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Q9BXS6

- NUSAP_HUMAN

UniProt

Q9BXS6 - NUSAP_HUMAN

Protein

Nucleolar and spindle-associated protein 1

Gene

NUSAP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Microtubule-associated protein with the capacity to bundle and stabilize microtubules By similarity. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.By similarity1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. establishment of mitotic spindle localization Source: MGI
    2. mitotic chromosome condensation Source: MGI
    3. mitotic cytokinesis Source: MGI
    4. mitotic sister chromatid segregation Source: MGI
    5. positive regulation of mitosis Source: MGI

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolar and spindle-associated protein 1
    Short name:
    NuSAP
    Gene namesi
    Name:NUSAP1
    Synonyms:ANKT
    ORF Names:BM-037, PRO0310
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:18538. NUSAP1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleusnucleolus By similarity. Cytoplasmcytoskeletonspindle By similarity. Chromosome By similarity
    Note: Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase By similarity. Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis By similarity. Localizes to multiple distinct regions of chromosomes throughout mitosis.By similarity2 Publications

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. cytoplasm Source: HPA
    3. nucleolus Source: HPA
    4. nucleus Source: HPA
    5. spindle microtubule Source: Ensembl

    Keywords - Cellular componenti

    Chromosome, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134987502.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Nucleolar and spindle-associated protein 1PRO_0000302034Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei124 – 1241Phosphoserine; by ATM1 Publication
    Modified residuei135 – 1351Phosphoserine2 Publications
    Modified residuei182 – 1821Phosphothreonine1 Publication
    Modified residuei240 – 2401Phosphoserine2 Publications
    Modified residuei244 – 2441Phosphothreonine1 Publication
    Modified residuei247 – 2471Phosphoserine1 Publication
    Modified residuei276 – 2761Phosphoserine1 Publication
    Modified residuei311 – 3111Phosphoserine1 Publication
    Modified residuei314 – 3141Phosphothreonine2 Publications
    Modified residuei338 – 3381Phosphothreonine1 Publication
    Modified residuei352 – 3521Phosphoserine2 Publications
    Modified residuei411 – 4111N6-acetyllysine1 Publication

    Post-translational modificationi

    Ubiquitinated. Ubiquitination by FZR1 may lead to proteasome-dependent degradation of this protein.1 Publication
    Phosphorylation by ATM in G2/M-phase induces mitotic arrest.4 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ9BXS6.
    PaxDbiQ9BXS6.
    PRIDEiQ9BXS6.

    PTM databases

    PhosphoSiteiQ9BXS6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BXS6.
    BgeeiQ9BXS6.
    CleanExiHS_NUSAP1.
    GenevestigatoriQ9BXS6.

    Organism-specific databases

    HPAiHPA042904.

    Interactioni

    Subunit structurei

    Interacts with DNA and microtubules. Microtubule bundling is inhibited by IPO7, KPNA2 and KPNB1 while association with DNA is also inhibited by IPO7 and KPNA2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi119376. 17 interactions.
    IntActiQ9BXS6. 1 interaction.
    MINTiMINT-5009420.
    STRINGi9606.ENSP00000260359.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BXS6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni237 – 382146Interaction with microtubulesBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili407 – 43226Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi384 – 3907KEN box

    Domaini

    The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination.

    Sequence similaritiesi

    Belongs to the NUSAP family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG43775.
    HOVERGENiHBG108204.
    InParanoidiQ9BXS6.
    OMAiAVITPFK.
    OrthoDBiEOG7BP85G.
    PhylomeDBiQ9BXS6.
    TreeFamiTF329459.

    Family and domain databases

    InterProiIPR026756. NuSAP.
    [Graphical view]
    PANTHERiPTHR15874. PTHR15874. 1 hit.

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BXS6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIIPSLEELD SLKYSDLQNL AKSLGLRANL RATKLLKALK GYIKHEARKG    50
    NENQDESQTS ASSCDETEIQ ISNQEEAERQ PLGHVTKTRR RCKTVRVDPD 100
    SQQNHSEIKI SNPTEFQNHE KQESQDLRAT AKVPSPPDEH QEAENAVSSG 150
    NRDSKVPSEG KKSLYTDESS KPGKNKRTAI TTPNFKKLHE AHFKEMESID 200
    QYIERKKKHF EEHNSMNELK QQPINKGGVR TPVPPRGRLS VASTPISQRR 250
    SQGRSCGPAS QSTLGLKGSL KRSAISAAKT GVRFSAATKD NEHKRSLTKT 300
    PARKSAHVTV SGGTPKGEAV LGTHKLKTIT GNSAAVITPF KLTTEATQTP 350
    VSNKKPVFDL KASLSRPLNY EPHKGKLKPW GQSKENNYLN QHVNRINFYK 400
    KTYKQPHLQT KEEQRKKREQ ERKEKKAKVL GMRRGLILAE D 441
    Length:441
    Mass (Da):49,452
    Last modified:June 1, 2001 - v1
    Checksum:i1400E1B9F3FB727F
    GO
    Isoform 2 (identifier: Q9BXS6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         221-221: Missing.

    Show »
    Length:440
    Mass (Da):49,324
    Checksum:iE903FADDD7341A2A
    GO
    Isoform 3 (identifier: Q9BXS6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         102-102: Missing.
         221-221: Missing.

    Show »
    Length:439
    Mass (Da):49,196
    Checksum:iBF3DB4438241D00E
    GO
    Isoform 4 (identifier: Q9BXS6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         102-116: Missing.
         221-221: Missing.

    Show »
    Length:425
    Mass (Da):47,570
    Checksum:iCD3A2D4A1838A7B4
    GO
    Isoform 5 (identifier: Q9BXS6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         102-102: Missing.

    Show »
    Length:440
    Mass (Da):49,324
    Checksum:i2496DFF76DAE07B5
    GO
    Isoform 6 (identifier: Q9BXS6-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         102-116: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:426
    Mass (Da):47,698
    Checksum:iDF04D86E64347EC2
    GO
    Isoform 7 (identifier: Q9BXS6-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-54: Missing.
         221-221: Missing.
         336-374: Missing.

    Show »
    Length:378
    Mass (Da):42,352
    Checksum:i67DC255E553C7481
    GO

    Sequence cautioni

    The sequence AAF24034.1 differs from that shown. Reason: Frameshift at position 205.
    The sequence AAF67624.1 differs from that shown. Reason: Frameshift at positions 175 and 205.
    The sequence AAH12887.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331T → D in AL833611. (PubMed:17974005)Curated
    Sequence conflicti43 – 431I → V in BAD96539. 1 PublicationCurated
    Sequence conflicti220 – 2201K → E in BAD96539. 1 PublicationCurated
    Sequence conflicti331 – 3311G → V in BAG56712. (PubMed:14702039)Curated
    Sequence conflicti441 – 4411D → DQ in AL833611. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331T → A.
    Corresponds to variant rs7178634 [ dbSNP | Ensembl ].
    VAR_057779
    Natural varianti33 – 331T → N.
    Corresponds to variant rs7178777 [ dbSNP | Ensembl ].
    VAR_057780

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei32 – 5423Missing in isoform 7. 1 PublicationVSP_046805Add
    BLAST
    Alternative sequencei102 – 11615Missing in isoform 4 and isoform 6. 2 PublicationsVSP_027910Add
    BLAST
    Alternative sequencei102 – 1021Missing in isoform 3 and isoform 5. 1 PublicationVSP_027911
    Alternative sequencei221 – 2211Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 4 PublicationsVSP_027912
    Alternative sequencei336 – 37439Missing in isoform 7. 1 PublicationVSP_046806Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF290612 mRNA. Translation: AAK28023.1.
    AF305711 mRNA. Translation: AAG25874.1.
    AF090915 mRNA. Translation: AAF24034.1. Frameshift.
    AK023483 mRNA. Translation: BAB14586.1.
    AK293168 mRNA. Translation: BAG56712.1.
    AK222819 mRNA. Translation: BAD96539.1.
    AL833611 mRNA. No translation available.
    AC087721 Genomic DNA. No translation available.
    CH471125 Genomic DNA. Translation: EAW92483.1.
    CH471125 Genomic DNA. Translation: EAW92486.1.
    BC001308 mRNA. Translation: AAH01308.1.
    BC010838 mRNA. Translation: AAH10838.2.
    BC012887 mRNA. Translation: AAH12887.2. Different initiation.
    BC024772 mRNA. Translation: AAH24772.1.
    AF217513 mRNA. Translation: AAF67624.1. Frameshift.
    CCDSiCCDS45234.1. [Q9BXS6-1]
    CCDS45236.1. [Q9BXS6-2]
    CCDS58356.1. [Q9BXS6-3]
    CCDS58357.1. [Q9BXS6-6]
    CCDS58358.1. [Q9BXS6-7]
    RefSeqiNP_001230071.1. NM_001243142.1. [Q9BXS6-3]
    NP_001230072.1. NM_001243143.1. [Q9BXS6-6]
    NP_001230073.1. NM_001243144.1. [Q9BXS6-7]
    NP_057443.2. NM_016359.4. [Q9BXS6-1]
    NP_060924.4. NM_018454.7. [Q9BXS6-2]
    XP_005254486.1. XM_005254429.1. [Q9BXS6-5]
    XP_005254487.1. XM_005254430.2. [Q9BXS6-4]
    UniGeneiHs.615092.

    Genome annotation databases

    EnsembliENST00000260359; ENSP00000260359; ENSG00000137804. [Q9BXS6-6]
    ENST00000414849; ENSP00000400746; ENSG00000137804. [Q9BXS6-2]
    ENST00000450592; ENSP00000401014; ENSG00000137804. [Q9BXS6-7]
    ENST00000559596; ENSP00000453403; ENSG00000137804. [Q9BXS6-1]
    ENST00000560177; ENSP00000453657; ENSG00000137804. [Q9BXS6-5]
    ENST00000560747; ENSP00000454097; ENSG00000137804. [Q9BXS6-3]
    GeneIDi51203.
    KEGGihsa:51203.
    UCSCiuc001znr.4. human. [Q9BXS6-2]
    uc001zns.4. human. [Q9BXS6-1]
    uc001znt.4. human.
    uc001znu.4. human. [Q9BXS6-5]
    uc001znv.4. human. [Q9BXS6-3]
    uc001znw.4. human. [Q9BXS6-4]

    Polymorphism databases

    DMDMi74717631.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF290612 mRNA. Translation: AAK28023.1 .
    AF305711 mRNA. Translation: AAG25874.1 .
    AF090915 mRNA. Translation: AAF24034.1 . Frameshift.
    AK023483 mRNA. Translation: BAB14586.1 .
    AK293168 mRNA. Translation: BAG56712.1 .
    AK222819 mRNA. Translation: BAD96539.1 .
    AL833611 mRNA. No translation available.
    AC087721 Genomic DNA. No translation available.
    CH471125 Genomic DNA. Translation: EAW92483.1 .
    CH471125 Genomic DNA. Translation: EAW92486.1 .
    BC001308 mRNA. Translation: AAH01308.1 .
    BC010838 mRNA. Translation: AAH10838.2 .
    BC012887 mRNA. Translation: AAH12887.2 . Different initiation.
    BC024772 mRNA. Translation: AAH24772.1 .
    AF217513 mRNA. Translation: AAF67624.1 . Frameshift.
    CCDSi CCDS45234.1. [Q9BXS6-1 ]
    CCDS45236.1. [Q9BXS6-2 ]
    CCDS58356.1. [Q9BXS6-3 ]
    CCDS58357.1. [Q9BXS6-6 ]
    CCDS58358.1. [Q9BXS6-7 ]
    RefSeqi NP_001230071.1. NM_001243142.1. [Q9BXS6-3 ]
    NP_001230072.1. NM_001243143.1. [Q9BXS6-6 ]
    NP_001230073.1. NM_001243144.1. [Q9BXS6-7 ]
    NP_057443.2. NM_016359.4. [Q9BXS6-1 ]
    NP_060924.4. NM_018454.7. [Q9BXS6-2 ]
    XP_005254486.1. XM_005254429.1. [Q9BXS6-5 ]
    XP_005254487.1. XM_005254430.2. [Q9BXS6-4 ]
    UniGenei Hs.615092.

    3D structure databases

    ProteinModelPortali Q9BXS6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119376. 17 interactions.
    IntActi Q9BXS6. 1 interaction.
    MINTi MINT-5009420.
    STRINGi 9606.ENSP00000260359.

    PTM databases

    PhosphoSitei Q9BXS6.

    Polymorphism databases

    DMDMi 74717631.

    Proteomic databases

    MaxQBi Q9BXS6.
    PaxDbi Q9BXS6.
    PRIDEi Q9BXS6.

    Protocols and materials databases

    DNASUi 51203.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260359 ; ENSP00000260359 ; ENSG00000137804 . [Q9BXS6-6 ]
    ENST00000414849 ; ENSP00000400746 ; ENSG00000137804 . [Q9BXS6-2 ]
    ENST00000450592 ; ENSP00000401014 ; ENSG00000137804 . [Q9BXS6-7 ]
    ENST00000559596 ; ENSP00000453403 ; ENSG00000137804 . [Q9BXS6-1 ]
    ENST00000560177 ; ENSP00000453657 ; ENSG00000137804 . [Q9BXS6-5 ]
    ENST00000560747 ; ENSP00000454097 ; ENSG00000137804 . [Q9BXS6-3 ]
    GeneIDi 51203.
    KEGGi hsa:51203.
    UCSCi uc001znr.4. human. [Q9BXS6-2 ]
    uc001zns.4. human. [Q9BXS6-1 ]
    uc001znt.4. human.
    uc001znu.4. human. [Q9BXS6-5 ]
    uc001znv.4. human. [Q9BXS6-3 ]
    uc001znw.4. human. [Q9BXS6-4 ]

    Organism-specific databases

    CTDi 51203.
    GeneCardsi GC15P041624.
    HGNCi HGNC:18538. NUSAP1.
    HPAi HPA042904.
    MIMi 612818. gene.
    neXtProti NX_Q9BXS6.
    PharmGKBi PA134987502.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43775.
    HOVERGENi HBG108204.
    InParanoidi Q9BXS6.
    OMAi AVITPFK.
    OrthoDBi EOG7BP85G.
    PhylomeDBi Q9BXS6.
    TreeFami TF329459.

    Miscellaneous databases

    GenomeRNAii 51203.
    NextBioi 35534796.
    PROi Q9BXS6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BXS6.
    Bgeei Q9BXS6.
    CleanExi HS_NUSAP1.
    Genevestigatori Q9BXS6.

    Family and domain databases

    InterProi IPR026756. NuSAP.
    [Graphical view ]
    PANTHERi PTHR15874. PTHR15874. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens liver nuclear protein mRNA."
      Qu X., Zhang C., Yu Y., Wu S., Wei H., Xing G., Zhai Y., Lu C., Wang M., He F.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal liver.
    2. "A novel nucleolar protein expressed in proliferating cells."
      Sato H., Tanaka Y., Taniguchi M.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Peripheral blood.
    3. "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs."
      Yu Y., Zhang C., Zhou G., Wu S., Qu X., Wei H., Xing G., Dong C., Zhai Y., Wan J., Ouyang S., Li L., Zhang S., Zhou K., Zhang Y., Wu C., He F.
      Genome Res. 11:1392-1403(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Fetal liver.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 7).
      Tissue: Neuroblastoma and Placenta.
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Liver.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    7. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-441 (ISOFORM 4).
      Tissue: Cervix, Lung, Lymph and Placenta.
    10. "A novel gene expressed in human bone marrow."
      Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-207 (ISOFORMS 1/2).
      Tissue: Bone marrow.
    11. "NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization."
      Raemaekers T., Ribbeck K., Beaudouin J., Annaert W., Van Camp M., Stockmans I., Smets N., Bouillon R., Ellenberg J., Carmeliet G.
      J. Cell Biol. 162:1017-1029(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "NuSAP is degraded by APC/C-Cdh1 and its overexpression results in mitotic arrest dependent of its microtubules' affinity."
      Li L., Zhou Y., Sun L., Xing G., Tian C., Sun J., Zhang L., He F.
      Cell. Signal. 19:2046-2055(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, UBIQUITINATION.
    13. "A role for NuSAP in linking microtubules to mitotic chromosomes."
      Ribbeck K., Raemaekers T., Carmeliet G., Mattaj I.W.
      Curr. Biol. 17:230-236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, ASSOCIATION WITH CHROMATIN.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135; THR-182; SER-240; THR-244; SER-247; THR-314 AND SER-352, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-338, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-411, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135; SER-240; SER-276; SER-311; THR-314 AND SER-352, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "ATM-mediated NuSAP phosphorylation induces mitotic arrest."
      Xie P., Li L., Xing G., Tian C., Yin Y., He F., Zhang L.
      Biochem. Biophys. Res. Commun. 404:413-418(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-124 BY ATM.

    Entry informationi

    Entry nameiNUSAP_HUMAN
    AccessioniPrimary (citable) accession number: Q9BXS6
    Secondary accession number(s): B4DDF1
    , E7ERR5, J3KN21, Q53GW2, Q8TBT4, Q96E58, Q96FJ1, Q9GZM9, Q9NZ85, Q9UI70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3