Q9BY31 (ZN717_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 717

Alternative name(s):
Krueppel-like factor X17

Gene names

Name:

ZNF717

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	904 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 22 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AAK28319.1 differs from that shown. Reason: Frameshift at position 685.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 904	904	Zinc finger protein 717		PRO_0000333738
Regions
	Domain	15 – 86	72	KRAB
	Zinc finger	202 – 224	23	C2H2-type 1; degenerate
	Zinc finger	259 – 270	12	C2H2-type 2; degenerate
	Zinc finger	276 – 298	23	C2H2-type 3; degenerate
	Zinc finger	304 – 326	23	C2H2-type 4
	Zinc finger	332 – 354	23	C2H2-type 5
	Zinc finger	360 – 382	23	C2H2-type 6
	Zinc finger	388 – 410	23	C2H2-type 7
	Zinc finger	416 – 438	23	C2H2-type 8
	Zinc finger	444 – 466	23	C2H2-type 9
	Zinc finger	472 – 494	23	C2H2-type 10
	Zinc finger	500 – 522	23	C2H2-type 11
	Zinc finger	528 – 550	23	C2H2-type 12
	Zinc finger	556 – 578	23	C2H2-type 13
	Zinc finger	584 – 606	23	C2H2-type 14
	Zinc finger	612 – 634	23	C2H2-type 15
	Zinc finger	642 – 659	18	C2H2-type 16; degenerate
	Zinc finger	731 – 742	12	C2H2-type 17; degenerate
	Zinc finger	748 – 770	23	C2H2-type 18
	Zinc finger	776 – 798	23	C2H2-type 19
	Zinc finger	804 – 826	23	C2H2-type 20
	Zinc finger	832 – 854	23	C2H2-type 21
	Zinc finger	860 – 882	23	C2H2-type 22
Natural variations
	Natural variant	432	1	T → I. Corresponds to variant rs6686263 [ dbSNP | Ensembl ].		VAR_059932
Experimental info
	Sequence conflict	664	1	R → H in AAK28319. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9BY31 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: 8740B06833A76B4A	FASTA	904	105,251
	10 20 30 40 50 60 MLETYNSLVS LQELVSFEEV AVHFTWEEWQ DLDDAQRTLY RDVMLETYSS LVSLGHCITK 70 80 90 100 110 120 PEMIFKLEQG AEPWIVEETP NLRLSAVQII DDLIERSHES HDRFFWQIVI TNSNTSTQER 130 140 150 160 170 180 VELGKTFNLN SNHVLNLIIN NGNSSGMKPG QFNDCQNMLF PIKPGETQSG EKPHVCDITR 190 200 210 220 230 240 RSHRHHEHLT QHHKIQTLLQ TFQCNEQGKT FNTEAMFFIH KRVHIVQTFG KYNEYEKACN 250 260 270 280 290 300 NSAVIVQVIT QVGQPTCCRK SDFTKHQQTH TGEKPYECVE CEKPSISKSD LMLQCKMPTE 310 320 330 340 350 360 EKPYACNWCE KLFSYKSSLI IHQRIHTGEK PYGCNECGKT FRRKSFLTLH ERTHTGDKPY 370 380 390 400 410 420 KCIECGKTFH CKSLLTLHHR THSGEKPYQC SECGKTFSQK SYLTIHHRTH TGEKPYACDH 430 440 450 460 470 480 CEEAFSHKSR LTVHQRTHTG EKPYECNECG KPFINKSNLR LHQRTHTGEK PYECNECGKT 490 500 510 520 530 540 FHRKSFLTIH QWTHTGEKPY ECNECGKTFR CKSFLTVHQR THAGEKPYAC NECGKTYSHK 550 560 570 580 590 600 SYLTVHHRTH TGEKPYECNE CGKSFHCKSF LTIHQRTHAG KKPYECNECE KTFINKLNLG 610 620 630 640 650 660 IHKITHTGER PYECNECGKT FRQKSNLSTH QGTHTGEKPY VCGKTFHRKS FLTIHQRTHT 670 680 690 700 710 720 GKNRMDVMNV EKLFVRNHTL LYIRELTPGK SPMNVMNVEN PFIRRQIFRS IKVFTRGRNP 730 740 750 760 770 780 MNVANVEKPC QKSVLTVHHR THTGEKPYEC NECGKTFCHK SNLSTHQGTH SGEKPYECDE 790 800 810 820 830 840 CRKTFYDKTV LTIHQRTHTG EKPFECKECR KTFSQKSKLF VHHRTHTGEK PFRCNECRKT 850 860 870 880 890 900 FSQKSGLSIH QRTHTGEKPY ECKECGKTFC QKSHLSRHQQ THIGEKSDVA EAGYVFPQNH SFFP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Identification of C2H2 zinc finger factor sequences in human heart." Brand N.J., Mullen A.J., Barton P.J.R. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 386-689. Tissue: Muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC108724 Genomic DNA. No translation available. AC133123 Genomic DNA. No translation available. AF226994 mRNA. Translation: AAK28319.1. Frameshift.
IPI	IPI00737799.
UniGene	Hs.556877.
3D structure databases
HSSP	HSSP built from PDB template 1XF7 based on UniProtKB P19544.
ProteinModelPortal	Q9BY31.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BY31. 1 interaction.
STRING	9606.ENSP00000383643.
PTM databases
PhosphoSite	Q9BY31.
Polymorphism databases
DMDM	189041707.
Proteomic databases
PaxDb	Q9BY31.
PRIDE	Q9BY31.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000400845; ENSP00000383643; ENSG00000227124.
Organism-specific databases
GeneCards	GC03M075758.
HGNC	HGNC:29448. ZNF717.
neXtProt	NX_Q9BY31.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOVERGEN	HBG018163.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q9BY31.
Bgee	Q9BY31.
CleanEx	HS_ZNF717.
Genevestigator	Q9BY31.
Family and domain databases
Gene3D	3.30.160.60. 21 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 19 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 17 hits. PS50157. ZINC_FINGER_C2H2_2. 19 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ZN717_HUMAN

Accession

Primary (citable) accession number: Q9BY31

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	May 1, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.