ID   GPR87_HUMAN             Reviewed;         358 AA.
AC   Q9BY21; Q5KU35; Q96JZ8; Q9BXC2;
DT   03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   24-JAN-2024, entry version 173.
DE   RecName: Full=G-protein coupled receptor 87;
DE   AltName: Full=G-protein coupled receptor 95;
GN   Name=GPR87; Synonyms=GPR95; ORFNames=FKSG78;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RA   Urakawa I., Hirose M., Yamano S., Okazaki H.;
RT   "Probable G-protein coupled receptor.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11574155; DOI=10.1016/s0378-1119(01)00651-5;
RA   Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O.,
RA   Lewis T., Evans J.F., George S.R., O'Dowd B.F.;
RT   "Discovery and mapping of ten novel G protein-coupled receptor genes.";
RL   Gene 275:83-91(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11273702; DOI=10.1006/jmbi.2001.4520;
RA   Wittenberger T., Schaller H.C., Hellebrand S.;
RT   "An expressed sequence tag (EST) data mining strategy succeeding in the
RT   discovery of new G-protein coupled receptors.";
RL   J. Mol. Biol. 307:799-813(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Kaighin V.A., Martin A.L., Aronstam R.S.;
RT   "Isolation of cDNA coding for human orphan G protein receptor 87.";
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung, Testis, and Urinary bladder;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 13-358.
RC   TISSUE=Heart;
RA   Wang Y.-G., Gong L.;
RT   "Identification of FKSG78, a novel gene encoding a putative G-protein-
RT   coupled receptor.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=17905198; DOI=10.1016/j.bbrc.2007.09.063;
RA   Tabata K., Baba K., Shiraishi A., Ito M., Fujita N.;
RT   "The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic
RT   acid receptor.";
RL   Biochem. Biophys. Res. Commun. 363:861-866(2007).
RN   [10]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=19602589; DOI=10.1158/0008-5472.can-09-0621;
RA   Zhang Y., Qian Y., Lu W., Chen X.;
RT   "The G protein-coupled receptor 87 is necessary for p53-dependent cell
RT   survival in response to genotoxic stress.";
RL   Cancer Res. 69:6049-6056(2009).
RN   [11]
RP   VARIANT [LARGE SCALE ANALYSIS] TYR-191.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: Receptor for lysophosphatidic acid (LPA). Necessary for
CC       p53/TP53-dependent survival in response to DNA damage.
CC       {ECO:0000269|PubMed:17905198, ECO:0000269|PubMed:19602589}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in placenta and prostate. Weaker
CC       expression in thymus. Not expressed in thalamus, hippocampus, pons or
CC       cerebellum. Overexpressed in squamous cell carcinoma of the lung.
CC       {ECO:0000269|PubMed:17905198}.
CC   -!- INDUCTION: By expression of p53/TP53 and by DNA damage in a TP53-
CC       dependent manner. {ECO:0000269|PubMed:19602589}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK29069.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB031548; BAD83583.1; -; mRNA.
DR   EMBL; AF411114; AAL26485.1; -; mRNA.
DR   EMBL; AF237763; AAK01858.1; -; mRNA.
DR   EMBL; EU883576; ACG60650.1; -; mRNA.
DR   EMBL; AK027784; BAB55366.1; -; mRNA.
DR   EMBL; CH471052; EAW78808.1; -; Genomic_DNA.
DR   EMBL; BC009540; AAH09540.2; -; mRNA.
DR   EMBL; BC112941; AAI12942.1; -; mRNA.
DR   EMBL; BC117565; AAI17566.1; -; mRNA.
DR   EMBL; BC132888; AAI32889.1; -; mRNA.
DR   EMBL; BC132890; AAI32891.1; -; mRNA.
DR   EMBL; AF345566; AAK29069.1; ALT_INIT; mRNA.
DR   CCDS; CCDS3157.1; -.
DR   RefSeq; NP_076404.3; NM_023915.3.
DR   AlphaFoldDB; Q9BY21; -.
DR   SMR; Q9BY21; -.
DR   BioGRID; 119807; 1.
DR   IntAct; Q9BY21; 6.
DR   MINT; Q9BY21; -.
DR   STRING; 9606.ENSP00000260843; -.
DR   ChEMBL; CHEMBL4523915; -.
DR   GuidetoPHARMACOLOGY; 122; -.
DR   TCDB; 3.A.16.1.4; the endoplasmic reticular retrotranslocon (er-rt) family.
DR   GlyCosmos; Q9BY21; 4 sites, 1 glycan.
DR   GlyGen; Q9BY21; 4 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9BY21; -.
DR   PhosphoSitePlus; Q9BY21; -.
DR   BioMuta; GPR87; -.
DR   DMDM; 37537842; -.
DR   MassIVE; Q9BY21; -.
DR   PaxDb; 9606-ENSP00000260843; -.
DR   PeptideAtlas; Q9BY21; -.
DR   ProteomicsDB; 79569; -.
DR   Antibodypedia; 18298; 283 antibodies from 29 providers.
DR   DNASU; 53836; -.
DR   Ensembl; ENST00000260843.5; ENSP00000260843.4; ENSG00000138271.6.
DR   GeneID; 53836; -.
DR   KEGG; hsa:53836; -.
DR   MANE-Select; ENST00000260843.5; ENSP00000260843.4; NM_023915.4; NP_076404.3.
DR   UCSC; uc003eyt.4; human.
DR   AGR; HGNC:4538; -.
DR   CTD; 53836; -.
DR   DisGeNET; 53836; -.
DR   GeneCards; GPR87; -.
DR   HGNC; HGNC:4538; GPR87.
DR   HPA; ENSG00000138271; Tissue enhanced (esophagus, skin, vagina).
DR   MIM; 606379; gene.
DR   neXtProt; NX_Q9BY21; -.
DR   OpenTargets; ENSG00000138271; -.
DR   PharmGKB; PA28931; -.
DR   VEuPathDB; HostDB:ENSG00000138271; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01060000248592; -.
DR   HOGENOM; CLU_009579_8_2_1; -.
DR   InParanoid; Q9BY21; -.
DR   OMA; YINTCTF; -.
DR   OrthoDB; 5390357at2759; -.
DR   PhylomeDB; Q9BY21; -.
DR   TreeFam; TF330969; -.
DR   PathwayCommons; Q9BY21; -.
DR   SignaLink; Q9BY21; -.
DR   BioGRID-ORCS; 53836; 12 hits in 1144 CRISPR screens.
DR   ChiTaRS; GPR87; human.
DR   GeneWiki; GPR87; -.
DR   GenomeRNAi; 53836; -.
DR   Pharos; Q9BY21; Tchem.
DR   PRO; PR:Q9BY21; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q9BY21; Protein.
DR   Bgee; ENSG00000138271; Expressed in tongue squamous epithelium and 93 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd15969; 7tmA_GPR87; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR008109; P2Y13_rcpt.
DR   PANTHER; PTHR24233:SF8; G-PROTEIN COUPLED RECEPTOR 87; 1.
DR   PANTHER; PTHR24233; P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01735; P2Y13PRNCPTR.
DR   PRINTS; PR01157; P2YPURNOCPTR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9BY21; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..358
FT                   /note="G-protein coupled receptor 87"
FT                   /id="PRO_0000069595"
FT   TOPO_DOM        1..47
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..75
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        97..116
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..159
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..256
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        278..297
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        319..358
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        25
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        114..192
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         191
FT                   /note="D -> Y (in a colorectal cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_035760"
FT   VARIANT         205
FT                   /note="T -> M (in dbSNP:rs35521104)"
FT                   /id="VAR_055921"
FT   CONFLICT        154
FT                   /note="S -> N (in Ref. 5; BAB55366)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   358 AA;  41436 MW;  FDF157295BE5D10F CRC64;
     MGFNLTLAKL PNNELHGQES HNSGNRSDGP GKNTTLHNEF DTIVLPVLYL IIFVASILLN
     GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVH DAGFGPWYFK FILCRYTSVL
     FYANMYTSIV FLGLISIDRY LKVVKPFGDS RMYSITFTKV LSVCVWVIMA VLSLPNIILT
     NGQPTEDNIH DCSKLKSPLG VKWHTAVTYV NSCLFVAVLV ILIGCYIAIS RYIHKSSRQF
     ISQSSRKRKH NQSIRVVVAV FFTCFLPYHL CRIPFTFSHL DRLLDESAQK ILYYCKEITL
     FLSACNVCLD PIIYFFMCRS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR IYYDYTDV
//