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Q9BXT5

- TEX15_HUMAN

UniProt

Q9BXT5 - TEX15_HUMAN

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Protein

Testis-expressed sequence 15 protein

Gene
TEX15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. fertilization Source: Ensembl
  2. homeostasis of number of cells within a tissue Source: Ensembl
  3. male genitalia development Source: Ensembl
  4. male meiosis Source: Ensembl
  5. protein localization to chromosome Source: Ensembl
  6. regulation of double-strand break repair via homologous recombination Source: Ensembl
  7. regulation of protein localization Source: Ensembl
  8. spermatogenesis Source: Ensembl
  9. synaptonemal complex assembly Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_27271. Meiotic recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed sequence 15 protein
Alternative name(s):
Cancer/testis antigen 42
Short name:
CT42
Gene namesi
Name:TEX15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:11738. TEX15.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27892789Testis-expressed sequence 15 proteinPRO_0000244483Add
BLAST

Proteomic databases

PaxDbiQ9BXT5.
PRIDEiQ9BXT5.

PTM databases

PhosphoSiteiQ9BXT5.

Expressioni

Tissue specificityi

Testis-specific. Also expressed in several cancers.2 Publications

Gene expression databases

ArrayExpressiQ9BXT5.
BgeeiQ9BXT5.
CleanExiHS_TEX15.
GenevestigatoriQ9BXT5.

Organism-specific databases

HPAiHPA036799.
HPA036800.

Interactioni

Protein-protein interaction databases

BioGridi121088. 1 interaction.
IntActiQ9BXT5. 1 interaction.
STRINGi9606.ENSP00000256246.

Structurei

3D structure databases

ProteinModelPortaliQ9BXT5.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1083 – 116179Ser-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG45350.
HOVERGENiHBG075407.
InParanoidiQ9BXT5.
OMAiKQRFRGM.
OrthoDBiEOG708VXT.
PhylomeDBiQ9BXT5.
TreeFamiTF332375.

Family and domain databases

InterProiIPR026616. TEX15.
[Graphical view]
PANTHERiPTHR22380. PTHR22380. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BXT5-1 [UniParc]FASTAAdd to Basket

« Hide

MPSDAKDSVN GDLLLNWTSL KNILSGLNAS FPLHNNTGSS TVTTSKSIKD     50
PRLMRREESM GEQSSTAGLN EVLQFEKSSD NVNSEIKSTP SNSASSSEVV 100
PGDCAVLTNG LDTPCFKTSV NDSQSWAHNM GSEDYDCIPP NKVTMAGQCK 150
DQGNFSFPIS VSNVVSEVEN QNHSEEKAQR AQQESGNAYT KEYSSHIFQD 200
SQSSDLKTIY QTGCQTSTVF PLKKKVSIDE YLQNTGKMKN FADLEDSSKH 250
EEKQTSWKEI DNDFTNETKI SPIDNYIVLH QEYKESESHN SFGKSCDKIL 300
ITQELEITKS STSTIKDKDE LDHLALEWQI TPSFESLSQK HPQHSVEYEG 350
NIHTSLAIAQ KLMELKLGKI NQNYASIITE AFPKPKDIPQ AKEMFIDTVI 400
SSYNIETAHD SSNCSITREH ICVHRKNENE PVSLENIQRD YKETAYVEDR 450
GQDHNLFCNS QLSNDIWLNV NFKKQTDREN QNEAKENSAS CVENNIENIY 500
GDKKQDSHTN ENFSNIDEKE DKNYHNIEIL SSEEFSTKFN LICREDNAVS 550
AATALLESEE DTISAVKQKD TENTGRSVEH LASTTFPKTA SSSVCVASNA 600
AIQIASATMP ALSLNNDDHQ IYQFKETCSS ESPDFGLLVK HRVSDCEIDT 650
DKNKSQESFH QSINENLVLQ SIELESEIEI ELEDCDDAFI FQQDTHSHEN 700
MLCEEFVTSY KALKSRISWE GLLALDNGEM EVLESTTGRE NSDQHYSKES 750
NYFYSSTQNN ETELTSPILL PDLQIKITNI FRPGFSPTAD SLALKDSFCT 800
HVTEATKPEI NKEDGEILGF DIYSQPFGEN ADYPCEDKVD NIRQESGPVS 850
NSEISLSFDL SRNTDVNHTS ENQNSESLFT EPSNVTTIDD GSRCFFTKSK 900
TDYNDTKNKK EVESRISKRK LHISSRDQNI PHKDLRRHKI YGRKRRLTSQ 950
DSSECFSSLS QGRIKTFSQS EKHIKSVLNI LSDEASLCKS KCLSRKLDKA 1000
VVHLKKAHRR VHTSLQLITK VGEERKGPLP KSYAIICNNF WESCDLQGYS 1050
SVSQRKYYST KHFSSKRKYD KRRKKRAPKA DISKSLTHVS KHKSYKTSGE 1100
KKCLSRKSMA SSVSKSHPTT SHMGEFCNQE HPESQLPVSS TSQSTSQSVY 1150
YNSSVSNPSL SEEHQPFSGK TAYLFSPDHS DEKLIEKENQ IDTAFLSSTS 1200
KYEKLEKHSA NHNVKDATKE NSCDANEVIN ESNSVSLSCI KENINSSTGN 1250
DCDATCIGHT KAKTDVLISV LDSNVKHFLN DLYQQGNLIL SDCKRNLEVK 1300
WTDPIERPKQ NIITGNFLMG PLNLTLIASK KYSIPQLSAA AVTDSEGESS 1350
KSYLDKQRIL TVDSFAASST VPHCEQSCRE KELLKTEQCS SGNCLHTDGN 1400
ETNVTENYEL DVASGTEEDK SYGENIVELS SSDSSLLLKD NVKGSSSETC 1450
IVKKDTEDRI TWKVKQAEKA KDSVYKRSMT EGSTVNTEYK NQKNQISEES 1500
CLNEKIITTN LIDSHLSTKN TTTESVPLKN TVSNPLNKRE KKGEIKVSKD 1550
SQSDLTLHSE IAYISKPGIL GVNHTPILPA HSETCKVPTL LKKPASYVSD 1600
FKEKHCSANH TALIANLSQI LQRADEASSL QILQEETKVC LNILPLFVEA 1650
FERKQECSVE QILISRELLV DQNLWNNCKH TLKPCAVDTL VELQMMMETI 1700
QFIENKKRHL EGEPTLRSLL WYDETLYAEL LGKPRGFQQQ SNFYPGFQGR 1750
LKYNAFCELQ TYHDQLVELL EETKREKNSY YVFLKYKRQV NECEAIMEHC 1800
SDCFDFSLSV PFTCGVNFGD SLEDLEILRK STLKLINVCG DSPKVHSYPG 1850
KQDHLWIIIE MISSKVNFIK NNEAVRVKIS LYGLEHIFFD AAKNLVWKER 1900
TQSFSKKYSQ KKDEERLLRV NKCAFSKLQK IYDTLSKDLN NEPISPIGLE 1950
EDTIIASRKS DHPINEATIS IENSKFNSNL LAHPDICCIS EILDQAEFAD 2000
LKKLQDLTLR CTDHLEILKK YFQMLQDNNM DNIFITEENV LDVVINHSHE 2050
AIILKPEAIE MYIEIVMVSE TIHFLKNSIA KKLDKQRFRG MLWFDLSLLP 2100
ELVQCQEKMA SFSFLKDNST DVCLWKVIET AVSELKKDLD IICKYNEAVN 2150
CSYAIHLLSR ELQELSEIKK LLKKSKYFIS TYIDFVPYIA SINYGSTVTE 2200
LEYNYNQFST LLKNVMSAPR KDLGKMAHIR KVMKTIEHMK MICTKNAELT 2250
ISFFLCQMLY NRRKILQLKR KEKMNIHIVK PGENNNKFSI STMLPPVSEC 2300
INKNISNSSK KRPSTVDKCE DSQEQQQDTT VSSCKKLKVD MKDVTKINRE 2350
KATFKHPRTT GSHPKSENKI VPSSCDSLKR NHLTPKKVEM QRSLPGSLLP 2400
LENPKDTCAS KSESKIDLTV SSDHFSGQQE NLNSMKKRNV NFSAAETKSD 2450
KKDCAAFAIC DQKSVHGTFS PDHGTLLQKF LKNSPDPTQK SCLSDINPET 2500
DVSLVPDASV LSKPIFCFVK DVHPDLEMND TVFELQDNDI VNSSIKNSSC 2550
MTSPEPICIQ NKIPTLQINK LQPTETESED KYMKDTLNPN TVHTFGASGH 2600
ITLNVNQGAE YSLSEQQNDK NSKVLMQNAA TYWNELPQSA CNPTYNSSEH 2650
LFGTSYPYSA WCVYQYSNSN GNAITQTYQG ITSYEVQPSP SGLLTTVAST 2700
AQGTHSNLLY SQYFTYFAGE PQANGFVPVN GYFQSQIPAS NFRQPIFSQY 2750
ASHQPLPQAT YPYLPNRFVP PEVPWVYAPW HQESFHPGH 2789
Length:2,789
Mass (Da):315,336
Last modified:October 5, 2010 - v2
Checksum:i1065EDD045C67BF6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti104 – 1041C → R.1 Publication
Corresponds to variant rs323347 [ dbSNP | Ensembl ].
VAR_060394
Natural varianti383 – 3831P → L.
Corresponds to variant rs9297162 [ dbSNP | Ensembl ].
VAR_060395
Natural varianti1035 – 10351I → V.1 Publication
Corresponds to variant rs323346 [ dbSNP | Ensembl ].
VAR_060396
Natural varianti1311 – 13111N → S.1 Publication
Corresponds to variant rs323345 [ dbSNP | Ensembl ].
VAR_060397
Natural varianti1337 – 13371L → V.1 Publication
Corresponds to variant rs323344 [ dbSNP | Ensembl ].
VAR_060398
Natural varianti1439 – 14391K → R.1 Publication
Corresponds to variant rs323343 [ dbSNP | Ensembl ].
VAR_060399
Natural varianti2138 – 21381D → N.
Corresponds to variant rs60474250 [ dbSNP | Ensembl ].
VAR_061711

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285605 mRNA. Translation: AAK31984.1.
AC009314 Genomic DNA. No translation available.
AC090281 Genomic DNA. No translation available.
CCDSiCCDS6080.1.
RefSeqiNP_112561.2. NM_031271.3.
UniGeneiHs.458316.
Hs.571446.

Genome annotation databases

EnsembliENST00000256246; ENSP00000256246; ENSG00000133863.
GeneIDi56154.
KEGGihsa:56154.
UCSCiuc003xil.3. human.

Polymorphism databases

DMDMi308153507.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285605 mRNA. Translation: AAK31984.1 .
AC009314 Genomic DNA. No translation available.
AC090281 Genomic DNA. No translation available.
CCDSi CCDS6080.1.
RefSeqi NP_112561.2. NM_031271.3.
UniGenei Hs.458316.
Hs.571446.

3D structure databases

ProteinModelPortali Q9BXT5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121088. 1 interaction.
IntActi Q9BXT5. 1 interaction.
STRINGi 9606.ENSP00000256246.

PTM databases

PhosphoSitei Q9BXT5.

Polymorphism databases

DMDMi 308153507.

Proteomic databases

PaxDbi Q9BXT5.
PRIDEi Q9BXT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256246 ; ENSP00000256246 ; ENSG00000133863 .
GeneIDi 56154.
KEGGi hsa:56154.
UCSCi uc003xil.3. human.

Organism-specific databases

CTDi 56154.
GeneCardsi GC08M030689.
H-InvDB HIX0007440.
HGNCi HGNC:11738. TEX15.
HPAi HPA036799.
HPA036800.
MIMi 605795. gene.
neXtProti NX_Q9BXT5.
PharmGKBi PA36455.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45350.
HOVERGENi HBG075407.
InParanoidi Q9BXT5.
OMAi KQRFRGM.
OrthoDBi EOG708VXT.
PhylomeDBi Q9BXT5.
TreeFami TF332375.

Enzyme and pathway databases

Reactomei REACT_27271. Meiotic recombination.

Miscellaneous databases

GenomeRNAii 56154.
NextBioi 61758.
PROi Q9BXT5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BXT5.
Bgeei Q9BXT5.
CleanExi HS_TEX15.
Genevestigatori Q9BXT5.

Family and domain databases

InterProi IPR026616. TEX15.
[Graphical view ]
PANTHERi PTHR22380. PTHR22380. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An abundance of X-linked genes expressed in spermatogonia."
    Wang P.J., McCarrey J.R., Yang F., Page D.C.
    Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS ARG-104; VAL-1035; SER-1311; VAL-1337 AND ARG-1439.
    Tissue: Testis.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia."
    Loriot A., Boon T., De Smet C.
    Int. J. Cancer 105:371-376(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.

Entry informationi

Entry nameiTEX15_HUMAN
AccessioniPrimary (citable) accession number: Q9BXT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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