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Q9BY31 (ZN717_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 717
Alternative name(s):
Krueppel-like factor X17
Gene names
Name:ZNF717
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length904 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation By similarity.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 22 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AAK28319.1 differs from that shown. Reason: Frameshift at position 685.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 904904Zinc finger protein 717
PRO_0000333738

Regions

Domain15 – 8672KRAB
Zinc finger202 – 22423C2H2-type 1; degenerate
Zinc finger259 – 27012C2H2-type 2; degenerate
Zinc finger276 – 29823C2H2-type 3; degenerate
Zinc finger304 – 32623C2H2-type 4
Zinc finger332 – 35423C2H2-type 5
Zinc finger360 – 38223C2H2-type 6
Zinc finger388 – 41023C2H2-type 7
Zinc finger416 – 43823C2H2-type 8
Zinc finger444 – 46623C2H2-type 9
Zinc finger472 – 49423C2H2-type 10
Zinc finger500 – 52223C2H2-type 11
Zinc finger528 – 55023C2H2-type 12
Zinc finger556 – 57823C2H2-type 13
Zinc finger584 – 60623C2H2-type 14
Zinc finger612 – 63423C2H2-type 15
Zinc finger642 – 65918C2H2-type 16; degenerate
Zinc finger731 – 74212C2H2-type 17; degenerate
Zinc finger748 – 77023C2H2-type 18
Zinc finger776 – 79823C2H2-type 19
Zinc finger804 – 82623C2H2-type 20
Zinc finger832 – 85423C2H2-type 21
Zinc finger860 – 88223C2H2-type 22

Natural variations

Natural variant4321T → I.
Corresponds to variant rs6686263 [ dbSNP | Ensembl ].
VAR_059932

Experimental info

Sequence conflict6641R → H in AAK28319. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9BY31 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 8740B06833A76B4A

FASTA904105,251
        10         20         30         40         50         60 
MLETYNSLVS LQELVSFEEV AVHFTWEEWQ DLDDAQRTLY RDVMLETYSS LVSLGHCITK 

        70         80         90        100        110        120 
PEMIFKLEQG AEPWIVEETP NLRLSAVQII DDLIERSHES HDRFFWQIVI TNSNTSTQER 

       130        140        150        160        170        180 
VELGKTFNLN SNHVLNLIIN NGNSSGMKPG QFNDCQNMLF PIKPGETQSG EKPHVCDITR 

       190        200        210        220        230        240 
RSHRHHEHLT QHHKIQTLLQ TFQCNEQGKT FNTEAMFFIH KRVHIVQTFG KYNEYEKACN 

       250        260        270        280        290        300 
NSAVIVQVIT QVGQPTCCRK SDFTKHQQTH TGEKPYECVE CEKPSISKSD LMLQCKMPTE 

       310        320        330        340        350        360 
EKPYACNWCE KLFSYKSSLI IHQRIHTGEK PYGCNECGKT FRRKSFLTLH ERTHTGDKPY 

       370        380        390        400        410        420 
KCIECGKTFH CKSLLTLHHR THSGEKPYQC SECGKTFSQK SYLTIHHRTH TGEKPYACDH 

       430        440        450        460        470        480 
CEEAFSHKSR LTVHQRTHTG EKPYECNECG KPFINKSNLR LHQRTHTGEK PYECNECGKT 

       490        500        510        520        530        540 
FHRKSFLTIH QWTHTGEKPY ECNECGKTFR CKSFLTVHQR THAGEKPYAC NECGKTYSHK 

       550        560        570        580        590        600 
SYLTVHHRTH TGEKPYECNE CGKSFHCKSF LTIHQRTHAG KKPYECNECE KTFINKLNLG 

       610        620        630        640        650        660 
IHKITHTGER PYECNECGKT FRQKSNLSTH QGTHTGEKPY VCGKTFHRKS FLTIHQRTHT 

       670        680        690        700        710        720 
GKNRMDVMNV EKLFVRNHTL LYIRELTPGK SPMNVMNVEN PFIRRQIFRS IKVFTRGRNP 

       730        740        750        760        770        780 
MNVANVEKPC QKSVLTVHHR THTGEKPYEC NECGKTFCHK SNLSTHQGTH SGEKPYECDE 

       790        800        810        820        830        840 
CRKTFYDKTV LTIHQRTHTG EKPFECKECR KTFSQKSKLF VHHRTHTGEK PFRCNECRKT 

       850        860        870        880        890        900 
FSQKSGLSIH QRTHTGEKPY ECKECGKTFC QKSHLSRHQQ THIGEKSDVA EAGYVFPQNH 


SFFP 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Identification of C2H2 zinc finger factor sequences in human heart."
Brand N.J., Mullen A.J., Barton P.J.R.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 386-689.
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC108724 Genomic DNA. No translation available.
AC133123 Genomic DNA. No translation available.
AF226994 mRNA. Translation: AAK28319.1. Frameshift.
UniGeneHs.556877.

3D structure databases

ProteinModelPortalQ9BY31.
SMRQ9BY31. Positions 10-63, 184-886.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9BY31. 1 interaction.
STRING9606.ENSP00000383643.

PTM databases

PhosphoSiteQ9BY31.

Polymorphism databases

DMDM189041707.

Proteomic databases

PaxDbQ9BY31.
PRIDEQ9BY31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000400845; ENSP00000383643; ENSG00000227124.

Organism-specific databases

GeneCardsGC03M075758.
HGNCHGNC:29448. ZNF717.
neXtProtNX_Q9BY31.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG018163.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9BY31.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9BY31.
BgeeQ9BY31.
CleanExHS_ZNF717.
GenevestigatorQ9BY31.

Family and domain databases

Gene3D3.30.160.60. 21 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ9BY31.

Entry information

Entry nameZN717_HUMAN
AccessionPrimary (citable) accession number: Q9BY31
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM