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Protein

G-protein coupled receptor 87

Gene

GPR87

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.2 Publications

GO - Molecular functioni

  1. G-protein coupled purinergic nucleotide receptor activity Source: GO_Central

GO - Biological processi

  1. G-protein coupled purinergic nucleotide receptor signaling pathway Source: GOC
  2. G-protein coupled receptor signaling pathway Source: GO_Central
  3. negative regulation of adenylate cyclase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 87
Alternative name(s):
G-protein coupled receptor 95
Gene namesi
Name:GPR87
Synonyms:GPR95
ORF Names:FKSG78
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4538. GPR87.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini69 – 757CytoplasmicSequence Analysis
Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini97 – 11620ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini138 – 15922CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini181 – 20828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini230 – 25627CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini278 – 29720ExtracellularSequence AnalysisAdd
BLAST
Transmembranei298 – 31821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini319 – 35840CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358G-protein coupled receptor 87PRO_0000069595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi114 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BY21.
PRIDEiQ9BY21.

PTM databases

PhosphoSiteiQ9BY21.

Expressioni

Tissue specificityi

Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.1 Publication

Inductioni

By expression of p53/TP53 and by DNA damage in a TP53-dependent manner.1 Publication

Gene expression databases

BgeeiQ9BY21.
CleanExiHS_GPR87.
GenevestigatoriQ9BY21.

Structurei

3D structure databases

ProteinModelPortaliQ9BY21.
SMRiQ9BY21. Positions 43-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146234.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ9BY21.
KOiK08389.
OMAiWIFFHIR.
OrthoDBiEOG7RZ5Q4.
PhylomeDBiQ9BY21.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BY21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFNLTLAKL PNNELHGQES HNSGNRSDGP GKNTTLHNEF DTIVLPVLYL
60 70 80 90 100
IIFVASILLN GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVH
110 120 130 140 150
DAGFGPWYFK FILCRYTSVL FYANMYTSIV FLGLISIDRY LKVVKPFGDS
160 170 180 190 200
RMYSITFTKV LSVCVWVIMA VLSLPNIILT NGQPTEDNIH DCSKLKSPLG
210 220 230 240 250
VKWHTAVTYV NSCLFVAVLV ILIGCYIAIS RYIHKSSRQF ISQSSRKRKH
260 270 280 290 300
NQSIRVVVAV FFTCFLPYHL CRIPFTFSHL DRLLDESAQK ILYYCKEITL
310 320 330 340 350
FLSACNVCLD PIIYFFMCRS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR

IYYDYTDV
Length:358
Mass (Da):41,436
Last modified:June 1, 2001 - v1
Checksum:iFDF157295BE5D10F
GO

Sequence cautioni

The sequence AAK29069.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541S → N in BAB55366 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti191 – 1911D → Y in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035760
Natural varianti205 – 2051T → M.
Corresponds to variant rs35521104 [ dbSNP | Ensembl ].
VAR_055921

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031548 mRNA. Translation: BAD83583.1.
AF411114 mRNA. Translation: AAL26485.1.
AF237763 mRNA. Translation: AAK01858.1.
EU883576 mRNA. Translation: ACG60650.1.
AK027784 mRNA. Translation: BAB55366.1.
CH471052 Genomic DNA. Translation: EAW78808.1.
BC009540 mRNA. Translation: AAH09540.2.
BC112941 mRNA. Translation: AAI12942.1.
BC117565 mRNA. Translation: AAI17566.1.
BC132888 mRNA. Translation: AAI32889.1.
BC132890 mRNA. Translation: AAI32891.1.
AF345566 mRNA. Translation: AAK29069.1. Different initiation.
CCDSiCCDS3157.1.
RefSeqiNP_076404.3. NM_023915.3.
UniGeneiHs.591292.

Genome annotation databases

EnsembliENST00000260843; ENSP00000260843; ENSG00000138271.
GeneIDi53836.
KEGGihsa:53836.
UCSCiuc003eyt.2. human.

Polymorphism databases

DMDMi37537842.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031548 mRNA. Translation: BAD83583.1.
AF411114 mRNA. Translation: AAL26485.1.
AF237763 mRNA. Translation: AAK01858.1.
EU883576 mRNA. Translation: ACG60650.1.
AK027784 mRNA. Translation: BAB55366.1.
CH471052 Genomic DNA. Translation: EAW78808.1.
BC009540 mRNA. Translation: AAH09540.2.
BC112941 mRNA. Translation: AAI12942.1.
BC117565 mRNA. Translation: AAI17566.1.
BC132888 mRNA. Translation: AAI32889.1.
BC132890 mRNA. Translation: AAI32891.1.
AF345566 mRNA. Translation: AAK29069.1. Different initiation.
CCDSiCCDS3157.1.
RefSeqiNP_076404.3. NM_023915.3.
UniGeneiHs.591292.

3D structure databases

ProteinModelPortaliQ9BY21.
SMRiQ9BY21. Positions 43-328.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi122.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9BY21.

Polymorphism databases

DMDMi37537842.

Proteomic databases

PaxDbiQ9BY21.
PRIDEiQ9BY21.

Protocols and materials databases

DNASUi53836.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260843; ENSP00000260843; ENSG00000138271.
GeneIDi53836.
KEGGihsa:53836.
UCSCiuc003eyt.2. human.

Organism-specific databases

CTDi53836.
GeneCardsiGC03M151012.
H-InvDBHIX0003778.
HGNCiHGNC:4538. GPR87.
MIMi606379. gene.
neXtProtiNX_Q9BY21.
PharmGKBiPA28931.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146234.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ9BY21.
KOiK08389.
OMAiWIFFHIR.
OrthoDBiEOG7RZ5Q4.
PhylomeDBiQ9BY21.
TreeFamiTF330969.

Miscellaneous databases

GeneWikiiGPR87.
GenomeRNAii53836.
NextBioi56178.
PROiQ9BY21.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BY21.
CleanExiHS_GPR87.
GenevestigatoriQ9BY21.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Probable G-protein coupled receptor."
    Urakawa I., Hirose M., Yamano S., Okazaki H.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Discovery and mapping of ten novel G protein-coupled receptor genes."
    Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
    Gene 275:83-91(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors."
    Wittenberger T., Schaller H.C., Hellebrand S.
    J. Mol. Biol. 307:799-813(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Isolation of cDNA coding for human orphan G protein receptor 87."
    Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung, Testis and Urinary bladder.
  8. "Identification of FKSG78, a novel gene encoding a putative G-protein-coupled receptor."
    Wang Y.-G., Gong L.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-358.
    Tissue: Heart.
  9. "The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor."
    Tabata K., Baba K., Shiraishi A., Ito M., Fujita N.
    Biochem. Biophys. Res. Commun. 363:861-866(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. "The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress."
    Zhang Y., Qian Y., Lu W., Chen X.
    Cancer Res. 69:6049-6056(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] TYR-191.

Entry informationi

Entry nameiGPR87_HUMAN
AccessioniPrimary (citable) accession number: Q9BY21
Secondary accession number(s): Q5KU35, Q96JZ8, Q9BXC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.