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Protein

Serine/threonine-protein kinase 31

Gene

STK31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei737 – 7371ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi716 – 7249ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 2681.
SignaLinkiQ9BXU1.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 31 (EC:2.7.11.1)
Alternative name(s):
Serine/threonine-protein kinase NYD-SPK
Sugen kinase 396
Short name:
SgK396
Gene namesi
Name:STK31
Synonyms:SGK396
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11407. STK31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36214.

Polymorphism and mutation databases

BioMutaiSTK31.
DMDMi143811463.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10191019Serine/threonine-protein kinase 31PRO_0000086715Add
BLAST

Proteomic databases

MaxQBiQ9BXU1.
PaxDbiQ9BXU1.
PRIDEiQ9BXU1.

PTM databases

PhosphoSiteiQ9BXU1.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiQ9BXU1.
CleanExiHS_STK31.
ExpressionAtlasiQ9BXU1. baseline and differential.
GenevisibleiQ9BXU1. HS.

Organism-specific databases

HPAiHPA023194.

Interactioni

Protein-protein interaction databases

BioGridi121097. 1 interaction.
IntActiQ9BXU1. 1 interaction.
STRINGi9606.ENSP00000348132.

Structurei

3D structure databases

ProteinModelPortaliQ9BXU1.
SMRiQ9BXU1. Positions 34-208, 765-940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 13760TudorPROSITE-ProRule annotationAdd
BLAST
Domaini710 – 1019310Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili298 – 35558Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 Tudor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG81566.
GeneTreeiENSGT00390000007287.
HOGENOMiHOG000154440.
HOVERGENiHBG062739.
InParanoidiQ9BXU1.
KOiK16316.
OMAiIPKVDQF.
OrthoDBiEOG7MPRD3.
PhylomeDBiQ9BXU1.
TreeFamiTF105335.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR016071. Staphylococal_nuclease_OB-fold.
IPR002999. Tudor.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50304. TUDOR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWVQGHSSRA SATESVSFSG IVQMDEDTHY DKVEDVVGSH IEDAVTFWAQ
60 70 80 90 100
SINRNKDIMK IGCSLSEVCP QASSVLGNLD PNKIYGGLFS EDQCWYRCKV
110 120 130 140 150
LKIISVEKCL VRYIDYGNTE ILNRSDIVEI PLELQFSSVA KKYKLWGLHI
160 170 180 190 200
PSDQEVTQFD QGTTFLGSLI FEKEIKMRIK ATSEDGTVIA QAEYGSVDIG
210 220 230 240 250
EEVLKKGFAE KCRLASRTDI CEEKKLDPGQ LVLRNLKSPI PLWGHRSNQS
260 270 280 290 300
TFSRPKGHLS EKMTLDLKDE NDAGNLITFP KESLAVGDFN LGSNVSLEKI
310 320 330 340 350
KQDQKLIEEN EKLKTEKDAL LESYKALELK VEQIAQELQQ EKAAAVDLTN
360 370 380 390 400
HLEYTLKTYI DTRMKNLAAK MEILKEMRHV DISVRFGKDL SDAIQVLDEG
410 420 430 440 450
CFTTPASLNG LEIIWAEYSL AQENIKTCEY VSEGNILIAQ RNEMQQKLYM
460 470 480 490 500
SVEDFILEVD ESSLNKRLKT LQDLSVSLEA VYGQAKEGAN SDEILKKFYD
510 520 530 540 550
WKCDKREEFT SVRSETDASL HRLVAWFQRT LKVFDLSVEG SLISEDAMDN
560 570 580 590 600
IDEILEKTES SVCKELEIAL VDQGDADKEI ISNTYSQVLQ KIHSEERLIA
610 620 630 640 650
TVQAKYKDSI EFKKQLIEYL NKSPSVDHLL SIKKTLKSLK ALLRWKLVEK
660 670 680 690 700
SNLEESDDPD GSQIEKIKEE ITQLRNNVFQ EIYHEREEYE MLTSLAQKWF
710 720 730 740 750
PELPLLHPEI GLLKYMNSGG LLTMSLERDL LDAEPMKELS SKRPLVRSEV
760 770 780 790 800
NGQIILLKGY SVDVDTEAKV IERAATYHRA WREAEGDSGL LPLIFLFLCK
810 820 830 840 850
SDPMAYLMVP YYPRANLNAV QANMPLNSEE TLKVMKGVAQ GLHTLHKADI
860 870 880 890 900
IHGSLHQNNV FALNREQGIV GDFDFTKSVS QRASVNMMVG DLSLMSPELK
910 920 930 940 950
MGKPASPGSD LYAYGCLLLW LSVQNQEFEI NKDGIPKVDQ FHLDDKVKSL
960 970 980 990 1000
LCSLICYRSS MTAEQVLNAE CFLMPKEQSV PNPEKDTEYT LYKKEEEIKT
1010
ENLDKCMEKT RNGEANFDC
Length:1,019
Mass (Da):115,694
Last modified:April 3, 2007 - v2
Checksum:iC2EFF005A820E102
GO
Isoform 2 (identifier: Q9BXU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: No experimental confirmation available.
Show »
Length:996
Mass (Da):113,260
Checksum:iE9D528F7DE7D2CDC
GO
Isoform 3 (identifier: Q9BXU1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     921-943: Missing.

Show »
Length:996
Mass (Da):113,013
Checksum:i753B3B79DBF556E8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti300 – 3001I → F in AAK17193 (Ref. 2) Curated
Sequence conflicti509 – 5091F → Y in AAK17193 (Ref. 2) Curated
Sequence conflicti621 – 6233NKS → KKI in AAK31978 (PubMed:11279525).Curated
Sequence conflicti715 – 7151Y → C in AAK17193 (Ref. 2) Curated
Sequence conflicti820 – 8201V → A in AAK17193 (Ref. 2) Curated
Sequence conflicti948 – 9481K → I in AAK17193 (Ref. 2) Curated
Sequence conflicti963 – 9631A → G in AAK17193 (Ref. 2) Curated
Sequence conflicti1000 – 10001T → P in AAK17193 (Ref. 2) Curated
Sequence conflicti1010 – 10101T → P in AAK31978 (PubMed:11279525).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711Q → H.2 Publications
Corresponds to variant rs6945306 [ dbSNP | Ensembl ].
VAR_031600
Natural varianti125 – 1251S → F.1 Publication
Corresponds to variant rs56268851 [ dbSNP | Ensembl ].
VAR_041150
Natural varianti261 – 2611E → K.1 Publication
Corresponds to variant rs10264952 [ dbSNP | Ensembl ].
VAR_031601
Natural varianti268 – 2681K → N.1 Publication
Corresponds to variant rs10264967 [ dbSNP | Ensembl ].
VAR_031602
Natural varianti277 – 2771I → K.1 Publication
Corresponds to variant rs55950645 [ dbSNP | Ensembl ].
VAR_041151
Natural varianti362 – 3621T → P.
Corresponds to variant rs35545265 [ dbSNP | Ensembl ].
VAR_031603
Natural varianti385 – 3851R → C.
Corresponds to variant rs35995607 [ dbSNP | Ensembl ].
VAR_051675
Natural varianti393 – 3931A → T.1 Publication
Corresponds to variant rs56244148 [ dbSNP | Ensembl ].
VAR_041152
Natural varianti410 – 4101G → E.1 Publication
Corresponds to variant rs4722266 [ dbSNP | Ensembl ].
VAR_031604
Natural varianti489 – 4891A → P.1 Publication
Corresponds to variant rs34414354 [ dbSNP | Ensembl ].
VAR_041153
Natural varianti600 – 6001A → T.1 Publication
Corresponds to variant rs55796076 [ dbSNP | Ensembl ].
VAR_041154
Natural varianti621 – 6211N → K.1 Publication
Corresponds to variant rs10263079 [ dbSNP | Ensembl ].
VAR_041155
Natural varianti623 – 6231S → I.1 Publication
Corresponds to variant rs10247878 [ dbSNP | Ensembl ].
VAR_041156
Natural varianti684 – 6841H → R.1 Publication
Corresponds to variant rs41273999 [ dbSNP | Ensembl ].
VAR_041157
Natural varianti684 – 6841H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
VAR_041158
Natural varianti709 – 7091E → K.1 Publication
Corresponds to variant rs56181834 [ dbSNP | Ensembl ].
VAR_041159
Natural varianti860 – 8601V → L in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_041160
Natural varianti1000 – 10001T → M.1 Publication
Corresponds to variant rs55794023 [ dbSNP | Ensembl ].
VAR_041161
Natural varianti1009 – 10091K → T.
Corresponds to variant rs33998018 [ dbSNP | Ensembl ].
VAR_031605
Natural varianti1010 – 10101T → S.1 Publication
Corresponds to variant rs56391043 [ dbSNP | Ensembl ].
VAR_041162

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323Missing in isoform 2. 1 PublicationVSP_024389Add
BLAST
Alternative sequencei921 – 94323Missing in isoform 3. 1 PublicationVSP_045210Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285599 mRNA. Translation: AAK31978.1.
AF332194 mRNA. Translation: AAK17193.1.
AK302689 mRNA. Translation: BAG63918.1.
AC003087 Genomic DNA. No translation available.
AC008176 Genomic DNA. No translation available.
BC059374 mRNA. Translation: AAH59374.1.
CCDSiCCDS43556.1. [Q9BXU1-2]
CCDS5386.1. [Q9BXU1-1]
CCDS59049.1. [Q9BXU1-3]
RefSeqiNP_001247433.1. NM_001260504.1. [Q9BXU1-2]
NP_001247434.1. NM_001260505.1. [Q9BXU1-3]
NP_113602.2. NM_031414.4. [Q9BXU1-1]
NP_116562.2. NM_032944.3. [Q9BXU1-2]
XP_011513752.1. XM_011515450.1. [Q9BXU1-2]
UniGeneiHs.309767.

Genome annotation databases

EnsembliENST00000354639; ENSP00000346660; ENSG00000196335. [Q9BXU1-2]
ENST00000355870; ENSP00000348132; ENSG00000196335.
ENST00000433467; ENSP00000411852; ENSG00000196335. [Q9BXU1-3]
GeneIDi56164.
KEGGihsa:56164.
UCSCiuc003sws.5. human. [Q9BXU1-1]
uc011jze.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285599 mRNA. Translation: AAK31978.1.
AF332194 mRNA. Translation: AAK17193.1.
AK302689 mRNA. Translation: BAG63918.1.
AC003087 Genomic DNA. No translation available.
AC008176 Genomic DNA. No translation available.
BC059374 mRNA. Translation: AAH59374.1.
CCDSiCCDS43556.1. [Q9BXU1-2]
CCDS5386.1. [Q9BXU1-1]
CCDS59049.1. [Q9BXU1-3]
RefSeqiNP_001247433.1. NM_001260504.1. [Q9BXU1-2]
NP_001247434.1. NM_001260505.1. [Q9BXU1-3]
NP_113602.2. NM_031414.4. [Q9BXU1-1]
NP_116562.2. NM_032944.3. [Q9BXU1-2]
XP_011513752.1. XM_011515450.1. [Q9BXU1-2]
UniGeneiHs.309767.

3D structure databases

ProteinModelPortaliQ9BXU1.
SMRiQ9BXU1. Positions 34-208, 765-940.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121097. 1 interaction.
IntActiQ9BXU1. 1 interaction.
STRINGi9606.ENSP00000348132.

Chemistry

BindingDBiQ9BXU1.
ChEMBLiCHEMBL6151.

PTM databases

PhosphoSiteiQ9BXU1.

Polymorphism and mutation databases

BioMutaiSTK31.
DMDMi143811463.

Proteomic databases

MaxQBiQ9BXU1.
PaxDbiQ9BXU1.
PRIDEiQ9BXU1.

Protocols and materials databases

DNASUi56164.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354639; ENSP00000346660; ENSG00000196335. [Q9BXU1-2]
ENST00000355870; ENSP00000348132; ENSG00000196335.
ENST00000433467; ENSP00000411852; ENSG00000196335. [Q9BXU1-3]
GeneIDi56164.
KEGGihsa:56164.
UCSCiuc003sws.5. human. [Q9BXU1-1]
uc011jze.3. human.

Organism-specific databases

CTDi56164.
GeneCardsiGC07P023749.
H-InvDBHIX0006524.
HGNCiHGNC:11407. STK31.
HPAiHPA023194.
MIMi605790. gene.
neXtProtiNX_Q9BXU1.
PharmGKBiPA36214.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG81566.
GeneTreeiENSGT00390000007287.
HOGENOMiHOG000154440.
HOVERGENiHBG062739.
InParanoidiQ9BXU1.
KOiK16316.
OMAiIPKVDQF.
OrthoDBiEOG7MPRD3.
PhylomeDBiQ9BXU1.
TreeFamiTF105335.

Enzyme and pathway databases

BRENDAi2.7.11.1. 2681.
SignaLinkiQ9BXU1.

Miscellaneous databases

GenomeRNAii56164.
NextBioi61796.
PROiQ9BXU1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BXU1.
CleanExiHS_STK31.
ExpressionAtlasiQ9BXU1. baseline and differential.
GenevisibleiQ9BXU1. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR016071. Staphylococal_nuclease_OB-fold.
IPR002999. Tudor.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50304. TUDOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An abundance of X-linked genes expressed in spermatogonia."
    Wang P.J., McCarrey J.R., Yang F., Page D.C.
    Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Cloning of a new protein kinase gene related to human testis development."
    Zhou Z.M.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-71.
    Tissue: Testis.
  6. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-71; PHE-125; LYS-261; ASN-268; LYS-277; THR-393; GLU-410; PRO-489; THR-600; LYS-621; ILE-623; ARG-684; TYR-684; LYS-709; LEU-860; MET-1000 AND SER-1010.

Entry informationi

Entry nameiSTK31_HUMAN
AccessioniPrimary (citable) accession number: Q9BXU1
Secondary accession number(s): B4DZ06
, B7WPP5, C9J4F9, Q6PCD3, Q9BXH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: April 3, 2007
Last modified: July 22, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Ser-854 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.