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Q9BY31

- ZN717_HUMAN

UniProt

Q9BY31 - ZN717_HUMAN

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Protein
Zinc finger protein 717
Gene
ZNF717
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri202 – 22423C2H2-type 1; degenerate
Add
BLAST
Zinc fingeri259 – 27012C2H2-type 2; degenerate
Add
BLAST
Zinc fingeri276 – 29823C2H2-type 3; degenerate
Add
BLAST
Zinc fingeri304 – 32623C2H2-type 4
Add
BLAST
Zinc fingeri332 – 35423C2H2-type 5
Add
BLAST
Zinc fingeri360 – 38223C2H2-type 6
Add
BLAST
Zinc fingeri388 – 41023C2H2-type 7
Add
BLAST
Zinc fingeri416 – 43823C2H2-type 8
Add
BLAST
Zinc fingeri444 – 46623C2H2-type 9
Add
BLAST
Zinc fingeri472 – 49423C2H2-type 10
Add
BLAST
Zinc fingeri500 – 52223C2H2-type 11
Add
BLAST
Zinc fingeri528 – 55023C2H2-type 12
Add
BLAST
Zinc fingeri556 – 57823C2H2-type 13
Add
BLAST
Zinc fingeri584 – 60623C2H2-type 14
Add
BLAST
Zinc fingeri612 – 63423C2H2-type 15
Add
BLAST
Zinc fingeri642 – 65918C2H2-type 16; degenerate
Add
BLAST
Zinc fingeri731 – 74212C2H2-type 17; degenerate
Add
BLAST
Zinc fingeri748 – 77023C2H2-type 18
Add
BLAST
Zinc fingeri776 – 79823C2H2-type 19
Add
BLAST
Zinc fingeri804 – 82623C2H2-type 20
Add
BLAST
Zinc fingeri832 – 85423C2H2-type 21
Add
BLAST
Zinc fingeri860 – 88223C2H2-type 22
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 717
Alternative name(s):
Krueppel-like factor X17
Gene namesi
Name:ZNF717
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:29448. ZNF717.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 904904Zinc finger protein 717
PRO_0000333738Add
BLAST

Proteomic databases

PaxDbiQ9BY31.
PRIDEiQ9BY31.

PTM databases

PhosphoSiteiQ9BY31.

Expressioni

Gene expression databases

ArrayExpressiQ9BY31.
BgeeiQ9BY31.
CleanExiHS_ZNF717.
GenevestigatoriQ9BY31.

Interactioni

Protein-protein interaction databases

IntActiQ9BY31. 1 interaction.
STRINGi9606.ENSP00000383643.

Structurei

3D structure databases

ProteinModelPortaliQ9BY31.
SMRiQ9BY31. Positions 172-886.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 8672KRAB
Add
BLAST

Sequence similaritiesi

Contains 22 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG018163.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9BY31.

Family and domain databases

Gene3Di3.30.160.60. 21 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BY31-1 [UniParc]FASTAAdd to Basket

« Hide

MLETYNSLVS LQELVSFEEV AVHFTWEEWQ DLDDAQRTLY RDVMLETYSS    50
LVSLGHCITK PEMIFKLEQG AEPWIVEETP NLRLSAVQII DDLIERSHES 100
HDRFFWQIVI TNSNTSTQER VELGKTFNLN SNHVLNLIIN NGNSSGMKPG 150
QFNDCQNMLF PIKPGETQSG EKPHVCDITR RSHRHHEHLT QHHKIQTLLQ 200
TFQCNEQGKT FNTEAMFFIH KRVHIVQTFG KYNEYEKACN NSAVIVQVIT 250
QVGQPTCCRK SDFTKHQQTH TGEKPYECVE CEKPSISKSD LMLQCKMPTE 300
EKPYACNWCE KLFSYKSSLI IHQRIHTGEK PYGCNECGKT FRRKSFLTLH 350
ERTHTGDKPY KCIECGKTFH CKSLLTLHHR THSGEKPYQC SECGKTFSQK 400
SYLTIHHRTH TGEKPYACDH CEEAFSHKSR LTVHQRTHTG EKPYECNECG 450
KPFINKSNLR LHQRTHTGEK PYECNECGKT FHRKSFLTIH QWTHTGEKPY 500
ECNECGKTFR CKSFLTVHQR THAGEKPYAC NECGKTYSHK SYLTVHHRTH 550
TGEKPYECNE CGKSFHCKSF LTIHQRTHAG KKPYECNECE KTFINKLNLG 600
IHKITHTGER PYECNECGKT FRQKSNLSTH QGTHTGEKPY VCGKTFHRKS 650
FLTIHQRTHT GKNRMDVMNV EKLFVRNHTL LYIRELTPGK SPMNVMNVEN 700
PFIRRQIFRS IKVFTRGRNP MNVANVEKPC QKSVLTVHHR THTGEKPYEC 750
NECGKTFCHK SNLSTHQGTH SGEKPYECDE CRKTFYDKTV LTIHQRTHTG 800
EKPFECKECR KTFSQKSKLF VHHRTHTGEK PFRCNECRKT FSQKSGLSIH 850
QRTHTGEKPY ECKECGKTFC QKSHLSRHQQ THIGEKSDVA EAGYVFPQNH 900
SFFP 904
Length:904
Mass (Da):105,251
Last modified:May 20, 2008 - v2
Checksum:i8740B06833A76B4A
GO

Sequence cautioni

The sequence AAK28319.1 differs from that shown. Reason: Frameshift at position 685.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti432 – 4321T → I.
Corresponds to variant rs6686263 [ dbSNP | Ensembl ].
VAR_059932

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti664 – 6641R → H in AAK28319. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC108724 Genomic DNA. No translation available.
AC133123 Genomic DNA. No translation available.
AF226994 mRNA. Translation: AAK28319.1. Frameshift.
UniGeneiHs.556877.

Genome annotation databases

EnsembliENST00000400845; ENSP00000383643; ENSG00000227124.

Polymorphism databases

DMDMi189041707.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC108724 Genomic DNA. No translation available.
AC133123 Genomic DNA. No translation available.
AF226994 mRNA. Translation: AAK28319.1 . Frameshift.
UniGenei Hs.556877.

3D structure databases

ProteinModelPortali Q9BY31.
SMRi Q9BY31. Positions 172-886.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9BY31. 1 interaction.
STRINGi 9606.ENSP00000383643.

PTM databases

PhosphoSitei Q9BY31.

Polymorphism databases

DMDMi 189041707.

Proteomic databases

PaxDbi Q9BY31.
PRIDEi Q9BY31.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400845 ; ENSP00000383643 ; ENSG00000227124 .

Organism-specific databases

GeneCardsi GC03M075758.
HGNCi HGNC:29448. ZNF717.
neXtProti NX_Q9BY31.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOVERGENi HBG018163.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9BY31.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

PROi Q9BY31.

Gene expression databases

ArrayExpressi Q9BY31.
Bgeei Q9BY31.
CleanExi HS_ZNF717.
Genevestigatori Q9BY31.

Family and domain databases

Gene3Di 3.30.160.60. 21 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of C2H2 zinc finger factor sequences in human heart."
    Brand N.J., Mullen A.J., Barton P.J.R.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 386-689.
    Tissue: Muscle.

Entry informationi

Entry nameiZN717_HUMAN
AccessioniPrimary (citable) accession number: Q9BY31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 3, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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