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Q9BXT5

- TEX15_HUMAN

UniProt

Q9BXT5 - TEX15_HUMAN

Protein

Testis-expressed sequence 15 protein

Gene

TEX15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. fertilization Source: Ensembl
    2. homeostasis of number of cells within a tissue Source: Ensembl
    3. male genitalia development Source: Ensembl
    4. male meiosis Source: Ensembl
    5. protein localization to chromosome Source: Ensembl
    6. regulation of double-strand break repair via homologous recombination Source: Ensembl
    7. regulation of protein localization Source: Ensembl
    8. spermatogenesis Source: Ensembl
    9. synaptonemal complex assembly Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_27271. Meiotic recombination.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-expressed sequence 15 protein
    Alternative name(s):
    Cancer/testis antigen 42
    Short name:
    CT42
    Gene namesi
    Name:TEX15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:11738. TEX15.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36455.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 27892789Testis-expressed sequence 15 proteinPRO_0000244483Add
    BLAST

    Proteomic databases

    PaxDbiQ9BXT5.
    PRIDEiQ9BXT5.

    PTM databases

    PhosphoSiteiQ9BXT5.

    Expressioni

    Tissue specificityi

    Testis-specific. Also expressed in several cancers.2 Publications

    Gene expression databases

    ArrayExpressiQ9BXT5.
    BgeeiQ9BXT5.
    CleanExiHS_TEX15.
    GenevestigatoriQ9BXT5.

    Organism-specific databases

    HPAiHPA036799.
    HPA036800.

    Interactioni

    Protein-protein interaction databases

    BioGridi121088. 1 interaction.
    IntActiQ9BXT5. 1 interaction.
    STRINGi9606.ENSP00000256246.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXT5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1083 – 116179Ser-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG45350.
    HOVERGENiHBG075407.
    InParanoidiQ9BXT5.
    OMAiKQRFRGM.
    OrthoDBiEOG708VXT.
    PhylomeDBiQ9BXT5.
    TreeFamiTF332375.

    Family and domain databases

    InterProiIPR026616. TEX15.
    [Graphical view]
    PANTHERiPTHR22380. PTHR22380. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9BXT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSDAKDSVN GDLLLNWTSL KNILSGLNAS FPLHNNTGSS TVTTSKSIKD     50
    PRLMRREESM GEQSSTAGLN EVLQFEKSSD NVNSEIKSTP SNSASSSEVV 100
    PGDCAVLTNG LDTPCFKTSV NDSQSWAHNM GSEDYDCIPP NKVTMAGQCK 150
    DQGNFSFPIS VSNVVSEVEN QNHSEEKAQR AQQESGNAYT KEYSSHIFQD 200
    SQSSDLKTIY QTGCQTSTVF PLKKKVSIDE YLQNTGKMKN FADLEDSSKH 250
    EEKQTSWKEI DNDFTNETKI SPIDNYIVLH QEYKESESHN SFGKSCDKIL 300
    ITQELEITKS STSTIKDKDE LDHLALEWQI TPSFESLSQK HPQHSVEYEG 350
    NIHTSLAIAQ KLMELKLGKI NQNYASIITE AFPKPKDIPQ AKEMFIDTVI 400
    SSYNIETAHD SSNCSITREH ICVHRKNENE PVSLENIQRD YKETAYVEDR 450
    GQDHNLFCNS QLSNDIWLNV NFKKQTDREN QNEAKENSAS CVENNIENIY 500
    GDKKQDSHTN ENFSNIDEKE DKNYHNIEIL SSEEFSTKFN LICREDNAVS 550
    AATALLESEE DTISAVKQKD TENTGRSVEH LASTTFPKTA SSSVCVASNA 600
    AIQIASATMP ALSLNNDDHQ IYQFKETCSS ESPDFGLLVK HRVSDCEIDT 650
    DKNKSQESFH QSINENLVLQ SIELESEIEI ELEDCDDAFI FQQDTHSHEN 700
    MLCEEFVTSY KALKSRISWE GLLALDNGEM EVLESTTGRE NSDQHYSKES 750
    NYFYSSTQNN ETELTSPILL PDLQIKITNI FRPGFSPTAD SLALKDSFCT 800
    HVTEATKPEI NKEDGEILGF DIYSQPFGEN ADYPCEDKVD NIRQESGPVS 850
    NSEISLSFDL SRNTDVNHTS ENQNSESLFT EPSNVTTIDD GSRCFFTKSK 900
    TDYNDTKNKK EVESRISKRK LHISSRDQNI PHKDLRRHKI YGRKRRLTSQ 950
    DSSECFSSLS QGRIKTFSQS EKHIKSVLNI LSDEASLCKS KCLSRKLDKA 1000
    VVHLKKAHRR VHTSLQLITK VGEERKGPLP KSYAIICNNF WESCDLQGYS 1050
    SVSQRKYYST KHFSSKRKYD KRRKKRAPKA DISKSLTHVS KHKSYKTSGE 1100
    KKCLSRKSMA SSVSKSHPTT SHMGEFCNQE HPESQLPVSS TSQSTSQSVY 1150
    YNSSVSNPSL SEEHQPFSGK TAYLFSPDHS DEKLIEKENQ IDTAFLSSTS 1200
    KYEKLEKHSA NHNVKDATKE NSCDANEVIN ESNSVSLSCI KENINSSTGN 1250
    DCDATCIGHT KAKTDVLISV LDSNVKHFLN DLYQQGNLIL SDCKRNLEVK 1300
    WTDPIERPKQ NIITGNFLMG PLNLTLIASK KYSIPQLSAA AVTDSEGESS 1350
    KSYLDKQRIL TVDSFAASST VPHCEQSCRE KELLKTEQCS SGNCLHTDGN 1400
    ETNVTENYEL DVASGTEEDK SYGENIVELS SSDSSLLLKD NVKGSSSETC 1450
    IVKKDTEDRI TWKVKQAEKA KDSVYKRSMT EGSTVNTEYK NQKNQISEES 1500
    CLNEKIITTN LIDSHLSTKN TTTESVPLKN TVSNPLNKRE KKGEIKVSKD 1550
    SQSDLTLHSE IAYISKPGIL GVNHTPILPA HSETCKVPTL LKKPASYVSD 1600
    FKEKHCSANH TALIANLSQI LQRADEASSL QILQEETKVC LNILPLFVEA 1650
    FERKQECSVE QILISRELLV DQNLWNNCKH TLKPCAVDTL VELQMMMETI 1700
    QFIENKKRHL EGEPTLRSLL WYDETLYAEL LGKPRGFQQQ SNFYPGFQGR 1750
    LKYNAFCELQ TYHDQLVELL EETKREKNSY YVFLKYKRQV NECEAIMEHC 1800
    SDCFDFSLSV PFTCGVNFGD SLEDLEILRK STLKLINVCG DSPKVHSYPG 1850
    KQDHLWIIIE MISSKVNFIK NNEAVRVKIS LYGLEHIFFD AAKNLVWKER 1900
    TQSFSKKYSQ KKDEERLLRV NKCAFSKLQK IYDTLSKDLN NEPISPIGLE 1950
    EDTIIASRKS DHPINEATIS IENSKFNSNL LAHPDICCIS EILDQAEFAD 2000
    LKKLQDLTLR CTDHLEILKK YFQMLQDNNM DNIFITEENV LDVVINHSHE 2050
    AIILKPEAIE MYIEIVMVSE TIHFLKNSIA KKLDKQRFRG MLWFDLSLLP 2100
    ELVQCQEKMA SFSFLKDNST DVCLWKVIET AVSELKKDLD IICKYNEAVN 2150
    CSYAIHLLSR ELQELSEIKK LLKKSKYFIS TYIDFVPYIA SINYGSTVTE 2200
    LEYNYNQFST LLKNVMSAPR KDLGKMAHIR KVMKTIEHMK MICTKNAELT 2250
    ISFFLCQMLY NRRKILQLKR KEKMNIHIVK PGENNNKFSI STMLPPVSEC 2300
    INKNISNSSK KRPSTVDKCE DSQEQQQDTT VSSCKKLKVD MKDVTKINRE 2350
    KATFKHPRTT GSHPKSENKI VPSSCDSLKR NHLTPKKVEM QRSLPGSLLP 2400
    LENPKDTCAS KSESKIDLTV SSDHFSGQQE NLNSMKKRNV NFSAAETKSD 2450
    KKDCAAFAIC DQKSVHGTFS PDHGTLLQKF LKNSPDPTQK SCLSDINPET 2500
    DVSLVPDASV LSKPIFCFVK DVHPDLEMND TVFELQDNDI VNSSIKNSSC 2550
    MTSPEPICIQ NKIPTLQINK LQPTETESED KYMKDTLNPN TVHTFGASGH 2600
    ITLNVNQGAE YSLSEQQNDK NSKVLMQNAA TYWNELPQSA CNPTYNSSEH 2650
    LFGTSYPYSA WCVYQYSNSN GNAITQTYQG ITSYEVQPSP SGLLTTVAST 2700
    AQGTHSNLLY SQYFTYFAGE PQANGFVPVN GYFQSQIPAS NFRQPIFSQY 2750
    ASHQPLPQAT YPYLPNRFVP PEVPWVYAPW HQESFHPGH 2789
    Length:2,789
    Mass (Da):315,336
    Last modified:October 5, 2010 - v2
    Checksum:i1065EDD045C67BF6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti104 – 1041C → R.1 Publication
    Corresponds to variant rs323347 [ dbSNP | Ensembl ].
    VAR_060394
    Natural varianti383 – 3831P → L.
    Corresponds to variant rs9297162 [ dbSNP | Ensembl ].
    VAR_060395
    Natural varianti1035 – 10351I → V.1 Publication
    Corresponds to variant rs323346 [ dbSNP | Ensembl ].
    VAR_060396
    Natural varianti1311 – 13111N → S.1 Publication
    Corresponds to variant rs323345 [ dbSNP | Ensembl ].
    VAR_060397
    Natural varianti1337 – 13371L → V.1 Publication
    Corresponds to variant rs323344 [ dbSNP | Ensembl ].
    VAR_060398
    Natural varianti1439 – 14391K → R.1 Publication
    Corresponds to variant rs323343 [ dbSNP | Ensembl ].
    VAR_060399
    Natural varianti2138 – 21381D → N.
    Corresponds to variant rs60474250 [ dbSNP | Ensembl ].
    VAR_061711

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285605 mRNA. Translation: AAK31984.1.
    AC009314 Genomic DNA. No translation available.
    AC090281 Genomic DNA. No translation available.
    CCDSiCCDS6080.1.
    RefSeqiNP_112561.2. NM_031271.3.
    UniGeneiHs.458316.
    Hs.571446.

    Genome annotation databases

    EnsembliENST00000256246; ENSP00000256246; ENSG00000133863.
    GeneIDi56154.
    KEGGihsa:56154.
    UCSCiuc003xil.3. human.

    Polymorphism databases

    DMDMi308153507.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285605 mRNA. Translation: AAK31984.1 .
    AC009314 Genomic DNA. No translation available.
    AC090281 Genomic DNA. No translation available.
    CCDSi CCDS6080.1.
    RefSeqi NP_112561.2. NM_031271.3.
    UniGenei Hs.458316.
    Hs.571446.

    3D structure databases

    ProteinModelPortali Q9BXT5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121088. 1 interaction.
    IntActi Q9BXT5. 1 interaction.
    STRINGi 9606.ENSP00000256246.

    PTM databases

    PhosphoSitei Q9BXT5.

    Polymorphism databases

    DMDMi 308153507.

    Proteomic databases

    PaxDbi Q9BXT5.
    PRIDEi Q9BXT5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256246 ; ENSP00000256246 ; ENSG00000133863 .
    GeneIDi 56154.
    KEGGi hsa:56154.
    UCSCi uc003xil.3. human.

    Organism-specific databases

    CTDi 56154.
    GeneCardsi GC08M030689.
    H-InvDB HIX0007440.
    HGNCi HGNC:11738. TEX15.
    HPAi HPA036799.
    HPA036800.
    MIMi 605795. gene.
    neXtProti NX_Q9BXT5.
    PharmGKBi PA36455.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45350.
    HOVERGENi HBG075407.
    InParanoidi Q9BXT5.
    OMAi KQRFRGM.
    OrthoDBi EOG708VXT.
    PhylomeDBi Q9BXT5.
    TreeFami TF332375.

    Enzyme and pathway databases

    Reactomei REACT_27271. Meiotic recombination.

    Miscellaneous databases

    GenomeRNAii 56154.
    NextBioi 61758.
    PROi Q9BXT5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BXT5.
    Bgeei Q9BXT5.
    CleanExi HS_TEX15.
    Genevestigatori Q9BXT5.

    Family and domain databases

    InterProi IPR026616. TEX15.
    [Graphical view ]
    PANTHERi PTHR22380. PTHR22380. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "An abundance of X-linked genes expressed in spermatogonia."
      Wang P.J., McCarrey J.R., Yang F., Page D.C.
      Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS ARG-104; VAL-1035; SER-1311; VAL-1337 AND ARG-1439.
      Tissue: Testis.
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia."
      Loriot A., Boon T., De Smet C.
      Int. J. Cancer 105:371-376(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.

    Entry informationi

    Entry nameiTEX15_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3