Protein kinase C and casein kinase substrate in neurons protein 1

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Q9BY11 (PACN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein kinase C and casein kinase substrate in neurons protein 1

Gene names

Name:	PACSIN1
Synonyms:	KIAA1379

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in vesicle formation and transport. Ref.6
Subunit structure	Homo- and hetero-aggregates with other PACSINs. Binds dynamin I, synaptojanin, synapsin I and the neural Wiskott-Aldrich syndrome protein (N-WASP) By similarity.
Subcellular location	Cytoplasm By similarity. Note: Colocalizes with dynamin I at vesicular structures in the cell body and neurites By similarity.
Tissue specificity	Highly expressed in brain and in a lesser extent in heart, pancreas and liver.
Post-translational modification	Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) Probable.
Sequence similarities	Belongs to the PACSIN family. Contains 1 FCH domain. Contains 1 SH3 domain.
Sequence caution	The sequence BAA92617.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Domain	Coiled coil SH3 domain
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	endocytosis Non-traceable author statement. Source: UniProtKB
Molecular function	protein kinase activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 444

444

Protein kinase C and casein kinase substrate in neurons protein 1

PRO_0000161792

Regions

Domain

13 – 76

FCH

Domain

385 – 444

SH3

Coiled coil

147 – 168

Potential

Coiled coil

184 – 220

Potential

Amino acid modifications

Modified residue

394

Phosphotyrosine By similarity

Natural variations

Natural variant

334

A → V.
Corresponds to variant rs41312309 [ dbSNP | Ensembl ].

VAR_053554

Secondary structure

444

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9BY11 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 6AAF801873770975
Show »

FASTA

444

50,966

        10         20         30         40         50         60 
MSSSYDEASL APEETTDSFW EVGNYKRTVK RIDDGHRLCN DLMNCVQERA KIEKAYGQQL 

        70         80         90        100        110        120 
TDWAKRWRQL IEKGPQYGSL ERAWGAIMTE ADKVSELHQE VKNNLLNEDL EKVKNWQKDA 

       130        140        150        160        170        180 
YHKQIMGGFK ETKEAEDGFR KAQKPWAKKM KELEAAKKAY HLACKEEKLA MTREMNSKTE 

       190        200        210        220        230        240 
QSVTPEQQKK LQDKVDKCKQ DVQKTQEKYE KVLEDVGKTT PQYMENMEQV FEQCQQFEEK 

       250        260        270        280        290        300 
RLVFLKEVLL DIKRHLNLAE NSSYIHVYRE LEQAIRGADA QEDLRWFRST SGPGMPMNWP 

       310        320        330        340        350        360 
QFEEWNPDLP HTTTKKEKQP KKAEGVALTN ATGAVESTSQ AGDRGSVSSY DRGQPYATEW 

       370        380        390        400        410        420 
SDDESGNPFG GSETNGGANP FEDDSKGVRV RALYDYDGQE QDELSFKAGD ELTKLGEEDE 

       430        440 
QGWCRGRLDS GQLGLYPANY VEAI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family." Sumoy L., Pluvinet R., Andreu N., Estivill X., Escarceller M. Gene 262:199-205(2001) [PubMed: 11179684] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Amygdala.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis." Modregger J., Ritter B., Witter B., Paulsson M., Plomann M. J. Cell Sci. 113:4511-4521(2000) [PubMed: 11082044] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF242529 mRNA. Translation: AAK29206.1.
AB037800 mRNA. Translation: BAA92617.2. Different initiation.
AL834211 mRNA. Translation: CAD38895.1.
BC040228 mRNA. Translation: AAH40228.1.

IPI

IPI00011515.

RefSeq

NP_001186512.1. NM_001199583.1.
NP_065855.1. NM_020804.3.

UniGene

Hs.520087.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3HAH	X-ray	2.77	A/B	1-325	[»]
3HAI	X-ray	2.88	A/B/C/D	1-308	[»]
3QNI	X-ray	2.80	A/B	1-307	[»]

ProteinModelPortal

Q9BY11.

SMR

Q9BY11. Positions 15-308, 388-443.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BY11. 16 interactions.

STRING

Q9BY11.

PTM databases

PhosphoSite

Q9BY11.

Polymorphism databases

DMDM

22256962.

Proteomic databases

PRIDE

Q9BY11.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000244458; ENSP00000244458; ENSG00000124507.

GeneID

29993.

KEGG

hsa:29993.

UCSC

uc003ojo.1. human.

Organism-specific databases

CTD

29993.

GeneCards

GC06P034480.

H-InvDB

HIX0005791.

HGNC

HGNC:8570. PACSIN1.

HPA

CAB009929.
HPA028852.

MIM

606512. gene.

neXtProt

NX_Q9BY11.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00510000046376.

HOGENOM

HBG446365.

HOVERGEN

HBG053486.

InParanoid

Q9BY11.

OMA

PDSLGWC.

OrthoDB

EOG4QVCC5.

PhylomeDB

Q9BY11.

Gene expression databases

ArrayExpress

Q9BY11.

Bgee

Q9BY11.

CleanEx

HS_PACSIN1.

Genevestigator

Q9BY11.

GermOnline

ENSG00000124507. Homo sapiens.

Family and domain databases

InterPro

IPR001060. FCH.
IPR001452. SH3_domain.
[Graphical view]

Pfam

PF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]

PRINTS

PR00452. SH3DOMAIN.

SMART

SM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF50044. SH3. 1 hit.

PROSITE

PS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

52788.

SOURCE

Search...

Entry information

Entry name

PACN1_HUMAN

Accession

Primary (citable) accession number: Q9BY11
Secondary accession number(s): Q9P2G8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents