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Protein

G-protein coupled receptor 87

Gene

GPR87

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138271-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 87
Alternative name(s):
G-protein coupled receptor 95
Gene namesi
Name:GPR87
Synonyms:GPR95
ORF Names:FKSG78
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4538. GPR87.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 68Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini69 – 75CytoplasmicSequence analysis7
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 116ExtracellularSequence analysisAdd BLAST20
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 159CytoplasmicSequence analysisAdd BLAST22
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 208ExtracellularSequence analysisAdd BLAST28
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini230 – 256CytoplasmicSequence analysisAdd BLAST27
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 297ExtracellularSequence analysisAdd BLAST20
Transmembranei298 – 318Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini319 – 358CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53836.
OpenTargetsiENSG00000138271.
PharmGKBiPA28931.

Chemistry databases

GuidetoPHARMACOLOGYi122.

Polymorphism and mutation databases

BioMutaiGPR87.
DMDMi37537842.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695951 – 358G-protein coupled receptor 87Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Glycosylationi33N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BY21.
PeptideAtlasiQ9BY21.
PRIDEiQ9BY21.

PTM databases

iPTMnetiQ9BY21.
PhosphoSitePlusiQ9BY21.

Expressioni

Tissue specificityi

Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.1 Publication

Inductioni

By expression of p53/TP53 and by DNA damage in a TP53-dependent manner.1 Publication

Gene expression databases

BgeeiENSG00000138271.
CleanExiHS_GPR87.
GenevisibleiQ9BY21. HS.

Organism-specific databases

HPAiHPA066313.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000260843.

Structurei

3D structure databases

ProteinModelPortaliQ9BY21.
SMRiQ9BY21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE7G. Eukaryota.
ENOG410YEMD. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ9BY21.
KOiK08389.
OMAiWIFFHIR.
OrthoDBiEOG091G09RZ.
PhylomeDBiQ9BY21.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BY21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFNLTLAKL PNNELHGQES HNSGNRSDGP GKNTTLHNEF DTIVLPVLYL
60 70 80 90 100
IIFVASILLN GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVH
110 120 130 140 150
DAGFGPWYFK FILCRYTSVL FYANMYTSIV FLGLISIDRY LKVVKPFGDS
160 170 180 190 200
RMYSITFTKV LSVCVWVIMA VLSLPNIILT NGQPTEDNIH DCSKLKSPLG
210 220 230 240 250
VKWHTAVTYV NSCLFVAVLV ILIGCYIAIS RYIHKSSRQF ISQSSRKRKH
260 270 280 290 300
NQSIRVVVAV FFTCFLPYHL CRIPFTFSHL DRLLDESAQK ILYYCKEITL
310 320 330 340 350
FLSACNVCLD PIIYFFMCRS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR

IYYDYTDV
Length:358
Mass (Da):41,436
Last modified:June 1, 2001 - v1
Checksum:iFDF157295BE5D10F
GO

Sequence cautioni

The sequence AAK29069 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154S → N in BAB55366 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035760191D → Y in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_055921205T → M.Corresponds to variant rs35521104dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031548 mRNA. Translation: BAD83583.1.
AF411114 mRNA. Translation: AAL26485.1.
AF237763 mRNA. Translation: AAK01858.1.
EU883576 mRNA. Translation: ACG60650.1.
AK027784 mRNA. Translation: BAB55366.1.
CH471052 Genomic DNA. Translation: EAW78808.1.
BC009540 mRNA. Translation: AAH09540.2.
BC112941 mRNA. Translation: AAI12942.1.
BC117565 mRNA. Translation: AAI17566.1.
BC132888 mRNA. Translation: AAI32889.1.
BC132890 mRNA. Translation: AAI32891.1.
AF345566 mRNA. Translation: AAK29069.1. Different initiation.
CCDSiCCDS3157.1.
RefSeqiNP_076404.3. NM_023915.3.
UniGeneiHs.591292.

Genome annotation databases

EnsembliENST00000260843; ENSP00000260843; ENSG00000138271.
GeneIDi53836.
KEGGihsa:53836.
UCSCiuc003eyt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031548 mRNA. Translation: BAD83583.1.
AF411114 mRNA. Translation: AAL26485.1.
AF237763 mRNA. Translation: AAK01858.1.
EU883576 mRNA. Translation: ACG60650.1.
AK027784 mRNA. Translation: BAB55366.1.
CH471052 Genomic DNA. Translation: EAW78808.1.
BC009540 mRNA. Translation: AAH09540.2.
BC112941 mRNA. Translation: AAI12942.1.
BC117565 mRNA. Translation: AAI17566.1.
BC132888 mRNA. Translation: AAI32889.1.
BC132890 mRNA. Translation: AAI32891.1.
AF345566 mRNA. Translation: AAK29069.1. Different initiation.
CCDSiCCDS3157.1.
RefSeqiNP_076404.3. NM_023915.3.
UniGeneiHs.591292.

3D structure databases

ProteinModelPortaliQ9BY21.
SMRiQ9BY21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000260843.

Chemistry databases

GuidetoPHARMACOLOGYi122.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9BY21.
PhosphoSitePlusiQ9BY21.

Polymorphism and mutation databases

BioMutaiGPR87.
DMDMi37537842.

Proteomic databases

PaxDbiQ9BY21.
PeptideAtlasiQ9BY21.
PRIDEiQ9BY21.

Protocols and materials databases

DNASUi53836.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260843; ENSP00000260843; ENSG00000138271.
GeneIDi53836.
KEGGihsa:53836.
UCSCiuc003eyt.4. human.

Organism-specific databases

CTDi53836.
DisGeNETi53836.
GeneCardsiGPR87.
H-InvDBHIX0003778.
HGNCiHGNC:4538. GPR87.
HPAiHPA066313.
MIMi606379. gene.
neXtProtiNX_Q9BY21.
OpenTargetsiENSG00000138271.
PharmGKBiPA28931.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE7G. Eukaryota.
ENOG410YEMD. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ9BY21.
KOiK08389.
OMAiWIFFHIR.
OrthoDBiEOG091G09RZ.
PhylomeDBiQ9BY21.
TreeFamiTF330969.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138271-MONOMER.

Miscellaneous databases

GeneWikiiGPR87.
GenomeRNAii53836.
PROiQ9BY21.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138271.
CleanExiHS_GPR87.
GenevisibleiQ9BY21. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR87_HUMAN
AccessioniPrimary (citable) accession number: Q9BY21
Secondary accession number(s): Q5KU35, Q96JZ8, Q9BXC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.