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Q9BXW4

- MLP3C_HUMAN

UniProt

Q9BXW4 - MLP3C_HUMAN

Protein

Microtubule-associated proteins 1A/1B light chain 3C

Gene

MAP1LC3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei126 – 1272Cleavage; by ATG4BBy similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3C
    Alternative name(s):
    Autophagy-related protein LC3 C
    Autophagy-related ubiquitin-like modifier LC3 C
    MAP1 light chain 3-like protein 3
    MAP1A/MAP1B light chain 3 C
    Short name:
    MAP1A/MAP1B LC3 C
    Microtubule-associated protein 1 light chain 3 gamma
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13353. MAP1LC3C.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication. Endomembrane system 1 Publication; Lipid-anchor 1 Publication. Cytoplasmic vesicleautophagosome membrane 1 Publication; Lipid-anchor 1 Publication
    Note: LC3-II binds to the autophagic membranes.

    GO - Cellular componenti

    1. autophagic vacuole Source: UniProtKB
    2. autophagic vacuole membrane Source: UniProtKB-SubCell
    3. cytoplasmic vesicle Source: UniProtKB-KW
    4. endomembrane system Source: UniProtKB-SubCell
    5. microtubule Source: UniProtKB-KW
    6. organelle membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi126 – 1261G → A: No processing of precursor. 1 Publication

    Organism-specific databases

    PharmGKBiPA142671482.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 126126Microtubule-associated proteins 1A/1B light chain 3CPRO_0000017204Add
    BLAST
    Propeptidei127 – 14721Removed in mature formPRO_0000017205Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi126 – 1261Phosphatidylethanolamine amidated glycine1 Publication

    Post-translational modificationi

    The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).1 Publication
    The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.1 Publication

    Keywords - PTMi

    Lipoprotein

    Proteomic databases

    PaxDbiQ9BXW4.
    PRIDEiQ9BXW4.

    Expressioni

    Tissue specificityi

    Most abundant in placenta, lung and ovary.1 Publication

    Gene expression databases

    BgeeiQ9BXW4.
    CleanExiHS_MAP1LC3C.
    GenevestigatoriQ9BXW4.

    Interactioni

    Subunit structurei

    3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins By similarity. Interacts with TP53INP1 and TP53INP2. Interacts with CALCOCO2. Interacts with TECPR2.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATG101Q9BSB42EBI-2603996,EBI-2946739
    ATG16L1Q676U54EBI-2603996,EBI-535909
    DYX1C1Q8WXU22EBI-2603996,EBI-2946907
    FYCO1Q9BQS82EBI-2603996,EBI-2869338
    GBASO753232EBI-2603996,EBI-307133
    IPO5O004102EBI-2603996,EBI-356424
    KBTBD6Q86V972EBI-2603996,EBI-2514778
    KBTBD7Q8WVZ92EBI-2603996,EBI-473695
    NBR1Q145963EBI-2603996,EBI-742698
    NEK9Q8TD192EBI-2603996,EBI-1044009
    RASSF1Q9NS232EBI-2603996,EBI-367363
    RASSF5Q8WWW02EBI-2603996,EBI-367390
    SF3A1Q154593EBI-2603996,EBI-1054743
    SQSTM1Q135012EBI-2603996,EBI-307104
    STK3Q131882EBI-2603996,EBI-992580
    TBC1D2BQ9UPU72EBI-2603996,EBI-2947180
    TECPR2O150402EBI-2603996,EBI-2946991
    UBA5Q9GZZ92EBI-2603996,EBI-747805
    ULK1O753852EBI-2603996,EBI-908831

    Protein-protein interaction databases

    BioGridi136855. 17 interactions.
    DIPiDIP-57020N.
    IntActiQ9BXW4. 51 interactions.
    STRINGi9606.ENSP00000349785.

    Structurei

    Secondary structure

    1
    147
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi13 – 164
    Helixi19 – 3214
    Beta strandi36 – 438
    Beta strandi48 – 503
    Beta strandi56 – 616
    Helixi66 – 7611
    Beta strandi77 – 793
    Beta strandi81 – 833
    Beta strandi86 – 894
    Turni90 – 923
    Helixi101 – 1088
    Beta strandi111 – 1133
    Beta strandi115 – 1217

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VVWX-ray2.50B1-126[»]
    3WAMX-ray1.75A8-125[»]
    3WAPX-ray3.10A8-125[»]
    ProteinModelPortaliQ9BXW4.
    SMRiQ9BXW4. Positions 13-126.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATG8 family.Curated

    Phylogenomic databases

    eggNOGiNOG245878.
    HOGENOMiHOG000232034.
    HOVERGENiHBG051706.
    InParanoidiQ9BXW4.
    KOiK10435.
    OMAiRYQKEKY.
    OrthoDBiEOG7XH6RV.
    PhylomeDBiQ9BXW4.
    TreeFamiTF312964.

    Family and domain databases

    InterProiIPR004241. Atg8_like.
    IPR027731. MAP1A/MAP1B_LC3C.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10969. PTHR10969. 1 hit.
    PTHR10969:SF24. PTHR10969:SF24. 1 hit.
    PfamiPF02991. Atg8. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BXW4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPPQKIPSV RPFKQRKSLA IRQEEVAGIR AKFPNKIPVV VERYPRETFL    50
    PPLDKTKFLV PQELTMTQFL SIIRSRMVLR ATEAFYLLVN NKSLVSMSAT 100
    MAEIYRDYKD EDGFVYMTYA SQETFGCLES AAPRDGSSLE DRPCNPL 147
    Length:147
    Mass (Da):16,852
    Last modified:June 1, 2001 - v1
    Checksum:iD3DFA8EE5985C3AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF276659 mRNA. Translation: AAK35152.1.
    BX571673 Genomic DNA. Translation: CAH72477.1.
    BC127722 mRNA. Translation: AAI27723.1.
    BC132986 mRNA. Translation: AAI32987.1.
    BC132988 mRNA. Translation: AAI32989.1.
    CCDSiCCDS31074.1.
    RefSeqiNP_001004343.1. NM_001004343.2.
    XP_005273196.1. XM_005273139.1.
    UniGeneiHs.534971.

    Genome annotation databases

    EnsembliENST00000357246; ENSP00000349785; ENSG00000197769.
    GeneIDi440738.
    KEGGihsa:440738.
    UCSCiuc001hzk.2. human.

    Polymorphism databases

    DMDMi84028113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF276659 mRNA. Translation: AAK35152.1 .
    BX571673 Genomic DNA. Translation: CAH72477.1 .
    BC127722 mRNA. Translation: AAI27723.1 .
    BC132986 mRNA. Translation: AAI32987.1 .
    BC132988 mRNA. Translation: AAI32989.1 .
    CCDSi CCDS31074.1.
    RefSeqi NP_001004343.1. NM_001004343.2.
    XP_005273196.1. XM_005273139.1.
    UniGenei Hs.534971.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VVW X-ray 2.50 B 1-126 [» ]
    3WAM X-ray 1.75 A 8-125 [» ]
    3WAP X-ray 3.10 A 8-125 [» ]
    ProteinModelPortali Q9BXW4.
    SMRi Q9BXW4. Positions 13-126.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 136855. 17 interactions.
    DIPi DIP-57020N.
    IntActi Q9BXW4. 51 interactions.
    STRINGi 9606.ENSP00000349785.

    Polymorphism databases

    DMDMi 84028113.

    Proteomic databases

    PaxDbi Q9BXW4.
    PRIDEi Q9BXW4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357246 ; ENSP00000349785 ; ENSG00000197769 .
    GeneIDi 440738.
    KEGGi hsa:440738.
    UCSCi uc001hzk.2. human.

    Organism-specific databases

    CTDi 440738.
    GeneCardsi GC01M242158.
    HGNCi HGNC:13353. MAP1LC3C.
    MIMi 609605. gene.
    neXtProti NX_Q9BXW4.
    PharmGKBi PA142671482.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245878.
    HOGENOMi HOG000232034.
    HOVERGENi HBG051706.
    InParanoidi Q9BXW4.
    KOi K10435.
    OMAi RYQKEKY.
    OrthoDBi EOG7XH6RV.
    PhylomeDBi Q9BXW4.
    TreeFami TF312964.

    Miscellaneous databases

    GenomeRNAii 440738.
    NextBioi 109492.
    PROi Q9BXW4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BXW4.
    CleanExi HS_MAP1LC3C.
    Genevestigatori Q9BXW4.

    Family and domain databases

    InterProi IPR004241. Atg8_like.
    IPR027731. MAP1A/MAP1B_LC3C.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10969. PTHR10969. 1 hit.
    PTHR10969:SF24. PTHR10969:SF24. 1 hit.
    Pfami PF02991. Atg8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B."
      He H., Dang Y., Dai F., Guo Z., Wu J., She X., Pei Y., Chen Y., Ling W., Wu C., Zhao S., Liu J.O., Yu L.
      J. Biol. Chem. 278:29278-29287(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF GLY-126.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates."
      Tanida I., Sou Y.-S., Ezaki J., Minematsu-Ikeguchi N., Ueno T., Kominami E.
      J. Biol. Chem. 279:36268-36276(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIPIDATION AT GLY-126, CLEAVAGE BY APG4B.
    5. "Network organization of the human autophagy system."
      Behrends C., Sowa M.E., Gygi S.P., Harper J.W.
      Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TECPR2.
    6. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
      Sancho A., Duran J., Garcia-Espana A., Mauvezin C., Alemu E.A., Lamark T., Macias M.J., Desalle R., Royo M., Sala D., Chicote J.U., Palacin M., Johansen T., Zorzano A.
      PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TP53INP1 AND TP53INP2.
    7. "The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation."
      Choy A., Dancourt J., Mugo B., O'Connor T.J., Isberg R.R., Melia T.J., Roy C.R.
      Science 338:1072-1076(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: DECONJUGATION BY LEGIONELLA RAVZ.
    8. "LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy."
      von Muhlinen N., Akutsu M., Ravenhill B.J., Foeglein A., Bloor S., Rutherford T.J., Freund S.M., Komander D., Randow F.
      Mol. Cell 48:329-342(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-126 IN COMPLEX WITH CALCOCO2, INTERACTION WITH CALCOCO2, FUNCTION.

    Entry informationi

    Entry nameiMLP3C_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXW4
    Secondary accession number(s): A0PJY8, A2RUP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3