ID   RNF17_HUMAN             Reviewed;        1623 AA.
AC   Q9BXT8; Q5T2J9; Q6P1W3; Q9BXT7; Q9NUY9;
DT   24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 3.
DT   24-JAN-2024, entry version 177.
DE   RecName: Full=RING finger protein 17;
DE   AltName: Full=Tudor domain-containing protein 4;
GN   Name=RNF17; Synonyms=TDRD4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
RC   TISSUE=Testis;
RX   PubMed=11279525; DOI=10.1038/86927;
RA   Wang P.J., McCarrey J.R., Yang F., Page D.C.;
RT   "An abundance of X-linked genes expressed in spermatogonia.";
RL   Nat. Genet. 27:422-426(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 765-1623 (ISOFORM 5), AND VARIANT
RP   LYS-1380.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 914-1623 (ISOFORM 4), AND VARIANT
RP   LYS-1380.
RC   TISSUE=Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   STRUCTURE BY NMR OF 949-1026.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of the tudor domain of tudor domain-containing protein
RT   4.";
RL   Submitted (OCT-2007) to the PDB data bank.
CC   -!- FUNCTION: Seems to be involved in regulation of transcriptional
CC       activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX
CC       heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3,
CC       MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with MXD1, MXD3, MXD4, MXI1 and PIWIL1. Self-
CC       associates (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Predominantly found in the cytoplasm. Component of a nuage in male
CC       germ cells (an electron-dense spherical cytoplasmic body present in
CC       late pachytene and diplotene spermatocytes and in elonging spermatids)
CC       (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=1;
CC         IsoId=Q9BXT8-3; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BXT8-1; Sequence=VSP_033073, VSP_033074;
CC       Name=3;
CC         IsoId=Q9BXT8-2; Sequence=VSP_005753, VSP_005754;
CC       Name=4;
CC         IsoId=Q9BXT8-4; Sequence=VSP_033076;
CC       Name=5;
CC         IsoId=Q9BXT8-5; Sequence=VSP_033075;
CC   -!- TISSUE SPECIFICITY: Testis specific.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH64847.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAA91972.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF285602; AAK31981.1; -; mRNA.
DR   EMBL; AF285603; AAK31982.1; -; mRNA.
DR   EMBL; AL354798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC064847; AAH64847.1; ALT_INIT; mRNA.
DR   EMBL; AK001907; BAA91972.1; ALT_INIT; mRNA.
DR   CCDS; CCDS9308.2; -. [Q9BXT8-3]
DR   RefSeq; NP_112567.2; NM_031277.2. [Q9BXT8-3]
DR   PDB; 2EQK; NMR; -; A=949-1026.
DR   PDBsum; 2EQK; -.
DR   AlphaFoldDB; Q9BXT8; -.
DR   SMR; Q9BXT8; -.
DR   BioGRID; 121096; 9.
DR   IntAct; Q9BXT8; 3.
DR   MINT; Q9BXT8; -.
DR   STRING; 9606.ENSP00000255324; -.
DR   GlyGen; Q9BXT8; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9BXT8; -.
DR   PhosphoSitePlus; Q9BXT8; -.
DR   BioMuta; RNF17; -.
DR   DMDM; 187608889; -.
DR   EPD; Q9BXT8; -.
DR   jPOST; Q9BXT8; -.
DR   MassIVE; Q9BXT8; -.
DR   MaxQB; Q9BXT8; -.
DR   PaxDb; 9606-ENSP00000255324; -.
DR   PeptideAtlas; Q9BXT8; -.
DR   ProteomicsDB; 79511; -. [Q9BXT8-3]
DR   ProteomicsDB; 79512; -. [Q9BXT8-1]
DR   ProteomicsDB; 79513; -. [Q9BXT8-2]
DR   ProteomicsDB; 79514; -. [Q9BXT8-4]
DR   ProteomicsDB; 79515; -. [Q9BXT8-5]
DR   Antibodypedia; 22496; 93 antibodies from 19 providers.
DR   DNASU; 56163; -.
DR   Ensembl; ENST00000255324.10; ENSP00000255324.5; ENSG00000132972.19. [Q9BXT8-3]
DR   Ensembl; ENST00000255325.6; ENSP00000255325.6; ENSG00000132972.19. [Q9BXT8-1]
DR   GeneID; 56163; -.
DR   KEGG; hsa:56163; -.
DR   MANE-Select; ENST00000255324.10; ENSP00000255324.5; NM_031277.3; NP_112567.2.
DR   UCSC; uc001upr.4; human. [Q9BXT8-3]
DR   AGR; HGNC:10060; -.
DR   CTD; 56163; -.
DR   DisGeNET; 56163; -.
DR   GeneCards; RNF17; -.
DR   HGNC; HGNC:10060; RNF17.
DR   HPA; ENSG00000132972; Tissue enriched (testis).
DR   MalaCards; RNF17; -.
DR   MIM; 605793; gene.
DR   neXtProt; NX_Q9BXT8; -.
DR   OpenTargets; ENSG00000132972; -.
DR   PharmGKB; PA34424; -.
DR   VEuPathDB; HostDB:ENSG00000132972; -.
DR   eggNOG; KOG2039; Eukaryota.
DR   eggNOG; KOG2279; Eukaryota.
DR   GeneTree; ENSGT00940000157559; -.
DR   HOGENOM; CLU_003202_1_0_1; -.
DR   InParanoid; Q9BXT8; -.
DR   OMA; TMQWSKK; -.
DR   OrthoDB; 3152325at2759; -.
DR   PhylomeDB; Q9BXT8; -.
DR   PathwayCommons; Q9BXT8; -.
DR   SignaLink; Q9BXT8; -.
DR   SIGNOR; Q9BXT8; -.
DR   BioGRID-ORCS; 56163; 13 hits in 1182 CRISPR screens.
DR   ChiTaRS; RNF17; human.
DR   EvolutionaryTrace; Q9BXT8; -.
DR   GenomeRNAi; 56163; -.
DR   Pharos; Q9BXT8; Tbio.
DR   PRO; PR:Q9BXT8; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; Q9BXT8; Protein.
DR   Bgee; ENSG00000132972; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 114 other cell types or tissues.
DR   ExpressionAtlas; Q9BXT8; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR   CDD; cd20414; Tudor_TDRD4_rpt1; 1.
DR   CDD; cd20415; Tudor_TDRD4_rpt2; 1.
DR   CDD; cd20416; Tudor_TDRD4_rpt3; 1.
DR   CDD; cd20417; Tudor_TDRD4_rpt4; 1.
DR   CDD; cd20418; Tudor_TDRD4_rpt5; 1.
DR   Gene3D; 2.30.30.140; -; 5.
DR   Gene3D; 2.40.50.90; -; 4.
DR   InterPro; IPR039117; RNF17.
DR   InterPro; IPR047845; RNF17-like_TUDOR_rpt1.
DR   InterPro; IPR047847; RNF17-like_TUDOR_rpt2.
DR   InterPro; IPR047848; RNF17-like_TUDOR_rpt3.
DR   InterPro; IPR047849; RNF17-like_TUDOR_rpt4.
DR   InterPro; IPR047850; RNF17-like_TUDOR_rpt5.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR16442; RING FINGER PROTEIN 17; 1.
DR   PANTHER; PTHR16442:SF1; RING FINGER PROTEIN 17; 1.
DR   Pfam; PF00567; TUDOR; 5.
DR   SMART; SM00333; TUDOR; 4.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF50199; Staphylococcal nuclease; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 5.
DR   PROSITE; PS50304; TUDOR; 4.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
DR   Genevisible; Q9BXT8; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Alternative splicing; Cytoplasm;
KW   Developmental protein; Differentiation; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Spermatogenesis; Zinc; Zinc-finger.
FT   CHAIN           1..1623
FT                   /note="RING finger protein 17"
FT                   /id="PRO_0000183165"
FT   DOMAIN          726..784
FT                   /note="Tudor 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   DOMAIN          962..1021
FT                   /note="Tudor 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   DOMAIN          1228..1285
FT                   /note="Tudor 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   DOMAIN          1479..1539
FT                   /note="Tudor 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   ZN_FING         32..75
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1438..1462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         234
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99MV7"
FT   VAR_SEQ         414..449
FT                   /note="SSAELVFVSHVIDPCHFYIRKYSQIKDAKVLEKKVN -> TCGTDDLGETPR
FT                   YPKKPLQKNSSVPFGSKADTVTTV (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:11279525"
FT                   /id="VSP_005753"
FT   VAR_SEQ         450..1623
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:11279525"
FT                   /id="VSP_005754"
FT   VAR_SEQ         651..653
FT                   /note="FKS -> DLI (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11279525"
FT                   /id="VSP_033073"
FT   VAR_SEQ         654..1623
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11279525"
FT                   /id="VSP_033074"
FT   VAR_SEQ         1320..1325
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_033075"
FT   VAR_SEQ         1326..1368
FT                   /note="ELPKNPWEKLSIHLYFDGMSLSYFMAYYKYCTSEHTEEMLKEK -> K (in
FT                   isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_033076"
FT   VARIANT         346
FT                   /note="K -> N (in dbSNP:rs1451568)"
FT                   /id="VAR_024613"
FT   VARIANT         467
FT                   /note="G -> S (in dbSNP:rs9581180)"
FT                   /id="VAR_028132"
FT   VARIANT         501
FT                   /note="S -> G (in dbSNP:rs9507413)"
FT                   /id="VAR_028133"
FT   VARIANT         573
FT                   /note="A -> P (in dbSNP:rs10161760)"
FT                   /id="VAR_052098"
FT   VARIANT         667
FT                   /note="H -> R (in dbSNP:rs9511451)"
FT                   /id="VAR_052099"
FT   VARIANT         1110
FT                   /note="N -> K (in dbSNP:rs3783082)"
FT                   /id="VAR_052100"
FT   VARIANT         1380
FT                   /note="E -> K (in dbSNP:rs9507425)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_052101"
FT   CONFLICT        361
FT                   /note="P -> S (in Ref. 1; AAK31981)"
FT                   /evidence="ECO:0000305"
FT   HELIX           949..955
FT                   /evidence="ECO:0007829|PDB:2EQK"
FT   STRAND          968..972
FT                   /evidence="ECO:0007829|PDB:2EQK"
FT   STRAND          974..976
FT                   /evidence="ECO:0007829|PDB:2EQK"
FT   STRAND          979..987
FT                   /evidence="ECO:0007829|PDB:2EQK"
FT   STRAND          989..996
FT                   /evidence="ECO:0007829|PDB:2EQK"
FT   TURN            998..1000
FT                   /evidence="ECO:0007829|PDB:2EQK"
FT   STRAND          1003..1007
FT                   /evidence="ECO:0007829|PDB:2EQK"
FT   TURN            1008..1010
FT                   /evidence="ECO:0007829|PDB:2EQK"
FT   STRAND          1011..1013
FT                   /evidence="ECO:0007829|PDB:2EQK"
FT   HELIX           1016..1019
FT                   /evidence="ECO:0007829|PDB:2EQK"
SQ   SEQUENCE   1623 AA;  184643 MW;  3E710E6DD706CDF9 CRC64;
     MAAEASKTGP SRSSYQRMGR KSQPWGAAEI QCTRCGRRVS RSSGHHCELQ CGHAFCELCL
     LMTEECTTII CPDCEVATAV NTRQRYYPMA GYIKEDSIME KLQPKTIKNC SQDFKKTADQ
     LTTGLERSAS TDKTLLNSSA VMLDTNTAEE IDEALNTAHH SFEQLSIAGK ALEHMQKQTI
     EERERVIEVV EKQFDQLLAF FDSRKKNLCE EFARTTDDYL SNLIKAKSYI EEKKNNLNAA
     MNIARALQLS PSLRTYCDLN QIIRTLQLTS DSELAQVSSP QLRNPPRLSV NCSEIICMFN
     NMGKIEFRDS TKCYPQENEI RQNVQKKYNN KKELSCYDTY PPLEKKKVDM SVLTSEAPPP
     PLQPETNDVH LEAKNFQPQK DVATASPKTI AVLPQMGSSP DVIIEEIIED NVESSAELVF
     VSHVIDPCHF YIRKYSQIKD AKVLEKKVNE FCNRSSHLDP SDILELGARI FVSSIKNGMW
     CRGTITELIP IEGRNTRKPC SPTRLFVHEV ALIQIFMVDF GNSEVLIVTG VVDTHVRPEH
     SAKQHIALND LCLVLRKSEP YTEGLLKDIQ PLAQPCSLKD IVPQNSNEGW EEEAKVEFLK
     MVNNKAVSMK VFREEDGVLI VDLQKPPPNK ISSDMPVSLR DALVFMELAK FKSQSLRSHF
     EKNTTLHYHP PILPKEMTDV SVTVCHINSP GDFYLQLIEG LDILFLLKTI EEFYKSEDGE
     NLEILCPVQD QACVAKFEDG IWYRAKVIGL PGHQEVEVKY VDFGNTAKIT IKDVRKIKDE
     FLNAPEKAIK CKLAYIEPYK RTMQWSKEAK EKFEEKAQDK FMTCSVIKIL EDNVLLVELF
     DSLGAPEMTT TSINDQLVKE GLASYEIGYI LKDNSQKHIE VWDPSPEEII SNEVHNLNPV
     SAKSLPNENF QSLYNKELPV HICNVISPEK IYVQWLLTEN LLNSLEEKMI AAYENSKWEP
     VKWENDMHCA VKIQDKNQWR RGQIIRMVTD TLVEVLLYDV GVELVVNVDC LRKLEENLKT
     MGRLSLECSL VDIRPAGGSD KWTATACDCL SLYLTGAVAT IILQVDSEEN NTTWPLPVKI
     FCRDEKGERV DVSKYLIKKG LALRERRINN LDNSHSLSEK SLEVPLEQED SVVTNCIKTN
     FDPDKKTADI ISEQKVSEFQ EKILEPRTTR GYKPPAIPNM NVFEATVSCV GDDGTIFVVP
     KLSEFELIKM TNEIQSNLKC LGLLEPYFWK KGEACAVRGS DTLWYRGKVM EVVGGAVRVQ
     YLDHGFTEKI PQCHLYPILL YPDIPQFCIP CQLHNTTPVG NVWQPDAIEV LQQLLSKRQV
     DIHIMELPKN PWEKLSIHLY FDGMSLSYFM AYYKYCTSEH TEEMLKEKPR SDHDKKYEEE
     QWEIRFEELL SAETDTPLLP PYLSSSLPSP GELYAVQVKH VVSPNEVYIC LDSIETSNQS
     NQHSDTDDSG VSGESESESL DEALQRVNKK VEALPPLTDF RTEMPCLAEY DDGLWYRAKI
     VAIKEFNPLS ILVQFVDYGS TAKLTLNRLC QIPSHLMRYP ARAIKVLLAG FKPPLRDLGE
     TRIPYCPKWS MEALWAMIDC LQGKQLYAVS MAPAPEQIVT LYDDEQHPVH MPLVEMGLAD
     KDE
//