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Q9BXU7

- UBP26_HUMAN

UniProt

Q9BXU7 - UBP26_HUMAN

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Protein

Ubiquitin carboxyl-terminal hydrolase 26

Gene

USP26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.By similarity1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei304 – 3041NucleophilePROSITE-ProRule annotation
Active sitei841 – 8411Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. protein deubiquitination Source: UniProtKB
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.046.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 26
Ubiquitin thioesterase 26
Ubiquitin-specific-processing protease 26
Gene namesi
Name:USP26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:13485. USP26.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi304 – 3041C → S: Results in increased AR signaling. 1 Publication

Organism-specific databases

PharmGKBiPA37782.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 913913Ubiquitin carboxyl-terminal hydrolase 26PRO_0000080655Add
BLAST

Proteomic databases

PaxDbiQ9BXU7.
PRIDEiQ9BXU7.

PTM databases

PhosphoSiteiQ9BXU7.

Expressioni

Gene expression databases

BgeeiQ9BXU7.
CleanExiHS_USP26.
GenevestigatoriQ9BXU7.

Interactioni

Subunit structurei

Interacts with AR.1 Publication

Protein-protein interaction databases

BioGridi123764. 4 interactions.
IntActiQ9BXU7. 2 interactions.
STRINGi9606.ENSP00000359869.

Structurei

3D structure databases

ProteinModelPortaliQ9BXU7.
SMRiQ9BXU7. Positions 16-106, 296-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 886592USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5533.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiQ9BXU7.
KOiK11850.
OMAiDAYDFER.
OrthoDBiEOG7HMS09.
PhylomeDBiQ9BXU7.
TreeFamiTF323032.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALFLRGFV QIGNCKTGIS KSKEAFIEAV ERKKKDRLVL YFKSGKYSTF
60 70 80 90 100
RLSDNIQNVV LKSYRGNQNH LHLTLQNNNG LFIEGLSSTD AEQLKIFLDR
110 120 130 140 150
VHQNEVQPPV RPGKGGSVFS STTQKEINKT SFHKVDEKSS SKSFEIAKGS
160 170 180 190 200
GTGVLQRMPL LTSKLTLTCG ELSENQHKKR KRMLSSSSEM NEEFLKENNS
210 220 230 240 250
VEYKKSKADC SRCVSYNREK QLKLKELEEN KKLECESSCI MNATGNPYLD
260 270 280 290 300
DIGLLQALTE KMVLVFLLQQ GYSDGYTKWD KLKLFFELFP EKICHGLPNL
310 320 330 340 350
GNTCYMNAVL QSLLSIPSFA DDLLNQSFPW GKIPLNALTM CLARLLFFKD
360 370 380 390 400
TYNIEIKEML LLNLKKAISA AAEIFHGNAQ NDAHEFLAHC LDQLKDNMEK
410 420 430 440 450
LNTIWKPKSE FGEDNFPKQV FADDPDTSGF SCPVITNFEL ELLHSIACKA
460 470 480 490 500
CGQVILKTEL NNYLSINLPQ RIKAHPSSIQ STFDLFFGAE ELEYKCAKCE
510 520 530 540 550
HKTSVGVHSF SRLPRILIVH LKRYSLNEFC ALKKNDQEVI ISKYLKVSSH
560 570 580 590 600
CNEGTRPPLP LSEDGEITDF QLLKVIRKMT SGNISVSWPA TKESKDILAP
610 620 630 640 650
HIGSDKESEQ KKGQTVFKGA SRRQQQKYLG KNSKPNELES VYSGDRAFIE
660 670 680 690 700
KEPLAHLMTY LEDTSLCQFH KAGGKPASSP GTPLSKVDFQ TVPENPKRKK
710 720 730 740 750
YVKTSKFVAF DRIINPTKDL YEDKNIRIPE RFQKVSEQTQ QCDGMRICEQ
760 770 780 790 800
APQQALPQSF PKPGTQGHTK NLLRPTKLNL QKSNRNSLLA LGSNKNPRNK
810 820 830 840 850
DILDKIKSKA KETKRNDDKG DHTYRLISVV SHLGKTLKSG HYICDAYDFE
860 870 880 890 900
KQIWFTYDDM RVLGIQEAQM QEDRRCTGYI FFYMHNEIFE EMLKREENAQ
910
LNSKEVEETL QKE
Length:913
Mass (Da):104,047
Last modified:June 1, 2001 - v1
Checksum:iBB70B09CDCBA3C48
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231T → TT.1 Publication
VAR_063413
Natural varianti165 – 1651L → S.1 Publication
Corresponds to variant rs61741870 [ dbSNP | Ensembl ].
VAR_063414
Natural varianti364 – 3641L → F.3 Publications
Corresponds to variant rs35397110 [ dbSNP | Ensembl ].
VAR_063415
Natural varianti475 – 4751H → Y.2 Publications
Corresponds to variant rs41299088 [ dbSNP | Ensembl ].
VAR_063416
Natural varianti517 – 5171L → F.1 Publication
VAR_063417
Natural varianti579 – 5791M → I.1 Publication
Corresponds to variant rs138385391 [ dbSNP | Ensembl ].
VAR_063418

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285593 mRNA. Translation: AAK31972.1.
Z81365 Genomic DNA. Translation: CAX30813.1.
BC069073 mRNA. Translation: AAH69073.1.
BC101190 mRNA. Translation: AAI01191.1.
BC101191 mRNA. Translation: AAI01192.1.
CCDSiCCDS14635.1.
RefSeqiNP_114113.1. NM_031907.1.
UniGeneiHs.333137.

Genome annotation databases

EnsembliENST00000370832; ENSP00000359869; ENSG00000134588.
ENST00000511190; ENSP00000423390; ENSG00000134588.
GeneIDi83844.
KEGGihsa:83844.
UCSCiuc010nrm.1. human.

Polymorphism databases

DMDMi18202739.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285593 mRNA. Translation: AAK31972.1 .
Z81365 Genomic DNA. Translation: CAX30813.1 .
BC069073 mRNA. Translation: AAH69073.1 .
BC101190 mRNA. Translation: AAI01191.1 .
BC101191 mRNA. Translation: AAI01192.1 .
CCDSi CCDS14635.1.
RefSeqi NP_114113.1. NM_031907.1.
UniGenei Hs.333137.

3D structure databases

ProteinModelPortali Q9BXU7.
SMRi Q9BXU7. Positions 16-106, 296-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123764. 4 interactions.
IntActi Q9BXU7. 2 interactions.
STRINGi 9606.ENSP00000359869.

Protein family/group databases

MEROPSi C19.046.

PTM databases

PhosphoSitei Q9BXU7.

Polymorphism databases

DMDMi 18202739.

Proteomic databases

PaxDbi Q9BXU7.
PRIDEi Q9BXU7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370832 ; ENSP00000359869 ; ENSG00000134588 .
ENST00000511190 ; ENSP00000423390 ; ENSG00000134588 .
GeneIDi 83844.
KEGGi hsa:83844.
UCSCi uc010nrm.1. human.

Organism-specific databases

CTDi 83844.
GeneCardsi GC0XM132158.
HGNCi HGNC:13485. USP26.
MIMi 300309. gene.
neXtProti NX_Q9BXU7.
PharmGKBi PA37782.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5533.
GeneTreei ENSGT00440000033542.
HOGENOMi HOG000060197.
HOVERGENi HBG055893.
InParanoidi Q9BXU7.
KOi K11850.
OMAi DAYDFER.
OrthoDBi EOG7HMS09.
PhylomeDBi Q9BXU7.
TreeFami TF323032.

Miscellaneous databases

GenomeRNAii 83844.
NextBioi 72811.
PROi Q9BXU7.
SOURCEi Search...

Gene expression databases

Bgeei Q9BXU7.
CleanExi HS_USP26.
Genevestigatori Q9BXU7.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An abundance of X-linked genes expressed in spermatogonia."
    Wang P.J., McCarrey J.R., Yang F., Page D.C.
    Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling."
    Dirac A.M., Bernards R.
    Mol. Cancer Res. 8:844-854(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-304, INTERACTION WITH AR.
  5. "Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism."
    Paduch D.A., Mielnik A., Schlegel P.N.
    Reprod. BioMed. Online 10:747-754(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PHE-364 AND TYR-475.
  6. "Sequence analysis of the X-linked USP26 gene in severe male factor infertility patients and fertile controls."
    Christensen G.L., Griffin J., Carrell D.T.
    Fertil. Steril. 90:851-852(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PHE-364 AND PHE-517.
  7. Cited for: VARIANTS THR-123 INS; SER-165; PHE-364; TYR-475 AND ILE-579.

Entry informationi

Entry nameiUBP26_HUMAN
AccessioniPrimary (citable) accession number: Q9BXU7
Secondary accession number(s): B9WRT6, Q5H9H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3