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Q9BXU1 (STK31_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase 31

EC=2.7.11.1
Alternative name(s):
Serine/threonine-protein kinase NYD-SPK
Sugen kinase 396
Short name=SgK396
Gene names
Name:STK31
Synonyms:SGK396
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1019 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Tissue specificity

Testis specific.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Contains 1 Tudor domain.

Caution

Ser-854 is present instead of the conserved Asp which is expected to be an active site residue.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BXU1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BXU1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9BXU1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     921-943: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10191019Serine/threonine-protein kinase 31
PRO_0000086715

Regions

Domain78 – 13760Tudor
Domain710 – 1019310Protein kinase
Nucleotide binding716 – 7249ATP By similarity
Coiled coil298 – 35558 Potential

Sites

Binding site7371ATP By similarity

Natural variations

Alternative sequence1 – 2323Missing in isoform 2.
VSP_024389
Alternative sequence921 – 94323Missing in isoform 3.
VSP_045210
Natural variant711Q → H. Ref.5 Ref.6
Corresponds to variant rs6945306 [ dbSNP | Ensembl ].
VAR_031600
Natural variant1251S → F. Ref.6
Corresponds to variant rs56268851 [ dbSNP | Ensembl ].
VAR_041150
Natural variant2611E → K. Ref.6
Corresponds to variant rs10264952 [ dbSNP | Ensembl ].
VAR_031601
Natural variant2681K → N. Ref.6
Corresponds to variant rs10264967 [ dbSNP | Ensembl ].
VAR_031602
Natural variant2771I → K. Ref.6
Corresponds to variant rs55950645 [ dbSNP | Ensembl ].
VAR_041151
Natural variant3621T → P.
Corresponds to variant rs35545265 [ dbSNP | Ensembl ].
VAR_031603
Natural variant3851R → C.
Corresponds to variant rs35995607 [ dbSNP | Ensembl ].
VAR_051675
Natural variant3931A → T. Ref.6
Corresponds to variant rs56244148 [ dbSNP | Ensembl ].
VAR_041152
Natural variant4101G → E. Ref.6
Corresponds to variant rs4722266 [ dbSNP | Ensembl ].
VAR_031604
Natural variant4891A → P. Ref.6
Corresponds to variant rs34414354 [ dbSNP | Ensembl ].
VAR_041153
Natural variant6001A → T. Ref.6
Corresponds to variant rs55796076 [ dbSNP | Ensembl ].
VAR_041154
Natural variant6211N → K. Ref.6
Corresponds to variant rs10263079 [ dbSNP | Ensembl ].
VAR_041155
Natural variant6231S → I. Ref.6
Corresponds to variant rs10247878 [ dbSNP | Ensembl ].
VAR_041156
Natural variant6841H → R. Ref.6
Corresponds to variant rs41273999 [ dbSNP | Ensembl ].
VAR_041157
Natural variant6841H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. Ref.6
VAR_041158
Natural variant7091E → K. Ref.6
Corresponds to variant rs56181834 [ dbSNP | Ensembl ].
VAR_041159
Natural variant8601V → L in a lung small cell carcinoma sample; somatic mutation. Ref.6
VAR_041160
Natural variant10001T → M. Ref.6
Corresponds to variant rs55794023 [ dbSNP | Ensembl ].
VAR_041161
Natural variant10091K → T.
Corresponds to variant rs33998018 [ dbSNP | Ensembl ].
VAR_031605
Natural variant10101T → S. Ref.6
Corresponds to variant rs56391043 [ dbSNP | Ensembl ].
VAR_041162

Experimental info

Sequence conflict3001I → F in AAK17193. Ref.2
Sequence conflict5091F → Y in AAK17193. Ref.2
Sequence conflict621 – 6233NKS → KKI in AAK31978. Ref.1
Sequence conflict7151Y → C in AAK17193. Ref.2
Sequence conflict8201V → A in AAK17193. Ref.2
Sequence conflict9481K → I in AAK17193. Ref.2
Sequence conflict9631A → G in AAK17193. Ref.2
Sequence conflict10001T → P in AAK17193. Ref.2
Sequence conflict10101T → P in AAK31978. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: C2EFF005A820E102

FASTA1,019115,694
        10         20         30         40         50         60 
MWVQGHSSRA SATESVSFSG IVQMDEDTHY DKVEDVVGSH IEDAVTFWAQ SINRNKDIMK 

        70         80         90        100        110        120 
IGCSLSEVCP QASSVLGNLD PNKIYGGLFS EDQCWYRCKV LKIISVEKCL VRYIDYGNTE 

       130        140        150        160        170        180 
ILNRSDIVEI PLELQFSSVA KKYKLWGLHI PSDQEVTQFD QGTTFLGSLI FEKEIKMRIK 

       190        200        210        220        230        240 
ATSEDGTVIA QAEYGSVDIG EEVLKKGFAE KCRLASRTDI CEEKKLDPGQ LVLRNLKSPI 

       250        260        270        280        290        300 
PLWGHRSNQS TFSRPKGHLS EKMTLDLKDE NDAGNLITFP KESLAVGDFN LGSNVSLEKI 

       310        320        330        340        350        360 
KQDQKLIEEN EKLKTEKDAL LESYKALELK VEQIAQELQQ EKAAAVDLTN HLEYTLKTYI 

       370        380        390        400        410        420 
DTRMKNLAAK MEILKEMRHV DISVRFGKDL SDAIQVLDEG CFTTPASLNG LEIIWAEYSL 

       430        440        450        460        470        480 
AQENIKTCEY VSEGNILIAQ RNEMQQKLYM SVEDFILEVD ESSLNKRLKT LQDLSVSLEA 

       490        500        510        520        530        540 
VYGQAKEGAN SDEILKKFYD WKCDKREEFT SVRSETDASL HRLVAWFQRT LKVFDLSVEG 

       550        560        570        580        590        600 
SLISEDAMDN IDEILEKTES SVCKELEIAL VDQGDADKEI ISNTYSQVLQ KIHSEERLIA 

       610        620        630        640        650        660 
TVQAKYKDSI EFKKQLIEYL NKSPSVDHLL SIKKTLKSLK ALLRWKLVEK SNLEESDDPD 

       670        680        690        700        710        720 
GSQIEKIKEE ITQLRNNVFQ EIYHEREEYE MLTSLAQKWF PELPLLHPEI GLLKYMNSGG 

       730        740        750        760        770        780 
LLTMSLERDL LDAEPMKELS SKRPLVRSEV NGQIILLKGY SVDVDTEAKV IERAATYHRA 

       790        800        810        820        830        840 
WREAEGDSGL LPLIFLFLCK SDPMAYLMVP YYPRANLNAV QANMPLNSEE TLKVMKGVAQ 

       850        860        870        880        890        900 
GLHTLHKADI IHGSLHQNNV FALNREQGIV GDFDFTKSVS QRASVNMMVG DLSLMSPELK 

       910        920        930        940        950        960 
MGKPASPGSD LYAYGCLLLW LSVQNQEFEI NKDGIPKVDQ FHLDDKVKSL LCSLICYRSS 

       970        980        990       1000       1010 
MTAEQVLNAE CFLMPKEQSV PNPEKDTEYT LYKKEEEIKT ENLDKCMEKT RNGEANFDC 

« Hide

Isoform 2 [UniParc].

Checksum: E9D528F7DE7D2CDC
Show »

FASTA996113,260
Isoform 3 [UniParc].

Checksum: 753B3B79DBF556E8
Show »

FASTA996113,013

References

« Hide 'large scale' references
[1]"An abundance of X-linked genes expressed in spermatogonia."
Wang P.J., McCarrey J.R., Yang F., Page D.C.
Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"Cloning of a new protein kinase gene related to human testis development."
Zhou Z.M.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Testis.
[4]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-71.
Tissue: Testis.
[6]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-71; PHE-125; LYS-261; ASN-268; LYS-277; THR-393; GLU-410; PRO-489; THR-600; LYS-621; ILE-623; ARG-684; TYR-684; LYS-709; LEU-860; MET-1000 AND SER-1010.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF285599 mRNA. Translation: AAK31978.1.
AF332194 mRNA. Translation: AAK17193.1.
AK302689 mRNA. Translation: BAG63918.1.
AC003087 Genomic DNA. No translation available.
AC008176 Genomic DNA. No translation available.
BC059374 mRNA. Translation: AAH59374.1.
CCDSCCDS43556.1. [Q9BXU1-2]
CCDS5386.1. [Q9BXU1-1]
CCDS59049.1. [Q9BXU1-3]
RefSeqNP_001247433.1. NM_001260504.1. [Q9BXU1-2]
NP_001247434.1. NM_001260505.1. [Q9BXU1-3]
NP_113602.2. NM_031414.4. [Q9BXU1-1]
NP_116562.2. NM_032944.3. [Q9BXU1-2]
UniGeneHs.309767.

3D structure databases

ProteinModelPortalQ9BXU1.
SMRQ9BXU1. Positions 34-208, 807-940.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121097. 1 interaction.
IntActQ9BXU1. 1 interaction.
STRING9606.ENSP00000348132.

Chemistry

BindingDBQ9BXU1.
ChEMBLCHEMBL6151.

PTM databases

PhosphoSiteQ9BXU1.

Polymorphism databases

DMDM143811463.

Proteomic databases

MaxQBQ9BXU1.
PaxDbQ9BXU1.
PRIDEQ9BXU1.

Protocols and materials databases

DNASU56164.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354639; ENSP00000346660; ENSG00000196335. [Q9BXU1-2]
ENST00000355870; ENSP00000348132; ENSG00000196335. [Q9BXU1-1]
ENST00000428484; ENSP00000406146; ENSG00000196335. [Q9BXU1-2]
ENST00000433467; ENSP00000411852; ENSG00000196335. [Q9BXU1-3]
GeneID56164.
KEGGhsa:56164.
UCSCuc003sws.5. human. [Q9BXU1-1]
uc011jze.3. human.

Organism-specific databases

CTD56164.
GeneCardsGC07P023749.
H-InvDBHIX0006524.
HGNCHGNC:11407. STK31.
HPAHPA023194.
MIM605790. gene.
neXtProtNX_Q9BXU1.
PharmGKBPA36214.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81566.
HOGENOMHOG000154440.
HOVERGENHBG062739.
InParanoidQ9BXU1.
KOK16316.
OMAIPKVDQF.
OrthoDBEOG7MPRD3.
PhylomeDBQ9BXU1.
TreeFamTF105335.

Enzyme and pathway databases

SignaLinkQ9BXU1.

Gene expression databases

ArrayExpressQ9BXU1.
BgeeQ9BXU1.
CleanExHS_STK31.
GenevestigatorQ9BXU1.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR016071. Staphylococal_nuclease_OB-fold.
IPR002999. Tudor.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTSM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMSSF50199. SSF50199. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50304. TUDOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi56164.
NextBio61796.
PROQ9BXU1.
SOURCESearch...

Entry information

Entry nameSTK31_HUMAN
AccessionPrimary (citable) accession number: Q9BXU1
Secondary accession number(s): B4DZ06 expand/collapse secondary AC list , B7WPP5, C9J4F9, Q6PCD3, Q9BXH8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM