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Protein

Ferritin heavy polypeptide-like 17

Gene

FTHL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281IronPROSITE-ProRule annotation
Metal bindingi66 – 661IronPROSITE-ProRule annotation
Metal bindingi108 – 1081IronPROSITE-ProRule annotation
Metal bindingi142 – 1421IronPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy polypeptide-like 17
Alternative name(s):
Cancer/testis antigen 38
Short name:
CT38
Gene namesi
Name:FTHL17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:3987. FTHL17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28402.

Polymorphism and mutation databases

BioMutaiFTHL17.
DMDMi18202740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Ferritin heavy polypeptide-like 17PRO_0000201068Add
BLAST

Proteomic databases

MaxQBiQ9BXU8.
PaxDbiQ9BXU8.
PRIDEiQ9BXU8.

Expressioni

Tissue specificityi

Testis specific. Also expressed in several cancers.1 Publication

Gene expression databases

BgeeiQ9BXU8.
CleanExiHS_FTHL17.
GenevisibleiQ9BXU8. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368207.

Structurei

3D structure databases

ProteinModelPortaliQ9BXU8.
SMRiQ9BXU8. Positions 7-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 160150Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiQ9BXU8.
OMAiAMESAFH.
OrthoDBiEOG7DRJ49.
PhylomeDBiQ9BXU8.
TreeFamiTF313885.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAQPSQVR QKYDTNCDAA INSHITLELY TSYLYLSMAF YFNRDDVALE
60 70 80 90 100
NFFRYFLRLS DDKMEHAQKL MRLQNLRGGH ICLHDIRKPE CQGWESGLVA
110 120 130 140 150
MESAFHLEKN VNQSLLDLYQ LAVEKGDPQL CHFLESHYLH EQVKTIKELG
160 170 180
GYVSNLRKIC SPEAGLAEYL FDKLTLGGRV KET
Length:183
Mass (Da):21,142
Last modified:June 1, 2001 - v1
Checksum:i7DA7DCEDDBE82583
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201Q → H.
Corresponds to variant rs16989319 [ dbSNP | Ensembl ].
VAR_033929
Natural varianti138 – 1381Y → H.
Corresponds to variant rs17340519 [ dbSNP | Ensembl ].
VAR_049060

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285592 mRNA. Translation: AAK31971.1.
BC069069 mRNA. Translation: AAH69069.2.
BC069538 mRNA. Translation: AAH69538.2.
BC100768 mRNA. Translation: AAI00769.1.
BC100769 mRNA. Translation: AAI00770.1.
BC100770 mRNA. Translation: AAI00771.1.
CCDSiCCDS14227.1.
RefSeqiNP_114100.1. NM_031894.2.
UniGeneiHs.333125.

Genome annotation databases

EnsembliENST00000359202; ENSP00000368207; ENSG00000132446.
GeneIDi53940.
KEGGihsa:53940.
UCSCiuc004dcl.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285592 mRNA. Translation: AAK31971.1.
BC069069 mRNA. Translation: AAH69069.2.
BC069538 mRNA. Translation: AAH69538.2.
BC100768 mRNA. Translation: AAI00769.1.
BC100769 mRNA. Translation: AAI00770.1.
BC100770 mRNA. Translation: AAI00771.1.
CCDSiCCDS14227.1.
RefSeqiNP_114100.1. NM_031894.2.
UniGeneiHs.333125.

3D structure databases

ProteinModelPortaliQ9BXU8.
SMRiQ9BXU8. Positions 7-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368207.

Polymorphism and mutation databases

BioMutaiFTHL17.
DMDMi18202740.

Proteomic databases

MaxQBiQ9BXU8.
PaxDbiQ9BXU8.
PRIDEiQ9BXU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359202; ENSP00000368207; ENSG00000132446.
GeneIDi53940.
KEGGihsa:53940.
UCSCiuc004dcl.1. human.

Organism-specific databases

CTDi53940.
GeneCardsiFTHL17.
HGNCiHGNC:3987. FTHL17.
MIMi300308. gene.
neXtProtiNX_Q9BXU8.
PharmGKBiPA28402.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiQ9BXU8.
OMAiAMESAFH.
OrthoDBiEOG7DRJ49.
PhylomeDBiQ9BXU8.
TreeFamiTF313885.

Miscellaneous databases

GenomeRNAii53940.
NextBioi56250.
PROiQ9BXU8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BXU8.
CleanExiHS_FTHL17.
GenevisibleiQ9BXU8. HS.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An abundance of X-linked genes expressed in spermatogonia."
    Wang P.J., McCarrey J.R., Yang F., Page D.C.
    Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia."
    Loriot A., Boon T., De Smet C.
    Int. J. Cancer 105:371-376(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.

Entry informationi

Entry nameiFHL17_HUMAN
AccessioniPrimary (citable) accession number: Q9BXU8
Secondary accession number(s): Q6NT24, Q6NTE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: November 11, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.