Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BY15 (EMR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
EGF-like module-containing mucin-like hormone receptor-like 3
Alternative name(s):
EGF-like module receptor 3
Gene names
Name:EMR3
ORF Names:UNQ683/PRO1562
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length652 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated neutrophils.

Subunit structure

Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) By similarity.

Subcellular location

EGF-like module-containing mucin-like hormone receptor-like 3: Cell membrane; Multi-pass membrane protein.

EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta: Cell membrane; Multi-pass membrane protein.

EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha: Secretedextracellular space. Note: A soluble form is also detected (alpha subunit).

Isoform 3: Secreted.

Tissue specificity

Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages.

Post-translational modification

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 2 EGF-like domains.

Contains 1 GPS domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BY15-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BY15-2)

The sequence of this isoform differs from the canonical sequence as follows:
     67-118: Missing.
Isoform 3 (identifier: Q9BY15-3)

The sequence of this isoform differs from the canonical sequence as follows:
     67-652: Missing.
Note: Soluble form.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 652631EGF-like module-containing mucin-like hormone receptor-like 3
PRO_0000012876
Chain22 – 338317EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha By similarity
PRO_0000296239
Chain339 – 652314EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta By similarity
PRO_0000296240

Regions

Topological domain22 – 357336Extracellular Potential
Transmembrane358 – 37821Helical; Name=1; Potential
Topological domain379 – 38911Cytoplasmic Potential
Transmembrane390 – 41021Helical; Name=2; Potential
Topological domain411 – 4166Extracellular Potential
Transmembrane417 – 43721Helical; Name=3; Potential
Topological domain438 – 46427Cytoplasmic Potential
Transmembrane465 – 48521Helical; Name=4; Potential
Topological domain486 – 50823Extracellular Potential
Transmembrane509 – 52921Helical; Name=5; Potential
Topological domain530 – 55728Cytoplasmic Potential
Transmembrane558 – 57821Helical; Name=6; Potential
Topological domain579 – 5802Extracellular Potential
Transmembrane581 – 60121Helical; Name=7; Potential
Topological domain602 – 65251Cytoplasmic Potential
Domain24 – 6643EGF-like 1
Domain67 – 11852EGF-like 2; calcium-binding Potential
Domain301 – 35050GPS

Sites

Site338 – 3392Cleavage By similarity

Amino acid modifications

Glycosylation341N-linked (GlcNAc...) Potential
Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation1451N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation2021N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation2791N-linked (GlcNAc...) Potential
Glycosylation3271N-linked (GlcNAc...) Potential
Glycosylation3341N-linked (GlcNAc...) Potential
Disulfide bond28 ↔ 37 By similarity
Disulfide bond31 ↔ 43 By similarity
Disulfide bond45 ↔ 65 By similarity
Disulfide bond71 ↔ 85 By similarity
Disulfide bond79 ↔ 94 By similarity
Disulfide bond96 ↔ 117 By similarity

Natural variations

Alternative sequence67 – 652586Missing in isoform 3.
VSP_009418
Alternative sequence67 – 11852Missing in isoform 2.
VSP_009417
Natural variant1271E → Q. Ref.2
Corresponds to variant rs4606855 [ dbSNP | Ensembl ].
VAR_024472
Natural variant2361A → V.
Corresponds to variant rs34226397 [ dbSNP | Ensembl ].
VAR_055926
Natural variant3851R → Q. Ref.1 Ref.2
Corresponds to variant rs8102646 [ dbSNP | Ensembl ].
VAR_060442

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 60DCD73BB0DBEB74

FASTA65272,621
        10         20         30         40         50         60 
MQGPLLLPGL CFLLSLFGAV TQKTKTSCAK CPPNASCVNN THCTCNHGYT SGSGQKLFTF 

        70         80         90        100        110        120 
PLETCNDINE CTPPYSVYCG FNAVCYNVEG SFYCQCVPGY RLHSGNEQFS NSNENTCQDT 

       130        140        150        160        170        180 
TSSKTTEGRK ELQKIVDKFE SLLTNQTLWR TEGRQEISST ATTILRDVES KVLETALKDP 

       190        200        210        220        230        240 
EQKVLKIQND SVAIETQAIT DNCSEERKTF NLNVQMNSMD IRCSDIIQGD TQGPSAIAFI 

       250        260        270        280        290        300 
SYSSLGNIIN ATFFEEMDKK DQVYLNSQVV SAAIGPKRNV SLSKSVTLTF QHVKMTPSTK 

       310        320        330        340        350        360 
KVFCVYWKST GQGSQWSRDG CFLIHVNKSH TMCNCSHLSS FAVLMALTSQ EEDPVLTVIT 

       370        380        390        400        410        420 
YVGLSVSLLC LLLAALTFLL CKAIRNTSTS LHLQLSLCLF LAHLLFLVGI DRTEPKVLCS 

       430        440        450        460        470        480 
IIAGALHYLY LAAFTWMLLE GVHLFLTARN LTVVNYSSIN RLMKWIMFPV GYGVPAVTVA 

       490        500        510        520        530        540 
ISAASWPHLY GTADRCWLHL DQGFMWSFLG PVCAIFSANL VLFILVFWIL KRKLSSLNSE 

       550        560        570        580        590        600 
VSTIQNTRML AFKATAQLFI LGCTWCLGLL QVGPAAQVMA YLFTIINSLQ GFFIFLVYCL 

       610        620        630        640        650 
LSQQVQKQYQ KWFREIVKSK SESETYTLSS KMGPDSKPSE GDVFPGQVKR KY 

« Hide

Isoform 2 [UniParc].

Checksum: 44594300E1B4F0A5
Show »

FASTA60066,786
Isoform 3 [UniParc].

Checksum: 0351F055DA4FD7C7
Show »

FASTA666,996

References

« Hide 'large scale' references
[1]"Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils."
Stacey M., Lin H.-H., Hilyard K.L., Gordon S., McKnight A.J.
J. Biol. Chem. 276:18863-18870(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-385.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLN-127 AND GLN-385.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF239764 mRNA. Translation: AAK15076.1.
AY358817 mRNA. Translation: AAQ89176.1.
AC022149 Genomic DNA. No translation available.
AC090427 Genomic DNA. No translation available.
AC135052 Genomic DNA. No translation available.
CCDSCCDS12315.1. [Q9BY15-1]
RefSeqNP_001276087.1. NM_001289158.1. [Q9BY15-2]
NP_001276088.1. NM_001289159.1.
NP_115960.2. NM_032571.4. [Q9BY15-1]
UniGeneHs.658712.

3D structure databases

ProteinModelPortalQ9BY15.
SMRQ9BY15. Positions 28-344, 456-602.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS63.003.
GPCRDBSearch...

PTM databases

PhosphoSiteQ9BY15.

Polymorphism databases

DMDM296434492.

Proteomic databases

PaxDbQ9BY15.
PRIDEQ9BY15.

Protocols and materials databases

DNASU84658.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253673; ENSP00000253673; ENSG00000131355. [Q9BY15-1]
ENST00000344373; ENSP00000340758; ENSG00000131355. [Q9BY15-2]
GeneID84658.
KEGGhsa:84658.
UCSCuc002mzi.4. human. [Q9BY15-1]
uc010dzp.3. human. [Q9BY15-2]

Organism-specific databases

CTD84658.
GeneCardsGC19M014730.
H-InvDBHIX0022599.
HGNCHGNC:23647. EMR3.
HPAHPA015638.
MIM606101. gene.
neXtProtNX_Q9BY15.
PharmGKBPA134956879.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG239437.
HOGENOMHOG000294115.
HOVERGENHBG048917.
InParanoidQ9BY15.
KOK08444.
OMAWSRDGCF.
OrthoDBEOG78H3SM.
PhylomeDBQ9BY15.
TreeFamTF316380.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9BY15.
BgeeQ9BY15.
CleanExHS_EMR3.
GenevestigatorQ9BY15.

Family and domain databases

InterProIPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF07645. EGF_CA. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTSM00179. EGF_CA. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiEMR3.
GenomeRNAi84658.
NextBio74625.
PROQ9BY15.
SOURCESearch...

Entry information

Entry nameEMR3_HUMAN
AccessionPrimary (citable) accession number: Q9BY15
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries