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Protein

Testis-expressed sequence 101 protein

Gene

TEX101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in signal transduction and promote protein tyrosine phosphorylation.By similarity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131126-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed sequence 101 protein
Alternative name(s):
Cell surface receptor NYD-SP8
Scleroderma-associated autoantigen
Spermatogenesis-related gene protein
Gene namesi
Name:TEX101
Synonyms:SGRG
ORF Names:UNQ867/PRO1884
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30722. TEX101.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83639.
OpenTargetsiENSG00000131126.
PharmGKBiPA134938764.

Polymorphism and mutation databases

BioMutaiTEX101.
DMDMi110816451.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000024762126 – 222Testis-expressed sequence 101 proteinAdd BLAST197
PropeptideiPRO_0000247622223 – 249Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Lipidationi222GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9BY14.
PeptideAtlasiQ9BY14.
PRIDEiQ9BY14.

PTM databases

iPTMnetiQ9BY14.
PhosphoSitePlusiQ9BY14.

Expressioni

Tissue specificityi

Detected in testis and spermatogonia. Not detected in spermatocytes. Detected in blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000131126.
CleanExiHS_TEX101.
ExpressionAtlasiQ9BY14. baseline and differential.
GenevisibleiQ9BY14. HS.

Organism-specific databases

HPAiHPA041915.
HPA042513.

Interactioni

Subunit structurei

Interacts with VAMP3.By similarity

Protein-protein interaction databases

BioGridi123703. 3 interactors.
IntActiQ9BY14. 2 interactors.
STRINGi9606.ENSP00000253435.

Structurei

3D structure databases

ProteinModelPortaliQ9BY14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini140 – 211UPAR/Ly6Add BLAST72

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0X3. Eukaryota.
ENOG41118MD. LUCA.
GeneTreeiENSGT00530000063351.
HOGENOMiHOG000294143.
HOVERGENiHBG094100.
InParanoidiQ9BY14.
OMAiSYSNYCE.
PhylomeDBiQ9BY14.
TreeFamiTF337286.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BY14-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTPRIQHLL ILLVLGASLL TSGLELYCQK GLSMTVEADP ANMFNWTTEE
60 70 80 90 100
VETCDKGALC QETILIIKAG TETAILATKG CIPEGEEAIT IVQHSSPPGL
110 120 130 140 150
IVTSYSNYCE DSFCNDKDSL SQFWEFSETT ASTVSTTLHC PTCVALGTCF
160 170 180 190 200
SAPSLPCPNG TTRCYQGKLE ITGGGIESSV EVKGCTAMIG CRLMSGILAV
210 220 230 240
GPMFVREACP HQLLTQPRKT ENGATCLPIP VWGLQLLLPL LLPSFIHFS
Length:249
Mass (Da):26,667
Last modified:July 25, 2006 - v2
Checksum:iCEDC82D7C4F04821
GO
Isoform 2 (identifier: Q9BY14-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGARQIQTSSSQTSPEEAM

Show »
Length:267
Mass (Da):28,557
Checksum:iCB25F49BD1FAB764
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157C → Y in AAK28327 (PubMed:16516155).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05988399G → V.Corresponds to variant rs35033974dbSNPEnsembl.1
Isoform 2 (identifier: Q9BY14-2)
Natural varianti4R → M.Corresponds to variant rs17849541dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0200291M → MGARQIQTSSSQTSPEEAM in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241268 mRNA. Translation: AAK28327.1.
AY014285 mRNA. Translation: AAK27310.1.
AF353396 mRNA. Translation: AAK38662.1.
AY359077 mRNA. Translation: AAQ89436.1.
BC001861 mRNA. Translation: AAH01861.2.
CCDSiCCDS12619.1. [Q9BY14-2]
CCDS59393.1. [Q9BY14-1]
RefSeqiNP_001123483.1. NM_001130011.1. [Q9BY14-1]
NP_113639.4. NM_031451.4. [Q9BY14-2]
UniGeneiHs.97978.

Genome annotation databases

EnsembliENST00000598265; ENSP00000472769; ENSG00000131126. [Q9BY14-1]
ENST00000602198; ENSP00000472308; ENSG00000131126. [Q9BY14-2]
GeneIDi83639.
KEGGihsa:83639.
UCSCiuc010xwo.3. human. [Q9BY14-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241268 mRNA. Translation: AAK28327.1.
AY014285 mRNA. Translation: AAK27310.1.
AF353396 mRNA. Translation: AAK38662.1.
AY359077 mRNA. Translation: AAQ89436.1.
BC001861 mRNA. Translation: AAH01861.2.
CCDSiCCDS12619.1. [Q9BY14-2]
CCDS59393.1. [Q9BY14-1]
RefSeqiNP_001123483.1. NM_001130011.1. [Q9BY14-1]
NP_113639.4. NM_031451.4. [Q9BY14-2]
UniGeneiHs.97978.

3D structure databases

ProteinModelPortaliQ9BY14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123703. 3 interactors.
IntActiQ9BY14. 2 interactors.
STRINGi9606.ENSP00000253435.

PTM databases

iPTMnetiQ9BY14.
PhosphoSitePlusiQ9BY14.

Polymorphism and mutation databases

BioMutaiTEX101.
DMDMi110816451.

Proteomic databases

PaxDbiQ9BY14.
PeptideAtlasiQ9BY14.
PRIDEiQ9BY14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000598265; ENSP00000472769; ENSG00000131126. [Q9BY14-1]
ENST00000602198; ENSP00000472308; ENSG00000131126. [Q9BY14-2]
GeneIDi83639.
KEGGihsa:83639.
UCSCiuc010xwo.3. human. [Q9BY14-1]

Organism-specific databases

CTDi83639.
DisGeNETi83639.
GeneCardsiTEX101.
HGNCiHGNC:30722. TEX101.
HPAiHPA041915.
HPA042513.
MIMi612665. gene.
neXtProtiNX_Q9BY14.
OpenTargetsiENSG00000131126.
PharmGKBiPA134938764.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0X3. Eukaryota.
ENOG41118MD. LUCA.
GeneTreeiENSGT00530000063351.
HOGENOMiHOG000294143.
HOVERGENiHBG094100.
InParanoidiQ9BY14.
OMAiSYSNYCE.
PhylomeDBiQ9BY14.
TreeFamiTF337286.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131126-MONOMER.

Miscellaneous databases

ChiTaRSiTEX101. human.
GenomeRNAii83639.
PROiQ9BY14.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131126.
CleanExiHS_TEX101.
ExpressionAtlasiQ9BY14. baseline and differential.
GenevisibleiQ9BY14. HS.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTX101_HUMAN
AccessioniPrimary (citable) accession number: Q9BY14
Secondary accession number(s): Q7L5R2, Q9BPY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 30, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.