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Protein

Zinc finger protein 717

Gene

ZNF717

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri202 – 224C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 270C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST12
Zinc fingeri276 – 298C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri584 – 606C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri612 – 634C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 659C2H2-type 16; degeneratePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri731 – 742C2H2-type 17; degeneratePROSITE-ProRule annotationAdd BLAST12
Zinc fingeri748 – 770C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri776 – 798C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri804 – 826C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri832 – 854C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri860 – 882C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 717
Alternative name(s):
Krueppel-like factor X17
Gene namesi
Name:ZNF717
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29448 ZNF717
neXtProtiNX_Q9BY31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi189041707

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003337381 – 904Zinc finger protein 717Add BLAST904

Proteomic databases

PaxDbiQ9BY31
PeptideAtlasiQ9BY31
PRIDEiQ9BY31
ProteomicsDBi79571

PTM databases

iPTMnetiQ9BY31
PhosphoSitePlusiQ9BY31

Expressioni

Gene expression databases

CleanExiHS_ZNF717

Interactioni

Protein-protein interaction databases

IntActiQ9BY31, 1 interactor
STRINGi9606.ENSP00000409514

Structurei

3D structure databases

ProteinModelPortaliQ9BY31
SMRiQ9BY31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 86KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri202 – 224C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 270C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST12
Zinc fingeri276 – 298C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri584 – 606C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri612 – 634C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 659C2H2-type 16; degeneratePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri731 – 742C2H2-type 17; degeneratePROSITE-ProRule annotationAdd BLAST12
Zinc fingeri748 – 770C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri776 – 798C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri804 – 826C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri832 – 854C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri860 – 882C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOVERGENiHBG018163
InParanoidiQ9BY31
PhylomeDBiQ9BY31

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequencei

Sequence statusi: Complete.

Q9BY31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLETYNSLVS LQELVSFEEV AVHFTWEEWQ DLDDAQRTLY RDVMLETYSS
60 70 80 90 100
LVSLGHCITK PEMIFKLEQG AEPWIVEETP NLRLSAVQII DDLIERSHES
110 120 130 140 150
HDRFFWQIVI TNSNTSTQER VELGKTFNLN SNHVLNLIIN NGNSSGMKPG
160 170 180 190 200
QFNDCQNMLF PIKPGETQSG EKPHVCDITR RSHRHHEHLT QHHKIQTLLQ
210 220 230 240 250
TFQCNEQGKT FNTEAMFFIH KRVHIVQTFG KYNEYEKACN NSAVIVQVIT
260 270 280 290 300
QVGQPTCCRK SDFTKHQQTH TGEKPYECVE CEKPSISKSD LMLQCKMPTE
310 320 330 340 350
EKPYACNWCE KLFSYKSSLI IHQRIHTGEK PYGCNECGKT FRRKSFLTLH
360 370 380 390 400
ERTHTGDKPY KCIECGKTFH CKSLLTLHHR THSGEKPYQC SECGKTFSQK
410 420 430 440 450
SYLTIHHRTH TGEKPYACDH CEEAFSHKSR LTVHQRTHTG EKPYECNECG
460 470 480 490 500
KPFINKSNLR LHQRTHTGEK PYECNECGKT FHRKSFLTIH QWTHTGEKPY
510 520 530 540 550
ECNECGKTFR CKSFLTVHQR THAGEKPYAC NECGKTYSHK SYLTVHHRTH
560 570 580 590 600
TGEKPYECNE CGKSFHCKSF LTIHQRTHAG KKPYECNECE KTFINKLNLG
610 620 630 640 650
IHKITHTGER PYECNECGKT FRQKSNLSTH QGTHTGEKPY VCGKTFHRKS
660 670 680 690 700
FLTIHQRTHT GKNRMDVMNV EKLFVRNHTL LYIRELTPGK SPMNVMNVEN
710 720 730 740 750
PFIRRQIFRS IKVFTRGRNP MNVANVEKPC QKSVLTVHHR THTGEKPYEC
760 770 780 790 800
NECGKTFCHK SNLSTHQGTH SGEKPYECDE CRKTFYDKTV LTIHQRTHTG
810 820 830 840 850
EKPFECKECR KTFSQKSKLF VHHRTHTGEK PFRCNECRKT FSQKSGLSIH
860 870 880 890 900
QRTHTGEKPY ECKECGKTFC QKSHLSRHQQ THIGEKSDVA EAGYVFPQNH

SFFP
Length:904
Mass (Da):105,251
Last modified:May 20, 2008 - v2
Checksum:i8740B06833A76B4A
GO

Sequence cautioni

The sequence AAK28319 differs from that shown. Reason: Frameshift at position 685.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti664R → H in AAK28319 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108724 Genomic DNA No translation available.
AC133123 Genomic DNA No translation available.
AF226994 mRNA Translation: AAK28319.1 Frameshift.
UniGeneiHs.556877

Genome annotation databases

EnsembliENST00000400845; ENSP00000383643; ENSG00000227124

Similar proteinsi

Entry informationi

Entry nameiZN717_HUMAN
AccessioniPrimary (citable) accession number: Q9BY31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 20, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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