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Protein

Tudor domain-containing protein 1

Gene

TDRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 206MYND-typePROSITE-ProRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000095627-MONOMER.
ReactomeiR-HSA-5601884. PIWI-interacting RNA (piRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Tudor domain-containing protein 1
Alternative name(s):
Cancer/testis antigen 41.1
Short name:
CT41.1
Gene namesi
Name:TDRD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11712. TDRD1.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi56165.
OpenTargetsiENSG00000095627.
PharmGKBiPA36430.

Polymorphism and mutation databases

BioMutaiTDRD1.
DMDMi206729901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001831611 – 1180Tudor domain-containing protein 1Add BLAST1180

Proteomic databases

MaxQBiQ9BXT4.
PaxDbiQ9BXT4.
PeptideAtlasiQ9BXT4.
PRIDEiQ9BXT4.

PTM databases

iPTMnetiQ9BXT4.
PhosphoSitePlusiQ9BXT4.

Expressioni

Tissue specificityi

Testis and ovary specific. Also expressed in several cancers.1 Publication

Gene expression databases

BgeeiENSG00000095627.
CleanExiHS_TDRD1.
ExpressionAtlasiQ9BXT4. baseline and differential.

Organism-specific databases

HPAiHPA037729.
HPA037730.

Interactioni

Subunit structurei

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Interacts with MAEL. Interacts with PIWIL1, PIWIL2 and PIWIL4 (when methylated on arginine residues). Interacts with TDRD12 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TFCP2Q128003EBI-10301451,EBI-717422

Protein-protein interaction databases

BioGridi121098. 5 interactors.
IntActiQ9BXT4. 3 interactors.
MINTiMINT-7242011.
STRINGi9606.ENSP00000251864.

Structurei

3D structure databases

ProteinModelPortaliQ9BXT4.
SMRiQ9BXT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini312 – 372Tudor 1PROSITE-ProRule annotationAdd BLAST61
Domaini541 – 600Tudor 2PROSITE-ProRule annotationAdd BLAST60
Domaini762 – 821Tudor 3PROSITE-ProRule annotationAdd BLAST60
Domaini990 – 1048Tudor 4PROSITE-ProRule annotationAdd BLAST59

Domaini

Tudor domains 2 and 3 have higher affinity for arginine-methylated peptides, tudor domain 1 is a poor binder due to an impaired aromatic cage.By similarity

Sequence similaritiesi

Belongs to the TDRD1 family.Curated
Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation
Contains 4 Tudor domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 206MYND-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IPR3. Eukaryota.
ENOG410ZWZX. LUCA.
GeneTreeiENSGT00730000110295.
HOVERGENiHBG108555.
InParanoidiQ9BXT4.
KOiK18405.
OMAiCVAKYTV.
OrthoDBiEOG091G00Z5.
PhylomeDBiQ9BXT4.
TreeFamiTF343710.

Family and domain databases

InterProiIPR002999. Tudor.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF00567. TUDOR. 4 hits.
PF01753. zf-MYND. 1 hit.
[Graphical view]
SMARTiSM00333. TUDOR. 4 hits.
[Graphical view]
PROSITEiPS50304. TUDOR. 4 hits.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BXT4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVKSPFNVM SRNNLEAPPC KMTEPFNFEK NENKLPPHES LRSPGTLPNH
60 70 80 90 100
PNFRLKSSEN GNKKNNFLLC EQTKQYLASQ EDNSVSSNPN GINGEVVGSK
110 120 130 140 150
GDRKKLPAGN SVSPPSAESN SPPKEVNIKP GNNVRPAKSK KLNKLVENSL
160 170 180 190 200
SISNPGLFTS LGPPLRSTTC HRCGLFGSLR CSQCKQTYYC STACQRRDWS
210 220 230 240 250
AHSIVCRPVQ PNFHKLENKS SIETKDVEVN NKSDCPLGVT KEIAIWAERI
260 270 280 290 300
MFSDLRSLQL KKTMEIKGTV TEFKHPGDFY VQLYSSEVLE YMNQLSASLK
310 320 330 340 350
ETYANVHEKD YIPVKGEVCI AKYTVDQTWN RAIIQNVDVQ QKKAHVLYID
360 370 380 390 400
YGNEEIIPLN RIYHLNRNID LFPPCAIKCF VANVIPAEGN WSSDCIKATK
410 420 430 440 450
PLLMEQYCSI KIVDILEEEV VTFAVEVELP NSGKLLDHVL IEMGYGLKPS
460 470 480 490 500
GQDSKKENAD QSDPEDVGKM TTENNIVVDK SDLIPKVLTL NVGDEFCGVV
510 520 530 540 550
AHIQTPEDFF CQQLQSGRKL AELQASLSKY CDQLPPRSDF YPAIGDICCA
560 570 580 590 600
QFSEDDQWYR ASVLAYASEE SVLVGYVDYG NFEILSLMRL CPIIPKLLEL
610 620 630 640 650
PMQAIKCVLA GVKPSLGIWT PEAICLMKKL VQNKIITVKV VDKLENSSLV
660 670 680 690 700
ELIDKSETPH VSVSKVLLDA GFAVGEQSMV TDKPSDVKET SVPLGVEGKV
710 720 730 740 750
NPLEWTWVEL GVDQTVDVVV CVIYSPGEFY CHVLKEDALK KLNDLNKSLA
760 770 780 790 800
EHCQQKLPNG FKAEIGQPCC AFFAGDGSWY RALVKEILPN GHVKVHFVDY
810 820 830 840 850
GNIEEVTADE LRMISSTFLN LPFQGIRCQL ADIQSRNKHW SEEAITRFQM
860 870 880 890 900
CVAGIKLQAR VVEVTENGIG VELTDLSTCY PRIISDVLID EHLVLKSASP
910 920 930 940 950
HKDLPNDRLV NKHELQVHVQ GLQATSSAEQ WKTIELPVDK TIQANVLEII
960 970 980 990 1000
SPNLFYALPK GMPENQEKLC MLTAELLEYC NAPKSRPPYR PRIGDACCAK
1010 1020 1030 1040 1050
YTSDDFWYRA VVLGTSDTDV EVLYADYGNI ETLPLCRVQP ITSSHLALPF
1060 1070 1080 1090 1100
QIIRCSLEGL MELNGSSSQL IIMLLKNFML NQNVMLSVKG ITKNVHTVSV
1110 1120 1130 1140 1150
EKCSENGTVD VADKLVTFGL AKNITPQRQS ALNTEKMYRM NCCCTELQKQ
1160 1170 1180
VEKHEHILLF LLNNSTNQNK FIEMKKLLKS
Length:1,180
Mass (Da):132,024
Last modified:September 23, 2008 - v2
Checksum:i9B024C7D94F1D7E1
GO
Isoform 2 (identifier: Q9BXT4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     554-610: Missing.
     775-831: Missing.

Show »
Length:1,066
Mass (Da):119,132
Checksum:iA45D1010B43A7716
GO
Isoform 3 (identifier: Q9BXT4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1180-1180: S → KTASLGGKPL

Note: No experimental confirmation available.
Show »
Length:1,189
Mass (Da):132,890
Checksum:i13C4483F73426DA6
GO
Isoform 4 (identifier: Q9BXT4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-291: Missing.
     328-375: Missing.
     554-610: Missing.
     1059-1134: Missing.

Note: No experimental confirmation available.
Show »
Length:708
Mass (Da):79,170
Checksum:iF0ECCC6F3C19BF9F
GO

Sequence cautioni

The sequence AAH35010 differs from that shown. Potential poly-A sequence.Curated
The sequence AAK31985 differs from that shown. Contaminating sequence.Curated
The sequence AAK31985 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14982 differs from that shown. Potential poly-A sequence.Curated
The sequence BAB14982 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251M → T in BAG53796 (PubMed:14702039).Curated1
Sequence conflicti1140M → T in AAK31985 (PubMed:11279525).Curated1
Sequence conflicti1178L → V in AAK31985 (PubMed:11279525).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057321864V → L.Corresponds to variant rs7914059dbSNPEnsembl.1
Natural variantiVAR_0573221138Y → C.Corresponds to variant rs34112549dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0366671 – 291Missing in isoform 4. 1 PublicationAdd BLAST291
Alternative sequenceiVSP_036668328 – 375Missing in isoform 4. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_035481554 – 610Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST57
Alternative sequenceiVSP_035482775 – 831Missing in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0366691059 – 1134Missing in isoform 4. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_0366701180S → KTASLGGKPL in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022023 Genomic DNA. No translation available.
AK122916 mRNA. Translation: BAG53796.1.
AK304331 mRNA. Translation: BAG65177.1.
CH471066 Genomic DNA. Translation: EAW49479.1.
CH471066 Genomic DNA. Translation: EAW49480.1.
BC035010 mRNA. Translation: AAH35010.1. Sequence problems.
BC063133 mRNA. Translation: AAH63133.1.
AF285606 mRNA. Translation: AAK31985.1. Sequence problems.
AK024735 mRNA. Translation: BAB14982.1. Sequence problems.
CCDSiCCDS7588.1. [Q9BXT4-3]
RefSeqiNP_942090.1. NM_198795.1. [Q9BXT4-3]
XP_005270035.1. XM_005269978.2. [Q9BXT4-3]
XP_011538261.1. XM_011539959.2. [Q9BXT4-3]
XP_011538262.1. XM_011539960.2. [Q9BXT4-3]
XP_011538263.1. XM_011539961.2. [Q9BXT4-3]
XP_011538264.1. XM_011539962.1. [Q9BXT4-3]
XP_011538265.1. XM_011539963.1. [Q9BXT4-1]
UniGeneiHs.333132.

Genome annotation databases

EnsembliENST00000251864; ENSP00000251864; ENSG00000095627. [Q9BXT4-3]
GeneIDi56165.
KEGGihsa:56165.
UCSCiuc001lbg.1. human. [Q9BXT4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022023 Genomic DNA. No translation available.
AK122916 mRNA. Translation: BAG53796.1.
AK304331 mRNA. Translation: BAG65177.1.
CH471066 Genomic DNA. Translation: EAW49479.1.
CH471066 Genomic DNA. Translation: EAW49480.1.
BC035010 mRNA. Translation: AAH35010.1. Sequence problems.
BC063133 mRNA. Translation: AAH63133.1.
AF285606 mRNA. Translation: AAK31985.1. Sequence problems.
AK024735 mRNA. Translation: BAB14982.1. Sequence problems.
CCDSiCCDS7588.1. [Q9BXT4-3]
RefSeqiNP_942090.1. NM_198795.1. [Q9BXT4-3]
XP_005270035.1. XM_005269978.2. [Q9BXT4-3]
XP_011538261.1. XM_011539959.2. [Q9BXT4-3]
XP_011538262.1. XM_011539960.2. [Q9BXT4-3]
XP_011538263.1. XM_011539961.2. [Q9BXT4-3]
XP_011538264.1. XM_011539962.1. [Q9BXT4-3]
XP_011538265.1. XM_011539963.1. [Q9BXT4-1]
UniGeneiHs.333132.

3D structure databases

ProteinModelPortaliQ9BXT4.
SMRiQ9BXT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121098. 5 interactors.
IntActiQ9BXT4. 3 interactors.
MINTiMINT-7242011.
STRINGi9606.ENSP00000251864.

PTM databases

iPTMnetiQ9BXT4.
PhosphoSitePlusiQ9BXT4.

Polymorphism and mutation databases

BioMutaiTDRD1.
DMDMi206729901.

Proteomic databases

MaxQBiQ9BXT4.
PaxDbiQ9BXT4.
PeptideAtlasiQ9BXT4.
PRIDEiQ9BXT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251864; ENSP00000251864; ENSG00000095627. [Q9BXT4-3]
GeneIDi56165.
KEGGihsa:56165.
UCSCiuc001lbg.1. human. [Q9BXT4-1]

Organism-specific databases

CTDi56165.
DisGeNETi56165.
GeneCardsiTDRD1.
H-InvDBHIX0009225.
HGNCiHGNC:11712. TDRD1.
HPAiHPA037729.
HPA037730.
MIMi605796. gene.
neXtProtiNX_Q9BXT4.
OpenTargetsiENSG00000095627.
PharmGKBiPA36430.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPR3. Eukaryota.
ENOG410ZWZX. LUCA.
GeneTreeiENSGT00730000110295.
HOVERGENiHBG108555.
InParanoidiQ9BXT4.
KOiK18405.
OMAiCVAKYTV.
OrthoDBiEOG091G00Z5.
PhylomeDBiQ9BXT4.
TreeFamiTF343710.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000095627-MONOMER.
ReactomeiR-HSA-5601884. PIWI-interacting RNA (piRNA) biogenesis.

Miscellaneous databases

GenomeRNAii56165.
PROiQ9BXT4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000095627.
CleanExiHS_TDRD1.
ExpressionAtlasiQ9BXT4. baseline and differential.

Family and domain databases

InterProiIPR002999. Tudor.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF00567. TUDOR. 4 hits.
PF01753. zf-MYND. 1 hit.
[Graphical view]
SMARTiSM00333. TUDOR. 4 hits.
[Graphical view]
PROSITEiPS50304. TUDOR. 4 hits.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTDRD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BXT4
Secondary accession number(s): A6NEN3
, A6NMN2, B3KVI4, B4E2L5, D3DRC2, Q4G0Y8, Q6P518, Q9H7B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.