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Q9BY15

- EMR3_HUMAN

UniProt

Q9BY15 - EMR3_HUMAN

Protein

EGF-like module-containing mucin-like hormone receptor-like 3

Gene

EMR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated neutrophils.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei338 – 3392CleavageBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB
    2. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_18372. Class B/2 (Secretin family receptors).

    Protein family/group databases

    MEROPSiS63.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EGF-like module-containing mucin-like hormone receptor-like 3
    Alternative name(s):
    EGF-like module receptor 3
    Cleaved into the following 2 chains:
    Gene namesi
    Name:EMR3
    ORF Names:UNQ683/PRO1562
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:23647. EMR3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell
    2. integral component of membrane Source: GDB
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134956879.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 652631EGF-like module-containing mucin-like hormone receptor-like 3PRO_0000012876Add
    BLAST
    Chaini22 – 338317EGF-like module-containing mucin-like hormone receptor-like 3 subunit alphaBy similarityPRO_0000296239Add
    BLAST
    Chaini339 – 652314EGF-like module-containing mucin-like hormone receptor-like 3 subunit betaBy similarityPRO_0000296240Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 37PROSITE-ProRule annotation
    Disulfide bondi31 ↔ 43PROSITE-ProRule annotation
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi45 ↔ 65PROSITE-ProRule annotation
    Disulfide bondi71 ↔ 85PROSITE-ProRule annotation
    Disulfide bondi79 ↔ 94PROSITE-ProRule annotation
    Disulfide bondi96 ↔ 117PROSITE-ProRule annotation
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9BY15.
    PRIDEiQ9BY15.

    PTM databases

    PhosphoSiteiQ9BY15.

    Expressioni

    Tissue specificityi

    Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages.

    Gene expression databases

    ArrayExpressiQ9BY15.
    BgeeiQ9BY15.
    CleanExiHS_EMR3.
    GenevestigatoriQ9BY15.

    Organism-specific databases

    HPAiHPA015638.

    Interactioni

    Subunit structurei

    Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit).By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BY15.
    SMRiQ9BY15. Positions 28-344, 456-602.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 357336ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini379 – 38911CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini411 – 4166ExtracellularSequence Analysis
    Topological domaini438 – 46427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini486 – 50823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini530 – 55728CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini579 – 5802ExtracellularSequence Analysis
    Topological domaini602 – 65251CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei358 – 37821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei390 – 41021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei509 – 52921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei558 – 57821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei581 – 60121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 6643EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini67 – 11852EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini301 – 35050GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239437.
    HOGENOMiHOG000294115.
    HOVERGENiHBG048917.
    InParanoidiQ9BY15.
    KOiK08444.
    OMAiWSRDGCF.
    OrthoDBiEOG78H3SM.
    PhylomeDBiQ9BY15.
    TreeFamiTF316380.

    Family and domain databases

    InterProiIPR022624. DUF3497.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR017981. GPCR_2-like.
    IPR001740. GPCR_2_EMR1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view]
    PRINTSiPR01128. EMR1HORMONER.
    PR00249. GPCRSECRETIN.
    SMARTiSM00179. EGF_CA. 1 hit.
    SM00303. GPS. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS01187. EGF_CA. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BY15-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQGPLLLPGL CFLLSLFGAV TQKTKTSCAK CPPNASCVNN THCTCNHGYT    50
    SGSGQKLFTF PLETCNDINE CTPPYSVYCG FNAVCYNVEG SFYCQCVPGY 100
    RLHSGNEQFS NSNENTCQDT TSSKTTEGRK ELQKIVDKFE SLLTNQTLWR 150
    TEGRQEISST ATTILRDVES KVLETALKDP EQKVLKIQND SVAIETQAIT 200
    DNCSEERKTF NLNVQMNSMD IRCSDIIQGD TQGPSAIAFI SYSSLGNIIN 250
    ATFFEEMDKK DQVYLNSQVV SAAIGPKRNV SLSKSVTLTF QHVKMTPSTK 300
    KVFCVYWKST GQGSQWSRDG CFLIHVNKSH TMCNCSHLSS FAVLMALTSQ 350
    EEDPVLTVIT YVGLSVSLLC LLLAALTFLL CKAIRNTSTS LHLQLSLCLF 400
    LAHLLFLVGI DRTEPKVLCS IIAGALHYLY LAAFTWMLLE GVHLFLTARN 450
    LTVVNYSSIN RLMKWIMFPV GYGVPAVTVA ISAASWPHLY GTADRCWLHL 500
    DQGFMWSFLG PVCAIFSANL VLFILVFWIL KRKLSSLNSE VSTIQNTRML 550
    AFKATAQLFI LGCTWCLGLL QVGPAAQVMA YLFTIINSLQ GFFIFLVYCL 600
    LSQQVQKQYQ KWFREIVKSK SESETYTLSS KMGPDSKPSE GDVFPGQVKR 650
    KY 652
    Length:652
    Mass (Da):72,621
    Last modified:May 18, 2010 - v2
    Checksum:i60DCD73BB0DBEB74
    GO
    Isoform 2 (identifier: Q9BY15-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         67-118: Missing.

    Show »
    Length:600
    Mass (Da):66,786
    Checksum:i44594300E1B4F0A5
    GO
    Isoform 3 (identifier: Q9BY15-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         67-652: Missing.

    Note: Soluble form.

    Show »
    Length:66
    Mass (Da):6,996
    Checksum:i0351F055DA4FD7C7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti127 – 1271E → Q.1 Publication
    Corresponds to variant rs4606855 [ dbSNP | Ensembl ].
    VAR_024472
    Natural varianti236 – 2361A → V.
    Corresponds to variant rs34226397 [ dbSNP | Ensembl ].
    VAR_055926
    Natural varianti385 – 3851R → Q.2 Publications
    Corresponds to variant rs8102646 [ dbSNP | Ensembl ].
    VAR_060442

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei67 – 652586Missing in isoform 3. CuratedVSP_009418Add
    BLAST
    Alternative sequencei67 – 11852Missing in isoform 2. 2 PublicationsVSP_009417Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239764 mRNA. Translation: AAK15076.1.
    AY358817 mRNA. Translation: AAQ89176.1.
    AC022149 Genomic DNA. No translation available.
    AC090427 Genomic DNA. No translation available.
    AC135052 Genomic DNA. No translation available.
    CCDSiCCDS12315.1. [Q9BY15-1]
    RefSeqiNP_001276087.1. NM_001289158.1. [Q9BY15-2]
    NP_001276088.1. NM_001289159.1.
    NP_115960.2. NM_032571.4. [Q9BY15-1]
    UniGeneiHs.658712.

    Genome annotation databases

    EnsembliENST00000253673; ENSP00000253673; ENSG00000131355. [Q9BY15-1]
    ENST00000344373; ENSP00000340758; ENSG00000131355. [Q9BY15-2]
    GeneIDi84658.
    KEGGihsa:84658.
    UCSCiuc002mzi.4. human. [Q9BY15-1]
    uc010dzp.3. human. [Q9BY15-2]

    Polymorphism databases

    DMDMi296434492.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239764 mRNA. Translation: AAK15076.1 .
    AY358817 mRNA. Translation: AAQ89176.1 .
    AC022149 Genomic DNA. No translation available.
    AC090427 Genomic DNA. No translation available.
    AC135052 Genomic DNA. No translation available.
    CCDSi CCDS12315.1. [Q9BY15-1 ]
    RefSeqi NP_001276087.1. NM_001289158.1. [Q9BY15-2 ]
    NP_001276088.1. NM_001289159.1.
    NP_115960.2. NM_032571.4. [Q9BY15-1 ]
    UniGenei Hs.658712.

    3D structure databases

    ProteinModelPortali Q9BY15.
    SMRi Q9BY15. Positions 28-344, 456-602.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S63.003.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9BY15.

    Polymorphism databases

    DMDMi 296434492.

    Proteomic databases

    PaxDbi Q9BY15.
    PRIDEi Q9BY15.

    Protocols and materials databases

    DNASUi 84658.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253673 ; ENSP00000253673 ; ENSG00000131355 . [Q9BY15-1 ]
    ENST00000344373 ; ENSP00000340758 ; ENSG00000131355 . [Q9BY15-2 ]
    GeneIDi 84658.
    KEGGi hsa:84658.
    UCSCi uc002mzi.4. human. [Q9BY15-1 ]
    uc010dzp.3. human. [Q9BY15-2 ]

    Organism-specific databases

    CTDi 84658.
    GeneCardsi GC19M014730.
    H-InvDB HIX0022599.
    HGNCi HGNC:23647. EMR3.
    HPAi HPA015638.
    MIMi 606101. gene.
    neXtProti NX_Q9BY15.
    PharmGKBi PA134956879.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG239437.
    HOGENOMi HOG000294115.
    HOVERGENi HBG048917.
    InParanoidi Q9BY15.
    KOi K08444.
    OMAi WSRDGCF.
    OrthoDBi EOG78H3SM.
    PhylomeDBi Q9BY15.
    TreeFami TF316380.

    Enzyme and pathway databases

    Reactomei REACT_18372. Class B/2 (Secretin family receptors).

    Miscellaneous databases

    GeneWikii EMR3.
    GenomeRNAii 84658.
    NextBioi 74625.
    PROi Q9BY15.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BY15.
    Bgeei Q9BY15.
    CleanExi HS_EMR3.
    Genevestigatori Q9BY15.

    Family and domain databases

    InterProi IPR022624. DUF3497.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR017981. GPCR_2-like.
    IPR001740. GPCR_2_EMR1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    PRINTSi PR01128. EMR1HORMONER.
    PR00249. GPCRSECRETIN.
    SMARTi SM00179. EGF_CA. 1 hit.
    SM00303. GPS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS01187. EGF_CA. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils."
      Stacey M., Lin H.-H., Hilyard K.L., Gordon S., McKnight A.J.
      J. Biol. Chem. 276:18863-18870(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-385.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLN-127 AND GLN-385.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiEMR3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BY15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3