Q9BXT2 (CCG6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent calcium channel gamma-6 subunit

Alternative name(s):
Neuronal voltage-gated calcium channel gamma-6 subunit

Gene names

Name:

CACNG6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.
Subunit structure	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	voltage-gated calcium channel complex Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	voltage-gated calcium channel activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Voltage-dependent calcium channel gamma-6 subunit		PRO_0000164684
Regions
	Transmembrane	43 – 63	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
	Transmembrane	169 – 189	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential
Natural variations
	Natural variant	252	1	C → S. Corresponds to variant rs12980121 [ dbSNP | Ensembl ].		VAR_061540

Sequences

	Sequence		Length	Mass (Da)
	Q9BXT2 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 674433E331FD9974	FASTA	260	28,129
	10 20 30 40 50 60 MMWSNFFLQE ENRRRGAAGR RRAHGQGRSG LTPEREGKVK LALLLAAVGA TLAVLSVGTE 70 80 90 100 110 120 FWVELNTYKA NGSAVCEAAH LGLWKACTKR LWQADVPVDR DTCGPAELPG EANCTYFKFF 130 140 150 160 170 180 TTGENARIFQ RTTKKEVNLA AAVIAVLGLA VMALGCLCII MVLSKGAEFL LRVGAVCFGL 190 200 210 220 230 240 SGLLLLVSLE VFRHSVRALL QRVSPEPPPA PRLTYEYSWS LGCGVGAGLI LLLGAGCFLL 250 260 LTLPSWPWGS LCPKRGHRAT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family." Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L. Genomics 71:339-350(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Calcium channel gamma subunits provide insights into the evolution of this gene family." Chu P.-J., Robertson H.M., Best P.M. Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF288386 mRNA. Translation: AAK20029.1. AF361352 mRNA. Translation: AAL50047.1. BC021552 mRNA. Translation: AAH21552.1.
IPI	IPI00011072.
RefSeq	NP_114103.2. NM_031897.2. NP_665813.1. NM_145814.1. NP_665814.1. NM_145815.1.
UniGene	Hs.631560.
3D structure databases
ProteinModelPortal	Q9BXT2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000252729.
Protein family/group databases
TCDB	8.A.16.1.2. Ca+ channel auxiliary subunit gamma1-gamma8 (CCAgamma) family.
Polymorphism databases
DMDM	20532019.
Proteomic databases
PaxDb	Q9BXT2.
PRIDE	Q9BXT2.
Protocols and materials databases
DNASU	59285.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252729; ENSP00000252729; ENSG00000130433.
GeneID	59285.
KEGG	hsa:59285.
UCSC	uc002qct.3. human.
Organism-specific databases
CTD	59285.
GeneCards	GC19P054495.
HGNC	HGNC:13625. CACNG6.
MIM	606898. gene.
neXtProt	NX_Q9BXT2.
PharmGKB	PA26020.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45843.
HOGENOM	HOG000293219.
HOVERGEN	HBG003868.
InParanoid	Q9BXT2.
KO	K04871.
OMA	GEANCTY.
OrthoDB	EOG441QCN.
PhylomeDB	Q9BXT2.
Gene expression databases
ArrayExpress	Q9BXT2.
Bgee	Q9BXT2.
CleanEx	HS_CACNG6.
Genevestigator	Q9BXT2.
GermOnline	ENSG00000130433. Homo sapiens.
Family and domain databases
InterPro	IPR008370. VDCC_g6su. IPR008368. VDCC_gsu. [Graphical view]
PRINTS	PR01792. VDCCGAMMA. PR01794. VDCCGAMMA6.
ProtoNet	Search...
Other
GenomeRNAi	59285.
NextBio	65178.
SOURCE	Search...

Entry information

Entry name

CCG6_HUMAN

Accession

Primary (citable) accession number: Q9BXT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.