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Protein

Ferritin heavy polypeptide-like 17

Gene

FTHL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi28IronPROSITE-ProRule annotation1
Metal bindingi66IronPROSITE-ProRule annotation1
Metal bindingi108IronPROSITE-ProRule annotation1
Metal bindingi142IronPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy polypeptide-like 17
Alternative name(s):
Cancer/testis antigen 38
Short name:
CT38
Gene namesi
Name:FTHL17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000132446.6
HGNCiHGNC:3987 FTHL17
MIMi300308 gene
neXtProtiNX_Q9BXU8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi53940
OpenTargetsiENSG00000132446
PharmGKBiPA28402

Polymorphism and mutation databases

BioMutaiFTHL17
DMDMi18202740

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002010681 – 183Ferritin heavy polypeptide-like 17Add BLAST183

Proteomic databases

MaxQBiQ9BXU8
PaxDbiQ9BXU8
PeptideAtlasiQ9BXU8
PRIDEiQ9BXU8
ProteomicsDBi79522

Expressioni

Tissue specificityi

Testis specific. Also expressed in several cancers.1 Publication

Gene expression databases

BgeeiENSG00000132446
CleanExiHS_FTHL17
GenevisibleiQ9BXU8 HS

Interactioni

Protein-protein interaction databases

IntActiQ9BXU8, 5 interactors
STRINGi9606.ENSP00000368207

Structurei

3D structure databases

ProteinModelPortaliQ9BXU8
SMRiQ9BXU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 160Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
GeneTreeiENSGT00760000119129
HOGENOMiHOG000223383
HOVERGENiHBG000410
InParanoidiQ9BXU8
OMAiENFFRYF
OrthoDBiEOG091G0J20
PhylomeDBiQ9BXU8
TreeFamiTF313885

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BXU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAQPSQVR QKYDTNCDAA INSHITLELY TSYLYLSMAF YFNRDDVALE
60 70 80 90 100
NFFRYFLRLS DDKMEHAQKL MRLQNLRGGH ICLHDIRKPE CQGWESGLVA
110 120 130 140 150
MESAFHLEKN VNQSLLDLYQ LAVEKGDPQL CHFLESHYLH EQVKTIKELG
160 170 180
GYVSNLRKIC SPEAGLAEYL FDKLTLGGRV KET
Length:183
Mass (Da):21,142
Last modified:June 1, 2001 - v1
Checksum:i7DA7DCEDDBE82583
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033929120Q → H. Corresponds to variant dbSNP:rs16989319Ensembl.1
Natural variantiVAR_049060138Y → H. Corresponds to variant dbSNP:rs17340519Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285592 mRNA Translation: AAK31971.1
BC069069 mRNA Translation: AAH69069.2
BC069538 mRNA Translation: AAH69538.2
BC100768 mRNA Translation: AAI00769.1
BC100769 mRNA Translation: AAI00770.1
BC100770 mRNA Translation: AAI00771.1
CCDSiCCDS14227.1
RefSeqiNP_114100.1, NM_031894.2
UniGeneiHs.333125

Genome annotation databases

EnsembliENST00000359202; ENSP00000368207; ENSG00000132446
GeneIDi53940
KEGGihsa:53940
UCSCiuc004dcl.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFHL17_HUMAN
AccessioniPrimary (citable) accession number: Q9BXU8
Secondary accession number(s): Q6NT24, Q6NTE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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