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Q9BXT5 (TEX15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testis-expressed sequence 15 protein
Alternative name(s):
Cancer/testis antigen 42
Short name=CT42
Gene names
Name:TEX15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2789 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Testis-specific. Also expressed in several cancers. Ref.1 Ref.3

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 27892789Testis-expressed sequence 15 protein
PRO_0000244483

Regions

Compositional bias1083 – 116179Ser-rich

Natural variations

Natural variant1041C → R. Ref.1
Corresponds to variant rs323347 [ dbSNP | Ensembl ].
VAR_060394
Natural variant3831P → L.
Corresponds to variant rs9297162 [ dbSNP | Ensembl ].
VAR_060395
Natural variant10351I → V. Ref.1
Corresponds to variant rs323346 [ dbSNP | Ensembl ].
VAR_060396
Natural variant13111N → S. Ref.1
Corresponds to variant rs323345 [ dbSNP | Ensembl ].
VAR_060397
Natural variant13371L → V. Ref.1
Corresponds to variant rs323344 [ dbSNP | Ensembl ].
VAR_060398
Natural variant14391K → R. Ref.1
Corresponds to variant rs323343 [ dbSNP | Ensembl ].
VAR_060399
Natural variant21381D → N.
Corresponds to variant rs60474250 [ dbSNP | Ensembl ].
VAR_061711

Sequences

Sequence LengthMass (Da)Tools
Q9BXT5 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: 1065EDD045C67BF6

FASTA2,789315,336
        10         20         30         40         50         60 
MPSDAKDSVN GDLLLNWTSL KNILSGLNAS FPLHNNTGSS TVTTSKSIKD PRLMRREESM 

        70         80         90        100        110        120 
GEQSSTAGLN EVLQFEKSSD NVNSEIKSTP SNSASSSEVV PGDCAVLTNG LDTPCFKTSV 

       130        140        150        160        170        180 
NDSQSWAHNM GSEDYDCIPP NKVTMAGQCK DQGNFSFPIS VSNVVSEVEN QNHSEEKAQR 

       190        200        210        220        230        240 
AQQESGNAYT KEYSSHIFQD SQSSDLKTIY QTGCQTSTVF PLKKKVSIDE YLQNTGKMKN 

       250        260        270        280        290        300 
FADLEDSSKH EEKQTSWKEI DNDFTNETKI SPIDNYIVLH QEYKESESHN SFGKSCDKIL 

       310        320        330        340        350        360 
ITQELEITKS STSTIKDKDE LDHLALEWQI TPSFESLSQK HPQHSVEYEG NIHTSLAIAQ 

       370        380        390        400        410        420 
KLMELKLGKI NQNYASIITE AFPKPKDIPQ AKEMFIDTVI SSYNIETAHD SSNCSITREH 

       430        440        450        460        470        480 
ICVHRKNENE PVSLENIQRD YKETAYVEDR GQDHNLFCNS QLSNDIWLNV NFKKQTDREN 

       490        500        510        520        530        540 
QNEAKENSAS CVENNIENIY GDKKQDSHTN ENFSNIDEKE DKNYHNIEIL SSEEFSTKFN 

       550        560        570        580        590        600 
LICREDNAVS AATALLESEE DTISAVKQKD TENTGRSVEH LASTTFPKTA SSSVCVASNA 

       610        620        630        640        650        660 
AIQIASATMP ALSLNNDDHQ IYQFKETCSS ESPDFGLLVK HRVSDCEIDT DKNKSQESFH 

       670        680        690        700        710        720 
QSINENLVLQ SIELESEIEI ELEDCDDAFI FQQDTHSHEN MLCEEFVTSY KALKSRISWE 

       730        740        750        760        770        780 
GLLALDNGEM EVLESTTGRE NSDQHYSKES NYFYSSTQNN ETELTSPILL PDLQIKITNI 

       790        800        810        820        830        840 
FRPGFSPTAD SLALKDSFCT HVTEATKPEI NKEDGEILGF DIYSQPFGEN ADYPCEDKVD 

       850        860        870        880        890        900 
NIRQESGPVS NSEISLSFDL SRNTDVNHTS ENQNSESLFT EPSNVTTIDD GSRCFFTKSK 

       910        920        930        940        950        960 
TDYNDTKNKK EVESRISKRK LHISSRDQNI PHKDLRRHKI YGRKRRLTSQ DSSECFSSLS 

       970        980        990       1000       1010       1020 
QGRIKTFSQS EKHIKSVLNI LSDEASLCKS KCLSRKLDKA VVHLKKAHRR VHTSLQLITK 

      1030       1040       1050       1060       1070       1080 
VGEERKGPLP KSYAIICNNF WESCDLQGYS SVSQRKYYST KHFSSKRKYD KRRKKRAPKA 

      1090       1100       1110       1120       1130       1140 
DISKSLTHVS KHKSYKTSGE KKCLSRKSMA SSVSKSHPTT SHMGEFCNQE HPESQLPVSS 

      1150       1160       1170       1180       1190       1200 
TSQSTSQSVY YNSSVSNPSL SEEHQPFSGK TAYLFSPDHS DEKLIEKENQ IDTAFLSSTS 

      1210       1220       1230       1240       1250       1260 
KYEKLEKHSA NHNVKDATKE NSCDANEVIN ESNSVSLSCI KENINSSTGN DCDATCIGHT 

      1270       1280       1290       1300       1310       1320 
KAKTDVLISV LDSNVKHFLN DLYQQGNLIL SDCKRNLEVK WTDPIERPKQ NIITGNFLMG 

      1330       1340       1350       1360       1370       1380 
PLNLTLIASK KYSIPQLSAA AVTDSEGESS KSYLDKQRIL TVDSFAASST VPHCEQSCRE 

      1390       1400       1410       1420       1430       1440 
KELLKTEQCS SGNCLHTDGN ETNVTENYEL DVASGTEEDK SYGENIVELS SSDSSLLLKD 

      1450       1460       1470       1480       1490       1500 
NVKGSSSETC IVKKDTEDRI TWKVKQAEKA KDSVYKRSMT EGSTVNTEYK NQKNQISEES 

      1510       1520       1530       1540       1550       1560 
CLNEKIITTN LIDSHLSTKN TTTESVPLKN TVSNPLNKRE KKGEIKVSKD SQSDLTLHSE 

      1570       1580       1590       1600       1610       1620 
IAYISKPGIL GVNHTPILPA HSETCKVPTL LKKPASYVSD FKEKHCSANH TALIANLSQI 

      1630       1640       1650       1660       1670       1680 
LQRADEASSL QILQEETKVC LNILPLFVEA FERKQECSVE QILISRELLV DQNLWNNCKH 

      1690       1700       1710       1720       1730       1740 
TLKPCAVDTL VELQMMMETI QFIENKKRHL EGEPTLRSLL WYDETLYAEL LGKPRGFQQQ 

      1750       1760       1770       1780       1790       1800 
SNFYPGFQGR LKYNAFCELQ TYHDQLVELL EETKREKNSY YVFLKYKRQV NECEAIMEHC 

      1810       1820       1830       1840       1850       1860 
SDCFDFSLSV PFTCGVNFGD SLEDLEILRK STLKLINVCG DSPKVHSYPG KQDHLWIIIE 

      1870       1880       1890       1900       1910       1920 
MISSKVNFIK NNEAVRVKIS LYGLEHIFFD AAKNLVWKER TQSFSKKYSQ KKDEERLLRV 

      1930       1940       1950       1960       1970       1980 
NKCAFSKLQK IYDTLSKDLN NEPISPIGLE EDTIIASRKS DHPINEATIS IENSKFNSNL 

      1990       2000       2010       2020       2030       2040 
LAHPDICCIS EILDQAEFAD LKKLQDLTLR CTDHLEILKK YFQMLQDNNM DNIFITEENV 

      2050       2060       2070       2080       2090       2100 
LDVVINHSHE AIILKPEAIE MYIEIVMVSE TIHFLKNSIA KKLDKQRFRG MLWFDLSLLP 

      2110       2120       2130       2140       2150       2160 
ELVQCQEKMA SFSFLKDNST DVCLWKVIET AVSELKKDLD IICKYNEAVN CSYAIHLLSR 

      2170       2180       2190       2200       2210       2220 
ELQELSEIKK LLKKSKYFIS TYIDFVPYIA SINYGSTVTE LEYNYNQFST LLKNVMSAPR 

      2230       2240       2250       2260       2270       2280 
KDLGKMAHIR KVMKTIEHMK MICTKNAELT ISFFLCQMLY NRRKILQLKR KEKMNIHIVK 

      2290       2300       2310       2320       2330       2340 
PGENNNKFSI STMLPPVSEC INKNISNSSK KRPSTVDKCE DSQEQQQDTT VSSCKKLKVD 

      2350       2360       2370       2380       2390       2400 
MKDVTKINRE KATFKHPRTT GSHPKSENKI VPSSCDSLKR NHLTPKKVEM QRSLPGSLLP 

      2410       2420       2430       2440       2450       2460 
LENPKDTCAS KSESKIDLTV SSDHFSGQQE NLNSMKKRNV NFSAAETKSD KKDCAAFAIC 

      2470       2480       2490       2500       2510       2520 
DQKSVHGTFS PDHGTLLQKF LKNSPDPTQK SCLSDINPET DVSLVPDASV LSKPIFCFVK 

      2530       2540       2550       2560       2570       2580 
DVHPDLEMND TVFELQDNDI VNSSIKNSSC MTSPEPICIQ NKIPTLQINK LQPTETESED 

      2590       2600       2610       2620       2630       2640 
KYMKDTLNPN TVHTFGASGH ITLNVNQGAE YSLSEQQNDK NSKVLMQNAA TYWNELPQSA 

      2650       2660       2670       2680       2690       2700 
CNPTYNSSEH LFGTSYPYSA WCVYQYSNSN GNAITQTYQG ITSYEVQPSP SGLLTTVAST 

      2710       2720       2730       2740       2750       2760 
AQGTHSNLLY SQYFTYFAGE PQANGFVPVN GYFQSQIPAS NFRQPIFSQY ASHQPLPQAT 

      2770       2780 
YPYLPNRFVP PEVPWVYAPW HQESFHPGH 

« Hide

References

« Hide 'large scale' references
[1]"An abundance of X-linked genes expressed in spermatogonia."
Wang P.J., McCarrey J.R., Yang F., Page D.C.
Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS ARG-104; VAL-1035; SER-1311; VAL-1337 AND ARG-1439.
Tissue: Testis.
[2]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia."
Loriot A., Boon T., De Smet C.
Int. J. Cancer 105:371-376(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF285605 mRNA. Translation: AAK31984.1.
AC009314 Genomic DNA. No translation available.
AC090281 Genomic DNA. No translation available.
RefSeqNP_112561.2. NM_031271.3.
UniGeneHs.458316.
Hs.571446.

3D structure databases

ProteinModelPortalQ9BXT5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121088. 1 interaction.
IntActQ9BXT5. 1 interaction.
STRING9606.ENSP00000256246.

PTM databases

PhosphoSiteQ9BXT5.

Polymorphism databases

DMDM308153507.

Proteomic databases

PaxDbQ9BXT5.
PRIDEQ9BXT5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256246; ENSP00000256246; ENSG00000133863.
GeneID56154.
KEGGhsa:56154.
UCSCuc003xil.3. human.

Organism-specific databases

CTD56154.
GeneCardsGC08M030689.
H-InvDBHIX0007440.
HGNCHGNC:11738. TEX15.
HPAHPA036799.
HPA036800.
MIM605795. gene.
neXtProtNX_Q9BXT5.
PharmGKBPA36455.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45350.
HOVERGENHBG075407.
InParanoidQ9BXT5.
OMAKQRFRGM.
OrthoDBEOG708VXT.
PhylomeDBQ9BXT5.
TreeFamTF332375.

Gene expression databases

ArrayExpressQ9BXT5.
BgeeQ9BXT5.
CleanExHS_TEX15.
GenevestigatorQ9BXT5.

Family and domain databases

InterProIPR026616. TEX15.
[Graphical view]
PANTHERPTHR22380. PTHR22380. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi56154.
NextBio61758.
PROQ9BXT5.
SOURCESearch...

Entry information

Entry nameTEX15_HUMAN
AccessionPrimary (citable) accession number: Q9BXT5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 5, 2010
Last modified: February 19, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM