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Q9BY31

- ZN717_HUMAN

UniProt

Q9BY31 - ZN717_HUMAN

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Protein

Zinc finger protein 717

Gene

ZNF717

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri202 – 22423C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 27012C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri500 – 52223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri556 – 57823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri584 – 60623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri612 – 63423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri642 – 65918C2H2-type 16; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri731 – 74212C2H2-type 17; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri748 – 77023C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri776 – 79823C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri804 – 82623C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri832 – 85423C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri860 – 88223C2H2-type 22PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 717
Alternative name(s):
Krueppel-like factor X17
Gene namesi
Name:ZNF717
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:29448. ZNF717.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 904904Zinc finger protein 717PRO_0000333738Add
BLAST

Proteomic databases

PaxDbiQ9BY31.
PRIDEiQ9BY31.

PTM databases

PhosphoSiteiQ9BY31.

Expressioni

Gene expression databases

BgeeiQ9BY31.
CleanExiHS_ZNF717.
GenevestigatoriQ9BY31.

Interactioni

Protein-protein interaction databases

IntActiQ9BY31. 1 interaction.
STRINGi9606.ENSP00000383643.

Structurei

3D structure databases

ProteinModelPortaliQ9BY31.
SMRiQ9BY31. Positions 172-886.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 8672KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 22 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri202 – 22423C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 27012C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri500 – 52223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri556 – 57823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri584 – 60623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri612 – 63423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri642 – 65918C2H2-type 16; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri731 – 74212C2H2-type 17; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri748 – 77023C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri776 – 79823C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri804 – 82623C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri832 – 85423C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri860 – 88223C2H2-type 22PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG018163.
InParanoidiQ9BY31.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9BY31.

Family and domain databases

Gene3Di3.30.160.60. 21 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BY31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLETYNSLVS LQELVSFEEV AVHFTWEEWQ DLDDAQRTLY RDVMLETYSS
60 70 80 90 100
LVSLGHCITK PEMIFKLEQG AEPWIVEETP NLRLSAVQII DDLIERSHES
110 120 130 140 150
HDRFFWQIVI TNSNTSTQER VELGKTFNLN SNHVLNLIIN NGNSSGMKPG
160 170 180 190 200
QFNDCQNMLF PIKPGETQSG EKPHVCDITR RSHRHHEHLT QHHKIQTLLQ
210 220 230 240 250
TFQCNEQGKT FNTEAMFFIH KRVHIVQTFG KYNEYEKACN NSAVIVQVIT
260 270 280 290 300
QVGQPTCCRK SDFTKHQQTH TGEKPYECVE CEKPSISKSD LMLQCKMPTE
310 320 330 340 350
EKPYACNWCE KLFSYKSSLI IHQRIHTGEK PYGCNECGKT FRRKSFLTLH
360 370 380 390 400
ERTHTGDKPY KCIECGKTFH CKSLLTLHHR THSGEKPYQC SECGKTFSQK
410 420 430 440 450
SYLTIHHRTH TGEKPYACDH CEEAFSHKSR LTVHQRTHTG EKPYECNECG
460 470 480 490 500
KPFINKSNLR LHQRTHTGEK PYECNECGKT FHRKSFLTIH QWTHTGEKPY
510 520 530 540 550
ECNECGKTFR CKSFLTVHQR THAGEKPYAC NECGKTYSHK SYLTVHHRTH
560 570 580 590 600
TGEKPYECNE CGKSFHCKSF LTIHQRTHAG KKPYECNECE KTFINKLNLG
610 620 630 640 650
IHKITHTGER PYECNECGKT FRQKSNLSTH QGTHTGEKPY VCGKTFHRKS
660 670 680 690 700
FLTIHQRTHT GKNRMDVMNV EKLFVRNHTL LYIRELTPGK SPMNVMNVEN
710 720 730 740 750
PFIRRQIFRS IKVFTRGRNP MNVANVEKPC QKSVLTVHHR THTGEKPYEC
760 770 780 790 800
NECGKTFCHK SNLSTHQGTH SGEKPYECDE CRKTFYDKTV LTIHQRTHTG
810 820 830 840 850
EKPFECKECR KTFSQKSKLF VHHRTHTGEK PFRCNECRKT FSQKSGLSIH
860 870 880 890 900
QRTHTGEKPY ECKECGKTFC QKSHLSRHQQ THIGEKSDVA EAGYVFPQNH

SFFP
Length:904
Mass (Da):105,251
Last modified:May 20, 2008 - v2
Checksum:i8740B06833A76B4A
GO

Sequence cautioni

The sequence AAK28319.1 differs from that shown. Reason: Frameshift at position 685.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti664 – 6641R → H in AAK28319. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti432 – 4321T → I.
Corresponds to variant rs6686263 [ dbSNP | Ensembl ].
VAR_059932

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC108724 Genomic DNA. No translation available.
AC133123 Genomic DNA. No translation available.
AF226994 mRNA. Translation: AAK28319.1. Frameshift.
UniGeneiHs.556877.

Genome annotation databases

EnsembliENST00000400845; ENSP00000383643; ENSG00000227124.

Polymorphism databases

DMDMi189041707.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC108724 Genomic DNA. No translation available.
AC133123 Genomic DNA. No translation available.
AF226994 mRNA. Translation: AAK28319.1 . Frameshift.
UniGenei Hs.556877.

3D structure databases

ProteinModelPortali Q9BY31.
SMRi Q9BY31. Positions 172-886.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9BY31. 1 interaction.
STRINGi 9606.ENSP00000383643.

PTM databases

PhosphoSitei Q9BY31.

Polymorphism databases

DMDMi 189041707.

Proteomic databases

PaxDbi Q9BY31.
PRIDEi Q9BY31.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400845 ; ENSP00000383643 ; ENSG00000227124 .

Organism-specific databases

GeneCardsi GC03M075758.
HGNCi HGNC:29448. ZNF717.
neXtProti NX_Q9BY31.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOVERGENi HBG018163.
InParanoidi Q9BY31.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9BY31.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

PROi Q9BY31.

Gene expression databases

Bgeei Q9BY31.
CleanExi HS_ZNF717.
Genevestigatori Q9BY31.

Family and domain databases

Gene3Di 3.30.160.60. 21 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of C2H2 zinc finger factor sequences in human heart."
    Brand N.J., Mullen A.J., Barton P.J.R.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 386-689.
    Tissue: Muscle.

Entry informationi

Entry nameiZN717_HUMAN
AccessioniPrimary (citable) accession number: Q9BY31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3