Reviewed,
UniProtKB/Swiss-Prot Q9BXW4 (MLP3C_HUMAN)
Last modified
February 9, 2010.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Microtubule-associated proteins 1A/1B light chain 3C Alternative name(s): Microtubule-associated protein 1 light chain 3 gamma MAP1A/MAP1B light chain 3 C Short name=MAP1A/MAP1B LC3 C MAP1 light chain 3-like protein 3 Autophagy-related protein LC3 C Autophagy-related ubiquitin-like modifier LC3 C | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 147 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probably involved in formation of autophagosomal vacuoles (autophagosomes) By similarity. |
| Subunit structure | 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins By similarity. |
| Subcellular location | Cytoplasm. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle › autophagosome membrane; Lipid-anchor. Note: LC3-II binds to the autophagic membranes. Ref.1 |
| Tissue specificity | Most abundant in placenta, lung and ovary. Ref.1 |
| Post-translational modification | The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. Ref.4 |
| Sequence similarities | Belongs to the MAP1 LC3 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Autophagy Ubl conjugation pathway |
| Cellular component | Cytoplasm Cytoplasmic vesicle Membrane Microtubule |
| PTM | Lipoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | autophagy Inferred from electronic annotation. Source: UniProtKB-KW modification-dependent protein catabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell autophagic vacuole Ref.1Inferred from sequence or structural similarity. Source: UniProtKB cytoplasmic vesicleInferred from electronic annotation. Source: UniProtKB-KW microtubuleInferred from electronic annotation. Source: UniProtKB-KW organelle membrane Ref.1Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 126 | 126 | Microtubule-associated proteins 1A/1B light chain 3C | PRO_0000017204 | |||||
| Propeptide | 127 – 147 | 21 | Removed in mature form | PRO_0000017205 | |||||
Amino acid modifications | |||||||||
| Lipidation | 126 | 1 | Phosphatidylethanolamine amidated glycine Probable | ||||||
Experimental info | |||||||||
| Mutagenesis | 126 | 1 | G → A: No processing of precursor. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B." He H., Dang Y., Dai F., Guo Z., Wu J., She X., Pei Y., Chen Y., Ling W., Wu C., Zhao S., Liu J.O., Yu L. J. Biol. Chem. 278:29278-29287(2003) [PubMed: 12740394] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF GLY-126. |
| [2] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates." Tanida I., Sou Y.-S., Ezaki J., Minematsu-Ikeguchi N., Ueno T., Kominami E. J. Biol. Chem. 279:36268-36276(2004) [PubMed: 15187094] [Abstract] Cited for: LIPIDATION, CLEAVAGE BY APG4B. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF276659 mRNA. Translation: AAK35152.1. BX571673 Genomic DNA. Translation: CAH72477.1. BC127722 mRNA. Translation: AAI27723.1. BC132986 mRNA. Translation: AAI32987.1. BC132988 mRNA. Translation: AAI32989.1. |
| IPI | IPI00387017. |
| RefSeq | NP_001004343.1. |
| UniGene | Hs.534971 |
3D structure databases | |
| SMR | Q9BXW4. Positions 11-123. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9BXW4. |
Proteomic databases | |
| PRIDE | Q9BXW4. |
Genome annotation databases | |
| Ensembl | ENST00000357246; ENSP00000349785; ENSG00000197769; Homo sapiens. [Genome view] |
| GeneID | 440738. |
| KEGG | hsa:440738. |
| UCSC | uc001hzk.1. human. |
Organism-specific databases | |
| CTD | 440738. |
| GeneCards | GC01M240225. |
| H-InvDB | HIX0028588. |
| HGNC | HGNC:13353. MAP1LC3C. |
| MIM | 609605. gene. |
| PharmGKB | PA142671482. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG07023. |
| HOGENOM | HBG592694. |
| HOVERGEN | Q9BXW4. |
| InParanoid | Q9BXW4. |
| OMA | IRSRMVL. |
| OrthoDB | EOG9QVFXK. |
| PhylomeDB | Q9BXW4. |
Gene expression databases | |
| ArrayExpress | Q9BXW4. |
| Bgee | Q9BXW4. |
| CleanEx | HS_MAP1LC3C. |
| Genevestigator | Q9BXW4. |
| GermOnline | ENSG00000197769. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004241. MAP1_LC3. [Graphical view] |
| PANTHER | PTHR10969. MAP1_LC3. 1 hit. |
| Pfam | PF02991. MAP1_LC3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 109492. |
| SOURCE | Search... |
Entry information
| Entry name | MLP3C_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BXW4 Secondary accession number(s): A0PJY8, A2RUP0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


