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Protein

Protein MAK16 homolog

Gene

MAK16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MAK16 homolog
Alternative name(s):
NNP78
Protein RBM13
Gene namesi
Name:MAK16
Synonyms:RBM13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:13703. MAK16.

Subcellular locationi

Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: HPA
  2. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394925.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Protein MAK16 homologPRO_0000203794Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Modified residuei197 – 1971Phosphoserine1 Publication
Modified residuei199 – 1991PhosphoserineBy similarity
Modified residuei200 – 2001Phosphoserine1 Publication
Modified residuei229 – 2291Phosphoserine3 Publications
Modified residuei232 – 2321Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BXY0.
PaxDbiQ9BXY0.
PRIDEiQ9BXY0.

2D gel databases

SWISS-2DPAGEQ9BXY0.

PTM databases

PhosphoSiteiQ9BXY0.

Expressioni

Gene expression databases

BgeeiQ9BXY0.
CleanExiHS_MAK16.
GenevestigatoriQ9BXY0.

Organism-specific databases

HPAiHPA044417.
HPA050574.

Interactioni

Protein-protein interaction databases

BioGridi124134. 8 interactions.
IntActiQ9BXY0. 1 interaction.
MINTiMINT-3058483.
STRINGi9606.ENSP00000353246.

Structurei

3D structure databases

ProteinModelPortaliQ9BXY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 24952Asp-richAdd
BLAST
Compositional biasi255 – 2595Poly-Glu

Sequence similaritiesi

Belongs to the MAK16 family.Curated

Phylogenomic databases

eggNOGiCOG5129.
GeneTreeiENSGT00390000012859.
HOGENOMiHOG000201538.
HOVERGENiHBG055328.
InParanoidiQ9BXY0.
KOiK14831.
OMAiIYWPNFL.
OrthoDBiEOG7TJ3KB.
PhylomeDBiQ9BXY0.
TreeFamiTF105759.

Family and domain databases

InterProiIPR029004. L28e/Mak16.
IPR006958. Mak16.
[Graphical view]
PfamiPF04874. Mak16. 1 hit.
PF01778. Ribosomal_L28e. 1 hit.
[Graphical view]
PIRSFiPIRSF003352. MAK16. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BXY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSDDVIWDT LGNKQFCSFK IRTKTQSFCR NEYSLTGLCN RSSCPLANSQ
60 70 80 90 100
YATIKEEKGQ CYLYMKVIER AAFPRRLWER VRLSKNYEKA LEQIDENLIY
110 120 130 140 150
WPRFIRHKCK QRFTKITQYL IRIRKLTLKR QRKLVPLSKK VERREKRREE
160 170 180 190 200
KALIAAQLDN AIEKELLERL KQDTYGDIYN FPIHAFDKAL EQQEAESDSS
210 220 230 240 250
DTEEKDDDDD DEEDVGKREF VEDGEVDESD ISDFEDMDKL DASSDEDQDG
260 270 280 290 300
KSSSEEEEEK ALSAKHKGKM PLRGPLQRKR AYVEIEYEQE TEPVAKAKTT
Length:300
Mass (Da):35,369
Last modified:July 19, 2005 - v2
Checksum:i2A757589C4749760
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001S → L in BAB55134 (PubMed:14702039).Curated
Sequence conflicti281 – 2811A → V in AAH39740 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti277 – 2771Q → R.2 Publications
Corresponds to variant rs6468171 [ dbSNP | Ensembl ].
VAR_023076

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251062 mRNA. Translation: AAK34952.1.
AK027469 mRNA. Translation: BAB55134.1.
AK314491 mRNA. Translation: BAG37091.1.
CH471080 Genomic DNA. Translation: EAW63400.1.
BC028230 mRNA. Translation: AAH28230.1.
BC039740 mRNA. Translation: AAH39740.1.
BC050528 mRNA. Translation: AAH50528.1.
CCDSiCCDS6089.1.
RefSeqiNP_115898.2. NM_032509.3.
UniGeneiHs.583805.

Genome annotation databases

EnsembliENST00000360128; ENSP00000353246; ENSG00000198042.
GeneIDi84549.
KEGGihsa:84549.
UCSCiuc003xjj.3. human.

Polymorphism databases

DMDMi71152029.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251062 mRNA. Translation: AAK34952.1.
AK027469 mRNA. Translation: BAB55134.1.
AK314491 mRNA. Translation: BAG37091.1.
CH471080 Genomic DNA. Translation: EAW63400.1.
BC028230 mRNA. Translation: AAH28230.1.
BC039740 mRNA. Translation: AAH39740.1.
BC050528 mRNA. Translation: AAH50528.1.
CCDSiCCDS6089.1.
RefSeqiNP_115898.2. NM_032509.3.
UniGeneiHs.583805.

3D structure databases

ProteinModelPortaliQ9BXY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124134. 8 interactions.
IntActiQ9BXY0. 1 interaction.
MINTiMINT-3058483.
STRINGi9606.ENSP00000353246.

PTM databases

PhosphoSiteiQ9BXY0.

Polymorphism databases

DMDMi71152029.

2D gel databases

SWISS-2DPAGEQ9BXY0.

Proteomic databases

MaxQBiQ9BXY0.
PaxDbiQ9BXY0.
PRIDEiQ9BXY0.

Protocols and materials databases

DNASUi84549.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360128; ENSP00000353246; ENSG00000198042.
GeneIDi84549.
KEGGihsa:84549.
UCSCiuc003xjj.3. human.

Organism-specific databases

CTDi84549.
GeneCardsiGC08P033342.
HGNCiHGNC:13703. MAK16.
HPAiHPA044417.
HPA050574.
neXtProtiNX_Q9BXY0.
PharmGKBiPA162394925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5129.
GeneTreeiENSGT00390000012859.
HOGENOMiHOG000201538.
HOVERGENiHBG055328.
InParanoidiQ9BXY0.
KOiK14831.
OMAiIYWPNFL.
OrthoDBiEOG7TJ3KB.
PhylomeDBiQ9BXY0.
TreeFamiTF105759.

Miscellaneous databases

GeneWikiiRBM13.
GenomeRNAii84549.
NextBioi74427.
PROiQ9BXY0.

Gene expression databases

BgeeiQ9BXY0.
CleanExiHS_MAK16.
GenevestigatoriQ9BXY0.

Family and domain databases

InterProiIPR029004. L28e/Mak16.
IPR006958. Mak16.
[Graphical view]
PfamiPF04874. Mak16. 1 hit.
PF01778. Ribosomal_L28e. 1 hit.
[Graphical view]
PIRSFiPIRSF003352. MAK16. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mao Y., Xie Y., Zhou Z., Zhao W., Zhao S., Wang W., Huang Y., Wang S., Tang R., Chen X., Wu C.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-277.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-277.
    Tissue: Brain, Testis and Uterus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229 AND SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229 AND SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197; SER-200; SER-229 AND SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMAK16_HUMAN
AccessioniPrimary (citable) accession number: Q9BXY0
Secondary accession number(s): B2RB44
, Q5U5T1, Q86UC4, Q96SY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 4, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.