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Protein

Serine/threonine-protein kinase 31

Gene

STK31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei737ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi716 – 724ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS06139-MONOMER.
BRENDAi2.7.11.1. 2681.
SignaLinkiQ9BXU1.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 31 (EC:2.7.11.1)
Alternative name(s):
Serine/threonine-protein kinase NYD-SPK
Sugen kinase 396
Short name:
SgK396
Gene namesi
Name:STK31
Synonyms:SGK396
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11407. STK31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi56164.
OpenTargetsiENSG00000196335.
PharmGKBiPA36214.

Chemistry databases

ChEMBLiCHEMBL6151.
GuidetoPHARMACOLOGYi2220.

Polymorphism and mutation databases

BioMutaiSTK31.
DMDMi143811463.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867151 – 1019Serine/threonine-protein kinase 31Add BLAST1019

Proteomic databases

MaxQBiQ9BXU1.
PaxDbiQ9BXU1.
PeptideAtlasiQ9BXU1.
PRIDEiQ9BXU1.

PTM databases

iPTMnetiQ9BXU1.
PhosphoSitePlusiQ9BXU1.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000196335.
CleanExiHS_STK31.
ExpressionAtlasiQ9BXU1. baseline and differential.
GenevisibleiQ9BXU1. HS.

Organism-specific databases

HPAiHPA023194.

Interactioni

Protein-protein interaction databases

BioGridi121097. 3 interactors.
IntActiQ9BXU1. 1 interactor.
STRINGi9606.ENSP00000348132.

Chemistry databases

BindingDBiQ9BXU1.

Structurei

3D structure databases

ProteinModelPortaliQ9BXU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 137TudorPROSITE-ProRule annotationAdd BLAST60
Domaini710 – 1019Protein kinasePROSITE-ProRule annotationAdd BLAST310

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili298 – 355Sequence analysisAdd BLAST58

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 Tudor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF5N. Eukaryota.
ENOG410XQIZ. LUCA.
GeneTreeiENSGT00390000007287.
HOGENOMiHOG000154440.
HOVERGENiHBG062739.
InParanoidiQ9BXU1.
KOiK16316.
OMAiNRNKDIM.
OrthoDBiEOG091G0PO7.
PhylomeDBiQ9BXU1.
TreeFamiTF105335.

Family and domain databases

Gene3Di2.40.50.90. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR016071. Staphylococal_nuclease_OB-fold.
IPR002999. Tudor.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
SM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50304. TUDOR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWVQGHSSRA SATESVSFSG IVQMDEDTHY DKVEDVVGSH IEDAVTFWAQ
60 70 80 90 100
SINRNKDIMK IGCSLSEVCP QASSVLGNLD PNKIYGGLFS EDQCWYRCKV
110 120 130 140 150
LKIISVEKCL VRYIDYGNTE ILNRSDIVEI PLELQFSSVA KKYKLWGLHI
160 170 180 190 200
PSDQEVTQFD QGTTFLGSLI FEKEIKMRIK ATSEDGTVIA QAEYGSVDIG
210 220 230 240 250
EEVLKKGFAE KCRLASRTDI CEEKKLDPGQ LVLRNLKSPI PLWGHRSNQS
260 270 280 290 300
TFSRPKGHLS EKMTLDLKDE NDAGNLITFP KESLAVGDFN LGSNVSLEKI
310 320 330 340 350
KQDQKLIEEN EKLKTEKDAL LESYKALELK VEQIAQELQQ EKAAAVDLTN
360 370 380 390 400
HLEYTLKTYI DTRMKNLAAK MEILKEMRHV DISVRFGKDL SDAIQVLDEG
410 420 430 440 450
CFTTPASLNG LEIIWAEYSL AQENIKTCEY VSEGNILIAQ RNEMQQKLYM
460 470 480 490 500
SVEDFILEVD ESSLNKRLKT LQDLSVSLEA VYGQAKEGAN SDEILKKFYD
510 520 530 540 550
WKCDKREEFT SVRSETDASL HRLVAWFQRT LKVFDLSVEG SLISEDAMDN
560 570 580 590 600
IDEILEKTES SVCKELEIAL VDQGDADKEI ISNTYSQVLQ KIHSEERLIA
610 620 630 640 650
TVQAKYKDSI EFKKQLIEYL NKSPSVDHLL SIKKTLKSLK ALLRWKLVEK
660 670 680 690 700
SNLEESDDPD GSQIEKIKEE ITQLRNNVFQ EIYHEREEYE MLTSLAQKWF
710 720 730 740 750
PELPLLHPEI GLLKYMNSGG LLTMSLERDL LDAEPMKELS SKRPLVRSEV
760 770 780 790 800
NGQIILLKGY SVDVDTEAKV IERAATYHRA WREAEGDSGL LPLIFLFLCK
810 820 830 840 850
SDPMAYLMVP YYPRANLNAV QANMPLNSEE TLKVMKGVAQ GLHTLHKADI
860 870 880 890 900
IHGSLHQNNV FALNREQGIV GDFDFTKSVS QRASVNMMVG DLSLMSPELK
910 920 930 940 950
MGKPASPGSD LYAYGCLLLW LSVQNQEFEI NKDGIPKVDQ FHLDDKVKSL
960 970 980 990 1000
LCSLICYRSS MTAEQVLNAE CFLMPKEQSV PNPEKDTEYT LYKKEEEIKT
1010
ENLDKCMEKT RNGEANFDC
Length:1,019
Mass (Da):115,694
Last modified:April 3, 2007 - v2
Checksum:iC2EFF005A820E102
GO
Isoform 2 (identifier: Q9BXU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: No experimental confirmation available.
Show »
Length:996
Mass (Da):113,260
Checksum:iE9D528F7DE7D2CDC
GO
Isoform 3 (identifier: Q9BXU1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     921-943: Missing.

Show »
Length:996
Mass (Da):113,013
Checksum:i753B3B79DBF556E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti300I → F in AAK17193 (Ref. 2) Curated1
Sequence conflicti509F → Y in AAK17193 (Ref. 2) Curated1
Sequence conflicti621 – 623NKS → KKI in AAK31978 (PubMed:11279525).Curated3
Sequence conflicti715Y → C in AAK17193 (Ref. 2) Curated1
Sequence conflicti820V → A in AAK17193 (Ref. 2) Curated1
Sequence conflicti948K → I in AAK17193 (Ref. 2) Curated1
Sequence conflicti963A → G in AAK17193 (Ref. 2) Curated1
Sequence conflicti1000T → P in AAK17193 (Ref. 2) Curated1
Sequence conflicti1010T → P in AAK31978 (PubMed:11279525).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03160071Q → H.2 PublicationsCorresponds to variant rs6945306dbSNPEnsembl.1
Natural variantiVAR_041150125S → F.1 PublicationCorresponds to variant rs56268851dbSNPEnsembl.1
Natural variantiVAR_031601261E → K.1 PublicationCorresponds to variant rs10264952dbSNPEnsembl.1
Natural variantiVAR_031602268K → N.1 PublicationCorresponds to variant rs10264967dbSNPEnsembl.1
Natural variantiVAR_041151277I → K.1 PublicationCorresponds to variant rs55950645dbSNPEnsembl.1
Natural variantiVAR_031603362T → P.Corresponds to variant rs35545265dbSNPEnsembl.1
Natural variantiVAR_051675385R → C.Corresponds to variant rs35995607dbSNPEnsembl.1
Natural variantiVAR_041152393A → T.1 PublicationCorresponds to variant rs56244148dbSNPEnsembl.1
Natural variantiVAR_031604410G → E.1 PublicationCorresponds to variant rs4722266dbSNPEnsembl.1
Natural variantiVAR_041153489A → P.1 PublicationCorresponds to variant rs34414354dbSNPEnsembl.1
Natural variantiVAR_041154600A → T.1 PublicationCorresponds to variant rs55796076dbSNPEnsembl.1
Natural variantiVAR_041155621N → K.1 PublicationCorresponds to variant rs10263079dbSNPEnsembl.1
Natural variantiVAR_041156623S → I.1 PublicationCorresponds to variant rs10247878dbSNPEnsembl.1
Natural variantiVAR_041157684H → R.1 PublicationCorresponds to variant rs41273999dbSNPEnsembl.1
Natural variantiVAR_041158684H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041159709E → K.1 PublicationCorresponds to variant rs56181834dbSNPEnsembl.1
Natural variantiVAR_041160860V → L in a lung small cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0411611000T → M.1 PublicationCorresponds to variant rs55794023dbSNPEnsembl.1
Natural variantiVAR_0316051009K → T.Corresponds to variant rs33998018dbSNPEnsembl.1
Natural variantiVAR_0411621010T → S.1 PublicationCorresponds to variant rs56391043dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0243891 – 23Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_045210921 – 943Missing in isoform 3. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285599 mRNA. Translation: AAK31978.1.
AF332194 mRNA. Translation: AAK17193.1.
AK302689 mRNA. Translation: BAG63918.1.
AC003087 Genomic DNA. No translation available.
AC008176 Genomic DNA. No translation available.
BC059374 mRNA. Translation: AAH59374.1.
CCDSiCCDS43556.1. [Q9BXU1-2]
CCDS5386.1. [Q9BXU1-1]
CCDS59049.1. [Q9BXU1-3]
RefSeqiNP_001247433.1. NM_001260504.1. [Q9BXU1-2]
NP_001247434.1. NM_001260505.1. [Q9BXU1-3]
NP_113602.2. NM_031414.4. [Q9BXU1-1]
NP_116562.2. NM_032944.3. [Q9BXU1-2]
UniGeneiHs.309767.

Genome annotation databases

EnsembliENST00000354639; ENSP00000346660; ENSG00000196335. [Q9BXU1-2]
ENST00000355870; ENSP00000348132; ENSG00000196335. [Q9BXU1-1]
ENST00000433467; ENSP00000411852; ENSG00000196335. [Q9BXU1-3]
GeneIDi56164.
KEGGihsa:56164.
UCSCiuc003sws.6. human. [Q9BXU1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285599 mRNA. Translation: AAK31978.1.
AF332194 mRNA. Translation: AAK17193.1.
AK302689 mRNA. Translation: BAG63918.1.
AC003087 Genomic DNA. No translation available.
AC008176 Genomic DNA. No translation available.
BC059374 mRNA. Translation: AAH59374.1.
CCDSiCCDS43556.1. [Q9BXU1-2]
CCDS5386.1. [Q9BXU1-1]
CCDS59049.1. [Q9BXU1-3]
RefSeqiNP_001247433.1. NM_001260504.1. [Q9BXU1-2]
NP_001247434.1. NM_001260505.1. [Q9BXU1-3]
NP_113602.2. NM_031414.4. [Q9BXU1-1]
NP_116562.2. NM_032944.3. [Q9BXU1-2]
UniGeneiHs.309767.

3D structure databases

ProteinModelPortaliQ9BXU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121097. 3 interactors.
IntActiQ9BXU1. 1 interactor.
STRINGi9606.ENSP00000348132.

Chemistry databases

BindingDBiQ9BXU1.
ChEMBLiCHEMBL6151.
GuidetoPHARMACOLOGYi2220.

PTM databases

iPTMnetiQ9BXU1.
PhosphoSitePlusiQ9BXU1.

Polymorphism and mutation databases

BioMutaiSTK31.
DMDMi143811463.

Proteomic databases

MaxQBiQ9BXU1.
PaxDbiQ9BXU1.
PeptideAtlasiQ9BXU1.
PRIDEiQ9BXU1.

Protocols and materials databases

DNASUi56164.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354639; ENSP00000346660; ENSG00000196335. [Q9BXU1-2]
ENST00000355870; ENSP00000348132; ENSG00000196335. [Q9BXU1-1]
ENST00000433467; ENSP00000411852; ENSG00000196335. [Q9BXU1-3]
GeneIDi56164.
KEGGihsa:56164.
UCSCiuc003sws.6. human. [Q9BXU1-1]

Organism-specific databases

CTDi56164.
DisGeNETi56164.
GeneCardsiSTK31.
H-InvDBHIX0006524.
HGNCiHGNC:11407. STK31.
HPAiHPA023194.
MIMi605790. gene.
neXtProtiNX_Q9BXU1.
OpenTargetsiENSG00000196335.
PharmGKBiPA36214.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF5N. Eukaryota.
ENOG410XQIZ. LUCA.
GeneTreeiENSGT00390000007287.
HOGENOMiHOG000154440.
HOVERGENiHBG062739.
InParanoidiQ9BXU1.
KOiK16316.
OMAiNRNKDIM.
OrthoDBiEOG091G0PO7.
PhylomeDBiQ9BXU1.
TreeFamiTF105335.

Enzyme and pathway databases

BioCyciZFISH:HS06139-MONOMER.
BRENDAi2.7.11.1. 2681.
SignaLinkiQ9BXU1.

Miscellaneous databases

GenomeRNAii56164.
PROiQ9BXU1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196335.
CleanExiHS_STK31.
ExpressionAtlasiQ9BXU1. baseline and differential.
GenevisibleiQ9BXU1. HS.

Family and domain databases

Gene3Di2.40.50.90. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR016071. Staphylococal_nuclease_OB-fold.
IPR002999. Tudor.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
SM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50304. TUDOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTK31_HUMAN
AccessioniPrimary (citable) accession number: Q9BXU1
Secondary accession number(s): B4DZ06
, B7WPP5, C9J4F9, Q6PCD3, Q9BXH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Ser-854 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.