Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9BY11 (PACN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein kinase C and casein kinase substrate in neurons protein 1
Gene names
Name:PACSIN1
Synonyms:KIAA1379
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in vesicle formation and transport. Ref.6

Subunit structure

Homo- and hetero-aggregates with other PACSINs. Binds dynamin I, synaptojanin, synapsin I and the neural Wiskott-Aldrich syndrome protein (N-WASP) By similarity.

Subcellular location

Cytoplasm By similarity. Note: Colocalizes with dynamin I at vesicular structures in the cell body and neurites By similarity.

Tissue specificity

Highly expressed in brain and in a lesser extent in heart, pancreas and liver.

Post-translational modification

Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) Probable.

Sequence similarities

Belongs to the PACSIN family.

Contains 1 FCH domain.

Contains 1 SH3 domain.

Sequence caution

The sequence BAA92617.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processEndocytosis
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   DomainCoiled coil
SH3 domain
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processendocytosis

Non-traceable author statement. Source: UniProtKB

   Molecular functionprotein kinase activity

Non-traceable author statement. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Protein kinase C and casein kinase substrate in neurons protein 1
PRO_0000161792

Regions

Domain13 – 7664FCH
Domain385 – 44460SH3
Coiled coil147 – 16822 Potential
Coiled coil184 – 22037 Potential

Amino acid modifications

Modified residue3941Phosphotyrosine By similarity

Natural variations

Natural variant3341A → V.
Corresponds to variant rs41312309 [ dbSNP | Ensembl ].
VAR_053554

Secondary structure

............................ 444
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9BY11 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 6AAF801873770975

FASTA44450,966
        10         20         30         40         50         60 
MSSSYDEASL APEETTDSFW EVGNYKRTVK RIDDGHRLCN DLMNCVQERA KIEKAYGQQL 

        70         80         90        100        110        120 
TDWAKRWRQL IEKGPQYGSL ERAWGAIMTE ADKVSELHQE VKNNLLNEDL EKVKNWQKDA 

       130        140        150        160        170        180 
YHKQIMGGFK ETKEAEDGFR KAQKPWAKKM KELEAAKKAY HLACKEEKLA MTREMNSKTE 

       190        200        210        220        230        240 
QSVTPEQQKK LQDKVDKCKQ DVQKTQEKYE KVLEDVGKTT PQYMENMEQV FEQCQQFEEK 

       250        260        270        280        290        300 
RLVFLKEVLL DIKRHLNLAE NSSYIHVYRE LEQAIRGADA QEDLRWFRST SGPGMPMNWP 

       310        320        330        340        350        360 
QFEEWNPDLP HTTTKKEKQP KKAEGVALTN ATGAVESTSQ AGDRGSVSSY DRGQPYATEW 

       370        380        390        400        410        420 
SDDESGNPFG GSETNGGANP FEDDSKGVRV RALYDYDGQE QDELSFKAGD ELTKLGEEDE 

       430        440 
QGWCRGRLDS GQLGLYPANY VEAI 

« Hide

References

« Hide 'large scale' references
[1]"PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family."
Sumoy L., Pluvinet R., Andreu N., Estivill X., Escarceller M.
Gene 262:199-205(2001) [PubMed: 11179684] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis."
Modregger J., Ritter B., Witter B., Paulsson M., Plomann M.
J. Cell Sci. 113:4511-4521(2000) [PubMed: 11082044] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF242529 mRNA. Translation: AAK29206.1.
AB037800 mRNA. Translation: BAA92617.2. Different initiation.
AL834211 mRNA. Translation: CAD38895.1.
BC040228 mRNA. Translation: AAH40228.1.
IPIIPI00011515.
RefSeqNP_001186512.1. NM_001199583.1.
NP_065855.1. NM_020804.3.
UniGeneHs.520087.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3HAHX-ray2.77A/B1-325[»]
3HAIX-ray2.88A/B/C/D1-308[»]
3QNIX-ray2.80A/B1-307[»]
ProteinModelPortalQ9BY11.
SMRQ9BY11. Positions 15-308, 388-443.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9BY11. 16 interactions.
STRINGQ9BY11.

PTM databases

PhosphoSiteQ9BY11.

Polymorphism databases

DMDM22256962.

Proteomic databases

PRIDEQ9BY11.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000244458; ENSP00000244458; ENSG00000124507.
GeneID29993.
KEGGhsa:29993.
UCSCuc003ojo.1. human.

Organism-specific databases

CTD29993.
GeneCardsGC06P034480.
H-InvDBHIX0005791.
HGNCHGNC:8570. PACSIN1.
HPACAB009929.
HPA028852.
MIM606512. gene.
neXtProtNX_Q9BY11.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

GeneTreeENSGT00510000046376.
HOGENOMHBG446365.
HOVERGENHBG053486.
InParanoidQ9BY11.
OMAPDSLGWC.
OrthoDBEOG4QVCC5.
PhylomeDBQ9BY11.

Gene expression databases

ArrayExpressQ9BY11.
BgeeQ9BY11.
CleanExHS_PACSIN1.
GenevestigatorQ9BY11.
GermOnlineENSG00000124507. Homo sapiens.

Family and domain databases

InterProIPR001060. FCH.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SH3. 1 hit.
PROSITEPS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio52788.
SOURCESearch...

Entry information

Entry namePACN1_HUMAN
AccessionPrimary (citable) accession number: Q9BY11
Secondary accession number(s): Q9P2G8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families