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Protein

Protein MAK16 homolog

Gene

MAK16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MAK16 homolog
Alternative name(s):
NNP78
Protein RBM13
Gene namesi
Name:MAK16
Synonyms:RBM13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:13703. MAK16.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84549.
OpenTargetsiENSG00000198042.
PharmGKBiPA162394925.

Polymorphism and mutation databases

BioMutaiMAK16.
DMDMi71152029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002037941 – 300Protein MAK16 homologAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki55Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei197PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BXY0.
MaxQBiQ9BXY0.
PaxDbiQ9BXY0.
PeptideAtlasiQ9BXY0.
PRIDEiQ9BXY0.

2D gel databases

SWISS-2DPAGEiQ9BXY0.

PTM databases

iPTMnetiQ9BXY0.
PhosphoSitePlusiQ9BXY0.
SwissPalmiQ9BXY0.

Expressioni

Gene expression databases

BgeeiENSG00000198042.
CleanExiHS_MAK16.
ExpressionAtlasiQ9BXY0. baseline and differential.
GenevisibleiQ9BXY0. HS.

Organism-specific databases

HPAiHPA044417.
HPA050574.

Interactioni

Protein-protein interaction databases

BioGridi124134. 69 interactors.
IntActiQ9BXY0. 10 interactors.
MINTiMINT-3058483.
STRINGi9606.ENSP00000353246.

Structurei

3D structure databases

ProteinModelPortaliQ9BXY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 249Asp-richAdd BLAST52
Compositional biasi255 – 259Poly-Glu5

Sequence similaritiesi

Belongs to the MAK16 family.Curated

Phylogenomic databases

eggNOGiKOG3064. Eukaryota.
COG5129. LUCA.
GeneTreeiENSGT00390000012859.
HOGENOMiHOG000201538.
HOVERGENiHBG055328.
InParanoidiQ9BXY0.
KOiK14831.
OMAiDIYNFSQ.
OrthoDBiEOG091G0KSQ.
PhylomeDBiQ9BXY0.
TreeFamiTF105759.

Family and domain databases

InterProiView protein in InterPro
IPR029004. L28e/Mak16.
IPR006958. Mak16.
PfamiView protein in Pfam
PF04874. Mak16. 1 hit.
PF01778. Ribosomal_L28e. 1 hit.
PIRSFiPIRSF003352. MAK16. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BXY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSDDVIWDT LGNKQFCSFK IRTKTQSFCR NEYSLTGLCN RSSCPLANSQ
60 70 80 90 100
YATIKEEKGQ CYLYMKVIER AAFPRRLWER VRLSKNYEKA LEQIDENLIY
110 120 130 140 150
WPRFIRHKCK QRFTKITQYL IRIRKLTLKR QRKLVPLSKK VERREKRREE
160 170 180 190 200
KALIAAQLDN AIEKELLERL KQDTYGDIYN FPIHAFDKAL EQQEAESDSS
210 220 230 240 250
DTEEKDDDDD DEEDVGKREF VEDGEVDESD ISDFEDMDKL DASSDEDQDG
260 270 280 290 300
KSSSEEEEEK ALSAKHKGKM PLRGPLQRKR AYVEIEYEQE TEPVAKAKTT
Length:300
Mass (Da):35,369
Last modified:July 19, 2005 - v2
Checksum:i2A757589C4749760
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200S → L in BAB55134 (PubMed:14702039).Curated1
Sequence conflicti281A → V in AAH39740 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023076277Q → R2 PublicationsCorresponds to variant dbSNP:rs6468171Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251062 mRNA. Translation: AAK34952.1.
AK027469 mRNA. Translation: BAB55134.1.
AK314491 mRNA. Translation: BAG37091.1.
CH471080 Genomic DNA. Translation: EAW63400.1.
BC028230 mRNA. Translation: AAH28230.1.
BC039740 mRNA. Translation: AAH39740.1.
BC050528 mRNA. Translation: AAH50528.1.
CCDSiCCDS6089.1.
RefSeqiNP_115898.2. NM_032509.3.
UniGeneiHs.583805.

Genome annotation databases

EnsembliENST00000360128; ENSP00000353246; ENSG00000198042.
GeneIDi84549.
KEGGihsa:84549.
UCSCiuc003xjj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMAK16_HUMAN
AccessioniPrimary (citable) accession number: Q9BXY0
Secondary accession number(s): B2RB44
, Q5U5T1, Q86UC4, Q96SY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: August 30, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families