Q9BXY0 (MAK16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein MAK16 homolog

Alternative name(s):
NNP78
Protein RBM13

Gene names

Name:	MAK16
Synonyms:	RBM13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus › nucleolus Ref.5 Ref.6.
Sequence similarities	Belongs to the MAK16 family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	Protein MAK16 homolog		PRO_0000203794
Regions
	Compositional bias	198 – 249	52	Asp-rich
	Compositional bias	255 – 259	5	Poly-Glu
Amino acid modifications
	Modified residue	197	1	Phosphoserine Ref.10
	Modified residue	200	1	Phosphoserine Ref.10
	Modified residue	229	1	Phosphoserine Ref.7 Ref.9 Ref.10
	Modified residue	232	1	Phosphoserine Ref.7 Ref.9 Ref.10
Natural variations
	Natural variant	277	1	Q → R. Ref.1 Ref.4 Corresponds to variant rs6468171 [ dbSNP | Ensembl ].		VAR_023076
Experimental info
	Sequence conflict	200	1	S → L in BAB55134. Ref.2
	Sequence conflict	281	1	A → V in AAH39740. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9BXY0 [UniParc]. Last modified July 19, 2005. Version 2. Checksum: 2A757589C4749760	FASTA	300	35,369
	10 20 30 40 50 60 MQSDDVIWDT LGNKQFCSFK IRTKTQSFCR NEYSLTGLCN RSSCPLANSQ YATIKEEKGQ 70 80 90 100 110 120 CYLYMKVIER AAFPRRLWER VRLSKNYEKA LEQIDENLIY WPRFIRHKCK QRFTKITQYL 130 140 150 160 170 180 IRIRKLTLKR QRKLVPLSKK VERREKRREE KALIAAQLDN AIEKELLERL KQDTYGDIYN 190 200 210 220 230 240 FPIHAFDKAL EQQEAESDSS DTEEKDDDDD DEEDVGKREF VEDGEVDESD ISDFEDMDKL 250 260 270 280 290 300 DASSDEDQDG KSSSEEEEEK ALSAKHKGKM PLRGPLQRKR AYVEIEYEQE TEPVAKAKTT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mao Y., Xie Y., Zhou Z., Zhao W., Zhao S., Wang W., Huang Y., Wang S., Tang R., Chen X., Wu C. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-277.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-277. Tissue: Brain, Testis and Uterus.
[5]	"Directed proteomic analysis of the human nucleolus." Andersen J.S., Lyon C.E., Fox A.H., Leung A.K.L., Lam Y.W., Steen H., Mann M., Lamond A.I. Curr. Biol. 12:1-11(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[6]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229 AND SER-232, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229 AND SER-232, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197; SER-200; SER-229 AND SER-232, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF251062 mRNA. Translation: AAK34952.1. AK027469 mRNA. Translation: BAB55134.1. AK314491 mRNA. Translation: BAG37091.1. CH471080 Genomic DNA. Translation: EAW63400.1. BC028230 mRNA. Translation: AAH28230.1. BC039740 mRNA. Translation: AAH39740.1. BC050528 mRNA. Translation: AAH50528.1.
IPI	IPI00332428.
RefSeq	NP_115898.2. NM_032509.3.
UniGene	Hs.583805.
3D structure databases
ProteinModelPortal	Q9BXY0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BXY0. 1 interaction.
STRING	9606.ENSP00000353246.
PTM databases
PhosphoSite	Q9BXY0.
Polymorphism databases
DMDM	71152029.
2D gel databases
SWISS-2DPAGE	Q9BXY0.
Proteomic databases
PaxDb	Q9BXY0.
PRIDE	Q9BXY0.
Protocols and materials databases
DNASU	84549.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360128; ENSP00000353246; ENSG00000198042.
GeneID	84549.
KEGG	hsa:84549.
UCSC	uc003xjj.3. human.
Organism-specific databases
CTD	84549.
GeneCards	GC08P033342.
HGNC	HGNC:13703. MAK16.
HPA	HPA044417. HPA050574.
neXtProt	NX_Q9BXY0.
PharmGKB	PA162394925.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5129.
HOGENOM	HOG000201538.
HOVERGEN	HBG055328.
InParanoid	Q9BXY0.
KO	K14831.
OMA	TQSFCRN.
OrthoDB	EOG4255TP.
PhylomeDB	Q9BXY0.
Gene expression databases
Bgee	Q9BXY0.
CleanEx	HS_MAK16.
Genevestigator	Q9BXY0.
GermOnline	ENSG00000198042. Homo sapiens.
Family and domain databases
InterPro	IPR006958. Mak16. [Graphical view]
PANTHER	PTHR23405:SF4. PTHR23405:SF4. 1 hit.
Pfam	PF04874. Mak16. 1 hit. [Graphical view]
PIRSF	PIRSF003352. MAK16. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	84549.
NextBio	74427.

Entry information

Entry name

MAK16_HUMAN

Accession

Primary (citable) accession number: Q9BXY0
Secondary accession number(s): B2RB44 , Q5U5T1, Q86UC4, Q96SY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.