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Q9BY31

- ZN717_HUMAN

UniProt

Q9BY31 - ZN717_HUMAN

Protein

Zinc finger protein 717

Gene

ZNF717

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri202 – 22423C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri259 – 27012C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 29823C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri332 – 35423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri360 – 38223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri388 – 41023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri416 – 43823C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri444 – 46623C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri472 – 49423C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri500 – 52223C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri528 – 55023C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri556 – 57823C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri584 – 60623C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri612 – 63423C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri642 – 65918C2H2-type 16; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri731 – 74212C2H2-type 17; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri748 – 77023C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri776 – 79823C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri804 – 82623C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri832 – 85423C2H2-type 21PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri860 – 88223C2H2-type 22PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 717
    Alternative name(s):
    Krueppel-like factor X17
    Gene namesi
    Name:ZNF717
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:29448. ZNF717.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 904904Zinc finger protein 717PRO_0000333738Add
    BLAST

    Proteomic databases

    PaxDbiQ9BY31.
    PRIDEiQ9BY31.

    PTM databases

    PhosphoSiteiQ9BY31.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BY31.
    BgeeiQ9BY31.
    CleanExiHS_ZNF717.
    GenevestigatoriQ9BY31.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9BY31. 1 interaction.
    STRINGi9606.ENSP00000383643.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BY31.
    SMRiQ9BY31. Positions 172-886.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 8672KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 22 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri202 – 22423C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri259 – 27012C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 29823C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri332 – 35423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri360 – 38223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri388 – 41023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri416 – 43823C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri444 – 46623C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri472 – 49423C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri500 – 52223C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri528 – 55023C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri556 – 57823C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri584 – 60623C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri612 – 63423C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri642 – 65918C2H2-type 16; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri731 – 74212C2H2-type 17; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri748 – 77023C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri776 – 79823C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri804 – 82623C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri832 – 85423C2H2-type 21PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri860 – 88223C2H2-type 22PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG018163.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9BY31.

    Family and domain databases

    Gene3Di3.30.160.60. 21 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 19 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 17 hits.
    PS50157. ZINC_FINGER_C2H2_2. 19 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BY31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLETYNSLVS LQELVSFEEV AVHFTWEEWQ DLDDAQRTLY RDVMLETYSS    50
    LVSLGHCITK PEMIFKLEQG AEPWIVEETP NLRLSAVQII DDLIERSHES 100
    HDRFFWQIVI TNSNTSTQER VELGKTFNLN SNHVLNLIIN NGNSSGMKPG 150
    QFNDCQNMLF PIKPGETQSG EKPHVCDITR RSHRHHEHLT QHHKIQTLLQ 200
    TFQCNEQGKT FNTEAMFFIH KRVHIVQTFG KYNEYEKACN NSAVIVQVIT 250
    QVGQPTCCRK SDFTKHQQTH TGEKPYECVE CEKPSISKSD LMLQCKMPTE 300
    EKPYACNWCE KLFSYKSSLI IHQRIHTGEK PYGCNECGKT FRRKSFLTLH 350
    ERTHTGDKPY KCIECGKTFH CKSLLTLHHR THSGEKPYQC SECGKTFSQK 400
    SYLTIHHRTH TGEKPYACDH CEEAFSHKSR LTVHQRTHTG EKPYECNECG 450
    KPFINKSNLR LHQRTHTGEK PYECNECGKT FHRKSFLTIH QWTHTGEKPY 500
    ECNECGKTFR CKSFLTVHQR THAGEKPYAC NECGKTYSHK SYLTVHHRTH 550
    TGEKPYECNE CGKSFHCKSF LTIHQRTHAG KKPYECNECE KTFINKLNLG 600
    IHKITHTGER PYECNECGKT FRQKSNLSTH QGTHTGEKPY VCGKTFHRKS 650
    FLTIHQRTHT GKNRMDVMNV EKLFVRNHTL LYIRELTPGK SPMNVMNVEN 700
    PFIRRQIFRS IKVFTRGRNP MNVANVEKPC QKSVLTVHHR THTGEKPYEC 750
    NECGKTFCHK SNLSTHQGTH SGEKPYECDE CRKTFYDKTV LTIHQRTHTG 800
    EKPFECKECR KTFSQKSKLF VHHRTHTGEK PFRCNECRKT FSQKSGLSIH 850
    QRTHTGEKPY ECKECGKTFC QKSHLSRHQQ THIGEKSDVA EAGYVFPQNH 900
    SFFP 904
    Length:904
    Mass (Da):105,251
    Last modified:May 20, 2008 - v2
    Checksum:i8740B06833A76B4A
    GO

    Sequence cautioni

    The sequence AAK28319.1 differs from that shown. Reason: Frameshift at position 685.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti664 – 6641R → H in AAK28319. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti432 – 4321T → I.
    Corresponds to variant rs6686263 [ dbSNP | Ensembl ].
    VAR_059932

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC108724 Genomic DNA. No translation available.
    AC133123 Genomic DNA. No translation available.
    AF226994 mRNA. Translation: AAK28319.1. Frameshift.
    UniGeneiHs.556877.

    Genome annotation databases

    EnsembliENST00000400845; ENSP00000383643; ENSG00000227124.

    Polymorphism databases

    DMDMi189041707.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC108724 Genomic DNA. No translation available.
    AC133123 Genomic DNA. No translation available.
    AF226994 mRNA. Translation: AAK28319.1 . Frameshift.
    UniGenei Hs.556877.

    3D structure databases

    ProteinModelPortali Q9BY31.
    SMRi Q9BY31. Positions 172-886.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9BY31. 1 interaction.
    STRINGi 9606.ENSP00000383643.

    PTM databases

    PhosphoSitei Q9BY31.

    Polymorphism databases

    DMDMi 189041707.

    Proteomic databases

    PaxDbi Q9BY31.
    PRIDEi Q9BY31.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000400845 ; ENSP00000383643 ; ENSG00000227124 .

    Organism-specific databases

    GeneCardsi GC03M075758.
    HGNCi HGNC:29448. ZNF717.
    neXtProti NX_Q9BY31.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG018163.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9BY31.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    PROi Q9BY31.

    Gene expression databases

    ArrayExpressi Q9BY31.
    Bgeei Q9BY31.
    CleanExi HS_ZNF717.
    Genevestigatori Q9BY31.

    Family and domain databases

    Gene3Di 3.30.160.60. 21 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 19 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 17 hits.
    PS50157. ZINC_FINGER_C2H2_2. 19 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Identification of C2H2 zinc finger factor sequences in human heart."
      Brand N.J., Mullen A.J., Barton P.J.R.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 386-689.
      Tissue: Muscle.

    Entry informationi

    Entry nameiZN717_HUMAN
    AccessioniPrimary (citable) accession number: Q9BY31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3