Q9BXT5 (TEX15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Testis-expressed sequence 15 protein

Alternative name(s):
Cancer/testis antigen 42
Short name=CT42

Gene names

Name:

TEX15

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2789 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity

Testis-specific. Also expressed in several cancers. Ref.1 Ref.3

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fertilization Inferred from electronic annotation. Source: Compara homeostasis of number of cells within a tissue Inferred from electronic annotation. Source: Compara male genitalia development Inferred from electronic annotation. Source: Compara male meiosis Inferred from electronic annotation. Source: Compara protein localization to chromosome Inferred from electronic annotation. Source: Compara regulation of double-strand break repair via homologous recombination Inferred from electronic annotation. Source: Compara regulation of protein localization Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from electronic annotation. Source: Compara synaptonemal complex assembly Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2789	2789	Testis-expressed sequence 15 protein		PRO_0000244483
Regions
	Compositional bias	1083 – 1161	79	Ser-rich
Natural variations
	Natural variant	104	1	C → R. Ref.1 Corresponds to variant rs323347 [ dbSNP | Ensembl ].		VAR_060394
	Natural variant	383	1	P → L. Corresponds to variant rs9297162 [ dbSNP | Ensembl ].		VAR_060395
	Natural variant	1035	1	I → V. Ref.1 Corresponds to variant rs323346 [ dbSNP | Ensembl ].		VAR_060396
	Natural variant	1311	1	N → S. Ref.1 Corresponds to variant rs323345 [ dbSNP | Ensembl ].		VAR_060397
	Natural variant	1337	1	L → V. Ref.1 Corresponds to variant rs323344 [ dbSNP | Ensembl ].		VAR_060398
	Natural variant	1439	1	K → R. Ref.1 Corresponds to variant rs323343 [ dbSNP | Ensembl ].		VAR_060399
	Natural variant	2138	1	D → N. Corresponds to variant rs60474250 [ dbSNP | Ensembl ].		VAR_061711

Sequences

	Sequence		Length	Mass (Da)
	Q9BXT5 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: 1065EDD045C67BF6	FASTA	2,789	315,336
	10 20 30 40 50 60 MPSDAKDSVN GDLLLNWTSL KNILSGLNAS FPLHNNTGSS TVTTSKSIKD PRLMRREESM 70 80 90 100 110 120 GEQSSTAGLN EVLQFEKSSD NVNSEIKSTP SNSASSSEVV PGDCAVLTNG LDTPCFKTSV 130 140 150 160 170 180 NDSQSWAHNM GSEDYDCIPP NKVTMAGQCK DQGNFSFPIS VSNVVSEVEN QNHSEEKAQR 190 200 210 220 230 240 AQQESGNAYT KEYSSHIFQD SQSSDLKTIY QTGCQTSTVF PLKKKVSIDE YLQNTGKMKN 250 260 270 280 290 300 FADLEDSSKH EEKQTSWKEI DNDFTNETKI SPIDNYIVLH QEYKESESHN SFGKSCDKIL 310 320 330 340 350 360 ITQELEITKS STSTIKDKDE LDHLALEWQI TPSFESLSQK HPQHSVEYEG NIHTSLAIAQ 370 380 390 400 410 420 KLMELKLGKI NQNYASIITE AFPKPKDIPQ AKEMFIDTVI SSYNIETAHD SSNCSITREH 430 440 450 460 470 480 ICVHRKNENE PVSLENIQRD YKETAYVEDR GQDHNLFCNS QLSNDIWLNV NFKKQTDREN 490 500 510 520 530 540 QNEAKENSAS CVENNIENIY GDKKQDSHTN ENFSNIDEKE DKNYHNIEIL SSEEFSTKFN 550 560 570 580 590 600 LICREDNAVS AATALLESEE DTISAVKQKD TENTGRSVEH LASTTFPKTA SSSVCVASNA 610 620 630 640 650 660 AIQIASATMP ALSLNNDDHQ IYQFKETCSS ESPDFGLLVK HRVSDCEIDT DKNKSQESFH 670 680 690 700 710 720 QSINENLVLQ SIELESEIEI ELEDCDDAFI FQQDTHSHEN MLCEEFVTSY KALKSRISWE 730 740 750 760 770 780 GLLALDNGEM EVLESTTGRE NSDQHYSKES NYFYSSTQNN ETELTSPILL PDLQIKITNI 790 800 810 820 830 840 FRPGFSPTAD SLALKDSFCT HVTEATKPEI NKEDGEILGF DIYSQPFGEN ADYPCEDKVD 850 860 870 880 890 900 NIRQESGPVS NSEISLSFDL SRNTDVNHTS ENQNSESLFT EPSNVTTIDD GSRCFFTKSK 910 920 930 940 950 960 TDYNDTKNKK EVESRISKRK LHISSRDQNI PHKDLRRHKI YGRKRRLTSQ DSSECFSSLS 970 980 990 1000 1010 1020 QGRIKTFSQS EKHIKSVLNI LSDEASLCKS KCLSRKLDKA VVHLKKAHRR VHTSLQLITK 1030 1040 1050 1060 1070 1080 VGEERKGPLP KSYAIICNNF WESCDLQGYS SVSQRKYYST KHFSSKRKYD KRRKKRAPKA 1090 1100 1110 1120 1130 1140 DISKSLTHVS KHKSYKTSGE KKCLSRKSMA SSVSKSHPTT SHMGEFCNQE HPESQLPVSS 1150 1160 1170 1180 1190 1200 TSQSTSQSVY YNSSVSNPSL SEEHQPFSGK TAYLFSPDHS DEKLIEKENQ IDTAFLSSTS 1210 1220 1230 1240 1250 1260 KYEKLEKHSA NHNVKDATKE NSCDANEVIN ESNSVSLSCI KENINSSTGN DCDATCIGHT 1270 1280 1290 1300 1310 1320 KAKTDVLISV LDSNVKHFLN DLYQQGNLIL SDCKRNLEVK WTDPIERPKQ NIITGNFLMG 1330 1340 1350 1360 1370 1380 PLNLTLIASK KYSIPQLSAA AVTDSEGESS KSYLDKQRIL TVDSFAASST VPHCEQSCRE 1390 1400 1410 1420 1430 1440 KELLKTEQCS SGNCLHTDGN ETNVTENYEL DVASGTEEDK SYGENIVELS SSDSSLLLKD 1450 1460 1470 1480 1490 1500 NVKGSSSETC IVKKDTEDRI TWKVKQAEKA KDSVYKRSMT EGSTVNTEYK NQKNQISEES 1510 1520 1530 1540 1550 1560 CLNEKIITTN LIDSHLSTKN TTTESVPLKN TVSNPLNKRE KKGEIKVSKD SQSDLTLHSE 1570 1580 1590 1600 1610 1620 IAYISKPGIL GVNHTPILPA HSETCKVPTL LKKPASYVSD FKEKHCSANH TALIANLSQI 1630 1640 1650 1660 1670 1680 LQRADEASSL QILQEETKVC LNILPLFVEA FERKQECSVE QILISRELLV DQNLWNNCKH 1690 1700 1710 1720 1730 1740 TLKPCAVDTL VELQMMMETI QFIENKKRHL EGEPTLRSLL WYDETLYAEL LGKPRGFQQQ 1750 1760 1770 1780 1790 1800 SNFYPGFQGR LKYNAFCELQ TYHDQLVELL EETKREKNSY YVFLKYKRQV NECEAIMEHC 1810 1820 1830 1840 1850 1860 SDCFDFSLSV PFTCGVNFGD SLEDLEILRK STLKLINVCG DSPKVHSYPG KQDHLWIIIE 1870 1880 1890 1900 1910 1920 MISSKVNFIK NNEAVRVKIS LYGLEHIFFD AAKNLVWKER TQSFSKKYSQ KKDEERLLRV 1930 1940 1950 1960 1970 1980 NKCAFSKLQK IYDTLSKDLN NEPISPIGLE EDTIIASRKS DHPINEATIS IENSKFNSNL 1990 2000 2010 2020 2030 2040 LAHPDICCIS EILDQAEFAD LKKLQDLTLR CTDHLEILKK YFQMLQDNNM DNIFITEENV 2050 2060 2070 2080 2090 2100 LDVVINHSHE AIILKPEAIE MYIEIVMVSE TIHFLKNSIA KKLDKQRFRG MLWFDLSLLP 2110 2120 2130 2140 2150 2160 ELVQCQEKMA SFSFLKDNST DVCLWKVIET AVSELKKDLD IICKYNEAVN CSYAIHLLSR 2170 2180 2190 2200 2210 2220 ELQELSEIKK LLKKSKYFIS TYIDFVPYIA SINYGSTVTE LEYNYNQFST LLKNVMSAPR 2230 2240 2250 2260 2270 2280 KDLGKMAHIR KVMKTIEHMK MICTKNAELT ISFFLCQMLY NRRKILQLKR KEKMNIHIVK 2290 2300 2310 2320 2330 2340 PGENNNKFSI STMLPPVSEC INKNISNSSK KRPSTVDKCE DSQEQQQDTT VSSCKKLKVD 2350 2360 2370 2380 2390 2400 MKDVTKINRE KATFKHPRTT GSHPKSENKI VPSSCDSLKR NHLTPKKVEM QRSLPGSLLP 2410 2420 2430 2440 2450 2460 LENPKDTCAS KSESKIDLTV SSDHFSGQQE NLNSMKKRNV NFSAAETKSD KKDCAAFAIC 2470 2480 2490 2500 2510 2520 DQKSVHGTFS PDHGTLLQKF LKNSPDPTQK SCLSDINPET DVSLVPDASV LSKPIFCFVK 2530 2540 2550 2560 2570 2580 DVHPDLEMND TVFELQDNDI VNSSIKNSSC MTSPEPICIQ NKIPTLQINK LQPTETESED 2590 2600 2610 2620 2630 2640 KYMKDTLNPN TVHTFGASGH ITLNVNQGAE YSLSEQQNDK NSKVLMQNAA TYWNELPQSA 2650 2660 2670 2680 2690 2700 CNPTYNSSEH LFGTSYPYSA WCVYQYSNSN GNAITQTYQG ITSYEVQPSP SGLLTTVAST 2710 2720 2730 2740 2750 2760 AQGTHSNLLY SQYFTYFAGE PQANGFVPVN GYFQSQIPAS NFRQPIFSQY ASHQPLPQAT 2770 2780 YPYLPNRFVP PEVPWVYAPW HQESFHPGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An abundance of X-linked genes expressed in spermatogonia." Wang P.J., McCarrey J.R., Yang F., Page D.C. Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS ARG-104; VAL-1035; SER-1311; VAL-1337 AND ARG-1439. Tissue: Testis.
[2]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia." Loriot A., Boon T., De Smet C. Int. J. Cancer 105:371-376(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF285605 mRNA. Translation: AAK31984.1. AC009314 Genomic DNA. No translation available. AC090281 Genomic DNA. No translation available.
IPI	IPI00010369.
RefSeq	NP_112561.2. NM_031271.3.
UniGene	Hs.458316. Hs.571446.
3D structure databases
ProteinModelPortal	Q9BXT5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000256246.
PTM databases
PhosphoSite	Q9BXT5.
Polymorphism databases
DMDM	308153507.
Proteomic databases
PaxDb	Q9BXT5.
PRIDE	Q9BXT5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000256246; ENSP00000256246; ENSG00000133863.
GeneID	56154.
KEGG	hsa:56154.
UCSC	uc003xil.3. human.
Organism-specific databases
CTD	56154.
GeneCards	GC08M030689.
H-InvDB	HIX0007440.
HGNC	HGNC:11738. TEX15.
HPA	HPA036800.
MIM	605795. gene.
neXtProt	NX_Q9BXT5.
PharmGKB	PA36455.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45350.
HOVERGEN	HBG075407.
InParanoid	Q9BXT5.
OMA	KQRFRGM.
OrthoDB	EOG45X7V6.
PhylomeDB	Q9BXT5.
Gene expression databases
ArrayExpress	Q9BXT5.
Bgee	Q9BXT5.
CleanEx	HS_TEX15.
Genevestigator	Q9BXT5.
GermOnline	ENSG00000133863. Homo sapiens.
Family and domain databases
InterPro	IPR026616. TEX15. [Graphical view]
PANTHER	PTHR22380. PTHR22380. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	56154.
NextBio	61758.
SOURCE	Search...

Entry information

Entry name

TEX15_HUMAN

Accession

Primary (citable) accession number: Q9BXT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 5, 2010
Last modified:	April 3, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.