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Protein

S phase cyclin A-associated protein in the endoplasmic reticulum

Gene

SCAPER

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri792 – 816C2H2-typeAdd BLAST25

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140386-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S phase cyclin A-associated protein in the endoplasmic reticulum
Short name:
S phase cyclin A-associated protein in the ER
Alternative name(s):
Zinc finger protein 291
Gene namesi
Name:SCAPER
Synonyms:KIAA1454, ZNF291
ORF Names:MSTP063
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:13081. SCAPER.

Subcellular locationi

  • Endoplasmic reticulum 1 Publication
  • Nucleus 1 Publication

  • Note: Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi26 – 28RNL → AAA: No effect on CCNA2/CDK2 complex-binding. 1 Publication3
Mutagenesisi199 – 201RSL → AAA: Loss of CCNA2/CDK2 complex-binding. 1 Publication3
Mutagenesisi678 – 680RAL → AAA: No effect on CCNA2/CDK2 complex-binding. 1 Publication3

Organism-specific databases

DisGeNETi49855.
OpenTargetsiENSG00000140386.
PharmGKBiPA162402512.

Polymorphism and mutation databases

BioMutaiSCAPER.
DMDMi510120715.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475131 – 1400S phase cyclin A-associated protein in the endoplasmic reticulumAdd BLAST1400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei832PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in vitro by the CCNA2/CDK2 complex.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BY12.
MaxQBiQ9BY12.
PaxDbiQ9BY12.
PeptideAtlasiQ9BY12.
PRIDEiQ9BY12.

PTM databases

iPTMnetiQ9BY12.
PhosphoSitePlusiQ9BY12.

Expressioni

Tissue specificityi

Widely expressed with highest expression in testis.1 Publication

Developmental stagei

Expressed at each stage of the cell cycle, including G0, although the expression is somewhat higher in late G1 and S phases.1 Publication

Gene expression databases

BgeeiENSG00000140386.
CleanExiHS_SCAPER.
ExpressionAtlasiQ9BY12. baseline and differential.
GenevisibleiQ9BY12. HS.

Organism-specific databases

HPAiHPA046253.
HPA061180.

Interactioni

Subunit structurei

Interacts with CCNA2/CDK2 complex, but not with CCNA2/CDC2, CCNB1/CDC2 or CCNE1/CDK2 complexes, at multiple phases of the cell cycle, including S and G2/M.1 Publication

Protein-protein interaction databases

BioGridi119067. 5 interactors.
IntActiQ9BY12. 5 interactors.
STRINGi9606.ENSP00000326924.

Structurei

3D structure databases

ProteinModelPortaliQ9BY12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi395 – 770Glu-richAdd BLAST376

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri792 – 816C2H2-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4722. Eukaryota.
ENOG410XPXB. LUCA.
GeneTreeiENSGT00390000011159.
HOGENOMiHOG000007543.
HOVERGENiHBG101202.
InParanoidiQ9BY12.
OMAiLLHAMCT.
OrthoDBiEOG091G030C.
PhylomeDBiQ9BY12.
TreeFamiTF324831.

Family and domain databases

InterProiIPR032446. SCAPER_N.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF16501. SCAPER_N. 1 hit.
[Graphical view]
SMARTiSM00451. ZnF_U1. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BY12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMASFQRSNS HDKVRRIVAE EGRTARNLIA WSVPLESKDD DGKPKCQTGG
60 70 80 90 100
KSKRTIQGTH KTTKQSTAVD CKITSSTTGD KHFDKSPTKT RHPRKIDLRA
110 120 130 140 150
RYWAFLFDNL RRAVDEIYVT CESDQSVVEC KEVLMMLDNY VRDFKALIDW
160 170 180 190 200
IQLQEKLEKT DAQSRPTSLA WEVKKMSPGR HVIPSPSTDR INVTSNARRS
210 220 230 240 250
LNFGGSTGTV PAPRLAPTGV SWADKVKAHH TGSTASSEIT PAQSCPPMTV
260 270 280 290 300
QKASRKNERK DAEGWETVQR GRPIRSRSTA VMPKVSLATE ATRSKDDSDK
310 320 330 340 350
ENVCLLPDES IQKGQFVGDG TSNTIESHPK DSLHSCDHPL AEKTQFTVST
360 370 380 390 400
LDDVKNSGSI RDNYVRTSEI SAVHIDTECV SVMLQAGTPP LQVNEEKFPA
410 420 430 440 450
EKARIENEMD PSDISNSMAE VLAKKEELAD RLEKANEEAI ASAIAEEEQL
460 470 480 490 500
TREIEAEENN DINIETDNDS DFSASMGSGS VSFCGMSMDW NDVLADYEAR
510 520 530 540 550
ESWRQNTSWG DIVEEEPARP PGHGIHMHEK LSSPSRKRTI AESKKKHEEK
560 570 580 590 600
QMKAQQLREK LREEKTLKLQ KLLEREKDVR KWKEELLDQR RRMMEEKLLH
610 620 630 640 650
AEFKREVQLQ AIVKKAQEEE AKVNEIAFIN TLEAQNKRHD VLSKLKEYEQ
660 670 680 690 700
RLNELQEERQ RRQEEKQARD EAVQERKRAL EAERQARVEE LLMKRKEQEA
710 720 730 740 750
RIEQQRQEKE KAREDAARER ARDREERLAA LTAAQQEAME ELQKKIQLKH
760 770 780 790 800
DESIRRHMEQ IEQRKEKAAE LSSGRHANTD YAPKLTPYER KKQCSLCNVL
810 820 830 840 850
ISSEVYLFSH VKGRKHQQAV RENTSIQGRE LSDEEVEHLS LKKYIIDIVV
860 870 880 890 900
ESTAPAEALK DGEERQKNKK KAKKIKARMN FRAKEYESLM ETKNSGSDSP
910 920 930 940 950
YKAKLQRLAK DLLKQVQVQD SGSWANNKVS ALDRTLGEIT RILEKENVAD
960 970 980 990 1000
QIAFQAAGGL TALEHILQAV VPATNVNTVL RIPPKSLCNA INVYNLTCNN
1010 1020 1030 1040 1050
CSENCSDVLF SNKITFLMDL LIHQLTVYVP DENNTILGRN TNKQVFEGLT
1060 1070 1080 1090 1100
TGLLKVSAVV LGCLIANRPD GNCQPATPKI PTQEMKNKPS QGDPFNNRVQ
1110 1120 1130 1140 1150
DLISYVVNMG LIDKLCACFL SVQGPVDENP KMAIFLQHAA GLLHAMCTLC
1160 1170 1180 1190 1200
FAVTGRSYSI FDNNRQDPTG LTAALQATDL AGVLHMLYCV LFHGTILDPS
1210 1220 1230 1240 1250
TASPKENYTQ NTIQVAIQSL RFFNSFAALH LPAFQSIVGA EGLSLAFRHM
1260 1270 1280 1290 1300
ASSLLGHCSQ VSCESLLHEV IVCVGYFTVN HPDNQVIVQS GRHPTVLQKL
1310 1320 1330 1340 1350
CQLPFQYFSD PRLIKVLFPS LIAACYNNHQ NKIILEQEMS CVLLATFIQD
1360 1370 1380 1390 1400
LAQTPGQAEN QPYQPKGKCL GSQDYLELAN RFPQQAWEEA RQFFLKKEKK
Length:1,400
Mass (Da):158,287
Last modified:May 29, 2013 - v2
Checksum:i9DBAF02F75CB1AA7
GO
Isoform 2 (identifier: Q9BY12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MMASFQRSNS...WSVPLESKDD → REATPPLRGL...DLGIEENLKS
     416-416: N → NVSAANL
     1236-1244: SIVGAEGLS → VPSIGLYRC
     1245-1400: Missing.

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:1,265
Mass (Da):142,698
Checksum:i435FBE3ABF98D826
GO
Isoform 3 (identifier: Q9BY12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-257: MMASFQRSNS...MTVQKASRKN → MKTKYIFCNIT

Show »
Length:1,154
Mass (Da):130,935
Checksum:i175334613BCA3513
GO

Sequence cautioni

The sequence AAG47945 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH15212 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI07416 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAK29205 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → V in AAK29205 (Ref. 1) Curated1
Sequence conflicti1262S → F in AAG47945 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0199781089P → T.2 PublicationsCorresponds to variant rs1607017dbSNPEnsembl.1
Natural variantiVAR_0599101139A → T.Corresponds to variant rs3743176dbSNPEnsembl.1
Natural variantiVAR_0528061140A → T.Corresponds to variant rs3743176dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0465031 – 257MMASF…ASRKN → MKTKYIFCNIT in isoform 3. 1 PublicationAdd BLAST257
Alternative sequenceiVSP_0314401 – 40MMASF…ESKDD → REATPPLRGLPAPPRHAPFP AGRFEPPRTKQGGRGSHTPW DYVINDLGIEENLKS in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_031441416N → NVSAANL in isoform 2. 1 Publication1
Alternative sequenceiVSP_0314421236 – 1244SIVGAEGLS → VPSIGLYRC in isoform 2. 1 Publication9
Alternative sequenceiVSP_0314431245 – 1400Missing in isoform 2. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242528 mRNA. Translation: AAK29205.1. Different initiation.
AB040887 mRNA. Translation: BAA95978.1.
AL137612 mRNA. Translation: CAB70841.1.
BX647285 mRNA. No translation available.
AC015798 Genomic DNA. No translation available.
AC016343 Genomic DNA. No translation available.
AC027243 Genomic DNA. No translation available.
AC051643 Genomic DNA. No translation available.
AC090179 Genomic DNA. No translation available.
AC090751 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99218.1.
BC015212 mRNA. Translation: AAH15212.1. Different initiation.
BC107415 mRNA. Translation: AAI07416.1. Sequence problems.
AF119814 mRNA. Translation: AAG47945.1. Different initiation.
BT006762 mRNA. Translation: AAP35408.1.
CCDSiCCDS53961.1. [Q9BY12-3]
CCDS53962.1. [Q9BY12-1]
PIRiT46314.
RefSeqiNP_001139395.1. NM_001145923.1. [Q9BY12-3]
NP_065894.2. NM_020843.2. [Q9BY12-1]
XP_005254476.1. XM_005254419.2. [Q9BY12-1]
XP_016877758.1. XM_017022269.1. [Q9BY12-1]
XP_016877759.1. XM_017022270.1. [Q9BY12-1]
UniGeneiHs.458986.

Genome annotation databases

EnsembliENST00000324767; ENSP00000326924; ENSG00000140386. [Q9BY12-1]
ENST00000538941; ENSP00000442190; ENSG00000140386. [Q9BY12-3]
ENST00000563290; ENSP00000454973; ENSG00000140386. [Q9BY12-1]
GeneIDi49855.
KEGGihsa:49855.
UCSCiuc002bbx.4. human. [Q9BY12-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242528 mRNA. Translation: AAK29205.1. Different initiation.
AB040887 mRNA. Translation: BAA95978.1.
AL137612 mRNA. Translation: CAB70841.1.
BX647285 mRNA. No translation available.
AC015798 Genomic DNA. No translation available.
AC016343 Genomic DNA. No translation available.
AC027243 Genomic DNA. No translation available.
AC051643 Genomic DNA. No translation available.
AC090179 Genomic DNA. No translation available.
AC090751 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99218.1.
BC015212 mRNA. Translation: AAH15212.1. Different initiation.
BC107415 mRNA. Translation: AAI07416.1. Sequence problems.
AF119814 mRNA. Translation: AAG47945.1. Different initiation.
BT006762 mRNA. Translation: AAP35408.1.
CCDSiCCDS53961.1. [Q9BY12-3]
CCDS53962.1. [Q9BY12-1]
PIRiT46314.
RefSeqiNP_001139395.1. NM_001145923.1. [Q9BY12-3]
NP_065894.2. NM_020843.2. [Q9BY12-1]
XP_005254476.1. XM_005254419.2. [Q9BY12-1]
XP_016877758.1. XM_017022269.1. [Q9BY12-1]
XP_016877759.1. XM_017022270.1. [Q9BY12-1]
UniGeneiHs.458986.

3D structure databases

ProteinModelPortaliQ9BY12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119067. 5 interactors.
IntActiQ9BY12. 5 interactors.
STRINGi9606.ENSP00000326924.

PTM databases

iPTMnetiQ9BY12.
PhosphoSitePlusiQ9BY12.

Polymorphism and mutation databases

BioMutaiSCAPER.
DMDMi510120715.

Proteomic databases

EPDiQ9BY12.
MaxQBiQ9BY12.
PaxDbiQ9BY12.
PeptideAtlasiQ9BY12.
PRIDEiQ9BY12.

Protocols and materials databases

DNASUi49855.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324767; ENSP00000326924; ENSG00000140386. [Q9BY12-1]
ENST00000538941; ENSP00000442190; ENSG00000140386. [Q9BY12-3]
ENST00000563290; ENSP00000454973; ENSG00000140386. [Q9BY12-1]
GeneIDi49855.
KEGGihsa:49855.
UCSCiuc002bbx.4. human. [Q9BY12-1]

Organism-specific databases

CTDi49855.
DisGeNETi49855.
GeneCardsiSCAPER.
HGNCiHGNC:13081. SCAPER.
HPAiHPA046253.
HPA061180.
MIMi611611. gene.
neXtProtiNX_Q9BY12.
OpenTargetsiENSG00000140386.
PharmGKBiPA162402512.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4722. Eukaryota.
ENOG410XPXB. LUCA.
GeneTreeiENSGT00390000011159.
HOGENOMiHOG000007543.
HOVERGENiHBG101202.
InParanoidiQ9BY12.
OMAiLLHAMCT.
OrthoDBiEOG091G030C.
PhylomeDBiQ9BY12.
TreeFamiTF324831.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140386-MONOMER.

Miscellaneous databases

ChiTaRSiSCAPER. human.
GenomeRNAii49855.
PROiQ9BY12.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140386.
CleanExiHS_SCAPER.
ExpressionAtlasiQ9BY12. baseline and differential.
GenevisibleiQ9BY12. HS.

Family and domain databases

InterProiIPR032446. SCAPER_N.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF16501. SCAPER_N. 1 hit.
[Graphical view]
SMARTiSM00451. ZnF_U1. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCAPE_HUMAN
AccessioniPrimary (citable) accession number: Q9BY12
Secondary accession number(s): F5H7X8
, H3BNR7, Q3B7X7, Q96BS9, Q9H3D8, Q9NT03, Q9P274
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: May 29, 2013
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.