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Protein

Emopamil-binding protein-like

Gene

EBPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Does not possess sterol isomerase activity and does not bind sigma ligands.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123179-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Emopamil-binding protein-like
Alternative name(s):
Emopamil-binding-related protein
Gene namesi
Name:EBPL
Synonyms:EBRP, ERP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:18061. EBPL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84650.
OpenTargetsiENSG00000123179.
PharmGKBiPA134875632.

Chemistry databases

ChEMBLiCHEMBL2311238.

Polymorphism and mutation databases

DMDMi18202741.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001743471 – 206Emopamil-binding protein-likeAdd BLAST206

Proteomic databases

PaxDbiQ9BY08.
PeptideAtlasiQ9BY08.
PRIDEiQ9BY08.
TopDownProteomicsiQ9BY08-1. [Q9BY08-1]

Expressioni

Tissue specificityi

Widely expressed with highest levels in liver, lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000123179.
CleanExiHS_EBPL.
ExpressionAtlasiQ9BY08. baseline and differential.
GenevisibleiQ9BY08. HS.

Organism-specific databases

HPAiHPA049891.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi124173. 1 interactor.
IntActiQ9BY08. 1 interactor.
STRINGi9606.ENSP00000242827.

Chemistry databases

BindingDBiQ9BY08.

Structurei

3D structure databases

ProteinModelPortaliQ9BY08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 184EXPERAPROSITE-ProRule annotationAdd BLAST146

Sequence similaritiesi

Belongs to the EBP family.Curated
Contains 1 EXPERA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4826. Eukaryota.
ENOG41101ES. LUCA.
GeneTreeiENSGT00530000063715.
HOVERGENiHBG051436.
InParanoidiQ9BY08.
OMAiKEKHYRH.
OrthoDBiEOG091G0OZ1.
PhylomeDBiQ9BY08.
TreeFamiTF314716.

Family and domain databases

InterProiIPR007905. EBP.
IPR033118. EXPERA.
[Graphical view]
PANTHERiPTHR14207. PTHR14207. 1 hit.
PfamiPF05241. EBP. 1 hit.
[Graphical view]
PROSITEiPS51751. EXPERA. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BY08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAEWELGAE AGGSLLLCAA LLAAGCALGL RLGRGQGAAD RGALIWLCYD
60 70 80 90 100
ALVHFALEGP FVYLSLVGNV ANSDGLIASL WKEYGKADAR WVYFDPTIVS
110 120 130 140 150
VEILTVALDG SLALFLIYAI VKEKYYRHFL QITLCVCELY GCWMTFLPEW
160 170 180 190 200
LTRSPNLNTS NWLYCWLYLF FFNGVWVLIP GLLLWQSWLE LKKMHQKETS

SVKKFQ
Length:206
Mass (Da):23,204
Last modified:June 1, 2001 - v1
Checksum:i7093AC7E638B89D0
GO
Isoform 2 (identifier: Q9BY08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-152: WKEYGKADAR...WMTFLPEWLT → CESRSVPQAG...SQDGLDLLTS
     153-206: Missing.

Note: No experimental confirmation available.
Show »
Length:152
Mass (Da):16,148
Checksum:i42BD497BDCF3CE6F
GO
Isoform 3 (identifier: Q9BY08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-102: EGPFVYLSLV...YFDPTIVSVE → AFPADHPVRV...AVLLALPVFF
     103-206: Missing.

Note: No experimental confirmation available.
Show »
Length:102
Mass (Da):10,873
Checksum:iB177377904C347D8
GO
Isoform 4 (identifier: Q9BY08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-97: WKEYGKADARWVYFDPT → CISCRSPCACASCMAAG
     98-206: Missing.

Note: No experimental confirmation available.
Show »
Length:97
Mass (Da):9,691
Checksum:iB68541E573B4A23F
GO
Isoform 5 (identifier: Q9BY08-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-87: WKEYGKA → S
     128-134: HFLQITL → DRVAWGE
     135-206: Missing.

Note: No experimental confirmation available.
Show »
Length:128
Mass (Da):13,611
Checksum:i2AF484853AD247BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31R → H in AAH92471 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03541758 – 102EGPFV…IVSVE → AFPADHPVRVRAVWLLDDLP PRVAHQKPQPQHQQLAVLLA LPVFF in isoform 3. CuratedAdd BLAST45
Alternative sequenceiVSP_03541881 – 152WKEYG…PEWLT → CESRSVPQAGAQWHHLGSLQ APPPRFTPFSCLSLPSSWDY RRPPPRLANFFVFLVETGFH HVSQDGLDLLTS in isoform 2. CuratedAdd BLAST72
Alternative sequenceiVSP_03541981 – 97WKEYG…YFDPT → CISCRSPCACASCMAAG in isoform 4. CuratedAdd BLAST17
Alternative sequenceiVSP_03542081 – 87WKEYGKA → S in isoform 5. Curated7
Alternative sequenceiVSP_03542198 – 206Missing in isoform 4. CuratedAdd BLAST109
Alternative sequenceiVSP_035422103 – 206Missing in isoform 3. CuratedAdd BLAST104
Alternative sequenceiVSP_035423128 – 134HFLQITL → DRVAWGE in isoform 5. Curated7
Alternative sequenceiVSP_035424135 – 206Missing in isoform 5. CuratedAdd BLAST72
Alternative sequenceiVSP_035425153 – 206Missing in isoform 2. CuratedAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243433 mRNA. Translation: AAK28348.1.
AL135901 Genomic DNA. Translation: CAI40717.1.
AL135901 Genomic DNA. Translation: CAI40718.1.
AL135901 Genomic DNA. Translation: CAI40719.2.
AL135901 Genomic DNA. Translation: CAI40720.1.
AL135901 Genomic DNA. Translation: CAI40721.1.
CH471075 Genomic DNA. Translation: EAX08832.1.
BC018478 mRNA. Translation: AAH18478.1.
BC092471 mRNA. Translation: AAH92471.1.
CCDSiCCDS9420.1. [Q9BY08-1]
RefSeqiNP_115954.1. NM_032565.4. [Q9BY08-1]
UniGeneiHs.433278.

Genome annotation databases

EnsembliENST00000242827; ENSP00000242827; ENSG00000123179. [Q9BY08-1]
ENST00000378268; ENSP00000367516; ENSG00000123179. [Q9BY08-2]
ENST00000378270; ENSP00000367519; ENSG00000123179. [Q9BY08-3]
ENST00000378272; ENSP00000367521; ENSG00000123179. [Q9BY08-4]
GeneIDi84650.
KEGGihsa:84650.
UCSCiuc001vdg.5. human. [Q9BY08-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243433 mRNA. Translation: AAK28348.1.
AL135901 Genomic DNA. Translation: CAI40717.1.
AL135901 Genomic DNA. Translation: CAI40718.1.
AL135901 Genomic DNA. Translation: CAI40719.2.
AL135901 Genomic DNA. Translation: CAI40720.1.
AL135901 Genomic DNA. Translation: CAI40721.1.
CH471075 Genomic DNA. Translation: EAX08832.1.
BC018478 mRNA. Translation: AAH18478.1.
BC092471 mRNA. Translation: AAH92471.1.
CCDSiCCDS9420.1. [Q9BY08-1]
RefSeqiNP_115954.1. NM_032565.4. [Q9BY08-1]
UniGeneiHs.433278.

3D structure databases

ProteinModelPortaliQ9BY08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124173. 1 interactor.
IntActiQ9BY08. 1 interactor.
STRINGi9606.ENSP00000242827.

Chemistry databases

BindingDBiQ9BY08.
ChEMBLiCHEMBL2311238.

Polymorphism and mutation databases

DMDMi18202741.

Proteomic databases

PaxDbiQ9BY08.
PeptideAtlasiQ9BY08.
PRIDEiQ9BY08.
TopDownProteomicsiQ9BY08-1. [Q9BY08-1]

Protocols and materials databases

DNASUi84650.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242827; ENSP00000242827; ENSG00000123179. [Q9BY08-1]
ENST00000378268; ENSP00000367516; ENSG00000123179. [Q9BY08-2]
ENST00000378270; ENSP00000367519; ENSG00000123179. [Q9BY08-3]
ENST00000378272; ENSP00000367521; ENSG00000123179. [Q9BY08-4]
GeneIDi84650.
KEGGihsa:84650.
UCSCiuc001vdg.5. human. [Q9BY08-1]

Organism-specific databases

CTDi84650.
DisGeNETi84650.
GeneCardsiEBPL.
HGNCiHGNC:18061. EBPL.
HPAiHPA049891.
neXtProtiNX_Q9BY08.
OpenTargetsiENSG00000123179.
PharmGKBiPA134875632.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4826. Eukaryota.
ENOG41101ES. LUCA.
GeneTreeiENSGT00530000063715.
HOVERGENiHBG051436.
InParanoidiQ9BY08.
OMAiKEKHYRH.
OrthoDBiEOG091G0OZ1.
PhylomeDBiQ9BY08.
TreeFamiTF314716.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123179-MONOMER.

Miscellaneous databases

ChiTaRSiEBPL. human.
GenomeRNAii84650.
PROiQ9BY08.

Gene expression databases

BgeeiENSG00000123179.
CleanExiHS_EBPL.
ExpressionAtlasiQ9BY08. baseline and differential.
GenevisibleiQ9BY08. HS.

Family and domain databases

InterProiIPR007905. EBP.
IPR033118. EXPERA.
[Graphical view]
PANTHERiPTHR14207. PTHR14207. 1 hit.
PfamiPF05241. EBP. 1 hit.
[Graphical view]
PROSITEiPS51751. EXPERA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEBPL_HUMAN
AccessioniPrimary (citable) accession number: Q9BY08
Secondary accession number(s): A6NJ59
, Q569H7, Q5JVN2, Q5JVN3, Q5JVN4, Q5JVN5, Q5JVN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.