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Q9BY21 (GPR87_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor 87
Alternative name(s):
G-protein coupled receptor 95
Gene names
Name:GPR87
Synonyms:GPR95
ORF Names:FKSG78
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Ref.9 Ref.10

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung. Ref.9

Induction

By expression of p53/TP53 and by DNA damage in a TP53-dependent manner. Ref.10

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAK29069.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358G-protein coupled receptor 87
PRO_0000069595

Regions

Topological domain1 – 4747Extracellular Potential
Transmembrane48 – 6821Helical; Name=1; Potential
Topological domain69 – 757Cytoplasmic Potential
Transmembrane76 – 9621Helical; Name=2; Potential
Topological domain97 – 11620Extracellular Potential
Transmembrane117 – 13721Helical; Name=3; Potential
Topological domain138 – 15922Cytoplasmic Potential
Transmembrane160 – 18021Helical; Name=4; Potential
Topological domain181 – 20828Extracellular Potential
Transmembrane209 – 22921Helical; Name=5; Potential
Topological domain230 – 25627Cytoplasmic Potential
Transmembrane257 – 27721Helical; Name=6; Potential
Topological domain278 – 29720Extracellular Potential
Transmembrane298 – 31821Helical; Name=7; Potential
Topological domain319 – 35840Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation251N-linked (GlcNAc...) Potential
Glycosylation331N-linked (GlcNAc...) Potential
Disulfide bond114 ↔ 192 By similarity

Natural variations

Natural variant1911D → Y in a colorectal cancer sample; somatic mutation. Ref.11
VAR_035760
Natural variant2051T → M.
Corresponds to variant rs35521104 [ dbSNP | Ensembl ].
VAR_055921

Experimental info

Sequence conflict1541S → N in BAB55366. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9BY21 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FDF157295BE5D10F

FASTA35841,436
        10         20         30         40         50         60 
MGFNLTLAKL PNNELHGQES HNSGNRSDGP GKNTTLHNEF DTIVLPVLYL IIFVASILLN 

        70         80         90        100        110        120 
GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVH DAGFGPWYFK FILCRYTSVL 

       130        140        150        160        170        180 
FYANMYTSIV FLGLISIDRY LKVVKPFGDS RMYSITFTKV LSVCVWVIMA VLSLPNIILT 

       190        200        210        220        230        240 
NGQPTEDNIH DCSKLKSPLG VKWHTAVTYV NSCLFVAVLV ILIGCYIAIS RYIHKSSRQF 

       250        260        270        280        290        300 
ISQSSRKRKH NQSIRVVVAV FFTCFLPYHL CRIPFTFSHL DRLLDESAQK ILYYCKEITL 

       310        320        330        340        350 
FLSACNVCLD PIIYFFMCRS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR IYYDYTDV 

« Hide

References

« Hide 'large scale' references
[1]"Probable G-protein coupled receptor."
Urakawa I., Hirose M., Yamano S., Okazaki H.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Discovery and mapping of ten novel G protein-coupled receptor genes."
Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors."
Wittenberger T., Schaller H.C., Hellebrand S.
J. Mol. Biol. 307:799-813(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Isolation of cDNA coding for human orphan G protein receptor 87."
Kaighin V.A., Martin A.L., Aronstam R.S.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung, Testis and Urinary bladder.
[8]"Identification of FKSG78, a novel gene encoding a putative G-protein-coupled receptor."
Wang Y.-G., Gong L.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-358.
Tissue: Heart.
[9]"The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor."
Tabata K., Baba K., Shiraishi A., Ito M., Fujita N.
Biochem. Biophys. Res. Commun. 363:861-866(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[10]"The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress."
Zhang Y., Qian Y., Lu W., Chen X.
Cancer Res. 69:6049-6056(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[11]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] TYR-191.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB031548 mRNA. Translation: BAD83583.1.
AF411114 mRNA. Translation: AAL26485.1.
AF237763 mRNA. Translation: AAK01858.1.
EU883576 mRNA. Translation: ACG60650.1.
AK027784 mRNA. Translation: BAB55366.1.
CH471052 Genomic DNA. Translation: EAW78808.1.
BC009540 mRNA. Translation: AAH09540.2.
BC112941 mRNA. Translation: AAI12942.1.
BC117565 mRNA. Translation: AAI17566.1.
BC132888 mRNA. Translation: AAI32889.1.
BC132890 mRNA. Translation: AAI32891.1.
AF345566 mRNA. Translation: AAK29069.1. Different initiation.
RefSeqNP_076404.3. NM_023915.3.
UniGeneHs.591292.

3D structure databases

ProteinModelPortalQ9BY21.
SMRQ9BY21. Positions 40-328.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY122.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9BY21.

Polymorphism databases

DMDM37537842.

Proteomic databases

PaxDbQ9BY21.
PRIDEQ9BY21.

Protocols and materials databases

DNASU53836.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000260843; ENSP00000260843; ENSG00000138271.
GeneID53836.
KEGGhsa:53836.
UCSCuc003eyt.2. human.

Organism-specific databases

CTD53836.
GeneCardsGC03M151012.
H-InvDBHIX0003778.
HGNCHGNC:4538. GPR87.
MIM606379. gene.
neXtProtNX_Q9BY21.
PharmGKBPA28931.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146234.
HOGENOMHOG000273884.
HOVERGENHBG108228.
InParanoidQ9BY21.
KOK08389.
OMAWIFFHIR.
OrthoDBEOG7RZ5Q4.
PhylomeDBQ9BY21.
TreeFamTF330969.

Gene expression databases

BgeeQ9BY21.
CleanExHS_GPR87.
GenevestigatorQ9BY21.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR87.
GenomeRNAi53836.
NextBio56178.
PROQ9BY21.
SOURCESearch...

Entry information

Entry nameGPR87_HUMAN
AccessionPrimary (citable) accession number: Q9BY21
Secondary accession number(s): Q5KU35, Q96JZ8, Q9BXC2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries