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Protein

Testis-expressed sequence 15 protein

Gene

TEX15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, DNA damage, DNA repair, Meiosis, Spermatogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133863-MONOMER.
ReactomeiR-HSA-912446. Meiotic recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed sequence 15 protein
Alternative name(s):
Cancer/testis antigen 42
Short name:
CT42
Gene namesi
Name:TEX15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:11738. TEX15.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56154.
OpenTargetsiENSG00000133863.
PharmGKBiPA36455.

Polymorphism and mutation databases

BioMutaiTEX15.
DMDMi308153507.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444831 – 2789Testis-expressed sequence 15 proteinAdd BLAST2789

Proteomic databases

EPDiQ9BXT5.
MaxQBiQ9BXT5.
PaxDbiQ9BXT5.
PeptideAtlasiQ9BXT5.
PRIDEiQ9BXT5.

PTM databases

iPTMnetiQ9BXT5.
PhosphoSitePlusiQ9BXT5.

Expressioni

Tissue specificityi

Detected in testis and ovary (PubMed:11279525). Also expressed in several cancers (PubMed:12704671).2 Publications

Gene expression databases

BgeeiENSG00000133863.
CleanExiHS_TEX15.
GenevisibleiQ9BXT5. HS.

Organism-specific databases

HPAiHPA036799.
HPA036800.

Interactioni

Protein-protein interaction databases

BioGridi121088. 4 interactors.
IntActiQ9BXT5. 1 interactor.
STRINGi9606.ENSP00000256246.

Structurei

3D structure databases

ProteinModelPortaliQ9BXT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1083 – 1161Ser-richAdd BLAST79

Sequence similaritiesi

Belongs to the TEX15 family.Curated

Phylogenomic databases

eggNOGiENOG410IESA. Eukaryota.
ENOG410XSS9. LUCA.
GeneTreeiENSGT00390000006260.
HOVERGENiHBG075407.
InParanoidiQ9BXT5.
OMAiKQRFRGM.
OrthoDBiEOG091G0IPI.
PhylomeDBiQ9BXT5.
TreeFamiTF332375.

Family and domain databases

InterProiIPR026616. TEX15.
IPR032765. TEX15_dom.
[Graphical view]
PANTHERiPTHR22380. PTHR22380. 2 hits.
PfamiPF15326. TEX15. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BXT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSDAKDSVN GDLLLNWTSL KNILSGLNAS FPLHNNTGSS TVTTSKSIKD
60 70 80 90 100
PRLMRREESM GEQSSTAGLN EVLQFEKSSD NVNSEIKSTP SNSASSSEVV
110 120 130 140 150
PGDCAVLTNG LDTPCFKTSV NDSQSWAHNM GSEDYDCIPP NKVTMAGQCK
160 170 180 190 200
DQGNFSFPIS VSNVVSEVEN QNHSEEKAQR AQQESGNAYT KEYSSHIFQD
210 220 230 240 250
SQSSDLKTIY QTGCQTSTVF PLKKKVSIDE YLQNTGKMKN FADLEDSSKH
260 270 280 290 300
EEKQTSWKEI DNDFTNETKI SPIDNYIVLH QEYKESESHN SFGKSCDKIL
310 320 330 340 350
ITQELEITKS STSTIKDKDE LDHLALEWQI TPSFESLSQK HPQHSVEYEG
360 370 380 390 400
NIHTSLAIAQ KLMELKLGKI NQNYASIITE AFPKPKDIPQ AKEMFIDTVI
410 420 430 440 450
SSYNIETAHD SSNCSITREH ICVHRKNENE PVSLENIQRD YKETAYVEDR
460 470 480 490 500
GQDHNLFCNS QLSNDIWLNV NFKKQTDREN QNEAKENSAS CVENNIENIY
510 520 530 540 550
GDKKQDSHTN ENFSNIDEKE DKNYHNIEIL SSEEFSTKFN LICREDNAVS
560 570 580 590 600
AATALLESEE DTISAVKQKD TENTGRSVEH LASTTFPKTA SSSVCVASNA
610 620 630 640 650
AIQIASATMP ALSLNNDDHQ IYQFKETCSS ESPDFGLLVK HRVSDCEIDT
660 670 680 690 700
DKNKSQESFH QSINENLVLQ SIELESEIEI ELEDCDDAFI FQQDTHSHEN
710 720 730 740 750
MLCEEFVTSY KALKSRISWE GLLALDNGEM EVLESTTGRE NSDQHYSKES
760 770 780 790 800
NYFYSSTQNN ETELTSPILL PDLQIKITNI FRPGFSPTAD SLALKDSFCT
810 820 830 840 850
HVTEATKPEI NKEDGEILGF DIYSQPFGEN ADYPCEDKVD NIRQESGPVS
860 870 880 890 900
NSEISLSFDL SRNTDVNHTS ENQNSESLFT EPSNVTTIDD GSRCFFTKSK
910 920 930 940 950
TDYNDTKNKK EVESRISKRK LHISSRDQNI PHKDLRRHKI YGRKRRLTSQ
960 970 980 990 1000
DSSECFSSLS QGRIKTFSQS EKHIKSVLNI LSDEASLCKS KCLSRKLDKA
1010 1020 1030 1040 1050
VVHLKKAHRR VHTSLQLITK VGEERKGPLP KSYAIICNNF WESCDLQGYS
1060 1070 1080 1090 1100
SVSQRKYYST KHFSSKRKYD KRRKKRAPKA DISKSLTHVS KHKSYKTSGE
1110 1120 1130 1140 1150
KKCLSRKSMA SSVSKSHPTT SHMGEFCNQE HPESQLPVSS TSQSTSQSVY
1160 1170 1180 1190 1200
YNSSVSNPSL SEEHQPFSGK TAYLFSPDHS DEKLIEKENQ IDTAFLSSTS
1210 1220 1230 1240 1250
KYEKLEKHSA NHNVKDATKE NSCDANEVIN ESNSVSLSCI KENINSSTGN
1260 1270 1280 1290 1300
DCDATCIGHT KAKTDVLISV LDSNVKHFLN DLYQQGNLIL SDCKRNLEVK
1310 1320 1330 1340 1350
WTDPIERPKQ NIITGNFLMG PLNLTLIASK KYSIPQLSAA AVTDSEGESS
1360 1370 1380 1390 1400
KSYLDKQRIL TVDSFAASST VPHCEQSCRE KELLKTEQCS SGNCLHTDGN
1410 1420 1430 1440 1450
ETNVTENYEL DVASGTEEDK SYGENIVELS SSDSSLLLKD NVKGSSSETC
1460 1470 1480 1490 1500
IVKKDTEDRI TWKVKQAEKA KDSVYKRSMT EGSTVNTEYK NQKNQISEES
1510 1520 1530 1540 1550
CLNEKIITTN LIDSHLSTKN TTTESVPLKN TVSNPLNKRE KKGEIKVSKD
1560 1570 1580 1590 1600
SQSDLTLHSE IAYISKPGIL GVNHTPILPA HSETCKVPTL LKKPASYVSD
1610 1620 1630 1640 1650
FKEKHCSANH TALIANLSQI LQRADEASSL QILQEETKVC LNILPLFVEA
1660 1670 1680 1690 1700
FERKQECSVE QILISRELLV DQNLWNNCKH TLKPCAVDTL VELQMMMETI
1710 1720 1730 1740 1750
QFIENKKRHL EGEPTLRSLL WYDETLYAEL LGKPRGFQQQ SNFYPGFQGR
1760 1770 1780 1790 1800
LKYNAFCELQ TYHDQLVELL EETKREKNSY YVFLKYKRQV NECEAIMEHC
1810 1820 1830 1840 1850
SDCFDFSLSV PFTCGVNFGD SLEDLEILRK STLKLINVCG DSPKVHSYPG
1860 1870 1880 1890 1900
KQDHLWIIIE MISSKVNFIK NNEAVRVKIS LYGLEHIFFD AAKNLVWKER
1910 1920 1930 1940 1950
TQSFSKKYSQ KKDEERLLRV NKCAFSKLQK IYDTLSKDLN NEPISPIGLE
1960 1970 1980 1990 2000
EDTIIASRKS DHPINEATIS IENSKFNSNL LAHPDICCIS EILDQAEFAD
2010 2020 2030 2040 2050
LKKLQDLTLR CTDHLEILKK YFQMLQDNNM DNIFITEENV LDVVINHSHE
2060 2070 2080 2090 2100
AIILKPEAIE MYIEIVMVSE TIHFLKNSIA KKLDKQRFRG MLWFDLSLLP
2110 2120 2130 2140 2150
ELVQCQEKMA SFSFLKDNST DVCLWKVIET AVSELKKDLD IICKYNEAVN
2160 2170 2180 2190 2200
CSYAIHLLSR ELQELSEIKK LLKKSKYFIS TYIDFVPYIA SINYGSTVTE
2210 2220 2230 2240 2250
LEYNYNQFST LLKNVMSAPR KDLGKMAHIR KVMKTIEHMK MICTKNAELT
2260 2270 2280 2290 2300
ISFFLCQMLY NRRKILQLKR KEKMNIHIVK PGENNNKFSI STMLPPVSEC
2310 2320 2330 2340 2350
INKNISNSSK KRPSTVDKCE DSQEQQQDTT VSSCKKLKVD MKDVTKINRE
2360 2370 2380 2390 2400
KATFKHPRTT GSHPKSENKI VPSSCDSLKR NHLTPKKVEM QRSLPGSLLP
2410 2420 2430 2440 2450
LENPKDTCAS KSESKIDLTV SSDHFSGQQE NLNSMKKRNV NFSAAETKSD
2460 2470 2480 2490 2500
KKDCAAFAIC DQKSVHGTFS PDHGTLLQKF LKNSPDPTQK SCLSDINPET
2510 2520 2530 2540 2550
DVSLVPDASV LSKPIFCFVK DVHPDLEMND TVFELQDNDI VNSSIKNSSC
2560 2570 2580 2590 2600
MTSPEPICIQ NKIPTLQINK LQPTETESED KYMKDTLNPN TVHTFGASGH
2610 2620 2630 2640 2650
ITLNVNQGAE YSLSEQQNDK NSKVLMQNAA TYWNELPQSA CNPTYNSSEH
2660 2670 2680 2690 2700
LFGTSYPYSA WCVYQYSNSN GNAITQTYQG ITSYEVQPSP SGLLTTVAST
2710 2720 2730 2740 2750
AQGTHSNLLY SQYFTYFAGE PQANGFVPVN GYFQSQIPAS NFRQPIFSQY
2760 2770 2780
ASHQPLPQAT YPYLPNRFVP PEVPWVYAPW HQESFHPGH
Length:2,789
Mass (Da):315,336
Last modified:October 5, 2010 - v2
Checksum:i1065EDD045C67BF6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060394104C → R.1 PublicationCorresponds to variant rs323347dbSNPEnsembl.1
Natural variantiVAR_060395383P → L.Corresponds to variant rs9297162dbSNPEnsembl.1
Natural variantiVAR_0603961035I → V.1 PublicationCorresponds to variant rs323346dbSNPEnsembl.1
Natural variantiVAR_0603971311N → S.1 PublicationCorresponds to variant rs323345dbSNPEnsembl.1
Natural variantiVAR_0603981337L → V.1 PublicationCorresponds to variant rs323344dbSNPEnsembl.1
Natural variantiVAR_0603991439K → R.1 PublicationCorresponds to variant rs323343dbSNPEnsembl.1
Natural variantiVAR_0617112138D → N.Corresponds to variant rs60474250dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285605 mRNA. Translation: AAK31984.1.
AC009314 Genomic DNA. No translation available.
AC090281 Genomic DNA. No translation available.
CCDSiCCDS6080.1.
RefSeqiNP_112561.2. NM_031271.3.
UniGeneiHs.458316.
Hs.571446.

Genome annotation databases

EnsembliENST00000256246; ENSP00000256246; ENSG00000133863.
GeneIDi56154.
KEGGihsa:56154.
UCSCiuc003xil.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285605 mRNA. Translation: AAK31984.1.
AC009314 Genomic DNA. No translation available.
AC090281 Genomic DNA. No translation available.
CCDSiCCDS6080.1.
RefSeqiNP_112561.2. NM_031271.3.
UniGeneiHs.458316.
Hs.571446.

3D structure databases

ProteinModelPortaliQ9BXT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121088. 4 interactors.
IntActiQ9BXT5. 1 interactor.
STRINGi9606.ENSP00000256246.

PTM databases

iPTMnetiQ9BXT5.
PhosphoSitePlusiQ9BXT5.

Polymorphism and mutation databases

BioMutaiTEX15.
DMDMi308153507.

Proteomic databases

EPDiQ9BXT5.
MaxQBiQ9BXT5.
PaxDbiQ9BXT5.
PeptideAtlasiQ9BXT5.
PRIDEiQ9BXT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256246; ENSP00000256246; ENSG00000133863.
GeneIDi56154.
KEGGihsa:56154.
UCSCiuc003xil.4. human.

Organism-specific databases

CTDi56154.
DisGeNETi56154.
GeneCardsiTEX15.
H-InvDBHIX0007440.
HGNCiHGNC:11738. TEX15.
HPAiHPA036799.
HPA036800.
MIMi605795. gene.
neXtProtiNX_Q9BXT5.
OpenTargetsiENSG00000133863.
PharmGKBiPA36455.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IESA. Eukaryota.
ENOG410XSS9. LUCA.
GeneTreeiENSGT00390000006260.
HOVERGENiHBG075407.
InParanoidiQ9BXT5.
OMAiKQRFRGM.
OrthoDBiEOG091G0IPI.
PhylomeDBiQ9BXT5.
TreeFamiTF332375.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133863-MONOMER.
ReactomeiR-HSA-912446. Meiotic recombination.

Miscellaneous databases

GenomeRNAii56154.
PROiQ9BXT5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133863.
CleanExiHS_TEX15.
GenevisibleiQ9BXT5. HS.

Family and domain databases

InterProiIPR026616. TEX15.
IPR032765. TEX15_dom.
[Graphical view]
PANTHERiPTHR22380. PTHR22380. 2 hits.
PfamiPF15326. TEX15. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEX15_HUMAN
AccessioniPrimary (citable) accession number: Q9BXT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.