ID   MLP3C_HUMAN             Reviewed;         147 AA.
AC   Q9BXW4; A0PJY8; A2RUP0;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-NOV-2009, entry version 53.
DE   RecName: Full=Microtubule-associated proteins 1A/1B light chain 3C;
DE   AltName: Full=Microtubule-associated protein 1 light chain 3 gamma;
DE   AltName: Full=MAP1A/1B light chain 3 C;
DE   AltName: Full=MAP1A/MAP1B LC3 C;
DE   AltName: Full=MAP1 light chain 3-like protein 3;
DE   AltName: Full=Autophagy-related protein LC3 C;
DE   AltName: Full=Autophagy-related ubiquitin-like modifier LC3 C;
DE   Flags: Precursor;
GN   Name=MAP1LC3C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP   AND MUTAGENESIS OF GLY-126.
RX   MEDLINE=22765575; PubMed=12740394; DOI=10.1074/jbc.M303800200;
RA   He H., Dang Y., Dai F., Guo Z., Wu J., She X., Pei Y., Chen Y.,
RA   Ling W., Wu C., Zhao S., Liu J.O., Yu L.;
RT   "Post-translational modifications of three members of the human
RT   MAP1LC3 family and detection of a novel type of modification for
RT   MAP1LC3B.";
RL   J. Biol. Chem. 278:29278-29287(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   LIPIDATION, AND CLEAVAGE BY APG4B.
RX   PubMed=15187094; DOI=10.1074/jbc.M401461200;
RA   Tanida I., Sou Y.-S., Ezaki J., Minematsu-Ikeguchi N., Ueno T.,
RA   Kominami E.;
RT   "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three
RT   human Atg8 homologues and delipidates microtubule-associated protein
RT   light chain 3- and GABAA receptor-associated protein-phospholipid
RT   conjugates.";
RL   J. Biol. Chem. 279:36268-36276(2004).
CC   -!- FUNCTION: Probably involved in formation of autophagosomal
CC       vacuoles (autophagosomes) (By similarity).
CC   -!- SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate
CC       with MAP1A and MAP1B proteins (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system; Lipid-
CC       anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor.
CC       Note=LC3-II binds to the autophagic membranes.
CC   -!- TISSUE SPECIFICITY: Most abundant in placenta, lung and ovary.
CC   -!- PTM: The precursor molecule is cleaved by APG4B/ATG4B to form the
CC       cytosolic form, LC3-I. This is activated by APG7L/ATG7,
CC       transferred to ATG3 and conjugated to phospholipid to form the
CC       membrane-bound form, LC3-II.
CC   -!- SIMILARITY: Belongs to the MAP1 LC3 family.
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DR   EMBL; AF276659; AAK35152.1; -; mRNA.
DR   EMBL; BX571673; CAH72477.1; -; Genomic_DNA.
DR   EMBL; BC127722; AAI27723.1; -; mRNA.
DR   EMBL; BC132986; AAI32987.1; -; mRNA.
DR   EMBL; BC132988; AAI32989.1; -; mRNA.
DR   IPI; IPI00387017; -.
DR   RefSeq; NP_001004343.1; -.
DR   UniGene; Hs.534971; -.
DR   HSSP; P60519; 1EO6.
DR   STRING; Q9BXW4; -.
DR   PRIDE; Q9BXW4; -.
DR   Ensembl; ENST00000357246; ENSP00000349785; ENSG00000197769; Homo sapiens.
DR   GeneID; 440738; -.
DR   KEGG; hsa:440738; -.
DR   UCSC; uc001hzk.1; human.
DR   CTD; 440738; -.
DR   GeneCards; GC01M240225; -.
DR   H-InvDB; HIX0028588; -.
DR   HGNC; HGNC:13353; MAP1LC3C.
DR   MIM; 609605; gene.
DR   PharmGKB; PA142671482; -.
DR   HOGENOM; Q9BXW4; -.
DR   HOVERGEN; Q9BXW4; -.
DR   OMA; IRSRMVL; -.
DR   NextBio; 109492; -.
DR   ArrayExpress; Q9BXW4; -.
DR   Bgee; Q9BXW4; -.
DR   CleanEx; HS_MAP1LC3C; -.
DR   Genevestigator; Q9BXW4; -.
DR   GermOnline; ENSG00000197769; Homo sapiens.
DR   GO; GO:0031225; C:anchored to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005776; C:autophagic vacuole; ISS:UniProtKB.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031090; C:organelle membrane; ISS:UniProtKB.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW.
DR   InterPro; IPR004241; MAP1_LC3.
DR   PANTHER; PTHR10969; MAP1_LC3; 1.
DR   Pfam; PF02991; MAP1_LC3; 1.
PE   1: Evidence at protein level;
KW   Autophagy; Complete proteome; Cytoplasm; Cytoplasmic vesicle;
KW   Lipoprotein; Membrane; Microtubule; Ubl conjugation pathway.
FT   CHAIN         1    126       Microtubule-associated proteins 1A/1B
FT                                light chain 3C.
FT                                /FTId=PRO_0000017204.
FT   PROPEP      127    147       Removed in mature form.
FT                                /FTId=PRO_0000017205.
FT   LIPID       126    126       Phosphatidylethanolamine amidated glycine
FT                                (Probable).
FT   MUTAGEN     126    126       G->A: No processing of precursor.
SQ   SEQUENCE   147 AA;  16852 MW;  D3DFA8EE5985C3AA CRC64;
     MPPPQKIPSV RPFKQRKSLA IRQEEVAGIR AKFPNKIPVV VERYPRETFL PPLDKTKFLV
     PQELTMTQFL SIIRSRMVLR ATEAFYLLVN NKSLVSMSAT MAEIYRDYKD EDGFVYMTYA
     SQETFGCLES AAPRDGSSLE DRPCNPL
//