Q9BY21 (GPR87_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein coupled receptor 87

Alternative name(s):
G-protein coupled receptor 95

Gene names

Name:	GPR87
Synonyms:	GPR95
ORF Names:	FKSG78

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Ref.9 Ref.10
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung. Ref.9
Induction	By expression of p53/TP53 and by DNA damage in a TP53-dependent manner. Ref.10
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence AAK29069.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	G-protein coupled receptor 87		PRO_0000069595
Regions
	Topological domain	1 – 47	47	Extracellular Potential
	Transmembrane	48 – 68	21	Helical; Name=1; Potential
	Topological domain	69 – 75	7	Cytoplasmic Potential
	Transmembrane	76 – 96	21	Helical; Name=2; Potential
	Topological domain	97 – 116	20	Extracellular Potential
	Transmembrane	117 – 137	21	Helical; Name=3; Potential
	Topological domain	138 – 159	22	Cytoplasmic Potential
	Transmembrane	160 – 180	21	Helical; Name=4; Potential
	Topological domain	181 – 208	28	Extracellular Potential
	Transmembrane	209 – 229	21	Helical; Name=5; Potential
	Topological domain	230 – 256	27	Cytoplasmic Potential
	Transmembrane	257 – 277	21	Helical; Name=6; Potential
	Topological domain	278 – 297	20	Extracellular Potential
	Transmembrane	298 – 318	21	Helical; Name=7; Potential
	Topological domain	319 – 358	40	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	25	1	N-linked (GlcNAc...) Potential
	Glycosylation	33	1	N-linked (GlcNAc...) Potential
	Disulfide bond	114 ↔ 192		By similarity
Natural variations
	Natural variant	191	1	D → Y in a colorectal cancer sample; somatic mutation. Ref.11		VAR_035760
	Natural variant	205	1	T → M. Corresponds to variant rs35521104 [ dbSNP | Ensembl ].		VAR_055921
Experimental info
	Sequence conflict	154	1	S → N in BAB55366. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q9BY21 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: FDF157295BE5D10F	FASTA	358	41,436
	10 20 30 40 50 60 MGFNLTLAKL PNNELHGQES HNSGNRSDGP GKNTTLHNEF DTIVLPVLYL IIFVASILLN 70 80 90 100 110 120 GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVH DAGFGPWYFK FILCRYTSVL 130 140 150 160 170 180 FYANMYTSIV FLGLISIDRY LKVVKPFGDS RMYSITFTKV LSVCVWVIMA VLSLPNIILT 190 200 210 220 230 240 NGQPTEDNIH DCSKLKSPLG VKWHTAVTYV NSCLFVAVLV ILIGCYIAIS RYIHKSSRQF 250 260 270 280 290 300 ISQSSRKRKH NQSIRVVVAV FFTCFLPYHL CRIPFTFSHL DRLLDESAQK ILYYCKEITL 310 320 330 340 350 FLSACNVCLD PIIYFFMCRS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR IYYDYTDV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Probable G-protein coupled receptor." Urakawa I., Hirose M., Yamano S., Okazaki H. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Discovery and mapping of ten novel G protein-coupled receptor genes." Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., Lewis T., Evans J.F., George S.R., O'Dowd B.F. Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors." Wittenberger T., Schaller H.C., Hellebrand S. J. Mol. Biol. 307:799-813(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Isolation of cDNA coding for human orphan G protein receptor 87." Kaighin V.A., Martin A.L., Aronstam R.S. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung, Testis and Urinary bladder.
[8]	"Identification of FKSG78, a novel gene encoding a putative G-protein-coupled receptor." Wang Y.-G., Gong L. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-358. Tissue: Heart.
[9]	"The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor." Tabata K., Baba K., Shiraishi A., Ito M., Fujita N. Biochem. Biophys. Res. Commun. 363:861-866(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[10]	"The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress." Zhang Y., Qian Y., Lu W., Chen X. Cancer Res. 69:6049-6056(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[11]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] TYR-191.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB031548 mRNA. Translation: BAD83583.1. AF411114 mRNA. Translation: AAL26485.1. AF237763 mRNA. Translation: AAK01858.1. EU883576 mRNA. Translation: ACG60650.1. AK027784 mRNA. Translation: BAB55366.1. CH471052 Genomic DNA. Translation: EAW78808.1. BC009540 mRNA. Translation: AAH09540.2. BC112941 mRNA. Translation: AAI12942.1. BC117565 mRNA. Translation: AAI17566.1. BC132888 mRNA. Translation: AAI32889.1. BC132890 mRNA. Translation: AAI32891.1. AF345566 mRNA. Translation: AAK29069.1. Different initiation.
IPI	IPI00306651.
RefSeq	NP_076404.3. NM_023915.3.
UniGene	Hs.591292.
3D structure databases
ProteinModelPortal	Q9BY21.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9BY21.
Polymorphism databases
DMDM	37537842.
Proteomic databases
PaxDb	Q9BY21.
PRIDE	Q9BY21.
Protocols and materials databases
DNASU	53836.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000260843; ENSP00000260843; ENSG00000138271.
GeneID	53836.
KEGG	hsa:53836.
UCSC	uc003eyt.2. human.
Organism-specific databases
CTD	53836.
GeneCards	GC03M151012.
H-InvDB	HIX0003778.
HGNC	HGNC:4538. GPR87.
MIM	606379. gene.
neXtProt	NX_Q9BY21.
PharmGKB	PA28931.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146234.
HOGENOM	HOG000273884.
HOVERGEN	HBG108228.
InParanoid	Q9BY21.
KO	K08389.
OMA	WIFFHIR.
OrthoDB	EOG490797.
PhylomeDB	Q9BY21.
Gene expression databases
Bgee	Q9BY21.
CleanEx	HS_GPR87.
Genevestigator	Q9BY21.
GermOnline	ENSG00000138271. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002286. P2_purnocptor. IPR008109. P2Y13_purnocptor. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01735. P2Y13PRNCPTR. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	53836.
NextBio	56178.
SOURCE	Search...

Entry information

Entry name

GPR87_HUMAN

Accession

Primary (citable) accession number: Q9BY21
Secondary accession number(s): Q5KU35, Q96JZ8, Q9BXC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.