Q9BXT8 (RNF17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RING finger protein 17

Alternative name(s):
Tudor domain-containing protein 4

Gene names

Name:	RNF17
Synonyms:	TDRD4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1623 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis By similarity.
Subunit structure	Interacts with MXD1, MXD3, MXD4, MXI1 and PIWIL1. Self-associates By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron-dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids) By similarity.
Tissue specificity	Testis specific.
Sequence similarities	Contains 1 RING-type zinc finger. Contains 4 Tudor domains.
Sequence caution	The sequence AAH64847.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA91972.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW spermatid development Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BXT8-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q9BXT8-1)

The sequence of this isoform differs from the canonical sequence as follows:
     651-653: FKS → DLI
     654-1623: Missing.

Isoform 3 (identifier: Q9BXT8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     414-449: SSAELVFVSHVIDPCHFYIRKYSQIKDAKVLEKKVN → TCGTDDLGETPRYPKKPLQKNSSVPFGSKADTVTTV
     450-1623: Missing.

Isoform 4 (identifier: Q9BXT8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1326-1368: ELPKNPWEKLSIHLYFDGMSLSYFMAYYKYCTSEHTEEMLKEK → K

Isoform 5 (identifier: Q9BXT8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1320-1325: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1623

1623

RING finger protein 17

PRO_0000183165

Regions

Domain

726 – 784

59

Tudor 1

Domain

962 – 1021

60

Tudor 2

Domain

1228 – 1285

58

Tudor 3

Domain

1479 – 1539

61

Tudor 4

Zinc finger

32 – 75

44

RING-type

Natural variations

Alternative sequence

414 – 449

36

SSAEL…EKKVN → TCGTDDLGETPRYPKKPLQK NSSVPFGSKADTVTTV in isoform 3.

VSP_005753

Alternative sequence

450 – 1623

1174

Missing in isoform 3.

VSP_005754

Alternative sequence

651 – 653

3

FKS → DLI in isoform 2.

VSP_033073

Alternative sequence

654 – 1623

970

Missing in isoform 2.

VSP_033074

Alternative sequence

1320 – 1325

6

Missing in isoform 5.

VSP_033075

Alternative sequence

1326 – 1368

43

ELPKN…MLKEK → K in isoform 4.

VSP_033076

Natural variant

346

1

K → N.
Corresponds to variant rs1451568 [ dbSNP | Ensembl ].

VAR_024613

Natural variant

467

1

G → S.
Corresponds to variant rs9581180 [ dbSNP | Ensembl ].

VAR_028132

Natural variant

501

1

S → G.
Corresponds to variant rs9507413 [ dbSNP | Ensembl ].

VAR_028133

Natural variant

573

1

A → P.
Corresponds to variant rs10161760 [ dbSNP | Ensembl ].

VAR_052098

Natural variant

667

1

H → R.
Corresponds to variant rs9511451 [ dbSNP | Ensembl ].

VAR_052099

Natural variant

1110

1

N → K.
Corresponds to variant rs3783082 [ dbSNP | Ensembl ].

VAR_052100

Natural variant

1380

1

E → K. Ref.3 Ref.4
Corresponds to variant rs9507425 [ dbSNP | Ensembl ].

VAR_052101

Experimental info

Sequence conflict

361

1

P → S in AAK31981. Ref.1

Secondary structure

1

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1623

Helix Strand Turn

Details...

Helix

949 – 955

7

Beta strand

968 – 972

5

Beta strand

974 – 976

3

Beta strand

979 – 987

9

Beta strand

989 – 996

8

Turn

998 – 1000

3

Beta strand

1003 – 1007

5

Turn

1008 – 1010

3

Beta strand

1011 – 1013

3

Helix

1016 – 1019

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 29, 2008. Version 3. Checksum: 3E710E6DD706CDF9	FASTA	1,623	184,643
	10 20 30 40 50 60 MAAEASKTGP SRSSYQRMGR KSQPWGAAEI QCTRCGRRVS RSSGHHCELQ CGHAFCELCL 70 80 90 100 110 120 LMTEECTTII CPDCEVATAV NTRQRYYPMA GYIKEDSIME KLQPKTIKNC SQDFKKTADQ 130 140 150 160 170 180 LTTGLERSAS TDKTLLNSSA VMLDTNTAEE IDEALNTAHH SFEQLSIAGK ALEHMQKQTI 190 200 210 220 230 240 EERERVIEVV EKQFDQLLAF FDSRKKNLCE EFARTTDDYL SNLIKAKSYI EEKKNNLNAA 250 260 270 280 290 300 MNIARALQLS PSLRTYCDLN QIIRTLQLTS DSELAQVSSP QLRNPPRLSV NCSEIICMFN 310 320 330 340 350 360 NMGKIEFRDS TKCYPQENEI RQNVQKKYNN KKELSCYDTY PPLEKKKVDM SVLTSEAPPP 370 380 390 400 410 420 PLQPETNDVH LEAKNFQPQK DVATASPKTI AVLPQMGSSP DVIIEEIIED NVESSAELVF 430 440 450 460 470 480 VSHVIDPCHF YIRKYSQIKD AKVLEKKVNE FCNRSSHLDP SDILELGARI FVSSIKNGMW 490 500 510 520 530 540 CRGTITELIP IEGRNTRKPC SPTRLFVHEV ALIQIFMVDF GNSEVLIVTG VVDTHVRPEH 550 560 570 580 590 600 SAKQHIALND LCLVLRKSEP YTEGLLKDIQ PLAQPCSLKD IVPQNSNEGW EEEAKVEFLK 610 620 630 640 650 660 MVNNKAVSMK VFREEDGVLI VDLQKPPPNK ISSDMPVSLR DALVFMELAK FKSQSLRSHF 670 680 690 700 710 720 EKNTTLHYHP PILPKEMTDV SVTVCHINSP GDFYLQLIEG LDILFLLKTI EEFYKSEDGE 730 740 750 760 770 780 NLEILCPVQD QACVAKFEDG IWYRAKVIGL PGHQEVEVKY VDFGNTAKIT IKDVRKIKDE 790 800 810 820 830 840 FLNAPEKAIK CKLAYIEPYK RTMQWSKEAK EKFEEKAQDK FMTCSVIKIL EDNVLLVELF 850 860 870 880 890 900 DSLGAPEMTT TSINDQLVKE GLASYEIGYI LKDNSQKHIE VWDPSPEEII SNEVHNLNPV 910 920 930 940 950 960 SAKSLPNENF QSLYNKELPV HICNVISPEK IYVQWLLTEN LLNSLEEKMI AAYENSKWEP 970 980 990 1000 1010 1020 VKWENDMHCA VKIQDKNQWR RGQIIRMVTD TLVEVLLYDV GVELVVNVDC LRKLEENLKT 1030 1040 1050 1060 1070 1080 MGRLSLECSL VDIRPAGGSD KWTATACDCL SLYLTGAVAT IILQVDSEEN NTTWPLPVKI 1090 1100 1110 1120 1130 1140 FCRDEKGERV DVSKYLIKKG LALRERRINN LDNSHSLSEK SLEVPLEQED SVVTNCIKTN 1150 1160 1170 1180 1190 1200 FDPDKKTADI ISEQKVSEFQ EKILEPRTTR GYKPPAIPNM NVFEATVSCV GDDGTIFVVP 1210 1220 1230 1240 1250 1260 KLSEFELIKM TNEIQSNLKC LGLLEPYFWK KGEACAVRGS DTLWYRGKVM EVVGGAVRVQ 1270 1280 1290 1300 1310 1320 YLDHGFTEKI PQCHLYPILL YPDIPQFCIP CQLHNTTPVG NVWQPDAIEV LQQLLSKRQV 1330 1340 1350 1360 1370 1380 DIHIMELPKN PWEKLSIHLY FDGMSLSYFM AYYKYCTSEH TEEMLKEKPR SDHDKKYEEE 1390 1400 1410 1420 1430 1440 QWEIRFEELL SAETDTPLLP PYLSSSLPSP GELYAVQVKH VVSPNEVYIC LDSIETSNQS 1450 1460 1470 1480 1490 1500 NQHSDTDDSG VSGESESESL DEALQRVNKK VEALPPLTDF RTEMPCLAEY DDGLWYRAKI 1510 1520 1530 1540 1550 1560 VAIKEFNPLS ILVQFVDYGS TAKLTLNRLC QIPSHLMRYP ARAIKVLLAG FKPPLRDLGE 1570 1580 1590 1600 1610 1620 TRIPYCPKWS MEALWAMIDC LQGKQLYAVS MAPAPEQIVT LYDDEQHPVH MPLVEMGLAD KDE
	Isoform 2 [UniParc]. Checksum: 444C911E916D20CD	FASTA	653	73,746
	10 20 30 40 50 60 MAAEASKTGP SRSSYQRMGR KSQPWGAAEI QCTRCGRRVS RSSGHHCELQ CGHAFCELCL 70 80 90 100 110 120 LMTEECTTII CPDCEVATAV NTRQRYYPMA GYIKEDSIME KLQPKTIKNC SQDFKKTADQ 130 140 150 160 170 180 LTTGLERSAS TDKTLLNSSA VMLDTNTAEE IDEALNTAHH SFEQLSIAGK ALEHMQKQTI 190 200 210 220 230 240 EERERVIEVV EKQFDQLLAF FDSRKKNLCE EFARTTDDYL SNLIKAKSYI EEKKNNLNAA 250 260 270 280 290 300 MNIARALQLS PSLRTYCDLN QIIRTLQLTS DSELAQVSSP QLRNPPRLSV NCSEIICMFN 310 320 330 340 350 360 NMGKIEFRDS TKCYPQENEI RQNVQKKYNN KKELSCYDTY PPLEKKKVDM SVLTSEAPPP 370 380 390 400 410 420 PLQPETNDVH LEAKNFQPQK DVATASPKTI AVLPQMGSSP DVIIEEIIED NVESSAELVF 430 440 450 460 470 480 VSHVIDPCHF YIRKYSQIKD AKVLEKKVNE FCNRSSHLDP SDILELGARI FVSSIKNGMW 490 500 510 520 530 540 CRGTITELIP IEGRNTRKPC SPTRLFVHEV ALIQIFMVDF GNSEVLIVTG VVDTHVRPEH 550 560 570 580 590 600 SAKQHIALND LCLVLRKSEP YTEGLLKDIQ PLAQPCSLKD IVPQNSNEGW EEEAKVEFLK 610 620 630 640 650 MVNNKAVSMK VFREEDGVLI VDLQKPPPNK ISSDMPVSLR DALVFMELAK DLI
	Isoform 3 [UniParc]. Checksum: 8F9E06F59E22DD6E	FASTA	449	50,477
	10 20 30 40 50 60 MAAEASKTGP SRSSYQRMGR KSQPWGAAEI QCTRCGRRVS RSSGHHCELQ CGHAFCELCL 70 80 90 100 110 120 LMTEECTTII CPDCEVATAV NTRQRYYPMA GYIKEDSIME KLQPKTIKNC SQDFKKTADQ 130 140 150 160 170 180 LTTGLERSAS TDKTLLNSSA VMLDTNTAEE IDEALNTAHH SFEQLSIAGK ALEHMQKQTI 190 200 210 220 230 240 EERERVIEVV EKQFDQLLAF FDSRKKNLCE EFARTTDDYL SNLIKAKSYI EEKKNNLNAA 250 260 270 280 290 300 MNIARALQLS PSLRTYCDLN QIIRTLQLTS DSELAQVSSP QLRNPPRLSV NCSEIICMFN 310 320 330 340 350 360 NMGKIEFRDS TKCYPQENEI RQNVQKKYNN KKELSCYDTY PPLEKKKVDM SVLTSEAPPP 370 380 390 400 410 420 PLQPETNDVH LEAKNFQPQK DVATASPKTI AVLPQMGSSP DVIIEEIIED NVETCGTDDL 430 440 GETPRYPKKP LQKNSSVPFG SKADTVTTV
	Isoform 4 [UniParc]. Checksum: E290A64D77F3578B	FASTA	1,581	179,508
	10 20 30 40 50 60 MAAEASKTGP SRSSYQRMGR KSQPWGAAEI QCTRCGRRVS RSSGHHCELQ CGHAFCELCL 70 80 90 100 110 120 LMTEECTTII CPDCEVATAV NTRQRYYPMA GYIKEDSIME KLQPKTIKNC SQDFKKTADQ 130 140 150 160 170 180 LTTGLERSAS TDKTLLNSSA VMLDTNTAEE IDEALNTAHH SFEQLSIAGK ALEHMQKQTI 190 200 210 220 230 240 EERERVIEVV EKQFDQLLAF FDSRKKNLCE EFARTTDDYL SNLIKAKSYI EEKKNNLNAA 250 260 270 280 290 300 MNIARALQLS PSLRTYCDLN QIIRTLQLTS DSELAQVSSP QLRNPPRLSV NCSEIICMFN 310 320 330 340 350 360 NMGKIEFRDS TKCYPQENEI RQNVQKKYNN KKELSCYDTY PPLEKKKVDM SVLTSEAPPP 370 380 390 400 410 420 PLQPETNDVH LEAKNFQPQK DVATASPKTI AVLPQMGSSP DVIIEEIIED NVESSAELVF 430 440 450 460 470 480 VSHVIDPCHF YIRKYSQIKD AKVLEKKVNE FCNRSSHLDP SDILELGARI FVSSIKNGMW 490 500 510 520 530 540 CRGTITELIP IEGRNTRKPC SPTRLFVHEV ALIQIFMVDF GNSEVLIVTG VVDTHVRPEH 550 560 570 580 590 600 SAKQHIALND LCLVLRKSEP YTEGLLKDIQ PLAQPCSLKD IVPQNSNEGW EEEAKVEFLK 610 620 630 640 650 660 MVNNKAVSMK VFREEDGVLI VDLQKPPPNK ISSDMPVSLR DALVFMELAK FKSQSLRSHF 670 680 690 700 710 720 EKNTTLHYHP PILPKEMTDV SVTVCHINSP GDFYLQLIEG LDILFLLKTI EEFYKSEDGE 730 740 750 760 770 780 NLEILCPVQD QACVAKFEDG IWYRAKVIGL PGHQEVEVKY VDFGNTAKIT IKDVRKIKDE 790 800 810 820 830 840 FLNAPEKAIK CKLAYIEPYK RTMQWSKEAK EKFEEKAQDK FMTCSVIKIL EDNVLLVELF 850 860 870 880 890 900 DSLGAPEMTT TSINDQLVKE GLASYEIGYI LKDNSQKHIE VWDPSPEEII SNEVHNLNPV 910 920 930 940 950 960 SAKSLPNENF QSLYNKELPV HICNVISPEK IYVQWLLTEN LLNSLEEKMI AAYENSKWEP 970 980 990 1000 1010 1020 VKWENDMHCA VKIQDKNQWR RGQIIRMVTD TLVEVLLYDV GVELVVNVDC LRKLEENLKT 1030 1040 1050 1060 1070 1080 MGRLSLECSL VDIRPAGGSD KWTATACDCL SLYLTGAVAT IILQVDSEEN NTTWPLPVKI 1090 1100 1110 1120 1130 1140 FCRDEKGERV DVSKYLIKKG LALRERRINN LDNSHSLSEK SLEVPLEQED SVVTNCIKTN 1150 1160 1170 1180 1190 1200 FDPDKKTADI ISEQKVSEFQ EKILEPRTTR GYKPPAIPNM NVFEATVSCV GDDGTIFVVP 1210 1220 1230 1240 1250 1260 KLSEFELIKM TNEIQSNLKC LGLLEPYFWK KGEACAVRGS DTLWYRGKVM EVVGGAVRVQ 1270 1280 1290 1300 1310 1320 YLDHGFTEKI PQCHLYPILL YPDIPQFCIP CQLHNTTPVG NVWQPDAIEV LQQLLSKRQV 1330 1340 1350 1360 1370 1380 DIHIMKPRSD HDKKYEEEQW EIRFEELLSA ETDTPLLPPY LSSSLPSPGE LYAVQVKHVV 1390 1400 1410 1420 1430 1440 SPNEVYICLD SIETSNQSNQ HSDTDDSGVS GESESESLDE ALQRVNKKVE ALPPLTDFRT 1450 1460 1470 1480 1490 1500 EMPCLAEYDD GLWYRAKIVA IKEFNPLSIL VQFVDYGSTA KLTLNRLCQI PSHLMRYPAR 1510 1520 1530 1540 1550 1560 AIKVLLAGFK PPLRDLGETR IPYCPKWSME ALWAMIDCLQ GKQLYAVSMA PAPEQIVTLY 1570 1580 DDEQHPVHMP LVEMGLADKD E
	Isoform 5 [UniParc]. Checksum: 8D65E390C2828F2A	FASTA	1,617	183,935
	10 20 30 40 50 60 MAAEASKTGP SRSSYQRMGR KSQPWGAAEI QCTRCGRRVS RSSGHHCELQ CGHAFCELCL 70 80 90 100 110 120 LMTEECTTII CPDCEVATAV NTRQRYYPMA GYIKEDSIME KLQPKTIKNC SQDFKKTADQ 130 140 150 160 170 180 LTTGLERSAS TDKTLLNSSA VMLDTNTAEE IDEALNTAHH SFEQLSIAGK ALEHMQKQTI 190 200 210 220 230 240 EERERVIEVV EKQFDQLLAF FDSRKKNLCE EFARTTDDYL SNLIKAKSYI EEKKNNLNAA 250 260 270 280 290 300 MNIARALQLS PSLRTYCDLN QIIRTLQLTS DSELAQVSSP QLRNPPRLSV NCSEIICMFN 310 320 330 340 350 360 NMGKIEFRDS TKCYPQENEI RQNVQKKYNN KKELSCYDTY PPLEKKKVDM SVLTSEAPPP 370 380 390 400 410 420 PLQPETNDVH LEAKNFQPQK DVATASPKTI AVLPQMGSSP DVIIEEIIED NVESSAELVF 430 440 450 460 470 480 VSHVIDPCHF YIRKYSQIKD AKVLEKKVNE FCNRSSHLDP SDILELGARI FVSSIKNGMW 490 500 510 520 530 540 CRGTITELIP IEGRNTRKPC SPTRLFVHEV ALIQIFMVDF GNSEVLIVTG VVDTHVRPEH 550 560 570 580 590 600 SAKQHIALND LCLVLRKSEP YTEGLLKDIQ PLAQPCSLKD IVPQNSNEGW EEEAKVEFLK 610 620 630 640 650 660 MVNNKAVSMK VFREEDGVLI VDLQKPPPNK ISSDMPVSLR DALVFMELAK FKSQSLRSHF 670 680 690 700 710 720 EKNTTLHYHP PILPKEMTDV SVTVCHINSP GDFYLQLIEG LDILFLLKTI EEFYKSEDGE 730 740 750 760 770 780 NLEILCPVQD QACVAKFEDG IWYRAKVIGL PGHQEVEVKY VDFGNTAKIT IKDVRKIKDE 790 800 810 820 830 840 FLNAPEKAIK CKLAYIEPYK RTMQWSKEAK EKFEEKAQDK FMTCSVIKIL EDNVLLVELF 850 860 870 880 890 900 DSLGAPEMTT TSINDQLVKE GLASYEIGYI LKDNSQKHIE VWDPSPEEII SNEVHNLNPV 910 920 930 940 950 960 SAKSLPNENF QSLYNKELPV HICNVISPEK IYVQWLLTEN LLNSLEEKMI AAYENSKWEP 970 980 990 1000 1010 1020 VKWENDMHCA VKIQDKNQWR RGQIIRMVTD TLVEVLLYDV GVELVVNVDC LRKLEENLKT 1030 1040 1050 1060 1070 1080 MGRLSLECSL VDIRPAGGSD KWTATACDCL SLYLTGAVAT IILQVDSEEN NTTWPLPVKI 1090 1100 1110 1120 1130 1140 FCRDEKGERV DVSKYLIKKG LALRERRINN LDNSHSLSEK SLEVPLEQED SVVTNCIKTN 1150 1160 1170 1180 1190 1200 FDPDKKTADI ISEQKVSEFQ EKILEPRTTR GYKPPAIPNM NVFEATVSCV GDDGTIFVVP 1210 1220 1230 1240 1250 1260 KLSEFELIKM TNEIQSNLKC LGLLEPYFWK KGEACAVRGS DTLWYRGKVM EVVGGAVRVQ 1270 1280 1290 1300 1310 1320 YLDHGFTEKI PQCHLYPILL YPDIPQFCIP CQLHNTTPVG NVWQPDAIEV LQQLLSKRQE 1330 1340 1350 1360 1370 1380 LPKNPWEKLS IHLYFDGMSL SYFMAYYKYC TSEHTEEMLK EKPRSDHDKK YEEEQWEIRF 1390 1400 1410 1420 1430 1440 EELLSAETDT PLLPPYLSSS LPSPGELYAV QVKHVVSPNE VYICLDSIET SNQSNQHSDT 1450 1460 1470 1480 1490 1500 DDSGVSGESE SESLDEALQR VNKKVEALPP LTDFRTEMPC LAEYDDGLWY RAKIVAIKEF 1510 1520 1530 1540 1550 1560 NPLSILVQFV DYGSTAKLTL NRLCQIPSHL MRYPARAIKV LLAGFKPPLR DLGETRIPYC 1570 1580 1590 1600 1610 PKWSMEALWA MIDCLQGKQL YAVSMAPAPE QIVTLYDDEQ HPVHMPLVEM GLADKDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An abundance of X-linked genes expressed in spermatogonia." Wang P.J., McCarrey J.R., Yang F., Page D.C. Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3). Tissue: Testis.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 765-1623 (ISOFORM 5), VARIANT LYS-1380. Tissue: Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 914-1623 (ISOFORM 4), VARIANT LYS-1380. Tissue: Placenta.
[5]	"Solution structure of the tudor domain of tudor domain-containing protein 4." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 949-1026.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF285602 mRNA. Translation: AAK31981.1.
AF285603 mRNA. Translation: AAK31982.1.
AL391560, AL354798 Genomic DNA. Translation: CAI15248.2.
AL354798, AL391560 Genomic DNA. Translation: CAM23326.1.
BC064847 mRNA. Translation: AAH64847.1. Different initiation.
AK001907 mRNA. Translation: BAA91972.1. Different initiation.

IPI

IPI00005061.
IPI00797087.
IPI00827865.
IPI00890741.
IPI00890818.

RefSeq

NP_112567.2. NM_031277.2.

UniGene

Hs.97464.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EQK	NMR	-	A	949-1026	[»]

ProteinModelPortal

Q9BXT8.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BXT8. 1 interaction.

MINT

MINT-7944917.

STRING

9606.ENSP00000255324.

PTM databases

PhosphoSite

Q9BXT8.

Polymorphism databases

DMDM

187608889.

Proteomic databases

PaxDb

Q9BXT8.

PRIDE

Q9BXT8.

Protocols and materials databases

DNASU

56163.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000255324; ENSP00000255324; ENSG00000132972.
ENST00000255326; ENSP00000255326; ENSG00000132972.
ENST00000381921; ENSP00000371346; ENSG00000132972.

GeneID

56163.

KEGG

hsa:56163.

UCSC

uc001upq.1. human.
uc001upr.3. human.
uc010aac.3. human.

Organism-specific databases

CTD

56163.

GeneCards

GC13P025338.

HGNC

HGNC:10060. RNF17.

HPA

HPA039699.
HPA040111.

MIM

605793. gene.

neXtProt

NX_Q9BXT8.

PharmGKB

PA34424.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG267246.

HOGENOM

HOG000074158.

HOVERGEN

HBG108414.

OMA

GVWYRAK.

OrthoDB

EOG4NZTSK.

PhylomeDB

Q9BXT8.

Gene expression databases

ArrayExpress

Q9BXT8.

Bgee

Q9BXT8.

CleanEx

HS_RNF17.

Genevestigator

Q9BXT8.

GermOnline

ENSG00000132972. Homo sapiens.

Family and domain databases

Gene3D

2.40.50.90. 1 hit.

InterPro

IPR006021. Staphylococcal_nuclease.
IPR002999. Tudor.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]

Pfam

PF00567. TUDOR. 5 hits.
[Graphical view]

SMART

SM00184. RING. 1 hit.
SM00333. TUDOR. 4 hits.
[Graphical view]

PROSITE

PS50304. TUDOR. 4 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9BXT8.

GenomeRNAi

56163.

NextBio

61792.

SOURCE

Search...

Entry information

Entry name

RNF17_HUMAN

Accession

Primary (citable) accession number: Q9BXT8
Secondary accession number(s): Q5T2J9 , Q6P1W3, Q9BXT7, Q9NUY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2001
Last sequence update:	April 29, 2008
Last modified:	May 29, 2013
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.