Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

EKC/KEOPS complex subunit GON7

Gene

GON7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.By similarity1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
EKC/KEOPS complex subunit GON7Curated
Gene namesi
Name:GON7Imported
ORF Names:C14orf142Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20356. GON7.

Subcellular locationi

GO - Cellular componenti

  • EKC/KEOPS complex Source: UniProtKB
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170270.
PharmGKBiPA134918457.

Polymorphism and mutation databases

BioMutaiC14orf142.
DMDMi212276431.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899451 – 100EKC/KEOPS complex subunit GON7Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BXV9.
MaxQBiQ9BXV9.
PaxDbiQ9BXV9.
PeptideAtlasiQ9BXV9.
PRIDEiQ9BXV9.

PTM databases

iPTMnetiQ9BXV9.
PhosphoSitePlusiQ9BXV9.

Expressioni

Gene expression databases

BgeeiENSG00000170270.
CleanExiHS_C14orf142.
ExpressionAtlasiQ9BXV9. baseline and differential.
GenevisibleiQ9BXV9. HS.

Organism-specific databases

HPAiHPA051832.

Interactioni

Subunit structurei

Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.1 Publication

Protein-protein interaction databases

BioGridi124114. 16 interactors.
IntActiQ9BXV9. 3 interactors.
STRINGi9606.ENSP00000306320.

Structurei

3D structure databases

ProteinModelPortaliQ9BXV9.
SMRiQ9BXV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J4PY. Eukaryota.
ENOG4111D7E. LUCA.
GeneTreeiENSGT00490000044274.
HOGENOMiHOG000111825.
HOVERGENiHBG107732.
InParanoidiQ9BXV9.
OMAiPCEAPGV.
OrthoDBiEOG091G14G7.
PhylomeDBiQ9BXV9.

Family and domain databases

InterProiView protein in InterPro
IPR027893. GON7_meta.
PfamiView protein in Pfam
PF15387. DUF4611. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BXV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLGEYVGQ EGKPQKLRVS CEAPGDGDPF QGLLSGVAQM KDMVTELFDP
60 70 80 90 100
LVQGEVQHRV AAAPDEDLDG DDEDDAEDEN NIDNRTNFDG PSAKRPKTPS
Length:100
Mass (Da):10,859
Last modified:November 4, 2008 - v2
Checksum:iD00127AC90DE0793
GO

Sequence cautioni

The sequence AAK07544 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021733 mRNA. Translation: AAH21733.2.
BC065216 mRNA. Translation: AAH65216.1.
BC107429 mRNA. Translation: AAI07430.2.
BC109390 mRNA. Translation: AAI09391.2.
CR613456 mRNA. No translation available.
CR590920 mRNA. No translation available.
AF277185 mRNA. Translation: AAK07544.1. Sequence problems.
CCDSiCCDS41981.1.
RefSeqiNP_115879.2. NM_032490.4.
UniGeneiHs.20142.

Genome annotation databases

EnsembliENST00000306954; ENSP00000306320; ENSG00000170270.
ENST00000621279; ENSP00000478863; ENSG00000275619.
GeneIDi84520.
KEGGihsa:84520.
UCSCiuc001ybl.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGON7_HUMAN
AccessioniPrimary (citable) accession number: Q9BXV9
Secondary accession number(s): Q0D2N1, Q0P6C4, Q3B7W5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 4, 2008
Last modified: July 5, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot