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Q9BXW4

- MLP3C_HUMAN

UniProt

Q9BXW4 - MLP3C_HUMAN

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Protein

Microtubule-associated proteins 1A/1B light chain 3C

Gene

MAP1LC3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei126 – 1272Cleavage; by ATG4BBy similarity

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated proteins 1A/1B light chain 3C
Alternative name(s):
Autophagy-related protein LC3 C
Autophagy-related ubiquitin-like modifier LC3 C
MAP1 light chain 3-like protein 3
MAP1A/MAP1B light chain 3 C
Short name:
MAP1A/MAP1B LC3 C
Microtubule-associated protein 1 light chain 3 gamma
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:13353. MAP1LC3C.

Subcellular locationi

Cytoplasmcytoskeleton 1 Publication. Endomembrane system 1 Publication; Lipid-anchor 1 Publication. Cytoplasmic vesicleautophagosome membrane 1 Publication; Lipid-anchor 1 Publication
Note: LC3-II binds to the autophagic membranes.

GO - Cellular componenti

  1. autophagic vacuole Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. microtubule Source: UniProtKB-KW
  4. organelle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi126 – 1261G → A: No processing of precursor. 1 Publication

Organism-specific databases

PharmGKBiPA142671482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126126Microtubule-associated proteins 1A/1B light chain 3CPRO_0000017204Add
BLAST
Propeptidei127 – 14721Removed in mature formPRO_0000017205Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi126 – 1261Phosphatidylethanolamine amidated glycine1 Publication

Post-translational modificationi

The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).1 Publication
The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.1 Publication

Keywords - PTMi

Lipoprotein

Proteomic databases

PaxDbiQ9BXW4.
PRIDEiQ9BXW4.

Expressioni

Tissue specificityi

Most abundant in placenta, lung and ovary.1 Publication

Gene expression databases

BgeeiQ9BXW4.
CleanExiHS_MAP1LC3C.
GenevestigatoriQ9BXW4.

Interactioni

Subunit structurei

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with TP53INP1 and TP53INP2. Interacts with CALCOCO2. Interacts with TECPR2.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG101Q9BSB42EBI-2603996,EBI-2946739
ATG16L1Q676U54EBI-2603996,EBI-535909
DYX1C1Q8WXU22EBI-2603996,EBI-2946907
FYCO1Q9BQS82EBI-2603996,EBI-2869338
GBASO753232EBI-2603996,EBI-307133
IPO5O004102EBI-2603996,EBI-356424
KBTBD6Q86V972EBI-2603996,EBI-2514778
KBTBD7Q8WVZ92EBI-2603996,EBI-473695
NBR1Q145963EBI-2603996,EBI-742698
NEK9Q8TD192EBI-2603996,EBI-1044009
RASSF1Q9NS232EBI-2603996,EBI-367363
RASSF5Q8WWW02EBI-2603996,EBI-367390
SF3A1Q154593EBI-2603996,EBI-1054743
SQSTM1Q135012EBI-2603996,EBI-307104
STK3Q131882EBI-2603996,EBI-992580
TBC1D2BQ9UPU72EBI-2603996,EBI-2947180
TECPR2O150402EBI-2603996,EBI-2946991
UBA5Q9GZZ92EBI-2603996,EBI-747805
ULK1O753852EBI-2603996,EBI-908831

Protein-protein interaction databases

BioGridi136855. 19 interactions.
DIPiDIP-57020N.
IntActiQ9BXW4. 51 interactions.
STRINGi9606.ENSP00000349785.

Structurei

Secondary structure

1
147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 164Combined sources
Helixi19 – 3214Combined sources
Beta strandi36 – 438Combined sources
Beta strandi48 – 503Combined sources
Beta strandi56 – 616Combined sources
Helixi66 – 7611Combined sources
Beta strandi77 – 793Combined sources
Beta strandi81 – 833Combined sources
Beta strandi86 – 894Combined sources
Turni90 – 923Combined sources
Helixi101 – 1088Combined sources
Beta strandi111 – 1133Combined sources
Beta strandi115 – 1217Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VVWX-ray2.50B1-126[»]
3WAMX-ray1.75A8-125[»]
3WAPX-ray3.10A8-125[»]
ProteinModelPortaliQ9BXW4.
SMRiQ9BXW4. Positions 13-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG8 family.Curated

Phylogenomic databases

eggNOGiNOG245878.
GeneTreeiENSGT00390000012937.
HOGENOMiHOG000232034.
HOVERGENiHBG051706.
InParanoidiQ9BXW4.
KOiK10435.
OMAiRYQKEKY.
OrthoDBiEOG7XH6RV.
PhylomeDBiQ9BXW4.
TreeFamiTF312964.

Family and domain databases

InterProiIPR004241. Atg8_like.
IPR027731. MAP1A/MAP1B_LC3C.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10969. PTHR10969. 1 hit.
PTHR10969:SF24. PTHR10969:SF24. 1 hit.
PfamiPF02991. Atg8. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BXW4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPPQKIPSV RPFKQRKSLA IRQEEVAGIR AKFPNKIPVV VERYPRETFL
60 70 80 90 100
PPLDKTKFLV PQELTMTQFL SIIRSRMVLR ATEAFYLLVN NKSLVSMSAT
110 120 130 140
MAEIYRDYKD EDGFVYMTYA SQETFGCLES AAPRDGSSLE DRPCNPL
Length:147
Mass (Da):16,852
Last modified:June 1, 2001 - v1
Checksum:iD3DFA8EE5985C3AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276659 mRNA. Translation: AAK35152.1.
BX571673 Genomic DNA. Translation: CAH72477.1.
BC127722 mRNA. Translation: AAI27723.1.
BC132986 mRNA. Translation: AAI32987.1.
BC132988 mRNA. Translation: AAI32989.1.
CCDSiCCDS31074.1.
RefSeqiNP_001004343.1. NM_001004343.2.
XP_005273196.1. XM_005273139.1.
UniGeneiHs.534971.

Genome annotation databases

EnsembliENST00000357246; ENSP00000349785; ENSG00000197769.
GeneIDi440738.
KEGGihsa:440738.
UCSCiuc001hzk.2. human.

Polymorphism databases

DMDMi84028113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276659 mRNA. Translation: AAK35152.1 .
BX571673 Genomic DNA. Translation: CAH72477.1 .
BC127722 mRNA. Translation: AAI27723.1 .
BC132986 mRNA. Translation: AAI32987.1 .
BC132988 mRNA. Translation: AAI32989.1 .
CCDSi CCDS31074.1.
RefSeqi NP_001004343.1. NM_001004343.2.
XP_005273196.1. XM_005273139.1.
UniGenei Hs.534971.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VVW X-ray 2.50 B 1-126 [» ]
3WAM X-ray 1.75 A 8-125 [» ]
3WAP X-ray 3.10 A 8-125 [» ]
ProteinModelPortali Q9BXW4.
SMRi Q9BXW4. Positions 13-126.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 136855. 19 interactions.
DIPi DIP-57020N.
IntActi Q9BXW4. 51 interactions.
STRINGi 9606.ENSP00000349785.

Polymorphism databases

DMDMi 84028113.

Proteomic databases

PaxDbi Q9BXW4.
PRIDEi Q9BXW4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357246 ; ENSP00000349785 ; ENSG00000197769 .
GeneIDi 440738.
KEGGi hsa:440738.
UCSCi uc001hzk.2. human.

Organism-specific databases

CTDi 440738.
GeneCardsi GC01M242158.
HGNCi HGNC:13353. MAP1LC3C.
MIMi 609605. gene.
neXtProti NX_Q9BXW4.
PharmGKBi PA142671482.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG245878.
GeneTreei ENSGT00390000012937.
HOGENOMi HOG000232034.
HOVERGENi HBG051706.
InParanoidi Q9BXW4.
KOi K10435.
OMAi RYQKEKY.
OrthoDBi EOG7XH6RV.
PhylomeDBi Q9BXW4.
TreeFami TF312964.

Miscellaneous databases

GenomeRNAii 440738.
NextBioi 109492.
PROi Q9BXW4.
SOURCEi Search...

Gene expression databases

Bgeei Q9BXW4.
CleanExi HS_MAP1LC3C.
Genevestigatori Q9BXW4.

Family and domain databases

InterProi IPR004241. Atg8_like.
IPR027731. MAP1A/MAP1B_LC3C.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10969. PTHR10969. 1 hit.
PTHR10969:SF24. PTHR10969:SF24. 1 hit.
Pfami PF02991. Atg8. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B."
    He H., Dang Y., Dai F., Guo Z., Wu J., She X., Pei Y., Chen Y., Ling W., Wu C., Zhao S., Liu J.O., Yu L.
    J. Biol. Chem. 278:29278-29287(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF GLY-126.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates."
    Tanida I., Sou Y.-S., Ezaki J., Minematsu-Ikeguchi N., Ueno T., Kominami E.
    J. Biol. Chem. 279:36268-36276(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIPIDATION AT GLY-126, CLEAVAGE BY APG4B.
  5. "Network organization of the human autophagy system."
    Behrends C., Sowa M.E., Gygi S.P., Harper J.W.
    Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TECPR2.
  6. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
    Sancho A., Duran J., Garcia-Espana A., Mauvezin C., Alemu E.A., Lamark T., Macias M.J., Desalle R., Royo M., Sala D., Chicote J.U., Palacin M., Johansen T., Zorzano A.
    PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53INP1 AND TP53INP2.
  7. "The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation."
    Choy A., Dancourt J., Mugo B., O'Connor T.J., Isberg R.R., Melia T.J., Roy C.R.
    Science 338:1072-1076(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: DECONJUGATION BY LEGIONELLA RAVZ.
  8. "LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy."
    von Muhlinen N., Akutsu M., Ravenhill B.J., Foeglein A., Bloor S., Rutherford T.J., Freund S.M., Komander D., Randow F.
    Mol. Cell 48:329-342(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-126 IN COMPLEX WITH CALCOCO2, INTERACTION WITH CALCOCO2, FUNCTION.

Entry informationi

Entry nameiMLP3C_HUMAN
AccessioniPrimary (citable) accession number: Q9BXW4
Secondary accession number(s): A0PJY8, A2RUP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3