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Q9BY15

- EMR3_HUMAN

UniProt

Q9BY15 - EMR3_HUMAN

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Protein

EGF-like module-containing mucin-like hormone receptor-like 3

Gene
EMR3, UNQ683/PRO1562
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated neutrophils.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei338 – 3392Cleavage By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_18372. Class B/2 (Secretin family receptors).

Protein family/group databases

MEROPSiS63.003.

Names & Taxonomyi

Protein namesi
Recommended name:
EGF-like module-containing mucin-like hormone receptor-like 3
Alternative name(s):
EGF-like module receptor 3
Cleaved into the following 2 chains:
Gene namesi
Name:EMR3
ORF Names:UNQ683/PRO1562
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23647. EMR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 357336Extracellular Reviewed predictionAdd
BLAST
Transmembranei358 – 37821Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini379 – 38911Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei390 – 41021Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini411 – 4166Extracellular Reviewed prediction
Transmembranei417 – 43721Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini438 – 46427Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei465 – 48521Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini486 – 50823Extracellular Reviewed predictionAdd
BLAST
Transmembranei509 – 52921Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini530 – 55728Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei558 – 57821Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini579 – 5802Extracellular Reviewed prediction
Transmembranei581 – 60121Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini602 – 65251Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
  2. integral component of membrane Source: GDB
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134956879.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 652631EGF-like module-containing mucin-like hormone receptor-like 3PRO_0000012876Add
BLAST
Chaini22 – 338317EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha By similarityPRO_0000296239Add
BLAST
Chaini339 – 652314EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta By similarityPRO_0000296240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 37 By similarity
Disulfide bondi31 ↔ 43 By similarity
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi45 ↔ 65 By similarity
Disulfide bondi71 ↔ 85 By similarity
Disulfide bondi79 ↔ 94 By similarity
Disulfide bondi96 ↔ 117 By similarity
Glycosylationi145 – 1451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi189 – 1891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi279 – 2791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi327 – 3271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi334 – 3341N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BY15.
PRIDEiQ9BY15.

PTM databases

PhosphoSiteiQ9BY15.

Expressioni

Tissue specificityi

Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages.

Gene expression databases

ArrayExpressiQ9BY15.
BgeeiQ9BY15.
CleanExiHS_EMR3.
GenevestigatoriQ9BY15.

Organism-specific databases

HPAiHPA015638.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9BY15.
SMRiQ9BY15. Positions 28-344, 456-602.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 6643EGF-like 1Add
BLAST
Domaini67 – 11852EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST
Domaini301 – 35050GPSAdd
BLAST

Sequence similaritiesi

Contains 2 EGF-like domains.
Contains 1 GPS domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239437.
HOGENOMiHOG000294115.
HOVERGENiHBG048917.
InParanoidiQ9BY15.
KOiK08444.
OMAiWSRDGCF.
OrthoDBiEOG78H3SM.
PhylomeDBiQ9BY15.
TreeFamiTF316380.

Family and domain databases

InterProiIPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF07645. EGF_CA. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTiSM00179. EGF_CA. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BY15-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQGPLLLPGL CFLLSLFGAV TQKTKTSCAK CPPNASCVNN THCTCNHGYT    50
SGSGQKLFTF PLETCNDINE CTPPYSVYCG FNAVCYNVEG SFYCQCVPGY 100
RLHSGNEQFS NSNENTCQDT TSSKTTEGRK ELQKIVDKFE SLLTNQTLWR 150
TEGRQEISST ATTILRDVES KVLETALKDP EQKVLKIQND SVAIETQAIT 200
DNCSEERKTF NLNVQMNSMD IRCSDIIQGD TQGPSAIAFI SYSSLGNIIN 250
ATFFEEMDKK DQVYLNSQVV SAAIGPKRNV SLSKSVTLTF QHVKMTPSTK 300
KVFCVYWKST GQGSQWSRDG CFLIHVNKSH TMCNCSHLSS FAVLMALTSQ 350
EEDPVLTVIT YVGLSVSLLC LLLAALTFLL CKAIRNTSTS LHLQLSLCLF 400
LAHLLFLVGI DRTEPKVLCS IIAGALHYLY LAAFTWMLLE GVHLFLTARN 450
LTVVNYSSIN RLMKWIMFPV GYGVPAVTVA ISAASWPHLY GTADRCWLHL 500
DQGFMWSFLG PVCAIFSANL VLFILVFWIL KRKLSSLNSE VSTIQNTRML 550
AFKATAQLFI LGCTWCLGLL QVGPAAQVMA YLFTIINSLQ GFFIFLVYCL 600
LSQQVQKQYQ KWFREIVKSK SESETYTLSS KMGPDSKPSE GDVFPGQVKR 650
KY 652
Length:652
Mass (Da):72,621
Last modified:May 18, 2010 - v2
Checksum:i60DCD73BB0DBEB74
GO
Isoform 2 (identifier: Q9BY15-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-118: Missing.

Show »
Length:600
Mass (Da):66,786
Checksum:i44594300E1B4F0A5
GO
Isoform 3 (identifier: Q9BY15-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-652: Missing.

Note: Soluble form.

Show »
Length:66
Mass (Da):6,996
Checksum:i0351F055DA4FD7C7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti127 – 1271E → Q.1 Publication
Corresponds to variant rs4606855 [ dbSNP | Ensembl ].
VAR_024472
Natural varianti236 – 2361A → V.
Corresponds to variant rs34226397 [ dbSNP | Ensembl ].
VAR_055926
Natural varianti385 – 3851R → Q.2 Publications
Corresponds to variant rs8102646 [ dbSNP | Ensembl ].
VAR_060442

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei67 – 652586Missing in isoform 3. VSP_009418Add
BLAST
Alternative sequencei67 – 11852Missing in isoform 2. VSP_009417Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF239764 mRNA. Translation: AAK15076.1.
AY358817 mRNA. Translation: AAQ89176.1.
AC022149 Genomic DNA. No translation available.
AC090427 Genomic DNA. No translation available.
AC135052 Genomic DNA. No translation available.
CCDSiCCDS12315.1. [Q9BY15-1]
RefSeqiNP_001276087.1. NM_001289158.1. [Q9BY15-2]
NP_001276088.1. NM_001289159.1.
NP_115960.2. NM_032571.4. [Q9BY15-1]
UniGeneiHs.658712.

Genome annotation databases

EnsembliENST00000253673; ENSP00000253673; ENSG00000131355. [Q9BY15-1]
ENST00000344373; ENSP00000340758; ENSG00000131355. [Q9BY15-2]
GeneIDi84658.
KEGGihsa:84658.
UCSCiuc002mzi.4. human. [Q9BY15-1]
uc010dzp.3. human. [Q9BY15-2]

Polymorphism databases

DMDMi296434492.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF239764 mRNA. Translation: AAK15076.1 .
AY358817 mRNA. Translation: AAQ89176.1 .
AC022149 Genomic DNA. No translation available.
AC090427 Genomic DNA. No translation available.
AC135052 Genomic DNA. No translation available.
CCDSi CCDS12315.1. [Q9BY15-1 ]
RefSeqi NP_001276087.1. NM_001289158.1. [Q9BY15-2 ]
NP_001276088.1. NM_001289159.1.
NP_115960.2. NM_032571.4. [Q9BY15-1 ]
UniGenei Hs.658712.

3D structure databases

ProteinModelPortali Q9BY15.
SMRi Q9BY15. Positions 28-344, 456-602.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S63.003.
GPCRDBi Search...

PTM databases

PhosphoSitei Q9BY15.

Polymorphism databases

DMDMi 296434492.

Proteomic databases

PaxDbi Q9BY15.
PRIDEi Q9BY15.

Protocols and materials databases

DNASUi 84658.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253673 ; ENSP00000253673 ; ENSG00000131355 . [Q9BY15-1 ]
ENST00000344373 ; ENSP00000340758 ; ENSG00000131355 . [Q9BY15-2 ]
GeneIDi 84658.
KEGGi hsa:84658.
UCSCi uc002mzi.4. human. [Q9BY15-1 ]
uc010dzp.3. human. [Q9BY15-2 ]

Organism-specific databases

CTDi 84658.
GeneCardsi GC19M014730.
H-InvDB HIX0022599.
HGNCi HGNC:23647. EMR3.
HPAi HPA015638.
MIMi 606101. gene.
neXtProti NX_Q9BY15.
PharmGKBi PA134956879.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239437.
HOGENOMi HOG000294115.
HOVERGENi HBG048917.
InParanoidi Q9BY15.
KOi K08444.
OMAi WSRDGCF.
OrthoDBi EOG78H3SM.
PhylomeDBi Q9BY15.
TreeFami TF316380.

Enzyme and pathway databases

Reactomei REACT_18372. Class B/2 (Secretin family receptors).

Miscellaneous databases

GeneWikii EMR3.
GenomeRNAii 84658.
NextBioi 74625.
PROi Q9BY15.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BY15.
Bgeei Q9BY15.
CleanExi HS_EMR3.
Genevestigatori Q9BY15.

Family and domain databases

InterProi IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF07645. EGF_CA. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTi SM00179. EGF_CA. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils."
    Stacey M., Lin H.-H., Hilyard K.L., Gordon S., McKnight A.J.
    J. Biol. Chem. 276:18863-18870(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-385.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLN-127 AND GLN-385.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiEMR3_HUMAN
AccessioniPrimary (citable) accession number: Q9BY15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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