359 mRNA. Translation: AAH03359.1.
CCDSCCDS13453.1.
RefSeqNP_001269964.1. NM_001283035.1.
NP_001269965.1. NM_001283036.1.
NP_001269966.1. NM_001283037.1.
NP_057491.2. NM_016407.4.
UniGeneHs.517134.

3D structure databases

ProteinModelPortalQ9BY42.
SMRQ9BY42. Positions 36-69.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119578. 3 interactions.
IntActQ9BY42. 2 interactions.
MINTMINT-3063696.
STRING9606.ENSP00000023939.

PTM databases

PhosphoSiteQ9BY42.

Polymorphism databases

DMDM313104242.

Proteomic databases

MaxQBQ9BY42.
PaxDbQ9BY42.
PRIDEQ9BY42.

Protocols and materials databases

DNASU51507.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000023939; ENSP00000023939; ENSG00000022277.
GeneID51507.
KEGGhsa:51507.
UCSCuc002xxt.2. human.

Organism-specific databases

CTD51507.
GeneCardsGC20P055045.
H-InvDBHIX0015933.
HGNCHGNC:15890. RTFDC1.
HPAHPA053986.
neXtProtNX_Q9BY42.
PharmGKBPA25756.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG307139.
HOVERGENHBG051164.
InParanoidQ9BY42.
OrthoDBEOG7BW0KH.
PhylomeDBQ9BY42.
TreeFamTF314621.

Gene expression databases

ArrayExpressQ9BY42.
BgeeQ9BY42.
CleanExHS_C20orf43.
GenevestigatorQ9BY42.

Family and domain databases

InterProIPR006735. DUF602.
IPR027799. Rtf2_RING-finger.
[Graphical view]
PANTHERPTHR12775. PTHR12775. 1 hit.
PfamPF04641. Rtf2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSC20orf43. human.
GeneWikiC20orf43.
GenomeRNAi51507.
NextBio55194.

Entry information

Entry nameRTF2_HUMAN
AccessionPrimary (citable) accession number: Q9BY42
Secondary accession number(s): E1P5Z9 expand/collapse secondary AC list , Q9BYL7, Q9HCV9, Q9NX29, Q9NZZ8, Q9P002, Q9UHW3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM