Reviewed, UniProtKB/Swiss-Prot Q9BXW4 (MLP3C_HUMAN)

Names and origin

Protein names

Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3C
Alternative name(s):
    Microtubule-associated protein 1 light chain 3 gamma
    MAP1A/MAP1B light chain 3 C
      Short name=MAP1A/MAP1B LC3 C
    MAP1 light chain 3-like protein 3
    Autophagy-related protein LC3 C
    Autophagy-related ubiquitin-like modifier LC3 C

Gene names

Name:

MAP1LC3C

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probably involved in formation of autophagosomal vacuoles (autophagosomes) By similarity.
Subunit structure	3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins By similarity.
Subcellular location	Cytoplasm. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle › autophagosome membrane; Lipid-anchor. Note: LC3-II binds to the autophagic membranes. Ref.1
Tissue specificity	Most abundant in placenta, lung and ovary. Ref.1
Post-translational modification	The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. Ref.4
Sequence similarities	Belongs to the MAP1 LC3 family.

Ontologies

Keywords
Biological process	Autophagy Ubl conjugation pathway
Cellular component	Cytoplasm Cytoplasmic vesicle Membrane Microtubule
PTM	Lipoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell autophagic vacuole Ref.1 Inferred from sequence or structural similarity. Source: UniProtKB cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW organelle membrane Ref.1 Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 126	126	Microtubule-associated proteins 1A/1B light chain 3C		PRO_0000017204
	Propeptide	127 – 147	21	Removed in mature form		PRO_0000017205
Amino acid modifications
	Lipidation	126	1	Phosphatidylethanolamine amidated glycine Probable
Experimental info
	Mutagenesis	126	1	G → A: No processing of precursor. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BXW4-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D3DFA8EE5985C3AA	FASTA	147	16,852
	10 20 30 40 50 60 MPPPQKIPSV RPFKQRKSLA IRQEEVAGIR AKFPNKIPVV VERYPRETFL PPLDKTKFLV 70 80 90 100 110 120 PQELTMTQFL SIIRSRMVLR ATEAFYLLVN NKSLVSMSAT MAEIYRDYKD EDGFVYMTYA 130 140 SQETFGCLES AAPRDGSSLE DRPCNPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B." He H., Dang Y., Dai F., Guo Z., Wu J., She X., Pei Y., Chen Y., Ling W., Wu C., Zhao S., Liu J.O., Yu L. J. Biol. Chem. 278:29278-29287(2003) [PubMed: 12740394] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF GLY-126.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates." Tanida I., Sou Y.-S., Ezaki J., Minematsu-Ikeguchi N., Ueno T., Kominami E. J. Biol. Chem. 279:36268-36276(2004) [PubMed: 15187094] [Abstract] Cited for: LIPIDATION, CLEAVAGE BY APG4B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF276659 mRNA. Translation: AAK35152.1. BX571673 Genomic DNA. Translation: CAH72477.1. BC127722 mRNA. Translation: AAI27723.1. BC132986 mRNA. Translation: AAI32987.1. BC132988 mRNA. Translation: AAI32989.1.
IPI	IPI00387017.
RefSeq	NP_001004343.1.
UniGene	Hs.534971
3D structure databases
SMR	Q9BXW4. Positions 11-123.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BXW4.
Proteomic databases
PRIDE	Q9BXW4.
Genome annotation databases
Ensembl	ENST00000357246; ENSP00000349785; ENSG00000197769; Homo sapiens. [Genome view]
GeneID	440738.
KEGG	hsa:440738.
UCSC	uc001hzk.1. human.
Organism-specific databases
CTD	440738.
GeneCards	GC01M240225.
H-InvDB	HIX0028588.
HGNC	HGNC:13353. MAP1LC3C.
MIM	609605. gene.
PharmGKB	PA142671482.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07023.
HOGENOM	HBG592694.
HOVERGEN	Q9BXW4.
InParanoid	Q9BXW4.
OMA	IRSRMVL.
OrthoDB	EOG9QVFXK.
PhylomeDB	Q9BXW4.
Gene expression databases
ArrayExpress	Q9BXW4.
Bgee	Q9BXW4.
CleanEx	HS_MAP1LC3C.
Genevestigator	Q9BXW4.
GermOnline	ENSG00000197769. Homo sapiens.
Family and domain databases
InterPro	IPR004241. MAP1_LC3. [Graphical view]
PANTHER	PTHR10969. MAP1_LC3. 1 hit.
Pfam	PF02991. MAP1_LC3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	109492.
SOURCE	Search...

Entry information

Entry name

MLP3C_HUMAN

Accession

Primary (citable) accession number: Q9BXW4
Secondary accession number(s): A0PJY8, A2RUP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.