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Q9BY21

- GPR87_HUMAN

UniProt

Q9BY21 - GPR87_HUMAN

Protein

G-protein coupled receptor 87

Gene

GPR87

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.2 Publications

    GO - Molecular functioni

    1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro

    GO - Biological processi

    1. negative regulation of adenylate cyclase activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 87
    Alternative name(s):
    G-protein coupled receptor 95
    Gene namesi
    Name:GPR87
    Synonyms:GPR95
    ORF Names:FKSG78
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:4538. GPR87.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28931.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358G-protein coupled receptor 87PRO_0000069595Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 192PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9BY21.
    PRIDEiQ9BY21.

    PTM databases

    PhosphoSiteiQ9BY21.

    Expressioni

    Tissue specificityi

    Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.1 Publication

    Inductioni

    By expression of p53/TP53 and by DNA damage in a TP53-dependent manner.1 Publication

    Gene expression databases

    BgeeiQ9BY21.
    CleanExiHS_GPR87.
    GenevestigatoriQ9BY21.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BY21.
    SMRiQ9BY21. Positions 34-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini69 – 757CytoplasmicSequence Analysis
    Topological domaini97 – 11620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15922CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 20828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini230 – 25627CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini278 – 29720ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini319 – 35840CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 6821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146234.
    HOGENOMiHOG000273884.
    HOVERGENiHBG108228.
    InParanoidiQ9BY21.
    KOiK08389.
    OMAiWIFFHIR.
    OrthoDBiEOG7RZ5Q4.
    PhylomeDBiQ9BY21.
    TreeFamiTF330969.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008109. P2Y13_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01735. P2Y13PRNCPTR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BY21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFNLTLAKL PNNELHGQES HNSGNRSDGP GKNTTLHNEF DTIVLPVLYL    50
    IIFVASILLN GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVH 100
    DAGFGPWYFK FILCRYTSVL FYANMYTSIV FLGLISIDRY LKVVKPFGDS 150
    RMYSITFTKV LSVCVWVIMA VLSLPNIILT NGQPTEDNIH DCSKLKSPLG 200
    VKWHTAVTYV NSCLFVAVLV ILIGCYIAIS RYIHKSSRQF ISQSSRKRKH 250
    NQSIRVVVAV FFTCFLPYHL CRIPFTFSHL DRLLDESAQK ILYYCKEITL 300
    FLSACNVCLD PIIYFFMCRS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR 350
    IYYDYTDV 358
    Length:358
    Mass (Da):41,436
    Last modified:June 1, 2001 - v1
    Checksum:iFDF157295BE5D10F
    GO

    Sequence cautioni

    The sequence AAK29069.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541S → N in BAB55366. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti191 – 1911D → Y in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035760
    Natural varianti205 – 2051T → M.
    Corresponds to variant rs35521104 [ dbSNP | Ensembl ].
    VAR_055921

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031548 mRNA. Translation: BAD83583.1.
    AF411114 mRNA. Translation: AAL26485.1.
    AF237763 mRNA. Translation: AAK01858.1.
    EU883576 mRNA. Translation: ACG60650.1.
    AK027784 mRNA. Translation: BAB55366.1.
    CH471052 Genomic DNA. Translation: EAW78808.1.
    BC009540 mRNA. Translation: AAH09540.2.
    BC112941 mRNA. Translation: AAI12942.1.
    BC117565 mRNA. Translation: AAI17566.1.
    BC132888 mRNA. Translation: AAI32889.1.
    BC132890 mRNA. Translation: AAI32891.1.
    AF345566 mRNA. Translation: AAK29069.1. Different initiation.
    CCDSiCCDS3157.1.
    RefSeqiNP_076404.3. NM_023915.3.
    UniGeneiHs.591292.

    Genome annotation databases

    EnsembliENST00000260843; ENSP00000260843; ENSG00000138271.
    GeneIDi53836.
    KEGGihsa:53836.
    UCSCiuc003eyt.2. human.

    Polymorphism databases

    DMDMi37537842.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031548 mRNA. Translation: BAD83583.1 .
    AF411114 mRNA. Translation: AAL26485.1 .
    AF237763 mRNA. Translation: AAK01858.1 .
    EU883576 mRNA. Translation: ACG60650.1 .
    AK027784 mRNA. Translation: BAB55366.1 .
    CH471052 Genomic DNA. Translation: EAW78808.1 .
    BC009540 mRNA. Translation: AAH09540.2 .
    BC112941 mRNA. Translation: AAI12942.1 .
    BC117565 mRNA. Translation: AAI17566.1 .
    BC132888 mRNA. Translation: AAI32889.1 .
    BC132890 mRNA. Translation: AAI32891.1 .
    AF345566 mRNA. Translation: AAK29069.1 . Different initiation.
    CCDSi CCDS3157.1.
    RefSeqi NP_076404.3. NM_023915.3.
    UniGenei Hs.591292.

    3D structure databases

    ProteinModelPortali Q9BY21.
    SMRi Q9BY21. Positions 34-327.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 122.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9BY21.

    Polymorphism databases

    DMDMi 37537842.

    Proteomic databases

    PaxDbi Q9BY21.
    PRIDEi Q9BY21.

    Protocols and materials databases

    DNASUi 53836.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260843 ; ENSP00000260843 ; ENSG00000138271 .
    GeneIDi 53836.
    KEGGi hsa:53836.
    UCSCi uc003eyt.2. human.

    Organism-specific databases

    CTDi 53836.
    GeneCardsi GC03M151012.
    H-InvDB HIX0003778.
    HGNCi HGNC:4538. GPR87.
    MIMi 606379. gene.
    neXtProti NX_Q9BY21.
    PharmGKBi PA28931.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146234.
    HOGENOMi HOG000273884.
    HOVERGENi HBG108228.
    InParanoidi Q9BY21.
    KOi K08389.
    OMAi WIFFHIR.
    OrthoDBi EOG7RZ5Q4.
    PhylomeDBi Q9BY21.
    TreeFami TF330969.

    Miscellaneous databases

    GeneWikii GPR87.
    GenomeRNAii 53836.
    NextBioi 56178.
    PROi Q9BY21.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BY21.
    CleanExi HS_GPR87.
    Genevestigatori Q9BY21.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008109. P2Y13_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01735. P2Y13PRNCPTR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Probable G-protein coupled receptor."
      Urakawa I., Hirose M., Yamano S., Okazaki H.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Discovery and mapping of ten novel G protein-coupled receptor genes."
      Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F.
      Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors."
      Wittenberger T., Schaller H.C., Hellebrand S.
      J. Mol. Biol. 307:799-813(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Isolation of cDNA coding for human orphan G protein receptor 87."
      Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung, Testis and Urinary bladder.
    8. "Identification of FKSG78, a novel gene encoding a putative G-protein-coupled receptor."
      Wang Y.-G., Gong L.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-358.
      Tissue: Heart.
    9. "The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor."
      Tabata K., Baba K., Shiraishi A., Ito M., Fujita N.
      Biochem. Biophys. Res. Commun. 363:861-866(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    10. "The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress."
      Zhang Y., Qian Y., Lu W., Chen X.
      Cancer Res. 69:6049-6056(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    11. Cited for: VARIANT [LARGE SCALE ANALYSIS] TYR-191.

    Entry informationi

    Entry nameiGPR87_HUMAN
    AccessioniPrimary (citable) accession number: Q9BY21
    Secondary accession number(s): Q5KU35, Q96JZ8, Q9BXC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3