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Q9BXS9

- S26A6_HUMAN

UniProt

Q9BXS9 - S26A6_HUMAN

Protein

Solute carrier family 26 member 6

Gene

SLC26A6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.
    Isoform 4: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.

    Enzyme regulationi

    Apical membrane chloride-formate exchange activity in the proximal tubules of the kidney and oxalate secretion in the duodenum are inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters) By similarity. Apical membrane chloride-bicarbonate exchange activity of the pancreatic duct is inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). Isoform 4, isoform 5 and isoform 6 chloride, bicarbonate and sulfate transport activities are inhibited by DIDS.By similarity3 Publications

    GO - Molecular functioni

    1. anion:anion antiporter activity Source: UniProtKB
    2. bicarbonate transmembrane transporter activity Source: UniProtKB
    3. chloride channel activity Source: UniProtKB-KW
    4. chloride transmembrane transporter activity Source: UniProtKB
    5. efflux transmembrane transporter activity Source: UniProtKB
    6. formate efflux transmembrane transporter activity Source: UniProtKB
    7. formate transmembrane transporter activity Source: UniProtKB
    8. formate uptake transmembrane transporter activity Source: UniProtKB
    9. oxalate transmembrane transporter activity Source: UniProtKB
    10. PDZ domain binding Source: UniProtKB
    11. protein binding Source: UniProtKB
    12. secondary active sulfate transmembrane transporter activity Source: InterPro
    13. sulfate transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. angiotensin-activated signaling pathway Source: UniProtKB
    2. anion transport Source: GOC
    3. bicarbonate transport Source: GOC
    4. cellular response to cAMP Source: UniProtKB
    5. cellular response to fructose stimulus Source: UniProtKB
    6. cellular response to interferon-gamma Source: UniProtKB
    7. chloride transmembrane transport Source: GOC
    8. chloride transport Source: GOC
    9. epithelial fluid transport Source: UniProtKB
    10. formate transport Source: UniProtKB
    11. intestinal absorption Source: UniProtKB
    12. intracellular pH elevation Source: UniProtKB
    13. ion transport Source: Reactome
    14. mannitol transport Source: UniProtKB
    15. oxalate transport Source: UniProtKB
    16. oxalic acid secretion Source: UniProtKB
    17. positive regulation of dipeptide transmembrane transport Source: UniProtKB
    18. protein kinase C signaling Source: UniProtKB
    19. regulation of intracellular pH Source: UniProtKB
    20. sperm capacitation Source: UniProtKB
    21. sulfate transmembrane transport Source: GOC
    22. sulfate transport Source: UniProtKB
    23. transepithelial chloride transport Source: UniProtKB
    24. transepithelial transport Source: UniProtKB
    25. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Chloride channel, Ion channel

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_19357. Multifunctional anion exchangers.

    Protein family/group databases

    TCDBi2.A.53.2.7. the sulfate permease (sulp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 26 member 6
    Alternative name(s):
    Anion exchange transporter
    Pendrin-like protein 1
    Short name:
    Pendrin-L1
    Gene namesi
    Name:SLC26A6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:14472. SLC26A6.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Apical cell membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein By similarity. Microsome By similarity
    Note: Localized in sperm membranes. Colocalizes with CFTR at the midpiece of sperm tail. Localizes to the apical membrane brush border of epithelial cells in the proximal tubules of kidney, of enterocytes of the small intestine and of gastric parietal cells in the stomach. May be translocated from the cytosolic surface of the cell membrane to the intracellular space by PKC in phorbol myristate acetate (PMA)-induced cells By similarity. Colocalized with CA2 at the surface of the cell membrane in order to form a bicarbonate transport metabolon; colocalization is reduced in phorbol myristate acetate (PMA)-induced cells.By similarity
    Isoform 4 : Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein
    Note: Localizes to the apical and basolateral surfaces of tubular wall cells in kidney and in the brush border of pancreatic duct cells.

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. basolateral plasma membrane Source: UniProtKB
    3. brush border membrane Source: UniProtKB
    4. chloride channel complex Source: UniProtKB-KW
    5. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    6. endoplasmic reticulum Source: UniProtKB-KW
    7. integral component of membrane Source: UniProtKB
    8. membrane Source: UniProtKB
    9. membrane-bounded vesicle Source: UniProtKB
    10. plasma membrane Source: UniProtKB
    11. sperm midpiece Source: UniProtKB
    12. vesicle membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi568 – 5703DVD → NVN: Does not inhibit cell membrane localization. Inhibits interaction with CA2 and bicarbonate transport.
    Mutagenesisi574 – 5741S → A: Does not inhibit interaction with CA2. Inhibits interaction with CA2 and bicarbonate transport in PMA-induced cells. 1 Publication
    Mutagenesisi603 – 6031S → A: Does not inhibit interaction with CA2. Does not inhibit interaction with CA2 and bicarbonate transport in PMA-induced cells. 1 Publication

    Organism-specific databases

    PharmGKBiPA37889.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759Solute carrier family 26 member 6PRO_0000080171Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei574 – 5741Phosphoserine; by PKC1 Publication
    Modified residuei603 – 6031Phosphoserine; by PKC1 Publication
    Modified residuei616 – 6161Phosphoserine1 Publication
    Modified residuei752 – 7521Phosphoserine2 Publications
    Modified residuei755 – 7551Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated on serine residues by PKC; the phosphorylation disrupts interaction with carbonic anhydrase CA2 and reduces bicarbonate transport activity in a phorbol myristate acetate (PMA)-induced manner.3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BXS9.
    PaxDbiQ9BXS9.
    PRIDEiQ9BXS9.

    PTM databases

    PhosphoSiteiQ9BXS9.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highest levels in kidney and pancreas. Lower expression in heart, skeletal muscle, liver and placenta. Also found in lung and brain. Isoform 4 is ubiquitously expressed. Isoform 6 is expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis and ovary. Isoform 5 is expressed weakly in placenta, lung, liver and pancreas.2 Publications

    Inductioni

    Down-regulated by pro-inflammatory cytokine IFN gamma.1 Publication

    Gene expression databases

    ArrayExpressiQ9BXS9.
    BgeeiQ9BXS9.
    CleanExiHS_SLC26A6.
    GenevestigatoriQ9BXS9.

    Organism-specific databases

    HPAiHPA048363.

    Interactioni

    Subunit structurei

    Interacts (via C-terminal domain) with PDZK1 (via C-terminal PDZ domain); the interaction induces chloride and oxalate exchange transport. Interacts with CFTR, SLC26A3 and SLC9A3R1 By similarity. Isoform 4 interacts (via C-terminal cytoplasmic domain) with CA2; the interaction stimulates chloride-bicarbonate exchange activity. Isoform 4 and isoform 5 interact with SLC9A3R1 (via the PDZ domains). Isoform 4 and isoform 5 interact with SLC9A3R2 (via the PDZ domains).By similarity2 Publications

    Protein-protein interaction databases

    BioGridi122373. 1 interaction.
    STRINGi9606.ENSP00000378920.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXS9.
    SMRiQ9BXS9. Positions 511-560, 667-739.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 115115CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini137 – 18650ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 26356CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini285 – 2939ExtracellularSequence Analysis
    Topological domaini315 – 34733CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini369 – 37911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini401 – 41616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini438 – 48447ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini506 – 759254CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei485 – 50521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini530 – 742213STASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    HOGENOMiHOG000006546.
    HOVERGENiHBG000639.
    KOiK14704.
    OMAiNNVEDCK.
    OrthoDBiEOG76T9QT.
    PhylomeDBiQ9BXS9.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    TIGRFAMsiTIGR00815. sulP. 1 hit.
    PROSITEiPS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BXS9-1) [UniParc]FASTAAdd to Basket

    Also known as: SLC26A6b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLADASGPR DTQALLSATQ AMDLRRRDYH MERPLLNQEH LEELGRWGSA    50
    PRTHQWRTWL QCSRARAYAL LLQHLPVLVW LPRYPVRDWL LGDLLSGLSV 100
    AIMQLPQGLA YALLAGLPPV FGLYSSFYPV FIYFLFGTSR HISVGTFAVM 150
    SVMVGSVTES LAPQALNDSM INETARDAAR VQVASTLSVL VGLFQVGLGL 200
    IHFGFVVTYL SEPLVRGYTT AAAVQVFVSQ LKYVFGLHLS SHSGPLSLIY 250
    TVLEVCWKLP QSKVGTVVTA AVAGVVLVVV KLLNDKLQQQ LPMPIPGELL 300
    TLIGATGISY GMGLKHRFEV DVVGNIPAGL VPPVAPNTQL FSKLVGSAFT 350
    IAVVGFAIAI SLGKIFALRH GYRVDSNQEL VALGLSNLIG GIFQCFPVSC 400
    SMSRSLVQES TGGNSQVAGA ISSLFILLII VKLGELFHDL PKAVLAAIII 450
    VNLKGMLRQL SDMRSLWKAN RADLLIWLVT FTATILLNLD LGLVVAVIFS 500
    LLLVVVRTQM PHYSVLGQVP DTDIYRDVAE YSEAKEVRGV KVFRSSATVY 550
    FANAEFYSDA LKQRCGVDVD FLISQKKKLL KKQEQLKLKQ LQKEEKLRKQ 600
    AASPKGASVS INVNTSLEDM RSNNVEDCKM MQVSSGDKME DATANGQEDS 650
    KAPDGSTLKA LGLPQPDFHS LILDLGALSF VDTVCLKSLK NIFHDFREIE 700
    VEVYMAACHS PVVSQLEAGH FFDASITKKH LFASVHDAVT FALQHPRPVP 750
    DSPVSVTRL 759
    Length:759
    Mass (Da):82,967
    Last modified:June 1, 2001 - v1
    Checksum:i63CB0B756C9675C6
    GO
    Isoform 2 (identifier: Q9BXS9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         602-631: ASPKGASVSINVNTSLEDMRSNNVEDCKMM → GPLLSACLAPQ

    Note: No experimental confirmation available.

    Show »
    Length:740
    Mass (Da):80,807
    Checksum:i9BBFAB68E0D8B2C5
    GO
    Isoform 3 (identifier: Q9BXS9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         632-632: Missing.

    Show »
    Length:758
    Mass (Da):82,839
    Checksum:i6CC16170D6F9F01C
    GO
    Isoform 4 (identifier: Q9BXS9-4) [UniParc]FASTAAdd to Basket

    Also known as: SLC26A6a

    The sequence of this isoform differs from the canonical sequence as follows:
         1-21: Missing.
         632-632: Missing.

    Show »
    Length:737
    Mass (Da):80,782
    Checksum:i1AFAFB8DEDB69E6E
    GO
    Isoform 5 (identifier: Q9BXS9-5) [UniParc]FASTAAdd to Basket

    Also known as: SLC26A6c

    The sequence of this isoform differs from the canonical sequence as follows:
         1-21: Missing.
         264-301: Missing.
         632-632: Missing.

    Show »
    Length:699
    Mass (Da):76,876
    Checksum:i8E03EA6F5DE56EFC
    GO
    Isoform 6 (identifier: Q9BXS9-6) [UniParc]FASTAAdd to Basket

    Also known as: SLC26A6d

    The sequence of this isoform differs from the canonical sequence as follows:
         1-21: Missing.
         632-759: QVSSGDKMED...PDSPVSVTRL → VRLEVGKEVT...SGSVVICHRI

    Show »
    Length:671
    Mass (Da):73,817
    Checksum:iB2C9AD808C256713
    GO
    Isoform 7 (identifier: Q9BXS9-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         145-216: GTFAVMSVMV...VTYLSEPLVR → ATPGPLPLLT...PLWATVPHLL
         217-252: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:723
    Mass (Da):79,159
    Checksum:iA3D9F408FD3DD9F3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti206 – 2061V → M.1 Publication
    Corresponds to variant rs13324142 [ dbSNP | Ensembl ].
    VAR_012776

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2121Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_046807Add
    BLAST
    Alternative sequencei145 – 21672GTFAV…EPLVR → ATPGPLPLLTAPGRPTGGAG PDPLRLRGHLPVRTSCPRLY HSCSCAGLRLTAQVCVWPPS EQPLWATVPHLL in isoform 7. 1 PublicationVSP_055273Add
    BLAST
    Alternative sequencei217 – 25236Missing in isoform 7. 1 PublicationVSP_055274Add
    BLAST
    Alternative sequencei264 – 30138Missing in isoform 5. CuratedVSP_047851Add
    BLAST
    Alternative sequencei602 – 63130ASPKG…DCKMM → GPLLSACLAPQ in isoform 2. 1 PublicationVSP_006169Add
    BLAST
    Alternative sequencei632 – 759128QVSSG…SVTRL → VRLEVGKEVTAVSCRDAGST CLMRNAMDPAAVGSRVLRRW QEEWGGWVRYSSGSVVICHR I in isoform 6. CuratedVSP_047852Add
    BLAST
    Alternative sequencei632 – 6321Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsVSP_040127

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF279265 mRNA. Translation: AAF81911.1.
    AF288410 mRNA. Translation: AAK19153.1.
    AF416721 mRNA. Translation: AAN07094.1.
    AB033288 mRNA. Translation: BAB69041.1.
    AK297695 mRNA. Translation: BAG60053.1.
    AC121252 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64901.1.
    CH471055 Genomic DNA. Translation: EAW64903.1.
    BC017697 mRNA. Translation: AAH17697.1.
    CCDSiCCDS43087.1. [Q9BXS9-1]
    CCDS46824.1. [Q9BXS9-2]
    CCDS46825.1. [Q9BXS9-3]
    CCDS63628.1. [Q9BXS9-7]
    RefSeqiNP_001035544.1. NM_001040454.1.
    NP_001268661.1. NM_001281732.1.
    NP_001268662.1. NM_001281733.1.
    NP_075062.2. NM_022911.2. [Q9BXS9-1]
    NP_599025.2. NM_134263.2. [Q9BXS9-3]
    NP_602298.2. NM_134426.2. [Q9BXS9-2]
    UniGeneiHs.631925.
    Hs.663208.

    Genome annotation databases

    EnsembliENST00000358747; ENSP00000351597; ENSG00000225697.
    ENST00000383733; ENSP00000373239; ENSG00000225697. [Q9BXS9-2]
    ENST00000395550; ENSP00000378920; ENSG00000225697. [Q9BXS9-1]
    ENST00000420764; ENSP00000404684; ENSG00000225697. [Q9BXS9-3]
    ENST00000455886; ENSP00000401066; ENSG00000225697. [Q9BXS9-7]
    GeneIDi65010.
    KEGGihsa:65010.
    UCSCiuc003cug.3. human. [Q9BXS9-1]
    uc003cui.3. human.
    uc003cuj.3. human. [Q9BXS9-2]

    Polymorphism databases

    DMDMi20140224.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF279265 mRNA. Translation: AAF81911.1 .
    AF288410 mRNA. Translation: AAK19153.1 .
    AF416721 mRNA. Translation: AAN07094.1 .
    AB033288 mRNA. Translation: BAB69041.1 .
    AK297695 mRNA. Translation: BAG60053.1 .
    AC121252 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64901.1 .
    CH471055 Genomic DNA. Translation: EAW64903.1 .
    BC017697 mRNA. Translation: AAH17697.1 .
    CCDSi CCDS43087.1. [Q9BXS9-1 ]
    CCDS46824.1. [Q9BXS9-2 ]
    CCDS46825.1. [Q9BXS9-3 ]
    CCDS63628.1. [Q9BXS9-7 ]
    RefSeqi NP_001035544.1. NM_001040454.1.
    NP_001268661.1. NM_001281732.1.
    NP_001268662.1. NM_001281733.1.
    NP_075062.2. NM_022911.2. [Q9BXS9-1 ]
    NP_599025.2. NM_134263.2. [Q9BXS9-3 ]
    NP_602298.2. NM_134426.2. [Q9BXS9-2 ]
    UniGenei Hs.631925.
    Hs.663208.

    3D structure databases

    ProteinModelPortali Q9BXS9.
    SMRi Q9BXS9. Positions 511-560, 667-739.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122373. 1 interaction.
    STRINGi 9606.ENSP00000378920.

    Protein family/group databases

    TCDBi 2.A.53.2.7. the sulfate permease (sulp) family.

    PTM databases

    PhosphoSitei Q9BXS9.

    Polymorphism databases

    DMDMi 20140224.

    Proteomic databases

    MaxQBi Q9BXS9.
    PaxDbi Q9BXS9.
    PRIDEi Q9BXS9.

    Protocols and materials databases

    DNASUi 65010.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358747 ; ENSP00000351597 ; ENSG00000225697 .
    ENST00000383733 ; ENSP00000373239 ; ENSG00000225697 . [Q9BXS9-2 ]
    ENST00000395550 ; ENSP00000378920 ; ENSG00000225697 . [Q9BXS9-1 ]
    ENST00000420764 ; ENSP00000404684 ; ENSG00000225697 . [Q9BXS9-3 ]
    ENST00000455886 ; ENSP00000401066 ; ENSG00000225697 . [Q9BXS9-7 ]
    GeneIDi 65010.
    KEGGi hsa:65010.
    UCSCi uc003cug.3. human. [Q9BXS9-1 ]
    uc003cui.3. human.
    uc003cuj.3. human. [Q9BXS9-2 ]

    Organism-specific databases

    CTDi 65010.
    GeneCardsi GC03M048664.
    HGNCi HGNC:14472. SLC26A6.
    HPAi HPA048363.
    MIMi 610068. gene.
    neXtProti NX_Q9BXS9.
    PharmGKBi PA37889.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0659.
    HOGENOMi HOG000006546.
    HOVERGENi HBG000639.
    KOi K14704.
    OMAi NNVEDCK.
    OrthoDBi EOG76T9QT.
    PhylomeDBi Q9BXS9.
    TreeFami TF313784.

    Enzyme and pathway databases

    Reactomei REACT_19357. Multifunctional anion exchangers.

    Miscellaneous databases

    GeneWikii SLC26A6.
    GenomeRNAii 65010.
    NextBioi 35473466.
    PROi Q9BXS9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BXS9.
    Bgeei Q9BXS9.
    CleanExi HS_SLC26A6.
    Genevestigatori Q9BXS9.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    TIGRFAMsi TIGR00815. sulP. 1 hit.
    PROSITEi PS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger."
      Lohi H., Kujala M., Kerkelae E., Saarialho-Kere U., Kestilae M., Kere J.
      Genomics 70:102-112(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family."
      Waldegger S., Moschen I., Ramirez A., Smith R.J.H., Ayadi H., Lang F., Kubisch C.
      Genomics 72:43-50(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT MET-206.
    3. "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1."
      Xie Q., Welch R., Mercado A., Romero M.F., Mount D.B.
      Am. J. Physiol. 283:F826-F838(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    4. "Molecular cloning of a new putative sulfate anion transporter."
      Ishibashi K.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Kidney.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
      Tissue: Lung.
    6. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Duodenum.
    9. "Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains."
      Lohi H., Lamprecht G., Markovich D., Heil A., Kujala M., Seidler U., Kere J.
      Am. J. Physiol. 284:C769-C779(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 4; 5 AND 6), FUNCTION, ENZYME REGULATION, INTERACTION WITH SLC9A3R1 AND SLC9A3R2, SUBCELLULAR LOCATION, TOPOLOGY.
    10. "Metabolon disruption: a mechanism that regulates bicarbonate transport."
      Alvarez B.V., Vilas G.L., Casey J.R.
      EMBO J. 24:2499-2511(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION (ISOFORM 4), ENZYME REGULATION, INTERACTION WITH CA2, PHOSPHORYLATION AT SER-574 AND SER-603 BY PKC, SUBCELLULAR LOCATION, MUTAGENESIS OF 568-ASP--ASP-570; SER-574 AND SER-603.
    11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-752, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Characterization of the 5'-flanking region and regulation of expression of human anion exchanger SLC26A6."
      Saksena S., Dwivedi A., Singla A., Gill R.K., Tyagi S., Borthakur A., Alrefai W.A., Ramaswamy K., Dudeja P.K.
      J. Cell. Biochem. 105:454-466(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    13. "Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1."
      Freel R.W., Morozumi M., Hatch M.
      Am. J. Physiol. 297:G918-G929(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION.
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-616; SER-752 AND SER-755, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiS26A6_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXS9
    Secondary accession number(s): B4DMZ1
    , Q548A7, Q96Q90, Q9NQU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3